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VASOKINOX 450 PPM MOL/MOL, COMPRESSED MEDICAL GAS

VASOKINOX 450 PPM MOL/MOL, COMPRESSED MEDICAL GAS

Ask a doctor about a prescription for VASOKINOX 450 PPM MOL/MOL, COMPRESSED MEDICAL GAS

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use VASOKINOX 450 PPM MOL/MOL, COMPRESSED MEDICAL GAS

Introduction

Package Leaflet: Information for the User

VasoKINOX 450 ppm mol/mol, Compressed Medical Gas

Nitric Oxide

Read all of this leaflet carefully before you start using this medicine because it contains important information for you

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or nurse.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you experience any side effects, talk to your doctor or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet

  1. What is VasoKINOX 450 ppm mol/mol, Compressed Medical Gas and what is it used for
  2. What you need to know before you use VasoKINOX 450 ppm mol/mol, Compressed Medical Gas
  3. How to use VasoKINOX 450 ppm mol/mol, Compressed Medical Gas
  4. Possible side effects
  5. Storage of VasoKINOX 450 ppm mol/mol Compressed Medical Gas
  6. Contents of the pack and other information

1. What is VasoKINOX and what is it used for

VasoKINOX is a gas mixture, consisting of nitric oxide and nitrogen, used for

treatment of newborns with pulmonary insufficiencyassociated with increased blood pressure in the pulmonary circulation

treatment of acute pulmonary hypertension(increased blood pressure in the pulmonary circulation) that may occur during cardiac surgery in adults and neonates, infants and young children, children and adolescents, from 0 to 17 years old

2. What you need to know before you use VasoKINOX

Do not use VasoKINOX:

  • in neonates with certain heart problems, such as abnormal circulation within the heart (right-to-left shunt, or with malignant right-to-left arterial canal)

Warnings and precautions

Talk to your doctor or nurse before you start using VasoKINOX.

  • Treatment with VasoKINOX should not be stopped abruptly.
  • Blood samples are taken before treatment and regularly during administration to monitor certain parameters.
  • There have been reports of fluid retention in the lungs with nitric oxide in patients with a disease caused by a blocked or narrow vein in the lungs. If you (as a patient) or your child (as a patient) experience shortness of breath or difficulty breathing, contact your doctor immediately.

Using VasoKINOX with other medicines

Tell your doctor if you are using, have recently used or might use any other medicines.

  • VasoKINOX should be used with caution if the following medicines are taken at the same time:
    • "Nitric oxide donors" (such as medicines containing sodium nitroprusside and nitroglycerin). Their effect may add up to that of VasoKINOX.
    • Medicines that generate methemoglobin (such as medicines containing nitrates and sulfonamides, prilocaine). They may increase the concentration of methemoglobin in the blood.
    • Prostacyclin and its analogues
  • It is up to the doctor to decide whether it is necessary to treat you with VasoKINOX and other medicines at the same time.

Pregnancy, breastfeeding and fertility

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine.

Pregnancy:

The effect of administering VasoKINOX in pregnant women is unknown.

As a precautionary measure, it is preferable to avoid using VasoKINOX during pregnancy.

Breastfeeding:

It is unknown whether nitric oxide/metabolites are excreted in human milk.

A decision must be made whether to discontinue breastfeeding or discontinue therapy with VasoKINOX, taking into account the benefits of breastfeeding for the child and the benefits of therapy for the woman.

Fertility:

No fertility studies have been performed.

3. How to use VasoKINOX

Follow exactly the administration instructions of this medicine as indicated by your doctor. In case of doubt, consult your doctor again.

  • VasoKINOX is a medical gas administered only in hospitals by healthcare professionals.
  • The doctor will determine the suitable doseof VasoKINOX, as well as the duration of treatment, depending on your clinical condition and age.
  • VasoKINOX is administered by inhalation, through mechanical ventilationafter dilution in an air/oxygen mixture to patients in intensive care units with respiratory support and also in the operating room.
  • When in contact with oxygen, nitric oxide can be converted into nitrogen dioxide, which irritates the bronchi. For this reason, during its administration, the inhaled concentrations of nitric oxide and nitrogen dioxide are constantly measured.
  • In certain clinical circumstances, it is possible to administer nitric oxide through ventilation with a maskfor a very short period of time (5 to 10 minutes).

If you use moreVasoKINOXthan you should:

Your doctor will take the necessary measures.

If you stop treatment withVasoKINOX:

At the end of treatment in intensive care, the doctor will gradually reduce the dose of VasoKINOX administered (withdrawal phase), monitoring the change in your condition.

In fact, an abrupt interruption of treatment after several hours of administration can cause a deterioration of the clinical condition: this is what is called a "rebound effect".

If you have any other questions about the use of this medicine, ask your doctor or nurse.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Very common side effects (affect more than 1 in 10 people) in association with VasoKINOX therapies include:

. Low platelet count in blood.

Common side effects (affect more than 1 in 100 people) in association with VasoKINOX therapies include:

. Low blood pressure, lack of air or pulmonary collapse.

Uncommon side effects (affect between 1 in 100 and 1 in 1,000 people) are:

. Increased amount of methemoglobin (a form of hemoglobin that cannot carry oxygen) that reduces the amount of oxygen released in the tissues.

Rare side effects (frequency cannot be estimated from the available data) are:

. Bradycardia (slow heart rate) or too low oxygen levels in the blood (oxygen desaturation/hypoxemia) due to abrupt interruption of treatment

. Headache, dizziness, dry throat or shortness of breath after accidental exposure to nitric oxide (e.g. equipment leak or burst)

You should inform the staff directly if you experience a headache while you are near your child during treatment with VasoKINOX.

Reporting of side effects:

If you experience any side effects, talk to your doctor or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: http://www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of VasoKINOX

  • Keep this medicine out of the sight and reach of children.
  • Do not use this medicine after the expiry date which is stated on the label.
  • This medicine does not require any special temperature conditions for storage.
  • The storage of VasoKINOX cylinders is carried out in the hospital.
  • The cylinder must be protected to avoid breakage and falls and must be kept away from any flammable or combustible material and moisture.
  • The cylinders must be kept in a vertical position and well secured and stored in a well-ventilated area.
  • When the gas cylinder is empty, do not dispose of it. The empty cylinders will be collected by the supplier.

6. Contents of the pack and other information

Composition ofVasoKINOX

  • The active substance is nitric oxide; its dose is 450 ppm mol/mol
    • The other components are nitrogen

Appearance of the product and contents of the pack

A 5-liter cylinder filled to 200 bar provides 0.94 m3 of gas at a pressure of 1 bar at 15°C.

A 11-liter cylinder filled to 200 bar provides 2.1 m3 of gas at a pressure of 1 bar at 15°C.

A 20-liter cylinder filled to 200 bar provides 3.8 m3 of gas at a pressure of 1 bar at 15°C.

Marketing authorisation holder and manufacturer

Marketing authorisation holder

AIR LIQUIDE SANTÉ INTERNATIONAL

75 Quai d’Orsay

75007 PARIS Cedex 07

FRANCE

Manufacturer

AIR LIQUIDE SANTÉ FRANCE

“Les Petits Carreaux”

2, avenue du Lys

94380 BONNEUIL-SUR-MARNE

FRANCE

This medicine has been authorised in the EEA Member States with the following names:

  • Austria: VasoKINOX 450 ppm mol/mol Gas zur medizinischen Anwendung, druckverdichtet
  • Belgium: VasoKINOX
  • Denmark: VasoKINOX
  • Germany: VasoKINOX 450 ppm (mol/mol), Gas zur medizinischen Anwendung, druckverdichtet
  • Italy: VasoKINOX
  • Luxembourg: VasoKINOX
  • Norway: Vasokinox
  • Poland: VasoKINOX
  • Portugal: VasoKINOX
  • Spain: VasoKINOX
  • Switzerland: Vasokinox
  • Netherlands: VasoKINOX

Date of last revision of this leaflet: May 2025

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

--------------------------------------------------------------------------------------------------------------------

This information is intended only for healthcare professionals:

To avoid any incidents, the following instructions must be strictly followed:

. Check that the equipment is in good condition before use

. Securely fasten the cylinders using chains or hooks in the basket to avoid accidental falls

. Never open a valve abruptly: open to the left, slowly and completely, then turn the valve a quarter turn

. Do not handle a cylinder whose valve is not protected by a tulip or protection system

. Use a specific ISO 5245 (2004) connector: No. 29 specific NO/N2 (100 ppm

. A pressure regulator that can withstand a pressure at least equal to 1.5 times the maximum operating pressure (200 bar) of the gas cylinder must be used

. For each new use, purge the pressure reducer/flow meter using a nitric oxide/nitrogen mixture

. Do not attempt to repair a faulty valve

. Do not tighten the pressure reducer/flow meter using a clamp, otherwise the seal may be damaged and the administration device may be damaged

. Evacuate exhaled gases to the outside (avoiding areas where they can accumulate). Before use, it must be ensured that the room has an adequate ventilation system for the evacuation of gases in case of an accident or accidental leaks

. Since nitric oxide is colorless and odorless, the use of a detection system is recommended in all rooms where it will be used or stored

. European reference agencies responsible for occupational safety and health recommend the following exposure limits for medical personnel during 8 hours:

  • NO: 2 ppm (2.5 mg/m3)
  • NO2: 0.5 ppm (0.96 mg/m3)

To comply with the above recommendations, an analysis of nitric oxide and nitrogen dioxide in the atmosphere must be implemented.

. The installation of a nitric oxide piping system with a gas cylinder supply source, fixed network, and terminal units is prohibited.

Alternatives to VASOKINOX 450 PPM MOL/MOL, COMPRESSED MEDICAL GAS in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to VASOKINOX 450 PPM MOL/MOL, COMPRESSED MEDICAL GAS in Poland

Dosage form: Gas, 800 ppm mol/mol
Active substance: nitric oxide
Prescription required
Dosage form: Gas, 800 ppm mol/mol
Active substance: nitric oxide
Prescription required
Dosage form: Gas, 200 ppm mol/mol
Active substance: nitric oxide
Prescription required
Dosage form: Gas, 800 ppm (v/v)
Active substance: nitric oxide
Manufacturer: Messer Austria GmbH
Prescription required
Dosage form: Gas, 450 ppm mol/mol
Active substance: nitric oxide
Prescription required
Dosage form: Capsules, 7 mg
Marketing authorisation holder (MAH): OMEDICAMED Unipessoal Lda
Prescription required

Alternative to VASOKINOX 450 PPM MOL/MOL, COMPRESSED MEDICAL GAS in Ukraine

Dosage form: gas, gas cylinder 2 liters
Active substance: nitric oxide
Manufacturer: Messer Avstria GmbH
Prescription required
Dosage form: tablets, 14 or 28 tablets in a container
Prescription required
Dosage form: capsules, 3.5 mg
Dosage form: capsules, 7 mg, 10 capsules in a blister
Dosage form: capsules, 7 mg, 10 capsules in a blister
Manufacturer: OM Farma SA
Prescription required
Dosage form: capsules, 3.5 mg; 10 capsules in a blister
Manufacturer: OM Farma SA
Prescription required

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