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STREPTOMYCIN SULFATE REIG JOFRE 1 g POWDER FOR INJECTABLE SOLUTION

Ask a doctor about a prescription for STREPTOMYCIN SULFATE REIG JOFRE 1 g POWDER FOR INJECTABLE SOLUTION

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Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use STREPTOMYCIN SULFATE REIG JOFRE 1 g POWDER FOR INJECTABLE SOLUTION

Introduction

Package Leaflet: Information for the User.

Streptomycin Reig Jofre 1 g powder for injectable solution

streptomycin (sulfate)

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack:

  1. What Streptomycin Reig Jofre is and what it is used for
  2. What you need to know before you use Streptomycin Reig Jofre
  3. How to use Streptomycin Reig Jofre
  4. Possible side effects
  5. Storing Streptomycin Reig Jofre
  6. Contents of the pack and other information

1. What Streptomycin Reig Jofre is and what it is used for

Streptomycin Reig Jofre is an antibiotic belonging to the aminoglycoside group, used to treat serious infections caused by bacteria.

Text in English about the use of antibiotics and the importance of following medical instructions

Streptomycin Reig Jofre is used in adults and children to treat the following infections:

  • Multidrug-resistant tuberculosis (in combination with other antitubercular medications)
  • Brucellosis (in combination with other antibiotics), also known as Malta fever.
  • Plague
  • Tularemia, an infection caused by contact with infected animals (mainly rabbits and hares)
  • In combination with other antibiotics, to treat endocarditis (inflammation of the inner lining of the heart) caused by bacteria called enterococci.

2. What you need to know before you start taking Streptomycin Reig Jofre

  • If you are allergic to streptomycin, aminoglycosides, or any of the other components of this medicine (listed in section 6).

Warnings and precautions

Talk to your doctor, pharmacist, or nurse before you start using Streptomycin Reig Jofre if:

  • you have a disease that affects nerve and muscle function, such as myasthenia gravis

or Parkinson's disease

  • you do not urinate regularly
  • you are dehydrated
  • you are receiving treatment for kidney problems
  • you have inner ear deafness
  • you are taking other antibiotics
  • you are pregnant or breastfeeding

In these cases, you will receive streptomycin only if your doctor considers it essential for the treatment of your disease. Your doctor will be especially careful when adjusting your streptomycin dose correctly.

Your doctor will be especially careful if you have a disease that affects nerve and muscle function, such as Parkinson's disease or myasthenia gravis, or if you receive a muscle relaxant during an operation, since streptomycin can have a blocking effect on nerve and muscle function.

It is possible that your infection will not respond to streptomycin if you did not respond to other aminoglycoside antibiotics. It is also possible that you will develop an allergic reaction to streptomycin if you are already allergic to another aminoglycoside.

To reduce the risk of nerve and kidney damage, your doctor will be especially careful when evaluating the following:

  • Monitoring of hearing, balance, and kidney function before, during, and after treatment.
  • Dose adjustment according to the degree of kidney function.
  • Monitoring of streptomycin levels in the blood during treatment if necessary.
  • If you already have nerve damage in the ear (hearing loss or balance problems) or if treatment is long-term, additional monitoring of balance and hearing function is required.
  • Avoiding the administration of other substances with potential harmful effects on the auditory nerve or kidneys in combination with streptomycin. If this is unavoidable, close monitoring of kidney function is required.
  • The level of body fluids and urine production should be within the normal range.

Interference with analytical tests:

Streptomycin may cause changes in blood or urine analysis values of certain substances such as urea, transaminases, alkaline phosphatase, bilirubin, creatinine, lactate dehydrogenase, sodium, potassium, magnesium, and calcium.

Other medicines and Streptomycin Reig Jofre

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

The simultaneous or sequential use of Streptomycin Reig Jofre with other medicines that may affect the kidneys or the nervous system (cisplatin, cyclosporin, neomycin, kanamycin, gentamicin, tobramycin, amikacin, netilmicin, paromomycin, capreomycin, amphotericin B, polymyxin B, colistin, vancomycin) should be avoided.

It should not be administered simultaneously or immediately after anesthesia or muscle relaxants.

Aminoglycosides, including streptomycin, may cause toxic effects on the ear, which can be potentiated by the administration of medications such as furosemide, mannitol, and possibly other diuretics.

There is a risk of masking signs of vestibular toxicity (related to balance and spatial control) with drugs used to treat vertigo.

Tell your doctor or pharmacist if you are using or have recently used other medicines, including those obtained without a prescription and herbal medicines.

Pregnancy and breastfeeding

Pregnancy

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine. This medicine should not be used during pregnancy unless it is absolutely necessary.

Breastfeeding

Tell your doctor if you are breastfeeding. The use of streptomycin sulfate is not recommended during breastfeeding.

Driving and using machines

There is no data on the influence of this medicine on the ability to drive and use machines. However, effects such as allergic reactions, blurred vision, deafness, or vertigo may occur, which can affect the ability to drive and use machines.

3. How to use Streptomycin Reig Jofre

This medicine will never be administered by yourself. A qualified person, such as a doctor or nurse, will administer it to you by intramuscular route.

Make sure to drink plenty of fluids while receiving streptomycin.

The recommended dose in adults is:

  • Tuberculosis, tularemia, brucellosis, and endocarditis: 15 mg/kg (maximum 1 g) per day, which can be divided into 2 administrations every 12 hours.
  • Plague: 30 mg/kg (maximum 2 g) per day, divided into 2 administrations every 12 hours.

Use in children over 1 month and adolescents:

  • Tuberculosis, tularemia, brucellosis, and endocarditis: 20-40 mg/kg (maximum 1g) per day, divided into 2-4 administrations every 6-12 hours.
  • Plague: 30 mg/kg (maximum 1g) per day, divided into 2 administrations every 12 hours.

You will not be given Streptomycin Reig Jofre for more than 2 weeks without your doctor reviewing your treatment.

Patients with kidney problems

If you have kidney problems, you will be monitored to adjust the streptomycin levels in your blood correctly, either by reducing the dose or increasing the time between individual doses. Your doctor will adjust the dosage regimen in this case.

If you receive more Streptomycin Reig Jofre than you should

It is very unlikely that you will be given too much Streptomycin Reig Jofre, but if you think you have been given too much, tell your doctor, pharmacist, or nurse immediately. Symptoms may include deafness, balance problems, kidney problems, and/or respiratory paralysis.

In case of overdose or accidental ingestion, consult your doctor or pharmacist or contact the Toxicology Information Service, Telephone 91 562 04 20, indicating the product and the amount administered.

If you forget to use Streptomycin Reig Jofre

If you think you have missed a dose of Streptomycin Reig Jofre, inform your doctor or nurse immediately.

If you stop using Streptomycin Reig Jofre

Your doctor will tell you how long to use Streptomycin Reig Jofre. Do not stop using this medicine without talking to your doctor first.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, Streptomycin Reig Jofre can cause side effects, although not everybody gets them.

Serious side effects

Tell your doctor immediately if you notice any of the following serious side effects, as you may need urgent medical treatment: severe deafness, blood in the urine, difficulty breathing, increased or decreased frequency of urination or urine volume, muscle weakness, and/or increased thirst.

Other side effects

Very common:may affect more than 1 in 10 people

  • Increased urea values in the blood
  • Kidney problems: renal failure (decreased function), high levels of proteins and blood in the urine, renal tubular necrosis (damage to the cells of the kidney tubules)

Common:may affect up to 1 in 10 people

  • Deafness, ringing in the ears
  • Balance problems

Uncommon:may affect up to 1 in 100 people

  • Skin problems (rash, hives)
  • Decreased appetite
  • Nervous system problems: dizziness, ataxia (difficulty coordinating movements), headache, drowsiness, paresthesia (tingling sensation), optic neuritis (inflammation of the optic nerve that can cause sudden partial or complete vision loss), nystagmus (uncontrolled eye movement).
  • Nausea, vomiting, stomatitis (inflamed mouth, painful and with mouth ulcers).
  • Blurred vision
  • Pain at the injection site

Rare:may affect up to 1 in 1,000 people

  • Fever
  • Increased liver enzymes
  • Changes in blood cell count
  • Nervous system problems: neuromuscular blockade (presents with weakness and fatigue), encephalopathy (brain malfunction), peripheral neuropathy (damage to peripheral nerves that presents with numbness in the limbs).
  • Respiratory depression

Very rare:may affect up to 1 in 10,000 people

  • Severe allergic reactions (anaphylactic reactions), with signs such as skin rash or itching; chest tightness or difficulty breathing; swelling of the eyelids, face, or lips; swelling or redness of the tongue; fever; joint pain; swelling of the lymph nodes.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Medicines Monitoring System for Human Use: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing Streptomycin Reig Jofre

Keep this medicine out of the sight and reach of children

Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of the month shown.

No special storage conditions are required. Use the reconstituted solution immediately.

Medicines should not be disposed of via wastewater or household waste. Dispose of the packaging and any unused medicine in the pharmacy's SIGRE collection point. If you are unsure, ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Contents of the pack and other information

  • The active substance is streptomycin sulfate. Each vial contains 1 g of streptomycin (as sulfate).
  • Excipients: none.

Appearance and packaging

Vials containing a sterile white or almost white powder. Pack containing 1 glass vial of 10 ml.

Pack containing 100 glass vials of 10 ml.

Marketing authorization holder and manufacturer

Reig Jofre Laboratory, S.A. Gran Capitán, 10

08970 Sant Joan Despí (Barcelona) Spain

Date of last revision of this leaflet:April 2025.

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.es

This information is intended only for healthcare professionals:

Administration

Streptomycin Reig Jofre 1 g is administered by intramuscular route. Dissolve 1 g of streptomycin in 3 ml of water for injectable preparations.

Reconstitution

The reconstitution of the solution should be performed at the time of administration.

Preparation of solutions for intramuscular injection

Streptomycin Reig Jofre 1g should be dissolved in 3 ml of solvent. The reconstituted solutions have a yellowish color. An increase in the intensity of the color may occur without affecting the potency of the drug. The solution should be examined before injection for any particles or turbidity. If foreign particles are observed, the solution should be discarded.

The streptomycin solution should not be mixed with other medicines due to the risk of precipitation. If necessary, they should be administered in separate solutions.

In general, it is recommended not to mix it with any other product in the same syringe.

Alternatives to STREPTOMYCIN SULFATE REIG JOFRE 1 g POWDER FOR INJECTABLE SOLUTION in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to STREPTOMYCIN SULFATE REIG JOFRE 1 g POWDER FOR INJECTABLE SOLUTION in Польща

Dosage form: Порошок, 1 г
Active substance: streptomycin
Prescription not required

Alternative to STREPTOMYCIN SULFATE REIG JOFRE 1 g POWDER FOR INJECTABLE SOLUTION in Україна

Dosage form: порошок, по 1,0 г флакон з порошком
Active substance: streptomycin
Manufacturer: PAT "Kiivmedpreparat
Prescription required
Dosage form: порошок, по 0,5 г флакон з порошком
Active substance: streptomycin
Manufacturer: PAT "Kiivmedpreparat
Prescription required

Online doctors for STREPTOMYCIN SULFATE REIG JOFRE 1 g POWDER FOR INJECTABLE SOLUTION

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for STREPTOMYCIN SULFATE REIG JOFRE 1 g POWDER FOR INJECTABLE SOLUTION – subject to medical assessment and local rules.

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Jonathan Marshall Ben Ami

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Dr. Jonathan Marshall Ben Ami is a licensed family medicine doctor in Spain. He provides comprehensive care for adults and children, combining general medicine with emergency care expertise to address both acute and chronic health concerns.

Dr. Ben Ami offers expert diagnosis, treatment, and follow-up for:

  • Respiratory infections (cold, flu, bronchitis, pneumonia).
  • ENT conditions such as sinusitis, ear infections, and tonsillitis.
  • Digestive issues including gastritis, acid reflux, and irritable bowel syndrome (IBS).
  • Urinary tract infections and other common infections.
  • Management of chronic diseases: high blood pressure, diabetes, thyroid disorders.
  • Acute conditions requiring urgent medical attention.
  • Headaches, migraines, and minor injuries.
  • Wound care, health check-ups, and ongoing prescriptions.

With a patient-focused and evidence-based approach, Dr. Ben Ami supports individuals at all stages of life — offering clear medical guidance, timely interventions, and continuity of care.

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Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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  • Supportive care for oncology patients – pain control, symptom relief, and side effect management.
  • Preventive medicine and health screenings.
  • Development of tailored treatment plans based on clinical guidelines.

With a patient-centred approach, Dr. Raevskii helps individuals manage both chronic illnesses and complex oncological cases. His consultations are guided by current medical standards and adapted to each patient’s needs.

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  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

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  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
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Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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What patients commonly consult her for:

  • High blood pressure, type 2 diabetes, cholesterol management
  • Cold and flu symptoms: fever, cough, sore throat
  • Fatigue, sleep problems, headaches, general discomfort
  • Ongoing care for chronic conditions and medication review
  • Help interpreting test results and lab reports
  • Preventive check-ups and advice on healthy lifestyle habits

Dr Kovalenko combines evidence-based practice with a respectful, patient-centred approach. She takes time to explain, listens attentively, and helps each person make confident, informed decisions about their health.

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For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
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  • recurrent infections in children
  • sports-related health questions
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Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
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Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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Gastroenterology – Digestive health:
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General internal medicine and preventive care:
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  • Lab test analysis, therapy adjustments, medication management.
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  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Dr. Ben Harbi offers reliable, accessible medical support through online consultations, helping patients make informed decisions about their health with a clear, structured, and compassionate approach.

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Maryna Kuznetsova

Cardiology16 years of experience

Dr Marina Kuznetsova is an internal medicine doctor and cardiologist with a PhD in medicine. She provides online consultations for adults with chronic and acute conditions, with a strong focus on cardiovascular health. Her approach is based on current clinical guidelines and evidence-based treatment strategies.

Areas of expertise:

  • dyslipidaemia and lipid metabolism disorders
  • prevention and management of atherosclerosis
  • blood pressure monitoring and antihypertensive therapy
  • arrhythmias: diagnosis, follow-up, and treatment adjustment
  • cardiovascular care and recovery support after Covid-19
Dr Kuznetsova helps patients manage cardiovascular risk factors, optimise long-term treatment, and gain clarity in complex health situations – all through accessible and structured online care.
CameraBook a video appointment
€50
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