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PULMOPRODIFF 0.25%/18% MEDICINAL GAS

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Prescription review online

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Talk to a doctor about this medicine

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use PULMOPRODIFF 0.25%/18% MEDICINAL GAS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

PulmoProDiff 0.25%/ 18% compressed medical gas

carbon monoxide (CO)/helium (He)

Read this package leaflet carefully before starting to use this medicine, as it contains important information for you.

  • Keep this package leaflet, as you may need to read it again.
  • If you have any questions, ask your doctor or nurse.
  • If you experience side effects, consult your doctor, even if they are side effects not listed in this package leaflet. See section 4.

Contents of the Package Leaflet

  1. What PulmoProDiff is and what it is used for
  2. What you need to know before starting to use PulmoProDiff
  3. How to use PulmoProDiff
  4. Possible side effects
  5. Storage of PulmoProDiff
  6. Contents of the pack and further information

1. What PulmoProDiff is and what it is used for

PulmoProDiff is a medical gas for exclusive use in the diagnosis of lung function. It is used during diagnostic tests of lung function: determination of diffusion capacity/transfer factor and lung volume.

The medical gas PulmoProDiff can only be used in patients who are able to perform the test, regardless of their age.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before starting to use PulmoProDiff

Do not use this medical gas:

Unless your doctor has asked you to undergo respiratory function tests.

Warnings and precautions

Consult your doctor before starting to use PulmoProDiff.

If you have a history of coronary artery disease, you may be at risk of myocardial ischemia caused by carbon monoxide, as indicated by changes in the ECG (ST segment descent).

Children

This medical gas should be used with caution in children due to the lack of data on the systemic toxicity of this mixture.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor before using this medical gas.

Driving and using machines

The use of this medical gas during respiratory function tests does not affect the ability to drive and use machines.

3. How to use PulmoProDiff

PulmoProDiff can only be used for respiratory function tests by inhalation and exactly as your doctor or the responsible medical staff has indicated. If you have any doubts, consult your doctor or the medical staff attending you.

Only the doctor or the responsible medical staff should decide the duration of the respiratory function test and the frequency of repetition of the test.

Safety instructions

Smoking or lighting open flames is not allowed in the room where the medical gas is being used.

If you have any doubts about the use of this medicine, consult your doctor or the medical staff attending you.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

During inhalation of this medical gas during respiratory function tests, very unlikely side effects such as dizziness, chest pain, and disorientation may occur. If any symptoms of this nature occur during the use of the medical gas, inhalation should be stopped immediately and medical treatment should be administered.

Reporting of side effects

If you experience any side effects, consult your doctor, pharmacist, or nurse, even if they are possible side effects not listed in this package leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of PulmoProDiff

Keep this medical gas out of the sight and reach of children.

Do not use this medical gas after the expiration date shown on the gas cylinder after CAD.

Do not dispose of the container of this medical gas; return it to the supplier.

These measures will help protect the environment.

Store below 50 °C.

All regulations regarding the handling of pressure vessels must be followed.

Store in the original gas cylinder. Do not transfer the contents of the original gas cylinder to another gas cylinder.

Store gas cylinders indoors, in well-ventilated rooms or outdoors under cover and protected from adverse weather conditions.

Protect gas cylinders from impacts, falls, oxidizing and flammable materials, humidity, heat sources, or ignition.

Different types of medical gas should be separated from each other. Full and empty gas cylinders should be stored separately.

6. Contents of the pack and further information

Composition of PulmoProDiff

  • The active ingredients are carbon monoxide and helium.
  • The other components are nitrogen and oxygen.

Appearance of the product and contents of the pack

PulmoProDiff is a colorless, odorless, and tasteless compressed medical gas.

10-liter aluminum gas cylinder (identified with a bright green tip and white body) filled to a pressure of 150 bar, equipped with a residual pressure valve made of copper with a specific outlet connection.

Marketing authorization holder and manufacturer

Marketing authorization holder

Messer Ibérica de Gases S.A.U.

Autovía Tarragona-Salou, km. 3.8

E-43480, Vilaseca (Tarragona)

Spain

Manufacturer

Messer Austria GmbH

Industriestraße 5

2352 Gumpoldskirchen

Austria

This medicine is authorized in the EEA member states under the following names:

PulmoProDiff Netherlands, Austria, Germany, Poland, Romania, and Spain

Zyplorin: Czech Republic

Date of the last revision of this package leaflet:

May 2023

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) (http://www.aemps.gob.es/

Online doctors for PULMOPRODIFF 0.25%/18% MEDICINAL GAS

Discuss questions about PULMOPRODIFF 0.25%/18% MEDICINAL GAS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

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Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

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Doctor

Dmytro Horobets

Family medicine 7 years exp.

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

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Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

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Doctor

Giorgi Eremeishvili

Urology 22 years exp.

Giorgi Eremeishvili is a top-category urologist, a Candidate of Medical Sciences, and a licensed physician in Spain. He provides expert assistance in the diagnosis and treatment of a wide range of urological conditions in both men and women, employing a comprehensive approach and evidence-based principles.

Key areas of expertise:

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Frequently Asked Questions

Is a prescription required for PULMOPRODIFF 0.25%/18% MEDICINAL GAS?
PULMOPRODIFF 0.25%/18% MEDICINAL GAS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
Who manufactures PULMOPRODIFF 0.25%/18% MEDICINAL GAS?
PULMOPRODIFF 0.25%/18% MEDICINAL GAS is manufactured by Messer Iberica De Gases, S.A.U.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of PULMOPRODIFF 0.25%/18% MEDICINAL GAS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether PULMOPRODIFF 0.25%/18% MEDICINAL GAS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to PULMOPRODIFF 0.25%/18% MEDICINAL GAS?
Other medicines with the same active substance () include MEDICAL AIR COMPRESSED GAS LINDE 200 BAR, COMPRESSED MEDICAL GAS, SYNTHETIC MEDICAL AIR METAL CARBIDES, 22% V/V, MEDICAL GAS, COMPRESSED, SYNTHETIC MEDICAL AIR NIPPON GASES 200 BAR, COMPRESSED MEDICAL GAS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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