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ONDANSETRON TEVA-RATIO 8 mg FILM-COATED TABLETS

ONDANSETRON TEVA-RATIO 8 mg FILM-COATED TABLETS

Ask a doctor about a prescription for ONDANSETRON TEVA-RATIO 8 mg FILM-COATED TABLETS

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use ONDANSETRON TEVA-RATIO 8 mg FILM-COATED TABLETS

Introduction

Package Leaflet: Information for the Patient

Ondansetron Teva-ratio 8mg Film-Coated Tablets EFG

ondansetron

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet. You may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Ondansetron Teva-ratio and what is it used for
  2. What you need to know before you take Ondansetron Teva-ratio
  3. How to take Ondansetron Teva-ratio
  4. Possible side effects
  5. Storage of Ondansetron Teva-ratio
  1. Contents of the pack and further information

1. What is Ondansetron Teva-ratio and what is it used for

Ondansetron Teva-ratio belongs to a group of medicines called antiemetics, which prevent vomiting and nausea (feeling sick or being sick).

Ondansetron Teva-ratio is used in:

  • treatment of nausea (feeling sick) and vomiting (being sick) caused by chemotherapy and radiotherapy in adults, children, and adolescents from 6 months to 17 years of age.
  • prevention and treatment of nausea and vomiting after an operation in adults.

2. What you need to know before you take Ondansetron Teva-ratio

Do not take Ondansetron Teva-ratio

  • if you are allergic to ondansetron or any of the other ingredients of this medicine (listed in section 6).
  • if you are taking apomorphine (a medicine used to treat Parkinson's disease).

It should not be given to children with a body surface area less than 0.6 m2 or with a body weight less than 10 kg. There are other pharmaceutical forms with a lower content of active substance for this group of patients.

Warnings and precautions

Consult your doctor or pharmacist before taking Ondansetron Teva-ratio if:

  • you are allergic to medicines similar to ondansetron (5-HT3 antagonists)
  • you have had heart problems, including irregular heartbeats (arrhythmias)
  • you have liver problems
  • you have intestinal obstruction or suffer from severe constipation
  • you have had intestinal or tonsil surgery
  • you have problems with your blood salt levels, such as potassium, sodium, or magnesium.

Taking Ondansetron Teva-ratio with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

Ondansetron Teva-ratio changes the effects and/or side effects of some medicines, including:

  • Apomorphine (a medicine used in the treatment of Parkinson's disease). There have been reports of severe drop in blood pressure and loss of consciousness when ondansetron is taken at the same time as apomorphine.
  • Carbamazepine or Phenytoin (used in the treatment of epilepsy).
  • Rifampicin (used in the treatment of tuberculosis).
  • Tramadol (used to relieve mild to moderate pain).

Medicines that affect the heart, such as certain cancer medicines (anthracyclines or trastuzumab) or medicines that prolong the QT interval (which can cause a change in the ECG with a risk of abnormal or irregular heartbeats, potentially life-threatening)

  • Fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram (Selective Serotonin Reuptake Inhibitors, used to treat depression and/or anxiety)
  • Venlafaxine or duloxetine (Serotonin and Noradrenaline Reuptake Inhibitors, used to treat depression and/or anxiety).

Pregnancy and breastfeeding

Ondansetron Teva-ratio should not be used during the first trimester of pregnancy. This is because Ondansetron Teva-ratio may slightly increase the risk of a baby being born with a cleft lip and/or cleft palate (openings or gaps in the upper lip or in the roof of the mouth). If you are already pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking Ondansetron Teva-ratio. If you are a woman of childbearing potential, you are advised to use an effective method of contraception.

Do not breastfeed if you are taking Ondansetron Teva-ratio, as small amounts of ondansetron pass into breast milk. Ask your doctor.

Driving and using machines

Ondansetron has no influence on the ability to drive and use machines.

Ondansetron Teva contains lactose

This medicine contains lactose. If your doctor has told you that you have an intolerance to some sugars, contact them before taking this medicine.

Ondansetron Teva-ratio contains sodium

This medicine contains less than 1 mmol sodium (23 mg) per film-coated tablet; it is essentially "sodium-free".

3. How to take Ondansetron Teva-ratio

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

The recommended dose is:

For the treatment of nausea and vomiting induced by chemotherapy and radiotherapy

  • Adults (including the elderly)

8 mg taken 1 to 2 hours before chemotherapy or radiotherapy, followed by 8 mg taken 12 hours later. 24 hours after chemotherapy or radiotherapy, it can be taken for up to 5 days, 8 mg twice a day.

  • Children (over 6 months) and adolescents

Ondansetron Teva-ratio can be administered initially as a single intravenous injection 15 minutes before chemotherapy, followed by tablets that can be taken 2 to 3 times a day for up to 5 days after chemotherapy. The dose of the tablets will depend on the body weight of your child and will be calculated by your doctor.

For the prevention of nausea and vomiting after an operation

  • Adults (including the elderly)

A dose of 16 mg can be taken 1 hour before anesthesia.

Alternatively, a dose of 8 mg can be taken 1 hour before anesthesia, followed by two more doses of 8 mg at 8-hour intervals.

  • Children (over 1 month) and adolescents

An intravenous injection containing ondansetron is recommended.

Patient with liver problems:

The total daily dose should not exceed 8 mg.

Ondansetron Teva-ratio should start working 1 to 2 hours after taking the dose. If you vomit the dose in the first hour, take another dose. Otherwise, continue taking your tablets as directed, but do not take more than your doctor has recommended. If you continue to feel sick, then you should inform your doctor.

Method of administration

The tablets should be swallowed whole, preferably with the help of a glass of water. The score line is only there to help you break the tablet into two halves if you have difficulty swallowing it whole.

If you take more Ondansetron Teva-ratio than you should

If you or your child take more Ondansetron Teva-ratio than you should, talk to your doctor or go to the nearest hospital immediately. Take the medicine with you.

An overdose can cause temporary vision problems, severe constipation, feeling dizzy or fainting.

Take this leaflet, any remaining tablets, and the packaging to the hospital or doctor so they know what tablets have been taken.

In case of overdose or accidental ingestion, contact the Toxicological Information Service, telephone 91562 04 20, indicating the medicine and the amount taken.

If you forget to take Ondansetron Teva-ratio

Do not take a double dose to make up for forgotten doses.

If you forget to take a tablet and feel sick or vomit, take one as soon as you remember and continue as before. If you forget to take a tablet and do not feel sick, then wait until the next dose as directed. Take the missed doses at the correct time.

If you stop taking Ondansetron Teva-ratio

Do not stop taking ondansetron without first talking to your doctor, even if you feel better.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

If you experience any of the following, stop taking the tablets and inform your doctor immediately or go to the casualty department of your nearest hospital:

Uncommon (may affect up to 1 in 100 people)

  • seizures

Rare (may affect up to 1 in 1,000 people)

  • an allergic reaction that causes swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, skin rash.
  • collapse
  • abnormal heart rhythms (sometimes causing loss of consciousness).

Very rare (may affect up to 1 in 10,000 people)

  • widespread skin rash with blisters and peeling, affecting a large area of the body (toxic epidermal necrolysis).

Other side effects include:

Very common(may affect more than 1 in 10 people)

  • headache.

Common(may affect up to 1 in 10 people)

  • feeling hot or flushed
  • constipation
  • changes in liver function test results (if you take ondansetron with a medicine called cisplatin; otherwise, this side effect is uncommon).

Uncommon(may affect up to 1 in 100 people)

  • poor vision or temporary loss of vision, which usually returns within 20 minutes.
  • unusual body movements, agitation.
  • hiccups
  • low blood pressure, which can make you feel weak or dizzy
  • irregular heartbeat or chest pain
  • slow heart rate

Rare(may affect up to 1 in 1,000 people)

  • feeling dizzy or faint.
  • blurred vision.

Very rare(may affect up to 1 in 10,000 people)

  • poor vision or temporary loss of vision after intravenous administration.

Frequency not known (cannot be estimated from the available data)

  • Myocardial ischemia (signs include: sudden chest pain or chest tightness).

Reporting of side effects:

If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Spanish Medicines Agency's website: www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Ondansetron Teva-ratio

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the blister and carton after EXP. The expiry date refers to the last day of that month.

This medicine does not require any special storage conditions.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and further information

Composition of Ondansetron Teva-ratio

  • The active substance is ondansetron. Each film-coated tablet contains 8 mg of ondansetron (as ondansetron hydrochloride dihydrate).
  • The other ingredients are:
  • Core of the tablet: lactose monohydrate, sodium carboxymethyl starch type A (derived from potato), microcrystalline cellulose, pregelatinized maize starch, magnesium stearate
  • Coating: hypromellose, titanium dioxide (E171), macrogol (400 and 6000), and yellow iron oxide (E172)

Appearance of the product and pack size

  • Ondansetron Teva-ratio 8 mg is presented as yellow, oblong, film-coated tablets with the number "8" engraved on one face and a score line on the other.
  • Ondansetron Teva-ratio 8 mg film-coated tablets are available in pack sizes of 2, 4, 5, 6, 9, 10, 15, 18, 30, 50, 100, and 500 film-coated tablets.

Not all pack sizes may be marketed.

Marketing authorisation holder and manufacturer:

Marketing authorisation holder

Teva Pharma, S.L.U.

C/ Anabel Segura, 11 Edificio Albatros B, 1ª Planta

Alcobendas, 28108 Madrid (Spain)

Manufacturers

Teva Pharmaceutical Works Company Ltd.

Pallagi Street 13

H-4042 Debrecen

Hungary

Or

Pharmachemie B.V.

Swensweg 5, Postbus 552, 2003 RN Haarlem

Netherlands

Or

Merckle GmbH

Ludwig-Merckle-Strasse 3

89143 Blaubeuren

Germany

This medicine is authorised in the Member States of the European Economic Area under the following names:

CZ: Ondansetron-Teva 8mg

DE: Ondansetron ratiopharm 4 mg & 8 mg Filmtabletten

ES: Ondansetrón Teva-ratio 4 mg & 8 mg comprimidos recubiertos con película EFG

IE: Ondansetron 4mg and 8mg Film-Coated Tablets

IT: Ondansetron Teva 4mg & 8mg Compresa rivestita con film

LT: Ondansetron-Teva 8 mg plevele dengtos tabletes

NL: Ondansetron 4 & 8 PCH, filmomhulde tabletten 4mg & 8mg

SE: Ondansetron Teva 4mg & 8mg Filmdragerad tablet

Date of last revision of this leaflet:July 2022

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

You can access detailed and updated information about this medicine by scanning the QR code included in the packaging with your smartphone. You can also access this information at the following internet address: https://cima.aemps.es/cima/dochtml/p/66914/P_66914.html

QR code + URL

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Alternative to ONDANSETRON TEVA-RATIO 8 mg FILM-COATED TABLETS in Ukraine

Dosage form: solution, 2 mg/ml in 2 ml or 4 ml ampoules
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