This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use MEPIVACAINE PHYSAN 20 mg/ml INJECTABLE SOLUTION

Introduction

Package Leaflet: Information for the User

Mepivacaine Physan20 mg/ml injectable solution

mepivacaine hydrochloride

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

Keep this leaflet, you may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not pass it on to others, as it may harm them, even if their symptoms are the same as yours.
If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack:

What Mepivacaine Physan is and what it is used for
What you need to know before you use Mepivacaine Physan
How to use Mepivacaine Physan
Possible side effects
Storage of Mepivacaine Physan
Contents of the pack and further information

1. What Mepivacaine Physan is and what it is used for

Mepivacaine Physan is a local anesthetic (an agent that reduces or eliminates sensations, affecting a particular region) that belongs to the amide subgroup.

Mepivacaine Physan has been prescribed for you to provide an anesthetic effect.

2. What you need to know before you use Mepivacaine Physan

Do not useMepivacaine Physan

if you are allergic to mepivacaine hydrochloride or to any of the other ingredients of this medicine (listed in section 6).
if you are allergic to any other local anesthetic of the same group (e.g., bupivacaine, lidocaine).
if you have heart rhythm disorders. Ask your doctor for advice, as Mepivacaine Physan may not be advisable for you.
if you have uncontrolled epilepsy.
if you have acute intermittent porphyria (a hereditary metabolic disorder that affects the nervous system and can cause mental disorders).

Warnings and precautions

Consult your doctor or pharmacist before starting to use Mepivacaine Physan

if you have any heart problems.
if you have severe liver disease.
if you have any kidney problems.
if you are a weakened or elderly patient.
For athletes, there is a possibility of positive results in anti-doping tests.

Other medicines and Mepivacaine Physan

Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines.

Mepivacaine Physan should be used with caution if you are receiving treatment with medicines with a similar structure to local anesthetics, such as those used for heart rhythm disorders (so-called class Ib antiarrhythmics, such as lidocaine), as this increases the risk of side effects.

Prolonged treatment with antiarrhythmics (medicines to control heart rhythm), psychotropic drugs (medicines that act on mental activity), or anticonvulsants (medicines against convulsions) may reduce sensitivity to anesthetics.

You should be careful if you are taking central nervous system depressant medicines at the same time, as they may increase the depressant effects.

Local irritation, swelling, or edema may occur when used at the same time as certain disinfectants.

Blood coagulation inhibitors (medicines to prevent blood clots) and anti-inflammatory medicines may increase the risk of bleeding.

UsingMepivacaine Physanwith alcohol

Excessive alcohol consumption may reduce sensitivity to anesthetics.

Pregnancy and breastfeeding

Consult your doctor or pharmacist before using any medicine.

Your doctor will prescribe Mepivacaine Physan, taking into account the benefit to you and the risk to your baby.

Mepivacaine Physan is excreted in breast milk, but the risk of the child suffering from adverse reactions does not seem likely if the recommended doses are respected.

Driving and using machines

The use of Mepivacaine Physan may have a mild effect on mental functions and may alter movement and coordination for a time.

Mepivacaine Physancontains sodium

Ampoules of 2 ml:

This medicine contains less than 23 mg of sodium (1 mmol) per ampoule; it is essentially "sodium-free".

Ampoules of 10 ml:

This medicine contains 28 mg of sodium (main component of table/cooking salt) in each ampoule. This is equivalent to 1.4% of the maximum recommended daily sodium intake for an adult.

.

3. How to use Mepivacaine Physan

Follow exactly the administration instructions of Mepivacaine Physan indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.

Mepivacaine Physan will be administered by your doctor in the form of an injection.

The dose, speed of administration, and duration of treatment will vary depending on the anesthetic procedure to be performed, the area to be anesthetized, and the patient's weight, clinical situation, and response.

If you use moreMepivacaine Physanthan you should

In case of overdose, adverse reactions may occur at the level of the heart and blood vessels: lowering of blood pressure and alteration of heart rhythm. Adverse effects may also occur at the level of the central nervous system: agitation, sensation of numbness of lips, tongue, and around the mouth, dizziness, vision and hearing disturbances, and ringing in the ears. Difficulty speaking, muscle stiffness, or spasms are more serious symptoms that precede generalized convulsions.

If these signs of toxicity appear, the injection of the anesthetic should be interrupted immediately.

In case of overdose or accidental ingestion, consult the Toxicology Information Service. Telephone 91 562 04 20.

If you have any other questions about the use of this product, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, Mepivacaine Physan can cause side effects, although not everybody gets them.

Rare side effects (observed in between 1 and 10 of every 10,000 patients)

Allergic reactions, including serious reactions (so-called anaphylactic shock), which include skin rash, difficulty breathing, and swelling of the tongue and throat.

Heart disorders and infarction (in cases of overdose).

Unconsciousness and convulsions (in cases of overdose).

Neurological reactions associated with the anesthetic techniques used, regardless of the anesthetic used.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if it is possible side effects not listed in this leaflet. You can also report them directly through the Spanish Medicines and Health Products Agency (AEMPS) website: www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

.

5. Storage of Mepivacaine Physan

Keep this medicine out of the sight and reach of children.

No special storage conditions are required.

Do not use Mepivacaine Physan after the expiry date stated on the ampoule and carton. The expiry date is the last day of the month indicated.

The unused solution should be disposed of in accordance with local regulations.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. FURTHER INFORMATION

Composition ofMepivacaine Physan

The active substance is Mepivacaine Hydrochloride 20.0 mg/ml.
The other ingredients are: Sodium Chloride, Sodium Hydroxide (for pH adjustment), and water for injectable preparations.

Appearance and packaging

Mepivacaine Physan 20 mg/ml injectable solution is packaged in glass ampoules.

The commercial presentation is a pack with 1 ampoule or clinical packs with 50 or 100 glass ampoules of 2 ml or 10 ml.

Marketing authorization holder

LAPHYSAN S.A.U.

Anabel Segura, 11 Edificio A, Planta 4, Puerta D,

28108 Alcobendas (Madrid)

Spain

Manufacturer:

LABORATORIOS BASI – INDUSTRIA FARMACÉUTICA, S.A.

Parque Industrial Manuel Lourenço Ferreira,

Nº 8, Nº 15 y Nº 16

3450-232 Mortágua – Portugal

Date of the last revision of this leaflet: July 2008

Detailed information on this medicine is available on the website of the Spanish Medicines and Health Products Agency (AEMPS) http://www.aemps.gob.es/

This information is intended only for healthcare professionals

Local and regional anesthetic procedures, except for those of a more trivial nature, should always be performed by professionals who are properly trained and in areas with immediate access to resuscitation equipment and medicines. Specialists should receive appropriate training for these procedures and be familiar with the diagnosis and treatment of side effects, systemic toxicity, or other complications.

When performing major blocks, a catheter should be inserted before injecting the anesthetic.

Taking this into account, as well as the anesthetic technique and the situation of the patients who are going to receive the treatment, the administration of the specialty should be carried out according to the guidelines described and the recommendations included in the different sections of the Technical Sheet ("Posology and method of administration"; "Special warnings and precautions for use"), so it is necessary to refer to the text of the same to ensure the correct use of the product.

The solutions should be used immediately after opening. Any remaining portion of the solution used should be discarded.

Incompatibilities

From a pH > 6.5, there is a risk of precipitation. This characteristic should be taken into account when adding alkaline solutions, such as carbonates.

.

Country of registration
Spain
Active substance
mepivacaine
Prescription required
Yes
Manufacturer
Laphysan S.A.U.
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
Alternatives to MEPIVACAINE PHYSAN 20 mg/ml INJECTABLE SOLUTION
ISOGAINE 30 mg/ml INJECTABLE SOLUTION
Dosage form: INJECTABLE, 54 mg
Active substance: mepivacaine
Manufacturer: Laboratorios Clarben S.A.
Prescription required
MEPIVACAINE B. BRAUN 10 mg/mL INJECTABLE SOLUTION
Dosage form: INJECTABLE, 10 mg/ml
Active substance: mepivacaine
Manufacturer: B Braun Medical S.A.
Prescription required
MEPIVACAINE B. BRAUN 20 mg/mL INJECTABLE SOLUTION
Dosage form: INJECTABLE, 20 mg/ml
Active substance: mepivacaine
Manufacturer: B Braun Medical S.A.
Prescription required

Alternatives to MEPIVACAINE PHYSAN 20 mg/ml INJECTABLE SOLUTION in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to MEPIVACAINE PHYSAN 20 mg/ml INJECTABLE SOLUTION in Polónia

Scandivin

Dosage form: Solução, 30 mg/ml

Active substance: mepivacaine

Manufacturer: Laboratorios INIBSA, S.A.

Prescription required

Mepidont 3%

Dosage form: Solução, 30 mg/ml

Active substance: mepivacaine

Manufacturer: Laboratorios Normon, S.A.

Prescription required

Scandonest 30 mg/ml

Dosage form: Solução, 30 mg/ml

Active substance: mepivacaine

Manufacturer: Septodont

Prescription required

Mepivastesin

Dosage form: Solução, 30 mg/ml

Active substance: mepivacaine

Importer: Solventum Germany GmbH

Prescription required

Alternative to MEPIVACAINE PHYSAN 20 mg/ml INJECTABLE SOLUTION in Ukraine

SKANDONEST 3 % PROSTIJ

Dosage form: solução, 3 %, 1.7 ml em uma cartucho

Active substance: mepivacaine

Manufacturer: SEPTODONT

Prescription required

MEPIFRIN-ZDOROV'A

Dosage form: solução, 30 mg/ml, 1.7 ml em ampola

Active substance: mepivacaine

Manufacturer: Tovaristvo z obmezenou vidpovidal'nistu "Farmacevticna kompania "Zdorov'a" (vsi stadii virobnictva, kontrol' akosti, vipusk serii)

Prescription required

Online doctors for MEPIVACAINE PHYSAN 20 mg/ml INJECTABLE SOLUTION

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for MEPIVACAINE PHYSAN 20 mg/ml INJECTABLE SOLUTION – subject to medical assessment and local rules.

5.0(7)

Svetlana Kovalenko

Family medicine15 years of experience

Dr Svetlana Kovalenko is a family medicine doctor with over 14 years of experience and a medical degree from Kharkiv National Medical University. She offers online consultations for adults, supporting patients with both acute and chronic conditions, preventive care, and personalised medical advice.

What patients commonly consult her for:

High blood pressure, type 2 diabetes, cholesterol management
Cold and flu symptoms: fever, cough, sore throat
Fatigue, sleep problems, headaches, general discomfort
Ongoing care for chronic conditions and medication review
Help interpreting test results and lab reports
Preventive check-ups and advice on healthy lifestyle habits

Dr Kovalenko combines evidence-based practice with a respectful, patient-centred approach. She takes time to explain, listens attentively, and helps each person make confident, informed decisions about their health.

Book a video appointment

Taisiya Minorskaya

Family medicine13 years of experience

Dr Taisiya Minorskaya is a family medicine doctor with an official licence to practise in Spain and over 12 years of clinical experience. She provides online consultations for adults and children, combining evidence-based medicine with a personalised, modern European approach.

She helps with:

Viral infections and cold symptoms (flu, sore throat, cough, runny nose)
Review and adjustment of antibiotics
Skin rashes and allergic reactions
Chronic condition flare-ups, high blood pressure, headaches, fatigue
Lab and test interpretation
Medication review and adaptation to European standards
Patient navigation: what tests are needed, which specialists to see, when an in-person visit is required

Dr Minorskaya also specialises in the diagnosis and management of gastrointestinal conditions, including bloating, abdominal pain, chronic nausea, IBS, and SIBO. She supports patients with unexplained physical symptoms that may be linked to somatisation or stress, helping them find relief and improve quality of life.

She offers care for people undergoing GLP-1 therapy (Ozempic, Mounjaro, and others) for weight management. Her support follows Spanish clinical guidelines, from treatment planning and side effect counselling to regular follow-ups and coordination with private or public healthcare providers.

Book a video appointment

Antonio Cayatte

General medicine44 years of experience

Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic.

His clinical background includes:

assessment of sudden or unclear symptoms
ongoing care for chronic conditions
follow-up after hospital discharge
interpretation of test results
medical support while abroad

Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association.

Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

Book a video appointment

Yevgen Yakovenko

General surgery12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

12+ years of clinical experience in university hospitals in Germany and Spain.
International education: Ukraine – Germany – Spain.
Member of the German Society of Surgeons (BDC).
Certified in radiological diagnostics and robotic surgery.
Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment

Anastasiia Hladkykh

Psychiatry15 years of experience

Dr Anastasiia Hladkykh is a physician-psychotherapist and psychologist with over 14 years of experience working with individuals struggling with various types of addictions and their families. She provides online consultations for adults, combining medical knowledge with deep psychological support and practical tools.

Key areas of expertise:

Addiction treatment: alcohol and drug dependence, gambling addiction, compulsive behaviours, codependent relationships.
Support for families of addicted individuals, behavioural correction within the family system, guidance for maintaining remission.
Mental health: depression, bipolar disorder, obsessive-compulsive disorder (OCD), anxiety disorders, phobias, PTSD, generalised anxiety, emotional trauma, and the psychological impact of loss or emigration.
Psychoeducation: explaining complex mental health concepts in simple language, helping patients and their families understand diagnoses and treatment steps.

Therapeutic approach:

Client-centred, straightforward, and empathetic – focused on practical outcomes and emotional stabilisation.
Prescribes medications when needed, but always aims to minimise unnecessary pharmaceutical use.
Certified in multiple evidence-based methods: CBT, NLP (Master Practitioner), Ericksonian hypnosis, symbol drama, art therapy, and systemic therapy.
Each consultation results in a clear, structured plan – patients leave knowing exactly what to do next.

Experience and background:

Member of the German association Gesundheitpraktikerin and the NGO “Mit dem Sonne in jedem Herzen.”
More than 18 publications in international peer-reviewed journals, translated into several languages.
Volunteer work with Ukrainian refugees and military personnel at the University Clinic of Regensburg.

Book a video appointment

Farouk Laafif

Psychiatry4 years of experience

Dr. Farouk Laafif is a psychiatrist providing online consultations for adults and adolescents facing emotional or mental health challenges. His clinical approach integrates psychopharmacology with psychotherapy, with a strong focus on the connection between mental and physical well-being.

He offers compassionate, evidence-based support for individuals dealing with:

depression and anxiety disorders
bipolar affective disorder
schizophrenia and other psychotic conditions
psychosomatic symptoms and chronic stress
treatment planning and medication adjustment

Dr. Laafif combines scientific expertise with human empathy, helping patients restore emotional balance, improve daily functioning, and regain confidence in their recovery journey.

Book a video appointment

Andrei Popov

General medicine7 years of experience

Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

He specialises in diagnosing and treating pain conditions that affect quality of life, including:

Chronic pain lasting more than 3 months.
Migraines and recurring headaches.
Neck, back, lower back, and joint pain.
Post-traumatic pain following injury or surgery.
Nerve-related pain, fibromyalgia, and neuralgia.

In addition to pain management, Dr. Popov helps patients with:

Respiratory infections (colds, bronchitis, pneumonia).
High blood pressure and metabolic conditions such as diabetes.
Preventive care and routine health check-ups.

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

Book a video appointment

Anna Biriukova

General medicine6 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
Leg swelling, chronic fatigue, reduced exercise tolerance.
EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
Post-COVID-19 cardiac monitoring and care.

Endocrinology – Diabetes, thyroid, metabolism:

Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
Individual treatment plans including oral medications and insulin therapy.
GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
Metabolic syndrome – obesity, lipid disorders, insulin resistance.

Gastroenterology – Digestive health:

Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).

General internal medicine and preventive care:

Respiratory infections – cough, colds, bronchitis.
Lab test analysis, therapy adjustments, medication management.
Adult vaccinations – planning, contraindications assessment.
Cancer prevention – screening strategies and risk assessment.
Holistic approach – symptom relief, complication prevention, and quality of life improvement.

Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.

Book a video appointment

Anna Kondratiuk

Psychiatry14 years of experience

Dr Anna Kondratiuk is a psychiatrist and psychotherapist with over 13 years of clinical experience in both inpatient and outpatient settings. She provides online consultations for adults, offering a balanced approach that combines evidence-based pharmacological treatment with psychotherapy.

Main areas of support:

Depression and burnout
Anxiety, panic attacks, phobias
Post-traumatic stress disorder (PTSD)
Psychosomatic symptoms and sleep disturbances
Health anxiety (hypochondria)
Mental health support in chronic physical illness
Adjustment disorders and low self-esteem

Dr Kondratiuk focuses on creating a safe and respectful therapeutic environment where patients feel heard and supported. Her goal is to help each person achieve lasting improvements in their mental well-being.

Book a video appointment

Alexander Nazarchuk

Allergology7 years of experience

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

You can consult Dr. Nazarchuk for:

Test interpretation and guidance on diagnostic plans.
Allergic rhinitis, hay fever, bronchial asthma (including severe cases).
Food and drug allergies, skin rashes, angioedema.
Atopic dermatitis, urticaria, contact allergies.
Allergen-specific immunotherapy (AIT) – initiation and ongoing management.
Abdominal pain, bloating, changes in bowel habits, nausea, heartburn.
High blood pressure and adjustment of baseline antihypertensive therapy.
Hyperlipidaemia and elevated cholesterol.
Cough, nasal congestion, fever, sore throat.
Anaemia, including iron deficiency and related conditions.
Other issues related to allergology and internal medicine.

During consultations, Dr. Nazarchuk takes a thorough, structured approach — analysing symptoms, identifying potential causes, and helping patients make informed decisions. Whether treatment, further investigation, or monitoring is needed, he explains each step clearly so you understand your health and how best to manage it.

Book a video appointment