


Ask a doctor about a prescription for LEDFOLIN 15 mg TABLETS
Package Leaflet: Information for the User
Lederfolin 15 mg Tablets
Folinic Acid
Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
Contents of the pack:
Lederfolin belongs to a group of medicines called detoxifying agents for the treatment of tumors.
This medicine is used in:
Do not take Lederfolin:
Warnings and precautions:
Consult your doctor or pharmacist before starting treatment with Lederfolin.
Taking Lederfolin with other medicines
Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines.
Certain medicines may interact with Lederfolin; in these cases, it may be necessary to change the dose or interrupt treatment with one of them.
It is essential that you inform your doctor if you are taking or have recently taken any of the following medicines:
Pregnancy and breastfeeding
If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor before using this medicine.
It is not known whether calcium folinate hydrate is excreted in breast milk.
Driving and using machines
There is no evidence that this medicine affects the ability to drive or use machines.
Lederfolin contains lactose and sodium
This medicine contains lactose. If your doctor has told you that you have an intolerance to certain sugars, consult with them before taking this medicine.
This medicine contains less than 1 mmol of sodium (23 mg) per tablet; this is essentially "sodium-free".
Follow exactly the administration instructions of this medicine indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.
Remember to take your medicine.
Your doctor will indicate the duration of your treatment with Lederfolin. Do not stop treatment before, as you will not achieve the desired therapeutic effect.
The tablets are scored. The score line should not be used to divide the tablet.
If you take more Lederfolin than you should:
If you have taken more Lederfolin than you should, consult your doctor or pharmacist immediately. No significant harm has been reported in patients who have received significantly higher doses of calcium folinate hydrate than recommended.
In case of overdose or accidental ingestion, consult the Toxicology Information Service, phone: 91/562.04.20.
If you forget to take Lederfolin
Do not take a double dose to make up for forgotten doses.
If you stop treatment with Lederfolin
If you have any other questions about the use of this medicine, ask your doctor or pharmacist.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
If you experience any side effect, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.
The following side effects are described according to their frequency of occurrence in patients treated:
Rare(at least 1 in 10,000 but less than 1 in 1,000 patients):
Very rare(at least 1 in 10,000 patients):
Frequency not known(cannot be estimated from available data):
There have been reports of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), some of which were fatal, in patients treated with calcium folinate hydrate in combination with other agents whose association with these disorders is known. It cannot be excluded that calcium folinate hydrate may have contributed to these cases of SJS/TEN.
Stevens-Johnson syndrome is a widespread rash with blisters and peeling of the skin, particularly around the mouth, nose, eyes, and genitals.
Toxic epidermal necrolysis is a widespread rash with blisters and peeling of the skin, particularly around the mouth, nose, eyes, and genitals, causing widespread skin peeling (more than 30% of the body surface).
Reporting of side effects
If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if it is possible that the side effects are not listed in this leaflet. You can also report side effects directly through the Spanish Medicines and Healthcare Products Agency (AEMPS) website: www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Do not store above 30°C.
Do not use this medicine after the expiry date which is stated on the packaging after "EXP". The expiry date is the last day of the month stated.
Medicines should not be disposed of via wastewater or household waste. Return any unused medicine to your pharmacist. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.
Composition of Lederfolin
Appearance of the product and pack contents
White, circular, scored tablets; available in PVC/Aluminum blister packs containing 10 tablets.
Marketing authorization holder
Pfizer, S.L.
Avda. de Europa, 20-B
Parque Empresarial La Moraleja
28108 Alcobendas (Madrid)
Pfizer Logo
Manufacturer
FARMASIERRA MANUFACTURING S.L.
Ctra. Irún, km.26, 200.
San Sebastián de los Reyes (Madrid) 28700 Spain
Date of last revision of this leaflet:July 2023
Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) http://www.aemps.es/
The average price of LEDFOLIN 15 mg TABLETS in October, 2025 is around 8.99 EUR. Prices may vary depending on the region, pharmacy, and whether a prescription is required. Always check with a local pharmacy or online source for the most accurate information.
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