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IKERVIS 1 mg/ml eye drops in emulsion

IKERVIS 1 mg/ml eye drops in emulsion

Ask a doctor about a prescription for IKERVIS 1 mg/ml eye drops in emulsion

5.0(38)
Doctor

Nuno Tavares Lopes

Family medicine17 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC. He offers online consultations in Portuguese, English, and Spanish — combining global expertise with a patient-centred, evidence-based approach.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use IKERVIS 1 mg/ml eye drops in emulsion

Introduction

Package Leaflet: Information for the Patient

IKERVIS 1 mg/ml Eye Drops, Emulsion

ciclosporin (ciclosporin)

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet

  1. What is IKERVIS and what is it used for
  2. What you need to know before you use IKERVIS
  3. How to use IKERVIS
  4. Possible side effects
  5. Storage of IKERVIS
  6. Contents of the pack and further information

1. What is IKERVIS and what is it used for

IKERVIS contains the active substance ciclosporin. Ciclosporin belongs to a group of medicines called immunodepressants, which are used to reduce inflammation.

IKERVIS is used to treat adults with severe keratitis (inflammation of the cornea, the transparent layer on the front of the eye). It is used in patients with dry eye syndrome who have not improved despite treatment with artificial tears.

You should consult a doctor if it worsens or does not improve.

You should visit your doctor's office at least every 6 months so that they can evaluate the effect of IKERVIS.

2. What you need to know before you use IKERVIS

Do not use IKERVIS:

  • if you are allergic to ciclosporin or any of the other ingredients of this medicine (listed in section 6);
  • if you have had or have cancer in or around the eye;
  • if you have an eye infection.

Warnings and precautions

Use IKERVIS only as eye drops for the affected eye(s).

Consult your doctor or pharmacist before starting to use IKERVIS:

  • if you have had a previous eye infection caused by the herpes virus that may have damaged the transparent front part of the eye (cornea);
  • if you are taking any medicine that contains steroids;
  • if you are taking any medicine to treat glaucoma.

Contact lenses may increase the damage to the transparent front part of the eye (cornea). Therefore, you should remove your contact lenses when going to bed, before using IKERVIS; you can put them back on when you wake up.

Children and adolescents

IKERVIS should not be used in children and adolescents under 18 years of age.

Other medicines and IKERVIS

Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines.

Consult your doctor if you are using a steroid eye drop with IKERVIS, as these may increase the risk of side effects.

You should use the IKERVIS eye drop at least 15 minutesafter using any other eye drop.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

Do not useIKERVIS if you are pregnant.

If you can become pregnant, you should use contraception while using this medicine.

It is likely that there will be very small amounts of IKERVIS in breast milk. If you are breastfeeding, ask your doctor for advice before using this medicine.

Driving and using machines

You may have blurred vision immediately after using the IKERVIS eye drop. Wait until your vision is clear before driving or using machines.

3. How to use IKERVIS

Follow the instructions for administration of this medicine exactly as told by your doctor or pharmacist. If you are unsure, consult your doctor or pharmacist again.

The recommended doseis one drop in the affected eye(s), once a day at bedtime.

Instructions for use

Follow these instructions carefully and consult your doctor or pharmacist if you have any questions.

Hands holding an auto-injector and pressing it against the thigh or abdomen for activation

1 2 3

  • Wash your hands.
  • If you wear contact lenses, remove them when going to bed, before using the eye drop; you can put them back on when you wake up.
  • Open the aluminum pouch, which contains 5 single-dose containers.
  • Take a single-dose container from the aluminum pouch and.
  • Gently shake the single-dose container before use.
  • Twist the cap to open it (image 1).
  • Lower the lower eyelid with the help of a finger (image 2).
  • Tilt your head back and look up at the ceiling.
  • Gently squeeze to release one drop of medicine into the eye. Make sure not to touch the eye with the tip of the single-dose container.
  • Blink several times to spread the medicine across the eye.
  • After using IKERVIS, press the corner of your eye next to your nose and gently close your eyelids for 2 minutes (image 3). This helps prevent IKERVIS from reaching other parts of your body.
  • If you use the eye drop in both eyes, repeat these steps in the other eye.
  • Discard the single-dose container after use, even if there is still some liquid left in it.
  • You should keep the remaining single-dose containers in the aluminum pouch.

If the drop falls outside the eye, try again.

If you use more IKERVIS than you should, rinse your eye with water. Do not apply more drops until the next scheduled dose.

If you forget to use IKERVIS, continue with the next scheduled dose.Do not apply a double dose to make up for forgotten doses. Do not use more than one drop per day in the affected eye(s).

If you stop treatment with IKERVISwithout consulting your doctor, the inflammation of the transparent front part of the eye (known as keratitis) will not be controlled and may lead to visual impairment.

If you have any further questions about the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following side effects have been reported:

The most common side effects occur in and around the eyes.

Very common (may affect more than 1 in 10 people)

Pain when applying the drops to the eye.

Common (may affect up to 1 in 10 people)

Irritation, redness, and increased tearing when applying the drops to the eye, redness of the eyelid, watery eyes, redness of the eye, blurred vision. Swelling of the eyelid, redness of the conjunctiva (thin membrane covering the front of the eye), eye irritation, eye pain.

Uncommon (may affect up to 1 in 100 people)

Uncommon side effects related to the eye:

Discomfort, itching, or irritation in or around the eye, including the feeling of having something in it. Irritation or swelling of the conjunctiva (thin membrane covering the front of the eye), eye allergy, changes in tear production, eye discharge, inflammation of the iris (colored part of the eye) or eyelid, deposits in the eye, bacterial infection or inflammation of the cornea (transparent front part of the eye), abrasion on the outer layer of the cornea, white spots on the cornea, cyst on the eyelid, itching of the eyelid, painful skin rash around the eye caused by the herpes zoster virus.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of IKERVIS

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the outer carton, aluminum pouch, and single-dose containers after ‘EXP’. The expiry date is the last day of the month stated.

Do not freeze.

After opening the aluminum pouches, the single-dose containers should be kept in them to protect them from light and to prevent evaporation. Discard any opened single-dose container with remaining emulsion immediately after use.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and further information

Composition of IKERVIS

  • The active substance is ciclosporin. One milliliter of IKERVIS contains 1 mg of ciclosporin.
  • The other ingredients are medium-chain triglycerides, cetalkonium chloride, glycerol, tyloxapol, poloxamer 188, sodium hydroxide (for pH adjustment), and water for injections.

Appearance and pack contents

IKERVIS is a white, milky eye drop emulsion.

It is supplied in single-dose containers made of low-density polyethylene (LDPE).

Each single-dose container contains 0.3 ml of eye drop emulsion.

The single-dose containers are packaged in a sealed aluminum pouch.

Pack sizes: 30 and 90 single-dose containers.

Not all pack sizes may be marketed.

Marketing authorisation holder

SANTEN Oy

Niittyhaankatu 20

33720 Tampere

Finland

Manufacturer

EXCELVISION

Rue de la Lombardière

ZI la Lombardière

F-07100 Annonay

France

SANTEN Oy

Niittyhaankatu 20

33720 Tampere

Finland

For further information about this medicine, please contact the local representative of the marketing authorisation holder:

België/Belgique/BelgienLietuva

Santen Oy Santen Oy

Tél/Tel: +32 (0) 24019172 Tel: +370 37 366628

????????Luxembourg/Luxemburg

Santen Oy Santen Oy

Тел.: +359 (0) 888 755 393 Tél/Tel: +352 (0) 27862006

Česká republikaMagyarország

Santen Oy Santen Oy

Tel: +420 234 102 170 Tel.: +36 (06) 16777305

DanmarkMalta

SantenPharma AB Santen Oy

Tlf: +45 78737843 Tel: +358 (0) 3 284 8111

DeutschlandNederland

Santen GmbH Santen Oy

Tel: +49 (0) 3030809610 Tel: +31 (0) 207139206

EestiNorge

Santen Oy SantenPharma AB

Tel: +372 5067559 Tlf: +47 21939612

ΕλλάδαÖsterreich

Santen Oy Santen Oy

Τηλ: +358 (0) 3 284 8111 Tel: +43 (0) 720116199

EspañaPolska

Santen Pharmaceutical Spain S.L. Santen Oy

Tel: +34 914 142 485 Tel.: +48 (0) 221168608

FrancePortugal

Santen Santen Oy

Tél: +33 (0) 1 70 75 26 84 Tel: +351 308 805 912

HrvatskaRomânia

Santen Oy Santen Oy

Tel: +358 (0) 3 284 8111 Tel: +40 (0) 316300603

IrelandSlovenija

Santen Oy Santen Oy

Tel: +353 (0) 16950008 Tel: +358 (0) 3 284 8111

ÍslandSlovenská republika

Santen Oy Santen Oy

Sími: +358 (0) 3 284 8111 Tel: +421 (01) 23 332 5519

ItaliaSuomi/Finland

Santen Italy S.r.l. Santen Oy

Tel: +39 0236009983 Puh/Tel: +358 (0) 974790211

ΚύπροςSverige

Santen Oy SantenPharma AB

Τηλ: +358 (0) 3 284 8111 Tel: +46 (0) 850598833

LatvijaUnited Kingdom

Santen Oy Santen UK Limited

Tel: +371 677 917 80 Tel: +44 (0) 845 075 4863

Date of last revision of this leaflet:

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

Alternatives to IKERVIS 1 mg/ml eye drops in emulsion in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to IKERVIS 1 mg/ml eye drops in emulsion in Ukraine

Dosage form: emulsion, 0.5 mg/ml; 0.4 ml in a vial
Active substance: ciclosporin
Manufacturer: Allergan Sejls LLS
Prescription required
Dosage form: drops, 1 mg/ml; #30 (5x6): 0.3 ml
Active substance: ciclosporin
Dosage form: drops, 40 mg/ml, 5 ml or 10 ml in a vial
Prescription required
Dosage form: drops, 40 mg/ml in 5 ml or 10 ml vials
Manufacturer: AT "Farmak
Prescription required
Dosage form: drops, 5 ml in a bottle
Prescription required

Alternative to IKERVIS 1 mg/ml eye drops in emulsion in Poland

Dosage form: Drops, (3 mg + 3 mg)/ml
Manufacturer: Excelevision
Prescription required
Dosage form: Tablet, 0.75 mg
Importer: FARMACOL S.A. PROFARM PS Sp. z o.o. Synoptis Industrial Sp. z o.o.
Prescription required

Online doctors for IKERVIS 1 mg/ml eye drops in emulsion

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for IKERVIS 1 mg/ml eye drops in emulsion – subject to medical assessment and local rules.

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Doctor

Nuno Tavares Lopes

Family medicine17 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC. He offers online consultations in Portuguese, English, and Spanish — combining global expertise with a patient-centred, evidence-based approach.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.
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Dr. Alhasan’s approach is based on thorough assessment, clear communication, and personalised care – helping patients understand their health and make informed decisions about their treatment.
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  • Post-traumatic pain following injury or surgery.
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In addition to pain management, Dr. Popov helps patients with:
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Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

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She offers care for people undergoing GLP-1 therapy (Ozempic, Mounjaro, and others) for weight management. Her support follows Spanish clinical guidelines, from treatment planning and side effect counselling to regular follow-ups and coordination with private or public healthcare providers.

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Areas of medical expertise:

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  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
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  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
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  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
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Experience and qualifications:

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  • International education: Ukraine – Germany – Spain.
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  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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  • rashes, allergic reactions, redness, insect bites
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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

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With a patient-centred approach, Dr. Raevskii helps individuals manage both chronic illnesses and complex oncological cases. His consultations are guided by current medical standards and adapted to each patient’s needs.

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