This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use ICATIBANTO CIPLA 30 mg Injectable Solution in Pre-filled Syringe

Introduction

Package Leaflet: Information for the User

Icatibant Cipla 30 mg Solution for Injection in Pre-filled Syringe EFG

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

Keep this leaflet, you may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet

What is Icatibant Cipla and what is it used for
What you need to know before you use Icatibant Cipla
How to use Icatibant Cipla
Possible side effects
Storage of Icatibant Cipla
Contents of the pack and other information

1. What is Icatibant Cipla and what is it used for

Icatibant Cipla contains the active substance icatibant.

This medicine is used to treat the symptoms of hereditary angioedema (HAE) in adults, adolescents, and children over 2 years of age.

In HAE, the levels of a substance in the blood called bradykinin increase, producing symptoms such as swelling, pain, nausea, and diarrhea.

Icatibant blocks the action of bradykinin and thus slows down the progression of the symptoms of an HAE attack.

2. What you need to know before you use Icatibant Cipla

Do not use Icatibant Cipla

if you are allergic to icatibant or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor before starting to use Icatibant Cipla:

If you have angina pectoris (reduced blood flow to the heart).
If you have recently had a stroke.

The side effects related to icatibant are similar to the symptoms of your own illness. Consult your doctor immediately if you notice that the symptoms of the attack worsen after you are given this medicine.

In addition:

You or your caregiver must learn the technique for subcutaneous injections (under the skin) before you self-administer or your caregiver administers this medicine to you.
Immediately after self-administering Icatibant Cipla or after your caregiver administers it to you while you are experiencing a laryngeal attack (obstruction of the upper airway), you should seek medical attention at a medical institution.
If your symptoms do not resolve after a self-administered injection of Icatibant Cipla or after an injection administered by your caregiver, you should consult your doctor about the administration of additional injections of this medicine. In adult patients, up to 2 additional injections can be administered within 24 hours.

Children and adolescents

This medicine is not recommended for use in children under 2 years of age or weighing less than 12 kg because it has not been studied in these patients.

Other medicines and Icatibant Cipla

Tell your doctor if you are taking, have recently taken, or might take any other medicines.

No interactions of Icatibant Cipla with other medicines are known. If you are taking any medicine that is an angiotensin-converting enzyme inhibitor (ACEI) (e.g., captopril, enalapril, ramipril, quinapril, lisinopril) to lower blood pressure or for any other reason, inform your doctor before using this medicine.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.

If you are breastfeeding, you should not breastfeed your child for 12 hours after the last administration of this medicine.

Driving and using machines

Do not drive or use machines if you feel tired or dizzy as a result of the HAE attack or after using this medicine.

Icatibant Cipla contains sodium

This medicine contains less than 1 mmol (23 milligrams) of sodium per syringe, so it is essentially "sodium-free".

3. How to use Icatibant Cipla

Follow the instructions for administration of this medicine exactly as indicated by your doctor. In case of doubt, consult your doctor again.

If you have never been administered Icatibant Cipla before, the first dose should always be injected by medical or nursing staff. Your doctor will discharge you when they consider it safe for you to go home.

After discussing with your doctor or nurse and learning the technique for subcutaneous injections (under the skin), you or your caregiver can administer this medicine to you if you have an HAE attack.

It is essential to inject Icatibant Cipla subcutaneously (under the skin) as soon as you notice an angioedema attack. The healthcare staff will teach you and your caregiver how to inject this medicine safely, following the instructions in the package leaflet.

When and how often should you use Icatibant Cipla?

Your doctor has determined the exact dose of this medicine and will tell you how often you should use it.

Adults

The recommended dose of Icatibant Cipla is one injection (3 ml, 30 mg) administered subcutaneously (under the skin) as soon as you notice the angioedema attack (e.g., with increased skin swelling, especially on the face and neck, or increased abdominal pain).
If you do not notice an improvement in symptoms after 6 hours, you should seek medical advice about the administration of additional injections of Icatibant Cipla. In adults, up to 2 additional injections can be administered within 24 hours.
You should not receive more than 3 injections in a 24-hour period, and if you need more than 8 injections in a month, consult your doctor.

Children and adolescents from 2 to 17 years

The recommended dose of this medicine is an injection of 1 ml up to a maximum of 3 ml, depending on body weight, administered subcutaneously (under the skin) as soon as symptoms of an angioedema attack appear (e.g., increased skin swelling, especially on the face and neck, or increased abdominal pain).
Consult the section on instructions for use to see the dose you should inject.
If you are unsure about the dose to inject, consult your doctor, pharmacist, or nurse.
If your symptoms worsen or do not improve, you should seek medical advice immediately.

How should Icatibant Cipla be administered?

Icatibant Cipla is administered by subcutaneous injection (under the skin). Each syringe should only be used once.

This medicine is injected with a short needle into the fatty tissue under the skin of the abdomen (belly).

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

The following step-by-step instructions are intended for:

self-administration (adults)
administration by a caregiver or healthcare professional for adults, adolescents, or children over 2 years of age (weighing at least 12 kg).

The instructions include the following main steps:

General information

2a) Preparation of the syringe for children and adolescents (2-17 years) weighing 65 kg or less

2b) Preparation of the syringe and needle for injection (all patients)

Preparation of the injection site
Injection of the solution
Disposal of injection materials

Step-by-step instructions for injection

General information

Clean the work surface (area) you are going to use before starting the process.
Wash your hands with water and soap
Remove the pre-filled syringe from the case
Unscrew and remove the cap from the end of the pre-filled syringe
Leave the pre-filled syringe once the cap is unscrewed

2a) Preparation of the syringe for children and adolescents (2-17 years) weighing 65 kg or less:

Important information for healthcare professionals and caregivers:

When the dose is less than 30 mg (3 ml), the following equipment is needed to extract the correct dose (see information below):

Icatibant Cipla pre-filled syringe (with icatibant solution)
Connector (adapter)
3 ml graduated syringe

Pre-filled syringe with medication showing retracted piston and needle guard in position A, separate needle in B, and ready-to-use syringe in C

The required injection volume in ml should be prepared in an empty 3 ml graduated syringe (see table below).

Table 1: Dosage guideline for children and adolescents

Body weight	Injection volume
12 kg to 25 kg	1.0 ml
26 kg to 40 kg	1.5 ml
41 kg to 50 kg	2.0 ml
51 kg to 65 kg	2.5 ml

Patients weighing more than 65 kgwill use the entire contents of the pre-filled syringe (3 ml).

Yellow triangle with black border and black exclamation mark in the center indicating warning If you are unsure about the volume of solution to extract, consult your doctor, pharmacist, or nurse

Remove the caps from each end of the connector.

Yellow triangle with black border and black exclamation mark in the center indicating warning or caution Avoid touching the ends of the connector and the tips of the syringe to avoid contamination.

Screw the connector onto the pre-filled syringe.

Attach the graduated syringe to the other end of the connector, making sure both connections fit securely.

Hypodermic needle with bevel showing liquid entry through the lumen and arrows indicating flow direction

Transfer the icatibant solution to the graduated syringe:

To initiate the transfer of the icatibant solution, push the plunger of the pre-filled syringe (on the left end of the image below).

Needle with metal cylinder showing internal parts such as piston and connectors with arrows indicating movement direction

If the icatibant solution does not start to transfer to the graduated syringe, gently pull the plunger of the graduated syringe until the icatibant solution starts to flow into the graduated syringe (see image below).

Pre-filled syringe with transparent cylinder showing plunger and metal connections at both ends, arrow indicating direction

Continue pushing the plunger of the pre-filled syringe until the required injection volume (dose) is transferred to the graduated syringe. Consult Table 1 for dosage information.

If there is air in the graduated syringe:

Turn the connected syringes so that the pre-filled syringe is on top (see image below).

Transparent syringe with retracted plunger showing liquid inside the cylinder and black arrows indicating movement direction

Push the plunger of the graduated syringe to transfer the air back to the pre-filled syringe (this step may need to be repeated several times).
Extract the required volume of icatibant solution.

Remove the pre-filled syringe and connector from the graduated syringe.

Dispose of the pre-filled syringe and connector in the sharps container or puncture-proof container.

2b) Preparation of the syringe and needle for injection: All patients (adults, adolescents, and children)

Syringe needle with bevel visible, held by a hand, showing sharp tip and transparent cylinder

Remove the blister pack from the needle cap
Remove the seal from the needle cap (the needle should remain inside the cap)

Syringe with needle inserted, showing angle of entry and arrow indicating direction of insertion

Hold the syringe firmly. Carefully connect the needle to the pre-filled syringe with the colorless solution.
Screw the pre-filled syringe onto the needle, still fixed in the cap
Pull the syringe to remove the needle from the cap. Do not pull the plunger.
The syringe is now ready to administer the injection

Preparation of the injection site

Hand holding skin fold with thumb and index finger, preparing for subcutaneous injection

Choose the injection site. The injection site should be a skin fold in the abdomen, approximately 5-10 cm (2-4 inches) below the navel, to one side or the other. The area should be at least 5 cm (2 inches) away from any scar. Do not choose an area with bruises, inflammation, or pain.

Clean the injection site by rubbing it with an alcohol swab and let it dry.

Injection of the solution

Hand holding syringe with needle inserted into the skin, safety device visible, and arrow indicating direction of insertion

Hold the syringe between two fingers, with your thumb on the end of the plunger

Check that there is no air in the syringe by pressing the plunger until the first drop appears at the tip of the needle

Hand holding syringe with needle inserted into the skin, showing subcutaneous injection technique with low angle

Hold the syringe with the needle pointing towards the skin at an angle of 45 to 90 degrees
Holding the syringe in one hand, gently take a skin fold between your thumb and fingers in the previously cleaned area
Holding the skin fold, bring the syringe close and quickly insert the needle into the fold
Slowly press the plunger with a firm pulse until all the fluid has been injected into the skin and no liquid remains in the syringe
Press slowly so that the process takes approximately 30 seconds
Release the skin fold and gently withdraw the needle

Disposal of injection materials

Hand holding syringe with needle inserted into a vial stopper, with arrow indicating direction of injection

Dispose of the syringe, needle, and cap in the sharps container or puncture-proof container for disposal of sharp objects that can harm others if not handled properly.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Almost all patients who receive Icatibant Cipla notice a reaction at the injection site (such as skin irritation, inflammation, pain, itching, redness of the skin, and burning). These effects are usually mild and improve without the need for any additional treatment.

Tell your doctor immediately if you notice that the symptoms of the attack worsen after you have received this medicine.

Very common(may affect more than 1 in 10 people):

Additional reactions at the injection site (feeling of pressure, bruising, decreased sensitivity and/or numbness, increased skin rash with itching and heat).

Common(may affect up to 1 in 10 people):

Nausea
Headache
Dizziness
Fever
Itching
Rash
Redness of the skin
Abnormal liver function tests

Frequency not known(cannot be estimated from the available data):

Hives (urticaria)

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Icatibant Cipla

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton after "EXP". The expiry date refers to the last day of the month shown.

Do not store above 25°C. Do not freeze.

Do not use this medicine if you notice that the syringe or needle packaging is damaged or if you notice visible signs of deterioration; for example, if the solution is cloudy, contains floating particles, or has changed color.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Container Content and Additional Information

Composition of Icatibant Cipla

The active ingredient is icatibant. Each pre-filled syringe contains 30 milligrams of icatibant (as acetate). Each ml of solution contains 10 mg of icatibant
The other components are sodium chloride, glacial acetic acid, sodium hydroxide (for pH adjustment) and water (see section 2).

Appearance of the Product and Container Content

Icatibant Cipla is presented as a clear and colorless injectable solution in a 3 ml glass pre-filled syringe. The container contains a hypodermic needle.

Icatibant Cipla is available in a single pack of one pre-filled syringe with one needle or in a multipack of three pre-filled syringes with three needles.

Only some pack sizes may be marketed.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder

Cipla Europe NV

De Keyserlei 58-60, Box 19,

2018 Antwerp, Belgium

Manufacturer

Pharmadox Healthcare Ltd.

KW20A Kordin Industrial Park

Paola PLA 3000

Malta

or

Eurofins PROXY Laboratories (PRX)

Archimedesweg 25 2333 CM Leiden

Netherlands

Local Representative

Cipla Europe NV branch in Spain,

C/Guzmán el Bueno, 133 Edif Britannia 28003 Madrid, Spain

This medicinal product is authorized in the Member States of the European Economic Area under the following names:

Germany	Icatibant Cipla 30 mg Injection Solution i.e. Prefilled Syringe
Denmark	Icatibant Cipla
Spain	Icatibanto Cipla 30 mg injectable solution in pre-filled syringe EFG
Norway	Icatibant Cipla

Date of the Last Revision of this Leaflet:September 2021

Detailed and updated information on this medicinal product is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) (http://www.aemps.gob.es/)

Country of registration
Spain
Active substance
icatibant
Prescription required
Yes
Manufacturer
Cipla Europe
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
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Online doctors for ICATIBANTO CIPLA 30 mg Injectable Solution in Pre-filled Syringe

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for ICATIBANTO CIPLA 30 mg Injectable Solution in Pre-filled Syringe – subject to medical assessment and local rules.

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Tomasz Grzelewski

Dermatology20 years of experience

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

seasonal and perennial allergies
allergic rhinitis and chronic nasal symptoms
asthma and breathing difficulties
food and medication allergies
urticaria, atopic dermatitis and skin reactions
recurrent infections in children
sports-related health questions
general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Areas of medical expertise:

Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
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Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
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Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

12+ years of clinical experience in university hospitals in Germany and Spain.
International education: Ukraine – Germany – Spain.
Member of the German Society of Surgeons (BDC).
Certified in radiological diagnostics and robotic surgery.
Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Dr. Ben Ami offers expert diagnosis, treatment, and follow-up for:

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Management of chronic diseases: high blood pressure, diabetes, thyroid disorders.
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Headaches, migraines, and minor injuries.
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With a patient-focused and evidence-based approach, Dr. Ben Ami supports individuals at all stages of life — offering clear medical guidance, timely interventions, and continuity of care.

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fever, chills, fatigue and viral symptoms
cough, sore throat, nasal congestion, breathing discomfort
bronchitis and mild asthma flare-ups
nausea, diarrhoea, abdominal pain, digestive infections
rashes, allergic reactions, redness, insect bites
muscle or joint pain, mild injuries, sprains
headache, dizziness, migraine symptoms
stress-related symptoms, sleep disturbances
questions about test results and treatment plans
management of chronic conditions in stable phases

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Dr. Lokchiri’s professional training includes:

Advanced Trauma Life Support (ATLS)
Basic and Advanced Cardiac Life Support (BLS/ACLS)
Pediatric Advanced Life Support (PALS)
Prehospital Trauma Life Support (PHTLS)
eFAST and critical care transthoracic echocardiography
aviation medicine

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General health concerns, prevention, and primary care.
Hypertension, type 1 and type 2 diabetes, metabolic issues.
Cold, cough, flu, respiratory infections, sore throat, fever.
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Skin rashes, mild allergic reactions, basic dermatological complaints.
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Dr. Ben Harbi offers reliable, accessible medical support through online consultations, helping patients make informed decisions about their health with a clear, structured, and compassionate approach.

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Anna Biriukova

General medicine5 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
Leg swelling, chronic fatigue, reduced exercise tolerance.
EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
Post-COVID-19 cardiac monitoring and care.

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Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
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Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
Metabolic syndrome – obesity, lipid disorders, insulin resistance.

Gastroenterology – Digestive health:

Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).

General internal medicine and preventive care:

Respiratory infections – cough, colds, bronchitis.
Lab test analysis, therapy adjustments, medication management.
Adult vaccinations – planning, contraindications assessment.
Cancer prevention – screening strategies and risk assessment.
Holistic approach – symptom relief, complication prevention, and quality of life improvement.

Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.

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Svetlana Kolomeeva

Cardiology17 years of experience

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Patients commonly seek her help for:

High blood pressure, headaches, dizziness, swelling, palpitations.
Diagnosis and management of hypertension, arrhythmias, and tachycardia.
Metabolic syndrome, excess weight, high cholesterol.
Chronic fatigue, insomnia, poor concentration, anxiety.
Respiratory symptoms: colds, flu, sore throat, cough, fever.
Digestive issues: heartburn, bloating, constipation, IBS symptoms.
Chronic conditions: diabetes, thyroid disorders.
Interpretation of lab tests and medical reports, therapy adjustment.
Second opinion and decision-making support.
Cardiovascular disease prevention and metabolic risk reduction.
Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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Mar Tabeshadze

Endocrinology10 years of experience

Dr. Mar Tabeshadze is a licensed endocrinologist and general practitioner in Spain. She provides online consultations for adults, offering medical support for a wide range of endocrine conditions and related health concerns.

Diagnostic consultations for suspected endocrine disorders
Management of thyroid conditions, including in pregnant women
Early detection and treatment of type 1 and type 2 diabetes, with personalised therapy plans
Obesity treatment: identifying underlying causes of weight gain, combining medication and non-pharmacological strategies, and long-term support
Diagnosis and treatment of endocrine-related skin, hair, and nail issues
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Dr. Tabeshadze takes a patient-centred approach based on evidence-based medicine. Her goal is to help patients achieve hormonal balance, manage chronic conditions effectively, and improve overall well-being through targeted, personalised care.

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Maryna Kuznetsova

Cardiology16 years of experience

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Areas of expertise:

dyslipidaemia and lipid metabolism disorders
prevention and management of atherosclerosis
blood pressure monitoring and antihypertensive therapy
arrhythmias: diagnosis, follow-up, and treatment adjustment
cardiovascular care and recovery support after Covid-19

Dr Kuznetsova helps patients manage cardiovascular risk factors, optimise long-term treatment, and gain clarity in complex health situations – all through accessible and structured online care.

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Antonio Cayatte

General medicine43 years of experience

Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic.

His clinical background includes: