This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use EVACUOL 7.5 mg/ml Oral Drops in Solution

Introduction

PACKAGE LEAFLET: INFORMATION FOR THE USER

Evacuol 7.5 mg/ml Oral drops in solution

Sodium picosulfate

Read all of this leaflet carefully because it contains important information for you.

This medicine can be obtained without a prescription. Nevertheless, to obtain the best results, it should be used properly.
Keep this leaflet, as you may need to read it again.
If you need advice or more information, consult your pharmacist.
It should not be used for more than 6 consecutive days. If symptoms worsen or persist after 6 days, you should consult a doctor.
If no defecation occurs after 72 hours, you should consult a doctor.
If you consider that any of the adverse effects you are suffering from is serious or if you notice any adverse effect not mentioned in this leaflet, inform your doctor or pharmacist.

Contents of the package leaflet:

What is Evacuol and what is it used for
Before taking Evacuol
How to take Evacuol
Possible side effects
Storage of Evacuol
Additional information

1. What is Evacuol and what is it used for

Evacuol belongs to the group of medicines called laxatives. Its laxative action is produced by direct stimulation of the large intestine. This stimulation produces the emptying of the fecal mass after a latency period, which depends on the sensitivity of each individual and the dose.

Evacuol is indicated, in adults and in children over 6 years, for the relief of symptoms of occasional constipation, such as that produced by bed rest or travel, and to facilitate evacuation in cases of hemorrhoids and anal fissures.

2. Before taking Evacuol

Do not take Evacuol

If you are allergic (hypersensitive) to sodium picosulfate or any of the other components of Evacuol.
If you have any inflammatory intestinal disease, acute abdominal pain, symptoms of appendicitis (nausea, vomiting, abdominal pain) or intestinal obstruction. In the case of having other significant abdominal discomfort, consult your doctor beforehand.
Evacuol should not be administered to children under 6 years.

Be careful with Evacuol

Do not take more doses than recommended in section 3. "How to take Evacuol". Prolonged treatment or with high doses of Evacuol can produce excessive loss of potassium, with a decrease in potassium in the blood, which can be worsened if Evacuol is administered together with other medicines that have a similar effect on potassium.

If the desired effect is not obtained by following the scheme indicated by the doctor or indicated in this leaflet, interrupt the treatment and consult your doctor.

If no defecation occurs after 72 hours, you should consult a doctor.

Avoid continuous use for more than 6 days, as there is a risk of habituation (getting used to) the laxative, which will make it impossible to achieve the expected effect.

Consult your doctor, even if any of the aforementioned circumstances have occurred to you at some point.

Use in the elderly

In the case of elderly patients, the loss of fluids due to repeated or excessive use can lead to weakness, low blood pressure, and psychomotor coordination problems.

Use of other medicines

Inform your doctor or pharmacist if you are using or have recently used other medicines, including those purchased without a prescription.

Due to the increased gastrointestinal transit caused by laxatives, the absorption of other medicines administered jointly may be affected.

The use of Evacuol together with medicines that affect electrolytes (potassium), such as amphotericin B (a medicine for the treatment of fungal infections), corticosteroids, tetracosactide, and diuretics (medicines that favor the elimination of urine), could worsen a possible decrease in potassium in the blood (hypokalemia) caused by Evacuol (see section "Be careful with Evacuol").

The simultaneous intake of antibiotics can lead to the loss of the laxative effect of sodium picosulfate (the active ingredient of Evacuol), as they can alter the gastrointestinal flora.

Also, inform your doctor if you are taking any of the following medicines:

Vincamine (a medicine for the treatment of cerebral circulatory insufficiency)
Bepridil, quinidine, sotalol, amiodarone (medicines used for heart rhythm disorders)
Digitalis glycosides (medicines used for heart failure)

Pregnancy and breastfeeding

Consult your doctor or pharmacist before using any medicine.

Pregnancy

In studies conducted in animals, no effects of sodium picosulfate (the active ingredient of this medicine) on the fetus have been observed. However, due to the lack of data in humans, it is advised, if possible, not to use it during pregnancy.

Breastfeeding

Sodium picosulfate (the active ingredient of the medicine) and its metabolites do not pass into breast milk, so it can be used by women during breastfeeding.

Driving and using machines

No effects that affect driving and the use of machines have been described.

Evacuol contains methyl parahydroxybenzoate

It can produce allergic reactions (possibly delayed) because it contains methyl parahydroxybenzoate.

Evacuol contains sorbitol

This medicine contains 151.7 mg of sorbitol in 5 drops (unit dose for adults) and 60.7 mg of sorbitol in 2 drops (unit dose for children over 6 years).

Sorbitol is a source of fructose. If your doctor has told you (or your child) that you suffer from an intolerance to certain sugars, or you have been diagnosed with hereditary fructose intolerance (HFI), a rare genetic disease, in which the patient cannot break down fructose, consult your doctor before taking this medicine.

3. How to take Evacuol

Follow these instructions unless your doctor has given you different instructions.

Posology

The presentation of Evacuol in the form of drops allows the dosage to be adapted for each individual case.

Given that the laxative effect occurs 8 to 12 hours after taking the medication, it is preferable to take it at night. In this way, the laxative effect can occur the next morning.

Use in adults

The initial dose in adult patients is 5 to 10 drops per day in a single dose. In case defecation does not occur the next morning, on the second night, 5 more drops can be taken, and so on, up to a maximum of 6 days, as summarized in the following table:

Day 1	Day 2	Day 3	Day 4	Day 5	Day 6
Night	Morning	Night	Morning	Night	Morning	Night	Morning	Night	Morning
5 drops	Defecates
Does not defecate	5 drops	Defecates
		Does not defecate	5 drops	Defecates
				Does not defecate	5 drops	Defecates
						Does not defecate	5 drops	Defecates

Use in children over 6 years

The initial dose in children over 6 years is 2 to 5 drops per day in a single dose. In case defecation does not occur the next morning, on the second night, 2 more drops can be taken, and so on, up to a maximum of 6 days, as summarized in the following table:

Day 1	Day 2	Day 3	Day 4	Day 5	Day 6
Night	Morning	Night	Morning	Night	Morning	Night	Morning	Night	Morning
2 drops	Defecates
Does not defecate	2 drops	Defecates
		Does not defecate	2 drops	Defecates
				Does not defecate	2 drops	Defecates
						Does not defecate	2 drops	Defecates

Method of administration

This medicine is for oral administration.

The medication can be taken alone or dissolved in a little water, milk, or fruit juice, etc.

If you think the action of Evacuol is too strong or too weak, inform your doctor or pharmacist.

If you take more Evacuol than you should

If you have taken more Evacuol than you should, consult your doctor or pharmacist immediately, go to the nearest hospital, or consult the Toxicology Information Service, phone: 915 620 420 (indicating the medicine and the amount ingested).

In case of overdose or prolonged use, as with other stimulant laxatives, gastrointestinal disorders with diarrhea and excessive loss of water and electrolytes, especially potassium, may appear, which can lead to muscle weakness and heart function disorders. If necessary, compensatory measures, such as the administration of large amounts of fluids and electrolytes, should be taken.

Also, in cases of prolonged use, there is a possibility of developing a purgative effect (excessive loss of fecal mass) or worsening constipation.

If you forget to take Evacuol

Do not take a double dose to make up for forgotten doses. Take the forgotten dose when you remember and then follow the usual schedule. However, if there are only a few hours left until the next dose, do not take the forgotten dose and wait to take the next dose at the corresponding time.

4. Possible side effects

Like all medicines, Evacuol can produce side effects, although not all people suffer from them.

Skin rashes, abdominal pain, and diarrhea (frequency unknown) may occur

These side effects may appear after high doses or prolonged treatments, are mild and transient, and disappear after defecation.

Reporting side effects

If you experience any type of side effect, consult your doctor, pharmacist, or nurse, even if it is a possible side effect that does not appear in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medicine.

5. Storage of Evacuol

Keep out of the reach and sight of children.

No special storage conditions are required.

Do not use Evacuol after the expiration date that appears on the packaging after EXP. The expiration date is the last day of the month indicated.

Medicines should not be thrown away through wastewater or household waste. Deposit the packaging and medicines that are no longer needed in the SIGRE collection point at the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and medicines that are no longer needed. This will help protect the environment.

6. Additional information

Composition of Evacuol

The active ingredient is sodium picosulfate. Each milliliter (approximately 15 drops) contains 7.5 mg of sodium picosulfate.
The other components are 70% sorbitol solution, methyl parahydroxybenzoate (E-218), purified water.

Appearance of the product and packaging content

Evacuol is presented as a clear, transparent, colorless, and odorless liquid for oral administration. Each bottle contains 30 milliliters and has a dropper for dosing the preparation.

Marketing authorization holder and manufacturer

Marketing authorization holder

Teofarma S.r.l.

Via F.lli Cervi, 8

27010 Valle Salimbene (PV) – Italy

Manufacturer

ALMIRALL HERMAL GmbH

Scholtzstraße 3

D-21465 Reinbek (Germany)

or

Manufacturer

Industrias Farmacéuticas Almirall, S.A.

Ctra. de Martorell, 41-61

08740 Sant Andreu de la Barca - Barcelona (Spain).

This leaflet was approved in December 2003

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Country of registration
Spain
Active substance
sodium picosulfate
Prescription required
No
Manufacturer
Teofarma S.R.L.
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
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Alternatives to EVACUOL 7.5 mg/ml Oral Drops in Solution in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to EVACUOL 7.5 mg/ml Oral Drops in Solution in Poland

Pikopil

Dosage form: Drops, 7.5 mg

Active substance: sodium picosulfate

Importer: Symphar Sp. z o.o.

Prescription not required

Pikopil

Dosage form: Tablets, 7.5 mg

Active substance: sodium picosulfate

Importer: Symphar Sp. z o.o.

Prescription not required

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Dosage form: Capsules, 375 mg

Manufacturer: Wrocławskie Zakłady Zielarskie "Herbapol" S.A.

Prescription not required

Normosan

Dosage form: Herbs, 22.02-29.79 mg anthraquinones converted to glucofrangulin A/1.4 g

Manufacturer: Herbapol - Lublin S.A.

Prescription not required

Alternative to EVACUOL 7.5 mg/ml Oral Drops in Solution in Ukraine

SLABILAKS-ZDOROV`A

Dosage form: tablets, 7.5 mg

Active substance: sodium picosulfate

Manufacturer: Tovaristvo z obmezenou vidpovidal'nistu "Farmacevticna kompania "Zdorov'a

Prescription not required

SLABILAKS-ZDOROV'A

Dosage form: drops, 7.5 mg/ml, 15 ml or 30 ml in a bottle

Active substance: sodium picosulfate

Manufacturer: Tovaristvo z obmezenou vidpovidal'nistu "Farmacevticna kompania "Zdorov'a

Prescription not required

REGULAKS PIKOSUL'FAT

Dosage form: drops, 7.5 mg/ml, 20 ml

Active substance: sodium picosulfate

Manufacturer: Krevel' Mojzel'bah GmbH

Prescription not required

PIKOSUL'FAT-SOFARMA

Dosage form: drops, 7.5 mg/ml, 15 ml

Active substance: sodium picosulfate

Manufacturer: AT "Sofarma" (virobnictvo nerozfasovanoi produkcii, pervinna ta vtorinna upakovka abo virobnictvo za povnim ciklom; dozvil na vipusk serii)

Prescription not required

PIKONORM

Dosage form: drops, 7.5 mg/ml 10 ml

Active substance: sodium picosulfate

Manufacturer: PrAT "Farmacevticna firma "Darnica

Prescription not required

PIKOLAKS

Dosage form: tablets, tablets 7.5mg

Active substance: sodium picosulfate

Manufacturer: AT "Farmak

Prescription not required

Online doctors for EVACUOL 7.5 mg/ml Oral Drops in Solution

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for EVACUOL 7.5 mg/ml Oral Drops in Solution – subject to medical assessment and local rules.

5.0(38)

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

12+ years of clinical experience in university hospitals in Germany and Spain.
International education: Ukraine – Germany – Spain.
Member of the German Society of Surgeons (BDC).
Certified in radiological diagnostics and robotic surgery.
Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Antonio Cayatte

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Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic.

His clinical background includes:

assessment of sudden or unclear symptoms
ongoing care for chronic conditions
follow-up after hospital discharge
interpretation of test results
medical support while abroad

Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association.

Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

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Andrei Popov

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Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

He specialises in diagnosing and treating pain conditions that affect quality of life, including:

Chronic pain lasting more than 3 months.
Migraines and recurring headaches.
Neck, back, lower back, and joint pain.
Post-traumatic pain following injury or surgery.
Nerve-related pain, fibromyalgia, and neuralgia.

In addition to pain management, Dr. Popov helps patients with:

Respiratory infections (colds, bronchitis, pneumonia).
High blood pressure and metabolic conditions such as diabetes.
Preventive care and routine health check-ups.

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

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Anna Biriukova

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Cardiology – Diagnosis and treatment of:

High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
Leg swelling, chronic fatigue, reduced exercise tolerance.
EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
Post-COVID-19 cardiac monitoring and care.

Endocrinology – Diabetes, thyroid, metabolism:

Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
Individual treatment plans including oral medications and insulin therapy.
GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
Metabolic syndrome – obesity, lipid disorders, insulin resistance.

Gastroenterology – Digestive health:

Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).

General internal medicine and preventive care:

Respiratory infections – cough, colds, bronchitis.
Lab test analysis, therapy adjustments, medication management.
Adult vaccinations – planning, contraindications assessment.
Cancer prevention – screening strategies and risk assessment.
Holistic approach – symptom relief, complication prevention, and quality of life improvement.

Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.

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Mar Tabeshadze

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Dr. Mar Tabeshadze is a licensed endocrinologist and general practitioner in Spain. She provides online consultations for adults, offering medical support for a wide range of endocrine conditions and related health concerns.

Diagnostic consultations for suspected endocrine disorders
Management of thyroid conditions, including in pregnant women
Early detection and treatment of type 1 and type 2 diabetes, with personalised therapy plans
Obesity treatment: identifying underlying causes of weight gain, combining medication and non-pharmacological strategies, and long-term support
Diagnosis and treatment of endocrine-related skin, hair, and nail issues
Ongoing care for patients with osteoporosis, pituitary, and adrenal gland disorders

Dr. Tabeshadze takes a patient-centred approach based on evidence-based medicine. Her goal is to help patients achieve hormonal balance, manage chronic conditions effectively, and improve overall well-being through targeted, personalised care.

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Maryna Kuznetsova

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Dr Marina Kuznetsova is an internal medicine doctor and cardiologist with a PhD in medicine. She provides online consultations for adults with chronic and acute conditions, with a strong focus on cardiovascular health. Her approach is based on current clinical guidelines and evidence-based treatment strategies.

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dyslipidaemia and lipid metabolism disorders
prevention and management of atherosclerosis
blood pressure monitoring and antihypertensive therapy
arrhythmias: diagnosis, follow-up, and treatment adjustment
cardiovascular care and recovery support after Covid-19

Dr Kuznetsova helps patients manage cardiovascular risk factors, optimise long-term treatment, and gain clarity in complex health situations – all through accessible and structured online care.

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Lina Travkina

Family medicine12 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

Preventive consultations and check-up planning.
Medical advice and follow-up consultations.
Test interpretation and diagnostic guidance.
Structured support for undiagnosed complaints.
Second opinion on diagnoses and treatment plans.
Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
Post-operative recovery support and pain management.
Preconception counselling and postpartum support.
Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Dmytro Horobets

Family medicine6 years of experience

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

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Karim BenHarbi

General medicine8 years of experience

Dr. Karim Ben Harbi is a licensed general practitioner based in Italy. He provides online consultations for adults and children, combining international clinical experience with evidence-based medicine. His care approach is focused on accurate diagnosis, preventive care, and personalised health guidance.

Dr. Ben Harbi received his medical degree from Sapienza University in Rome. His training included hands-on experience in diverse settings — tropical medicine, rural healthcare, and urban outpatient practice. He also conducted clinical research in microbiology, exploring the role of the gut microbiome in chronic gastrointestinal issues.

You can consult Dr. Ben Harbi for:

General health concerns, prevention, and primary care.
Hypertension, type 1 and type 2 diabetes, metabolic issues.
Cold, cough, flu, respiratory infections, sore throat, fever.
Chronic digestive issues: bloating, gastritis, IBS, microbiome imbalance.
Skin rashes, mild allergic reactions, basic dermatological complaints.
Medication guidance, treatment adjustments, prescription review.
Paediatric concerns — fever, infections, general well-being.
Lifestyle optimisation: stress, sleep, weight, and diet counselling.

Dr. Ben Harbi offers reliable, accessible medical support through online consultations, helping patients make informed decisions about their health with a clear, structured, and compassionate approach.

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Khrystyna Habrykevych

Gastroenterology6 years of experience

Dr Khrystyna Habrykevych is a gastroenterologist providing online consultations for adults with digestive and abdominal health concerns. She helps patients understand the causes of their symptoms, interpret test results, and choose appropriate next steps – whether it’s further investigation, treatment, or lifestyle adjustments.

Common reasons for consultation include: