This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION

Introduction

Package Leaflet: Information for the User

DUKORAL suspension and effervescent granule for oral suspension

Cholera vaccine (inactivated, oral)

Read all of this leaflet carefully before you start using this vaccine, because it contains important information for you.

Keep this leaflet, you may need to read it again.
If you have any further questions, ask your doctor, pharmacist, or nurse.
This vaccine has been prescribed for you, do not pass it on to others.
If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if they are not listed in this leaflet. See section 4.
Make sure to mix the vaccine with the buffer solution as described in this leaflet. See section 3.

Contents of thepackage leaflet

What is Dukoral and what is it used for
What you need to know before you start using Dukoral
How to use Dukoral
Possible side effects
Storage of Dukoral
Contents of the pack and further information

1. What is Dukoral and what is it used for

Dukoral is an oral cholera vaccine that stimulates the intestinal immune defenses. The vaccine protects adults and children from 2 years of age against cholera.

Dukoral makes the body produce its own protection against cholera. After receiving the vaccine, the body will create substances called antibodies that fight the toxin and cholera bacteria that cause diarrhea.

2. What you need to know before you start using Dukoral

Do not use Dukoral

? if you are allergic to any of the components of the vaccine (listed in section 6) or to formaldehyde.

? if you have an acute gastric disorder or an infection accompanied by fever (vaccination should be postponed).

Warnings and precautions

Talk to your doctor before starting to take Dukoral

? if you are receiving treatment that affects your immune system

? if you have an immune system disease (including HIV infection).

The vaccine may provide a lower level of protection than that which occurs in people without immune system impairment.

The vaccine does not provide complete protection and it is important to follow dietary and hygiene recommendations to avoid contracting diseases that cause diarrhea.

Children

Do not administer this vaccine to children under 2 years of age as protection has not been studied in this group.

Use ofDukoral withother medicines

Tell your doctor if you are taking, have recently taken, or might take any other medicine.

Do not take any other medicine from one hour before to one hour after administration of the vaccine.

Use of Dukoral with food and drinks

Avoid ingestion of food and drinks from one hour before to one hour after administration of the vaccine.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor before taking the vaccine.

Driving and using machines

There is no reason to suspect that Dukoral affects the ability to drive and use machines.

Dukoralcontains sodium

Dukoral contains approximately 1.1 g of sodium per dose, which should be taken into account in patients with low-sodium diets.

3. How to use Dukoral

Follow the instructions for administration of the medicine contained in this leaflet or as indicated by your doctor. In case of doubt, consult your doctor again.

Adults and children from 6 years of age:The primary vaccination consists of two doses orally (by mouth) separated by a minimum interval of one week (up to six weeks).

Take the first dose no later than two weeks before starting your trip.
Take the second dose at least one week after the first dose and at least one week before your trip.

It takes approximately one week for protection to begin after the last dose.

To achieve continued protection, revaccination is recommended after two years. If it has been less than two years since your last dose of the vaccine, a single dose will renew your protection. If it has been more than two years since your last dose of the vaccine, primary vaccination should be repeated (2 doses).

Children from 2 to less than 6 years of age:The primary vaccination consists of three doses taken orally (by mouth) separated by a minimum interval of one week (up to six weeks). Only half of the buffer solution should be mixed with the vaccine.

Administer the first dose to the child no later than three weeks before starting your trip.
Administer the second dose to the child at least one week after the first dose.
Administer the third dose to the child at least one week after the second dose and at least one week before your trip.

It takes approximately one week for protection to begin after the last dose. To achieve continued protection, revaccination is recommended after six months. If it has been less than six months since the last dose of the vaccine, a single dose will renew protection. If it has been more than six months since the last vaccination, primary vaccination should be repeated (3 doses).

The suspension is a white suspension that is supplied in a glass vial for single dose. Each vial comes with a sachet containing a white, effervescent granule of sodium bicarbonate. The effervescent granule should be dissolved in a glass of cold water, and the resulting buffer solution should be mixed with the suspension. It is important to use the buffer solution, as it protects the vaccine against gastric acid.

Drink the entire mixture within 2 hours after mixing with the buffer solution.

Instructions for use:

Powder pouring into a glass with 150ml of water, stir, mix gently and drink within 2 hours according to the instructions

To prepare the buffer solution, dissolve the effervescent granule in a glass of cold water (approx. 150 ml) by gently stirring.

Do not use any other liquid.

For children from 2 to less than 6 years:discard half of the buffer solution.

Shake the Dukoral suspension vial (1 vial = 1 dose).

Pour the contents of the Dukoral suspension vial into the glass of buffer solution (see 1). Mix by gently stirring.
Drink the entire mixture within 2 hours. Avoid ingestion of food and drinks from one hour before to one hour after drinking the mixture.

If you take more Dukoral than you should

If you take the doses with a time interval of less than one week, contact your doctor, pharmacist, or nurse.

As each vial of Dukoral contains only one dose, it is unlikely that an overdose will occur.

If you have taken more than one dose at a time, contact your doctor, pharmacist, or nurse.

If you forget to take Dukoral

You can take the second dose of Dukoral up to 6 weeks after the first dose (children from 2 to less than 6 years of age have to take 3 doses). If more than 6 weeks have passed, contact your doctor, pharmacist, or nurse.

If you have any further questions on the use of this vaccine, ask your doctor, pharmacist, or nurse.

4. Possible side effects

Like all medicines, Dukoral can cause side effects, although not everybody gets them.

Contact a doctor immediately if you experience the following serious side effects:

Severe diarrhea with loss of body water
Severe allergic reactions that cause swelling of the face or throat and difficulty breathing

Other side effects:

Uncommon side effects (may affect up to 1 in 100 people)

Diarrhea, stomach pain, abdominal cramps, abdominal rumbling, abdominal swelling, gas in the stomach, and general abdominal discomfort
Headache

Rare side effects (may affect up to 1 in 1,000 people)

Fever
General malaise, feeling of dizziness
Nausea, vomiting, loss or decreased appetite
Swelling, inflammation inside the nose, and cough

Very rare side effects (may affect up to 1 in 10,000 people)

Rash
Sore throat, decreased sense of taste
Fatigue/feeling of tiredness
Sweating, chills
Joint pain
Difficulty sleeping

Other side effects (frequency cannot be estimated from the available data)

Pseudo-flu symptoms, respiratory symptoms, chills, general pain, weakness
Hives, itching
Swelling of the lymph nodes

Numbness or tingling

High blood pressure

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if they are not listed in this leaflet. You can also report them directly through the national reporting system included in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Dukoral

Keep this medicine out of the sight and reach of children.

Do not use Dukoral after the expiry date which is stated on the carton after EXP. The expiry date is the last day of the month stated.

Store in a refrigerator (between 2°C and 8°C). Do not freeze.

The product from the vial and sachet unopened, stored in the outer carton, remains stable at temperatures not above 25°C for a period of 14 days. At the end of this period, the product should be used or discarded.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and further information

Composition of Dukoral

The active substances are: 31.25x10^9 bacteria* of the following strains of V. choleraeO1: classical biotype Inaba (inactivated by heat), El Tor biotype Inaba (inactivated with formalin), classical biotype Ogawa (inactivated by heat), classical biotype Ogawa (inactivated with formalin). Recombinant cholera toxin B subunit (TCBr), 1 mg.

*bacterial content prior to inactivation

The other components of the suspension that contains the vaccine are sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium chloride, and water for injections.

The effervescent granule contains sodium bicarbonate, citric acid, sodium carbonate, sodium saccharin, sodium citrate, and raspberry flavor.

Appearance of the product and contents of the pack

Dukoral is presented as a suspension and effervescent granule for oral suspension. The suspension is a white suspension that is presented in a vial. The effervescent granule is white with a raspberry flavor and is supplied in a sachet.

Dukoral is presented in packs of 1, 2, and 20 doses. Not all pack sizes may be marketed.

Marketing authorisation holder and manufacturer

Valneva Sweden AB, 105 21 Stockholm, Sweden.

[email protected]

Date of last revision ofthis leaflet:MM/AAAA

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

On the European Medicines Agency website, you can find this leaflet in all languages of the European Union/European Economic Area.

How much does DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION cost in Spain ( 2025)?

The average price of DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION in November, 2025 is around 49.39 EUR. Prices may vary depending on the region, pharmacy, and whether a prescription is required. Always check with a local pharmacy or online source for the most accurate information.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

12+ years of clinical experience in university hospitals in Germany and Spain.
International education: Ukraine – Germany – Spain.
Member of the German Society of Surgeons (BDC).
Certified in radiological diagnostics and robotic surgery.
Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

DUKORAL SUSPENSION AND EFFERVSCENT GRANULES FOR ORAL SUSPENSION

Svetlana Kovalenko

Anna Biriukova

Svetlana Kovalenko

Anna Biriukova