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DAXAS 250 micrograms tablets

DAXAS 250 micrograms tablets

Ask a doctor about a prescription for DAXAS 250 micrograms tablets

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Doctor

Tomasz Grzelewski

Dermatology20 years of experience

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use DAXAS 250 micrograms tablets

Introduction

Package Leaflet: Information for the Patient

Daxas 250micrograms tablets

roflumilast

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Daxas and what is it used for
  2. What you need to know before you take Daxas
  3. How to take Daxas
  4. Possible side effects
  5. Storage of Daxas
  6. Contents of the pack and other information

1. What is Daxas and what is it used for

Daxas contains the active substance roflumilast, which is a phosphodiesterase-4 inhibitor anti-inflammatory. Roflumilast reduces the activity of phosphodiesterase-4, a protein that occurs naturally in the body's cells. When the activity of this protein is reduced, inflammation in the lungs decreases. This helps to stop the narrowing of the airways that occurs in chronic obstructive pulmonary disease (COPD). Therefore, Daxas relieves respiratory problems.

Daxas is used for the maintenance treatment of severe COPD in adults who have had frequent worsening of their COPD symptoms (exacerbations) in the past and who have chronic bronchitis. COPD is a chronic lung disease that results in the narrowing of the airways (obstruction) and swelling and irritation of the walls of the small airways in the lungs (inflammation). This leads to symptoms such as coughing, wheezing, chest tightness, or difficulty breathing. Daxas should be used in combination with bronchodilators.

2. What you need to know before you take Daxas

Do not take Daxas

- if you are allergic to roflumilast or any of the other ingredients of this medicine (listed in section 6)

- if you have moderate or severe liver problems.

Warnings and precautions

Consult your doctor or pharmacist before starting treatment with Daxas.

Sudden episodes of shortness of breath (dyspnea)

Daxas is not indicated for the treatment of acute bronchospasm (sudden episodes of shortness of breath). To relieve a sudden episode of shortness of breath, it is very important that your doctor provides you with another medicine that you will have available at all times to overcome such episodes. Daxas will not help you in these situations.

Body weight

You should check your weight periodically. Consult your doctor if, while taking this medicine, you notice an unintentional weight loss (not due to diet or exercise).

Other diseases

Daxas is not recommended if you have one or more of the following diseases:

  • severe immunological diseases such as HIV infection, multiple sclerosis (MS), systemic lupus erythematosus (SLE), or progressive multifocal leukoencephalopathy (PML)
  • severe acute infectious diseases such as acute hepatitis
  • cancer (except for patients with basal cell carcinoma, a type of slow-growing skin cancer)
  • severe heart disease

There is limited experience with Daxas in these diseases. If you are diagnosed with any of these diseases, consult your doctor.

Experience with the use of Daxas in patients with a previous diagnosis of tuberculosis, viral hepatitis, viral herpes, or herpes zoster is also limited. Consult your doctor if you have any of these diseases.

Symptoms you should be aware of

During the first few weeks of treatment with Daxas, you may experience diarrhea, nausea, abdominal pain, or headache. If these side effects do not disappear after the first few weeks of treatment, consult your doctor.

Daxas is not recommended in patients with a history of depression associated with suicidal ideation or behavior. You may also experience difficulty sleeping, anxiety, nervousness, or depression. Before starting treatment with Daxas, inform your doctor if you have any of these symptoms or if you are taking any other medication that may increase the likelihood of these side effects. You or your caregivers should immediately inform your doctor about any change in behavior or mood and any suicidal thoughts you may have.

Children and adolescents

Do not give this medicine to children or adolescents under 18 years of age.

Other medicines and Daxas

Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines, especially the following:

  • a medicine that contains theophylline (a medicine used to treat respiratory diseases), or
  • a medicine used to treat immunological diseases, such as methotrexate, azathioprine, infliximab, etanercept, or prolonged use of oral corticosteroids.
  • a medicine that contains fluvoxamine (a medicine used to treat anxiety and depression), enoxacin (a medicine used to treat bacterial infections), or cimetidine (a medicine used to treat stomach ulcers or acidity).

The effect of Daxas may be reduced if it is combined with rifampicin (a type of antibiotic) or with phenobarbital, carbamazepine, or phenytoin (medicines used to treat epilepsy). Consult your doctor.

Daxas can be combined with other medicines for the treatment of COPD, such as bronchodilators and inhaled or oral corticosteroids. Do not stop taking these medicines or reduce their dose unless your doctor tells you to.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor or pharmacist before using this medicine.

You should not become pregnant during treatment with this medicine and should use an effective contraceptive method during treatment, as Daxas may be harmful to the fetus.

Driving and using machines

Daxas has no or negligible influence on the ability to drive and use machines.

Daxas contains lactose

If your doctor has told you that you have an intolerance to some sugars, consult them before taking this medicine.

3. How to take Daxas

Follow exactly the instructions of administration of this medicine given by your doctor. If you are unsure, consult your doctor or pharmacist again.

  • During the first 28 days- the recommended initial dose is one 250 microgram tablet of roflumilast once a day.
    • The initial dose is a low dose that is used to help your body get used to the medicine before starting the full dose. With this low dose, you will not get the full effect of the medicine, so it is essential that you switch to the full dose (called the "maintenance dose") after 28 days.
  • After 28days -the recommended maintenance dose is one 500 microgram tablet once a day.

Take the tablet with water. You can take it with or without food. Take it every day at the same time.

It may take several weeks for Daxas to produce its beneficial effect.

If you take more Daxas than you should

If you have taken more tablets than you should, you may experience the following symptoms: headache, nausea, diarrhea, dizziness, palpitations, confusion, mucous, and low blood pressure. Go to your doctor or pharmacist immediately. If possible, take the medicine and this leaflet with you.

If you forget to take Daxas

If you forget to take a tablet at the scheduled time, take it as soon as you remember on the same day. If you have forgotten to take it for the entire day, continue taking the normal dose the next day. Continue taking the medicine at the usual time. Do not take a double dose to make up for forgotten doses.

If you stop taking Daxas

It is essential that you continue taking Daxas for the period indicated by your doctor, even when you no longer have symptoms, to control lung function.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

You may experience diarrhea, nausea, stomach pain, or headache during the first few weeks of treatment with Daxas. If these side effects do not disappear after the first few weeks of treatment, consult your doctor.

Some side effects can be serious. In clinical studies and post-marketing experience, rare cases of suicidal thoughts and behaviors (including suicide) have been reported. Inform your doctor immediately if you have any suicidal thoughts. You may also experience insomnia (frequent), anxiety (uncommon), nervousness (rare), panic attacks (rare), or depressive mood (rare).

In rare cases, allergic reactions may occur. Allergic reactions can affect the skin and, in rare cases, cause swelling of the eyelids, face, lips, and tongue, which can lead to difficulty breathing or a decrease in blood pressure and rapid heart rate. If you experience an allergic reaction, stop taking Daxas and contact your doctor immediately or go to the emergency department of the nearest hospital. Bring all your medicines and this leaflet with you and provide all the information about your current medication.

Other side effects include the following:

Common side effects(may affect up to 1 in 10 people)

  • diarrhea, nausea, stomach pain
  • weight loss, decreased appetite
  • headache

Uncommon side effects(may affect up to 1 in 100 people)

  • tremors, feeling of spinning (vertigo), dizziness
  • feeling of rapid or irregular heartbeat (palpitations)
  • gastritis, vomiting
  • acid reflux from the stomach to the throat (acid reflux), indigestion
  • rash
  • muscle pain, muscle weakness, or cramps
  • back pain
  • feeling of weakness or tiredness; general malaise

Rare side effects(may affect up to 1 in 1,000 people)

  • breast enlargement in men
  • loss of taste
  • respiratory tract infections (except pneumonia)
  • blood in the stool, constipation
  • elevated liver and muscle enzymes (observed in blood tests)
  • hives (urticaria)

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Daxas

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton and blister after "EXP". The expiry date is the last day of the month stated.

This medicine does not require any special storage conditions.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and other information

Composition of Daxas

The active substance is roflumilast.

Each 250 microgram tablet of Daxas contains 250 micrograms of roflumilast. The other ingredients are lactose monohydrate (see section 2 "Daxas contains lactose"), corn starch, povidone, and magnesium stearate.

Appearance and packaging

The 250 microgram tablets of Daxas are white or almost white with "D" engraved on one side and "250" on the other.

Each pack contains 28 tablets.

Marketing authorisation holder

AstraZeneca AB

SE-151 85 Södertälje

Sweden

Manufacturer

Corden Pharma GmbH

Otto-Hahn-Str.

68723 Plankstadt

Germany

You can obtain further information on this medicine from the representative of the marketing authorisation holder in your country:

België/Belgique/Belgien

AstraZeneca S.A./N.V.

Tel: +32 2 370 48 11

Lietuva

UAB AstraZeneca Lietuva

Tel: +370 5 2660550

Text in Bulgarian language showing the name of the company AstraZeneca Bulgaria EOOD and its phone number

Luxembourg/Luxemburg

AstraZeneca S.A./N.V.

Tél/Tel: +32 2 370 48 11

Ceská republika

AstraZeneca Czech Republic s.r.o.

Tel: +420 222 807 111

Magyarország

AstraZeneca Kft.

Tel.: +36 1 883 6500

Danmark

AstraZeneca A/S

Tlf: +45 43 66 64 62

Malta

Associated Drug Co. Ltd

Tel: +356 2277 8000

Deutschland

AstraZeneca GmbH

Tel: +49 40 809034100

Nederland

AstraZeneca BV

Tel: +31 85 808 9900

Eesti

AstraZeneca

Tel: +372 6549 600

Norge

AstraZeneca AS

Tlf: +47 21 00 64 00

Ελλ?δα

AstraZeneca A.E.

Τηλ: +30 210 6871500

Österreich

AstraZeneca Österreich GmbH

Tel: +43 1 711 31 0

España

AstraZeneca Farmacéutica Spain, S.A.

Tel: +34 91 301 91 00

Polska

AstraZeneca Pharma Poland Sp. z o.o.

Tel.: +48 22 245 73 00

Francia

AstraZeneca

Tél: +33 1 41 29 40 00

Portugal

AstraZeneca Produtos Farmacêuticos, Lda.

Tel: +351 21 434 61 00

Hrvatska

AstraZeneca d.o.o.

Tel: +385 1 4628 000

România

AstraZeneca Pharma SRL

Tel: +40 21 317 60 41

Ireland

AstraZeneca Pharmaceuticals (Ireland) DAC

Tel: +353 1609 7100

Slovenija

AstraZeneca UK Limited

Tel: +386 1 51 35 600

Ísland

Vistor hf.

Sími: +354 535 7000

Slovenská republika

AstraZeneca AB, o.z.

Tel: +421 2 5737 7777

Italia

Simesa S.p.A.

Tel: +39 02 00704500

Suomi/Finland

AstraZeneca Oy

Puh/Tel: +358 10 23 010

Κ?προς

Αλ?κτωρ Φαρµακευτικ? Λτδ

Τηλ: +357 22490305

Sverige

AstraZeneca AB

Tel: +46 8 553 26 000

Latvija

SIA AstraZeneca Latvija

Tel: +371 67377100

Reino Unido (Northern Ireland)

AstraZeneca UK Ltd

Tel: +44 1582 836 836

Date of last revision of this leaflet

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu

About the medicine

How much does DAXAS 250 micrograms tablets cost in Spain ( 2025)?

The average price of DAXAS 250 micrograms tablets in December, 2025 is around 16.19 EUR. Prices may vary depending on the region, pharmacy, and whether a prescription is required. Always check with a local pharmacy or online source for the most accurate information.

Online doctors for DAXAS 250 micrograms tablets

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for DAXAS 250 micrograms tablets – subject to medical assessment and local rules.

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Doctor

Tomasz Grzelewski

Dermatology20 years of experience

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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Her approach is never one-size-fits-all – each consultation begins with a deep dive into your unique health history, test results, and emotional landscape. Consultations are available in Ukrainian, Polish, and Russian.
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  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
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  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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  • Hoarseness, loss of voice, laryngitis.
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  • Snoring, mouth breathing, enlarged adenoids.
  • Frequent colds, lingering post-viral symptoms.
  • Foreign objects in the ear or nose.
  • ENT-related check-ups and chronic condition follow-up.

Dr. Fursenko helps patients manage symptoms early, avoid complications, and receive timely treatment. Online ENT consultations are a convenient way to access care for both urgent and recurring conditions — from anywhere.

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