Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

12+ years of clinical experience in university hospitals in Germany and Spain.
International education: Ukraine – Germany – Spain.
Member of the German Society of Surgeons (BDC).
Certified in radiological diagnostics and robotic surgery.
Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use CEMIDON B6 150 MG/25 MG TABLETS

Introduction

Package Leaflet: Information for the Patient

Cemidon B6150 mg/25 mg tablets

isoniazid/pyridoxine

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

Keep this leaflet, you may need to read it again.
If you have any further questions, ask your doctor or pharmacist.

This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

What is Cemidon B6 and what is it used for
What you need to know before you take Cemidon B6
How to take Cemidon B6
Possible side effects
Storage of Cemidon B6
Contents of the pack and other information

1. What is Cemidon B6 and what is it used for

Cemidon B6 is a combination of two medicinal substances. It contains isoniazid, an antibiotic belonging to the group of antitubercular medicines, and vitamin B6.

Antibiotics are used to treat bacterial infections and are not effective against viral infections such as the flu or the common cold.

It is essential that you follow the instructions regarding dosage, intake, and treatment duration indicated by your doctor.

Do not store or reuse this medicine. If you have any leftover antibiotic after finishing the treatment, return it to the pharmacy for proper disposal. Do not throw away medicines via wastewater or household waste.

Cemidon B6 is indicated for the treatment of tuberculosis and, exceptionally, for the treatment of atypical mycobacterial infections.

Additionally, it is used for the prevention of:

Asymptomatic acute infection identified by tuberculin test.
People at risk of reactivating tuberculosis.
Contact with a person with tuberculosis.

2. What you need to know before you take Cemidon B6

Do not take Cemidon B6

If you are allergic to the active substances or to any of the other components of this medicine (listed in section 6).
If you have severe liver problems.
If you have ever suffered from a severe skin rash or peeling of the skin, blisters, and/or ulcers in the mouth after taking Cemidon.

Warnings and precautions

Consult your doctor or pharmacist before starting to take Cemidon B6.

Be particularly careful:

If you have a history of seizures or neurological problems. Medicines to prevent seizures should be administered in case of risk.
If you have any liver function disorder. In this case, your doctor will monitor your liver function weekly during the first month and then monthly while the treatment lasts. If any injury appears, your doctor will suspend the treatment.
If you have an alcohol addiction problem.
If you have any kidney disease. Your doctor will prescribe the most suitable dose for you.
There have been reports of severe skin reactions, such as: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acne, lymph node inflammation, and generalized acute pustular exanthema (GPEA) associated with Cemidon treatment. Stop taking Cemidon and seek immediate medical attention if you notice any of the symptoms described in section 4.

Other medicines and Cemidon B6

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including those without a prescription.

In particular, inform your doctor or pharmacist if you are using any of the following medicines:

Medicines used for the treatment of epilepsy (phenytoin, carbamazepine). Your doctor may adjust the dose of this medicine.

Aluminum salts (medicines for the treatment of gastric acidity). They should be taken with a separation of more than 2 hours between the intake of both products.
Halogenated anesthetics (medicines used in surgical interventions). It is recommended to interrupt the treatment with Cemidon one week before the intervention and not to restart it until 15 days have passed.
Oral anticoagulants (medicines used to prevent the formation of blood clots) such as acenocoumarol.
Glucocorticoids (such as prednisolone).
Ketoconazole (a medicine for the treatment of fungal infections). The intake of Cemidon should be spaced at least 12 hours apart. Your doctor may adjust the dose of the ketoconazole-based medicine.
Antibiotic medicines used for the treatment of tuberculosis (pyrazinamide, rifampicin) should increase clinical and biological monitoring.

Taking Cemidon B6with food, drinks, and alcohol

Isoniazid interacts with foods containing a substance called tyramine, which is present in foods such as cheese and red wine. Similarly, if taken with foods containing a substance called histamine (e.g., tuna or other tropical fish), it can cause an exaggerated response with headache, sweating, palpitations, flushing, and decreased blood pressure. Therefore, your doctor will indicate that you should not take foods containing tyramine or histamine during your treatment with Cemidon B6.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

In case of pregnancy, do not administer Cemidon B6 unless the potential benefits outweigh the possible risks associated with the treatment. Your doctor will make this assessment.

Breastfeeding women should consult their doctor before taking this medicine, as isoniazid passes into breast milk.

Driving and using machines

Cemidon B6 may affect your ability to drive or use machines, as it can cause blurred vision and/or dizziness.

Cemidon B6150 mg/25 mg tablets contain tartrazine.

This medicine may cause allergic reactions because it contains tartrazine. It can cause asthma, especially in patients allergic to acetylsalicylic acid.

3. How to take Cemidon B6

Follow exactly the administration instructions of this medicine indicated by your doctor or pharmacist. If in doubt, consult your doctor or pharmacist again.

The recommended dose is:

Adults and adolescents with a weight over 45 kg:

Treatment:
5mg/kg daily up to a maximum of 300 mg.
or 10 mg/kg three times a week.
or 15 mg/kg twice a week.
Prevention: 300 mg daily, for at least six months.

Use in children and adolescents

Treatment in children and adolescents with a weight of 45 kg or less: the recommended dose is 10 mg/kg daily. The maximum daily dose should not exceed 300 mg.
Prevention in children under 5 years or immunodepressed: 7-15 mg/kg daily (maximum 300 mg), for at least six months.

There is no data available on the use of isoniazid in children under 3 months of age.

Method of administration

It is recommended to take the medicine in the morning on an empty stomach, at least 30 minutes before or 2 hours after meals.

The score line is only for breaking the tablet if you find it difficult to swallow it whole.

Due to its size, Cemidon tablets are not suitable for the treatment of adults, children, or adolescents who cannot swallow the tablets.

If you think the effect of Cemidon B6 is too strong or too weak, tell your doctor or pharmacist.

If you take more Cemidon B6than you should

If you have taken more Cemidon B6 than you should, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: (91) 562 04 20, indicating the medicine and the amount ingested.

After an overdose of this medicine, you can expect the appearance of nausea, vomiting, dizziness, visual disturbances, or hallucinations, increased levels of acid in the body, appearance of acetone in urine, and high blood sugar levels. With higher doses, respiratory depression and central depression may occur, leading to convulsions and deep coma.

If you forget to take Cemidon B6

Do not take a double dose to make up for forgotten doses.

If you stop taking Cemidon B6

Your doctor will indicate the duration of your treatment with Cemidon B6. Do not stop the treatment before, even if you feel better. If you stop taking the treatment too soon, the infection could reappear.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Uncommon side effects(may affect up to 1 in 100 people):

Hepatitis (inflammation of the liver).

Rare side effects(may affect up to 1 in 1,000 people):

Toxic epidermal necrolysis (skin reaction that causes large areas of skin with blisters and peeling, potentially life-threatening), drug reaction with eosinophilia and systemic symptoms (severe skin reaction characterized by widespread skin rash, lymph node inflammation, and increased number of certain blood cells, such as eosinophils).

Frequency not known(cannot be estimated from the available data):

Agranulocytosis (decrease in a type of white blood cell, granulocytes), aplastic anemia (bone marrow failure to produce enough blood cells), hemolytic anemia (destruction of red blood cells), eosinophilia (increase in a type of white blood cell, eosinophils),
acidosis (increase in acid levels in the body), low blood glucose levels, nicotinic acid deficiency (vitamin B3 deficiency), anorexia,
hyperactivity, euphoria, insomnia, manic episodes, acute delirium, depression,
peripheral neuropathy (nerve damage outside the brain and spinal cord), optic neuritis (inflammation of the optic nerve), seizures,
visual disturbances, blurred vision,
breast enlargement in men,
deafness, tinnitus, vertigo,
vasculitis (inflammation of blood vessels),
liver failure (severe liver damage), acute liver disorders, liver damage, jaundice (yellowing of the skin and eyes),
constipation, dry mouth, nausea, vomiting, pancreatitis (inflammation of the pancreas), stomach pain (abdominal pain),
lung injuries that cause inflammation or scarring (interstitial lung disease),
acute skin reactions, Stevens-Johnson syndrome (severe skin reaction with blisters and peeling, especially around the mouth, nose, eyes, and genitals), acne, lymph node inflammation,
widespread skin rash, red and scaly, with bumps under the skin and blisters,

accompanied by fever. The symptoms usually appear at the start of treatment (acute generalized pustular exanthema),

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Medicines and Healthcare Products Agency (AEMPS) website: http://www.aemps.gob.es.

5. Storage of Cemidon B6

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry date refers to the last day of the month shown.

This medicine should be stored in a cool and dry place. Store protected from light at a temperature not exceeding 25°C.

Medicines should not be disposed of via wastewater or household waste. Place the empty packaging and any unused medicine in the pharmacy's SIGRE collection point. Ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Contents of the pack and other information

Composition of Cemidon B6

The active substances are isoniazid and pyridoxine.
The other components (excipients) are: gum arabic (E-414), hydroxyethyl methylcellulose, talc, magnesium stearate, tartrazine (E-102).

Appearance of the product and pack contents

Cemidon B6 150 mg/25 mg tablets are yellow, biconvex, and scored, with a diameter of approximately 8.2 mm.

Each pack contains 50 tablets in a PVC-PVDC-Aluminum blister pack.

Marketing authorization holder and manufacturer

Marketing authorization holder

CHIESI ESPAÑA, S.A.U.

Plaça d’Europa, 41-43, 10th floor

08908 L’Hospitalet de Llobregat

Barcelona (Spain)

Manufacturer

LABORATORIOS ALCALA FARMA S.L.

Avenida de Madrid, 82

28802 Alcalá de Henares

Madrid (Spain)

Date of the last revision of this leaflet:August 2025

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS): http://www.aemps.gob.es.

How much does CEMIDON B6 150 MG/25 MG TABLETS cost in Spain ( 2025)?

The average price of CEMIDON B6 150 MG/25 MG TABLETS in October, 2025 is around 3.64 EUR. Prices may vary depending on the region, pharmacy, and whether a prescription is required. Always check with a local pharmacy or online source for the most accurate information.

CEMIDON B6 150 MG/25 MG TABLETS

Taisiya Minorskaya

Yevgen Yakovenko

Taisiya Minorskaya

Yevgen Yakovenko