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AVONEX 30 micrograms/0.5 ml SOLUTION FOR INJECTION IN PRE-FILLED PEN

AVONEX 30 micrograms/0.5 ml SOLUTION FOR INJECTION IN PRE-FILLED PEN

Ask a doctor about a prescription for AVONEX 30 micrograms/0.5 ml SOLUTION FOR INJECTION IN PRE-FILLED PEN

5.0(38)
Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use AVONEX 30 micrograms/0.5 ml SOLUTION FOR INJECTION IN PRE-FILLED PEN

Introduction

Package Leaflet: Information for the User

AVONEX 30 micrograms/0.5 ml solution for injection in pre-filled pen

(interferon beta-1a)

Pre-filled Pen

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

Even if you have used Avonex before, some of the information may have changed.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only, and you should not pass it on to others.

It may harm them, even if their signs of illness are the same as yours.

  • If you experience any side effects, talk to your doctor or pharmacist, even if they are listed in this leaflet. See section 4.

(Information Notes)

This leaflet is updated from time to time.

Check for updates to this leaflet each time you renew your prescription.

(Information Notes)

If you have any further questions, ask your doctor or pharmacist.

Contents of the Package Leaflet

  1. What is AVONEX and what is it used for
  2. What you need to know before you start using AVONEX
  1. How to use AVONEX PEN
  2. Possible side effects
  1. Storage of AVONEX PEN
  2. Contents of the pack and further information
  1. How to inject yourself using AVONEX PEN

1. What is AVONEX and what is it used for

(Information Notes)

Avonex works best when you use it:

  • at the same time
  • once a week
  • regularly

Do not stop your treatment with Avonex without talking to your doctor first.

What is AVONEX?

Avonex Pen is used to inject Avonex.The active substance of Avonex is a protein called interferon beta-1a.Interferons are natural substances produced by your body to protect you from infections and diseases. The Avonex protein is produced with exactly the same ingredients as the interferon beta present in the human body.

What is AVONEX used for?

Avonex is used to treat multiple sclerosis (MS).Treatment with Avonex may help prevent it from getting worse, although it will not cure MS.

Each patient has specific symptoms of MS.These may include:

  • Feeling of instability or dizziness, walking problems, muscle stiffness and spasms, fatigue, tingling in the face, arms or legs
  • Acute or chronic pain, bladder and bowel problems, sexual problems and vision problems
  • Difficulty thinking and concentrating, depression.

MS also tends to flare up from time to time: this is what is known as a relapse.

Avonex may help reduce the number of relapses you may have and slow down the disabling effects of MS.Your doctor will explain how long you can use Avonex or when to stop treatment.

How does AVONEX work?

Multiple sclerosis is associated with nerve damage (in the brain or spinal cord). In MS, your body's defense system reacts against your own myelin, i.e., the insulation that surrounds nerve fibers. When myelin is damaged, messages between the brain and other parts of the body are disrupted. This is what causes the symptoms of MS. Avonex appears to work by preventing your body's defense system from attacking myelin.

2. What you need to know before you start using AVONEX

(Information Notes)

Avonex and allergic reactions

As Avonex is made from a protein, there is a small chance that an allergic reaction may occur.

Additional information on depression

Do not use Avonex if you have severe depression or have suicidal thoughts. If you have depression, your doctor may still prescribe Avonex, but it is important that you let them know if you have had depression or any other problem that affects your mood.

Do not use AVONEX

  • if you are allergicto interferon beta or any of the other ingredients of this medicine (listed in section 6);
  • if you have severe depressionor have suicidal thoughts.

Talk to your doctor immediately in any of these cases.

Warnings and precautions

Talk to your doctor before you start using Avonex if you have or have had in the past:

  • Depressionor problems that affect your mood
  • Suicidal thoughts.

You must inform your doctor immediately of any changes in your mood, suicidal thoughts, unusual feelings of sadness, anxiety or hopelessness.

  • Epilepsyor other uncontrolled seizure disorders
  • Severe kidney or liver problems
  • Low white blood cell or platelet counts,which may increase the risk of infection, bleeding or anemia
  • Heart problemsthat may cause symptoms such as chest pain (angina),especially after any activity; swelling of ankles, difficulty breathing (congestive heart failure)or an irregular heartbeat (arrhythmias).
  • Irritation at the injection site that can cause skin and tissue damage (injection site necrosis). When you are ready to administer the injection, carefully follow the instructions in section 7 "How to inject AVONEX PEN" at the end of this leaflet. This will reduce the risk of injection site reactions.

Talk to your doctor if you have any of these conditionsor if they get worse while you are using Avonex.

During treatment, blood clots may form in small blood vessels. These clots could affect your kidneys. This can happen after several weeks or several years after starting treatment with Avonex.

Your doctor may want to check your blood pressure, blood (platelet count) and kidney function.

Tell your doctor that you are using Avonex:

  • If you are going to have a blood test.Avonex may interfere with the results.

(Information Notes)

There may be times when you need to remind other healthcare professionals that you are being treated with Avonex.For example, if you are prescribed other medicines or if you have a blood test, Avonex may interact with other medicines or with the test results.

Pediatric population

Avonex is not recommended for use in children and adolescents as the data on the use of Avonex in this population are limited. Avonex must not be used in children under 10 years of age because it has not been established whether it would work for them and whether it would be safe.

Other medicines and AVONEX

Tell your doctorif you are using, have recently used or might use any other medicines, especially for the treatment of epilepsy or depression. Avonex may affect other medicines or be affected by them. This also includes any medicine obtained without a prescription.

Pregnancy and breastfeeding

If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

No harmful effects on the baby are expected. Avonex can be used during breastfeeding.

Driving and using machines

If you feel dizzy, do not drive.Avonex can make some people feel dizzy. If this happens to you or if you experience any other side effect that may affect your ability, do not drive or use machines.

Important information about some of the ingredients of Avonex:

This medicine is essentially sodium-free. It contains less than 23 mg (1 mmol) of sodium per weekly dose.

3. How to use AVONEX PEN

(Information Notes)

There is more information on how to inject yourself using Avonex Pen on the back of this leaflet.

Recommended weekly dose

One injection using Avonex Pen, once a week.

Try to use Avonex at the same time on the same day each week.

Self-injection

You can self-inject using Avonex Pen without the help of your doctor if you have been taught how to do it. See the self-injection instructions at the end of this leaflet (see section 7, How to inject yourself using AVONEX PEN).

If you have problemshandling Avonex Pen, ask your doctor for help.

Duration of treatment with AVONEX

Your doctor will tell you how long you should use Avonex. It is important that you use Avonex regularly. Do not make any changes that your doctor has not told you to make.

If you inject more AVONEX than you should

You should administer the injection using only one Avonex Pen, once a week. If you have used more than one Avonex Pen within three days, contact your doctor or pharmacist immediately for advice.

If you miss an injection

If you miss your usual weekly dose,inject a dose as soon as possible. Then wait a week before using Avonex Pen again. Continue with your injection on that day of each week. If you have a preferred day for using Avonex, talk to your doctor to adjust the dose and get back to your preferred day. Do not administer two injections to make up for the missed injection.

4. Possible Adverse Effects

(Informative Notes)

Although the list of possible adverse effects may seem worrisome, it is possible that you will not experience any of them.

Like all medicines, this medicine can cause adverse effects, although not all people suffer from them.

Severe adverse effects: seek medical help.

Severe allergic reactions

If you experience any of the following symptoms:

  • Swelling of the face, lips, or tongue
  • Difficulty breathing
  • Rash.

Call a doctor immediately.Do not use Avonex until you have spoken with a doctor.

Depression

If you experience any symptoms of depression:

  • Unusual feeling of sadness, anxiety, or hopelessness.

Call a doctor immediately.

Liver problems

If you experience any of the following symptoms:

  • Yellowing of the skin or the white part of the eyes (jaundice)
  • Generalized itching
  • Feeling of discomfort (nausea and vomiting)
  • Bruises that appear easily on the skin.

Call a doctor immediatelyas they may be manifestations of a possible liver problem.

Adverse effects observed in clinical trials.

(Informative Notes)

Adverse effects observed in clinical trials.

These are adverse effects reported by people during the evaluation of Avonex. The figures are based on the number of people who presented them. They give an idea of the likelihood that you will develop similar adverse effects.

Very common adverse effects(may affect more than 1 in 10 people)

  • Pseudoflu-like symptoms: headache, muscle pain, chills, or fever: see Pseudoflu-like symptoms, below
  • Headache.

Common adverse effects(may affect up to 1 in 10 people)

  • Lack of appetite
  • Feeling of weakness and fatigue
  • Difficulty sleeping
  • Depression
  • Facial flushing
  • Nasal discharge
  • Diarrhea (soft stools)
  • Feeling of discomfort (nausea or vomiting)
  • Numbness or tingling of the skin
  • Rash, skin bruising
  • Increased sweating, night sweats
  • Pain in muscles, joints, arms, legs, or neck
  • Muscle cramps, stiffness in muscles and joints
  • Pain, bruising, and redness at the injection site
  • Changes in blood tests. The symptoms you may experience are fatigue, repeated infections, bruising, or bleeding without apparent cause.

Uncommon adverse effects(may affect up to 1 in 100 people)

  • Hair loss
  • Changes in menstruation
  • Burning sensation at the injection site.

Rare adverse effects(may affect up to 1 in 1,000 people)

  • Difficulty breathing
  • Kidney problems, including scarring that can reduce kidney function

If you experience any of the following symptoms:

  • Foamy urine
  • Fatigue
  • Swelling, especially of ankles and eyelids, and weight gain.

Inform your doctor as they may be manifestations of a possible kidney problem.

  • Blood clots in small blood vessels that can affect your kidneys (thrombotic thrombocytopenic purpura or hemolytic uremic syndrome). The symptoms may include an increase in bruising, bleeding, fever, extreme weakness, headache, dizziness, or fainting. Your doctor may find changes in your blood and kidney function.

If you are concerned about any of the effects, talk to your doctor.

Other adverse effects

(Informative Notes)

These effects have been observed in people using Avonex, but we do not know how frequently they occur.

If you feel dizzy, do not drive.

  • Thyroid dysfunction or excess activity
  • Nervousness or anxiety, emotional instability, irrational thoughts or hallucinations (seeing or hearing things that are not real), confusion, or suicide
  • Numbness, dizziness, seizures, or epileptic fits, and migraines
  • Perception of your heartbeat (palpitations), rapid or irregular heartbeat, or heart problems accompanied by the following symptoms: reduced exercise capacity, inability to stay lying down, difficulty breathing, or swelling of ankles
  • Liver problems, such as those described previously
  • Urticaria or pseudovesicular rash, itching, worsening of existing psoriasis
  • Swelling or bleeding at the injection site, tissue destruction (necrosis), or chest pain after an injection
  • Weight gain or loss
  • Changes in test results, such as variations in liver function tests
  • Pulmonary arterial hypertension: a disease in which there is a significant narrowing of the blood vessels in the lungs, causing an increase in pressure in the blood vessels that carry blood from the heart to the lungs. Pulmonary arterial hypertension was observed at different times, even several years after starting treatment with interferon beta-containing medications.

If you are concerned about any of the effects, talk to your doctor.

Injection site effects

  • Fainting sensation:The first injection of Avonex may be administered by your doctor. You may feel dizzy. You may even faint. It is unlikely to happen again.
  • Immediately after the injection, you may notice tense or very weak muscles,as if you were going to repeat the experience. It is rare. It only occurs when self-injecting, and the effects pass quickly. They can occur at any time after starting treatment with Avonex.
  • If you notice any skin irritation or other skin problemafter an injection, talk to your doctor.

Pseudoflu-like symptoms

(Informative Notes)

Three simple ways to reduce the impact of pseudoflu-like symptoms:

  • Administer the injection with Avonex Pen just before bedtime.This way, the effects can pass while you sleep.
  • Take paracetamol or ibuprofen 30 minutes beforethe injection with Avonex Pen and continue taking it for a day. Talk to your doctor or pharmacist about the appropriate dose.
  • If you have a fever, drink plenty of waterto stay hydrated.

Some people report that after using Avonex Pen, they feel like they have the flu.

The signs are:

  • Headache
  • Muscle pain
  • Chills or fever.

These symptoms do not actually correspond to the flu

You cannot transmit them to anyone. They are more frequent when using Avonex for the first time. The pseudoflu-like symptoms gradually decrease as more injections are administered.

Children (10 years of age or older) and adolescents

In clinical trials, some adverse effects were reported more frequently in children and adolescents than in adults, e.g., muscle pain, pain in a limb, fatigue, and joint pain.

Reporting adverse effects

If you experience any type of adverse effect, consult your doctor or pharmacist, even if it is a possible adverse effect that is not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es. By reporting adverse effects, you can contribute to providing more information on the safety of this medicine.

In order to improve the traceability of this medicine, your doctor or pharmacist must record the name and batch number of the medicine administered to you in your medical history. You may also want to take note of this information in case you are asked for it in the future.

5. Storage of Avonex Pen

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiration date shown on the label.

Avonex Pen contains a pre-filled syringe of Avonex. Store in the original packaging to

protect it from light.

Store in the refrigerator (between 2°C and 8°C). Do not freeze.

Avonex Pen can also be stored at room temperature (between 15°C and 30°C) for a

maximum of one week.

Do not use Avonex Pen if you observe that:

  • The pen is broken.
  • The solution has color and you can see particles floating.
  • The closure guarantee capsule is broken.

Medicines should not be disposed of through wastewater or household waste. Ask your pharmacist how to dispose of the packaging and medicines you no longer need. This will help protect the environment.

6. Container Contents and Additional Information

Composition of AVONEX PEN

The active ingredientis: interferon beta-1a 30 micrograms/0.5 ml.

The other componentsare: sodium acetate trihydrate, glacial acetic acid, arginine hydrochloride, polysorbate 20, and water for injectables.

Appearance of AVONEX PEN and Container Contents

Each individual container contains an Avonex Pen, a needle, and a pen protector. Avonex Pen contains a pre-loaded Avonex syringe and should only be used after receiving proper training. Avonex Pen is available in packs of four or twelve, for one month or three months of injection.

Marketing Authorization Holder and Manufacturer

The marketing authorization holder is:

Biogen Netherlands B.V.

Prins Mauritslaan 13

1171 LP Badhoevedorp

Netherlands

Avonex is manufactured by:

FUJIFILM Diosynth Biotechnologies Denmark ApS

Biotek Allé 1,

DK-3400 Hillerød,

Denmark

Biogen Netherlands B.V.

Prins Mauritslaan 13

1171 LP Badhoevedorp

Netherlands

Contact your local representative if you want a version of this leaflet with larger text.

You can request more information about this medicine by contacting the local representative of the marketing authorization holder.

België/Belgique/Belgien

Biogen Belgium NV/SA

Tel: +32 2 2191218

Lietuva

Biogen Lithuania UAB

Tel: +370 5 259 6176

Text in Bulgarian language with contact information of the company EVOFARMA including address and phone number

Luxembourg/Luxemburg

Biogen Belgium NV/SA

Tel: +32 2 2191218

Ceská republika

Biogen (Czech Republic) s.r.o.

Tel: +420 255 706 200

Magyarország

Biogen Hungary Kft.

Tel.: +36 1 899 9883

Danmark

Biogen Denmark A/S

Tlf.: +45 77 41 57 57

Malta

Pharma. MT Ltd.

Tel: +356 21337008

Deutschland

Biogen GmbH

Tel: +49 (0) 89 99 6170

Nederland

Biogen Netherlands B.V.

Tel: +31 20 542 2000

Eesti

Biogen Estonia OÜ

Tel: +372 618 9551

Norge

Biogen Norway AS

Tlf: +47 23 40 01 00

Ελλάδα

Genesis Pharma SA

Τηλ: +30 210 8771500

Österreich

Biogen Austria GmbH

Tel: +43 1 484 46 13

España

Biogen Spain S.L.

Tel: +34 91 310 7110

Polska

Biogen Poland Sp. z o.o.

Tel: +48 22 351 51 00

France

Biogen France SAS

Tél: +33 (0)1 41 37 9595

Portugal

Biogen Portugal

Sociedade Farmacêutica, Unipessoal Lda.

Tel: +351 21 318 8450

Hrvatska

Biogen Pharma d.o.o.

Tel: +385 1 775 73 22

România

Johnson & Johnson Romania S.R.L.

Tel: +40 21 207 18 00

Ireland

Biogen Idec (Ireland) Ltd.

Tel: +353 (0)1 463 7799

Slovenija

Biogen Pharma d.o.o.

Tel: +386 1 511 02 90

Ísland

Icepharma hf

Sími: +354 540 8000

Slovenská republika

Biogen Slovakia s.r.o.

Tel: +421 2 323 34008

Italia

Biogen Italia s.r.l.

Tel: +39 02 584 9901

Suomi/Finland

Biogen Finland Oy

Puh/Tel: +358 207 401 200

Κύπρος

Genesis Pharma Cyprus Ltd

Τηλ: +357 22 76 57 15

Sverige

Biogen Sweden AB

Tel: +46 8 594 113 60

Latvija

Biogen Latvia SIA

Tel: +371 68 688 158

Date of last revision of this leaflet:08/2024.

Detailed information on this medicine is available on the European Medicines Agency website: https://www.ema.europa.eu.

This leaflet can be found in all languages of the European Union/European Economic Area on the European Medicines Agency website.

  1. How to inject using AVONEX PEN

Avonex Pen (single use)

Alternatives to AVONEX 30 micrograms/0.5 ml SOLUTION FOR INJECTION IN PRE-FILLED PEN in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to AVONEX 30 micrograms/0.5 ml SOLUTION FOR INJECTION IN PRE-FILLED PEN in Ukraine

Dosage form: solution, 44 mcg (12 million IU) / 0.5 ml
Active substance: interferon beta-1a
Manufacturer: Merk Serono S.p.A.
Prescription required
Dosage form: solution, 22 mcg (6 million IU) / 0.5 ml
Active substance: interferon beta-1a
Manufacturer: Merk Serono S.p.A.
Prescription required
Dosage form: powder, 6000000 IU (30 mcg)
Active substance: interferon beta-1a
Manufacturer: TOV "FZ "BIOFARMA
Prescription required

Online doctors for AVONEX 30 micrograms/0.5 ml SOLUTION FOR INJECTION IN PRE-FILLED PEN

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for AVONEX 30 micrograms/0.5 ml SOLUTION FOR INJECTION IN PRE-FILLED PEN – subject to medical assessment and local rules.

5.0(38)
Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Andrei Popov

General medicine6 years of experience

Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

He specialises in diagnosing and treating pain conditions that affect quality of life, including:

  • Chronic pain lasting more than 3 months.
  • Migraines and recurring headaches.
  • Neck, back, lower back, and joint pain.
  • Post-traumatic pain following injury or surgery.
  • Nerve-related pain, fibromyalgia, and neuralgia.
In addition to pain management, Dr. Popov helps patients with:
  • Respiratory infections (colds, bronchitis, pneumonia).
  • High blood pressure and metabolic conditions such as diabetes.
  • Preventive care and routine health check-ups.

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

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Anna Biriukova

General medicine5 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Mar Tabeshadze

Endocrinology10 years of experience

Dr. Mar Tabeshadze is a licensed endocrinologist and general practitioner in Spain. She provides online consultations for adults, offering medical support for a wide range of endocrine conditions and related health concerns.

  • Diagnostic consultations for suspected endocrine disorders
  • Management of thyroid conditions, including in pregnant women
  • Early detection and treatment of type 1 and type 2 diabetes, with personalised therapy plans
  • Obesity treatment: identifying underlying causes of weight gain, combining medication and non-pharmacological strategies, and long-term support
  • Diagnosis and treatment of endocrine-related skin, hair, and nail issues
  • Ongoing care for patients with osteoporosis, pituitary, and adrenal gland disorders
Dr. Tabeshadze takes a patient-centred approach based on evidence-based medicine. Her goal is to help patients achieve hormonal balance, manage chronic conditions effectively, and improve overall well-being through targeted, personalised care.
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Maryna Kuznetsova

Cardiology16 years of experience

Dr Marina Kuznetsova is an internal medicine doctor and cardiologist with a PhD in medicine. She provides online consultations for adults with chronic and acute conditions, with a strong focus on cardiovascular health. Her approach is based on current clinical guidelines and evidence-based treatment strategies.

Areas of expertise:

  • dyslipidaemia and lipid metabolism disorders
  • prevention and management of atherosclerosis
  • blood pressure monitoring and antihypertensive therapy
  • arrhythmias: diagnosis, follow-up, and treatment adjustment
  • cardiovascular care and recovery support after Covid-19
Dr Kuznetsova helps patients manage cardiovascular risk factors, optimise long-term treatment, and gain clarity in complex health situations – all through accessible and structured online care.
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October 2814:00
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Lina Travkina

Family medicine12 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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€70
October 2915:00
October 2915:45
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Dmytro Horobets

Family medicine6 years of experience

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
  • Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
  • Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
  • Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

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November 109:30
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Karim BenHarbi

General medicine8 years of experience

Dr. Karim Ben Harbi is a licensed general practitioner based in Italy. He provides online consultations for adults and children, combining international clinical experience with evidence-based medicine. His care approach is focused on accurate diagnosis, preventive care, and personalised health guidance.

Dr. Ben Harbi received his medical degree from Sapienza University in Rome. His training included hands-on experience in diverse settings — tropical medicine, rural healthcare, and urban outpatient practice. He also conducted clinical research in microbiology, exploring the role of the gut microbiome in chronic gastrointestinal issues.

You can consult Dr. Ben Harbi for:

  • General health concerns, prevention, and primary care.
  • Hypertension, type 1 and type 2 diabetes, metabolic issues.
  • Cold, cough, flu, respiratory infections, sore throat, fever.
  • Chronic digestive issues: bloating, gastritis, IBS, microbiome imbalance.
  • Skin rashes, mild allergic reactions, basic dermatological complaints.
  • Medication guidance, treatment adjustments, prescription review.
  • Paediatric concerns — fever, infections, general well-being.
  • Lifestyle optimisation: stress, sleep, weight, and diet counselling.

Dr. Ben Harbi offers reliable, accessible medical support through online consultations, helping patients make informed decisions about their health with a clear, structured, and compassionate approach.

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Jonathan Marshall Ben Ami

Family medicine8 years of experience

Dr. Jonathan Marshall Ben Ami is a licensed family medicine doctor in Spain. He provides comprehensive care for adults and children, combining general medicine with emergency care expertise to address both acute and chronic health concerns.

Dr. Ben Ami offers expert diagnosis, treatment, and follow-up for:

  • Respiratory infections (cold, flu, bronchitis, pneumonia).
  • ENT conditions such as sinusitis, ear infections, and tonsillitis.
  • Digestive issues including gastritis, acid reflux, and irritable bowel syndrome (IBS).
  • Urinary tract infections and other common infections.
  • Management of chronic diseases: high blood pressure, diabetes, thyroid disorders.
  • Acute conditions requiring urgent medical attention.
  • Headaches, migraines, and minor injuries.
  • Wound care, health check-ups, and ongoing prescriptions.

With a patient-focused and evidence-based approach, Dr. Ben Ami supports individuals at all stages of life — offering clear medical guidance, timely interventions, and continuity of care.

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€55
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Svetlana Kolomeeva

Cardiology17 years of experience

Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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Container contents – Avonex Pen, needle, and Avonex Pen protector

Injector pen with white cylinder, notched protector, blue button, and transparent needle cap, also showing label and cap

Avonex Pen – prepared for injection

Injector pen with white cylinder and blue button, showing display, oval and notched area with indicative arrows

Avonex Pen – after injection (prepared for disposal)

Avonex Pen white and blue with circular viewing window and yellow cap indicated with red arrows

You should have received training on how to use Avonex Pen.

These notes are a reminder. If you have any doubts or problems, consult your doctor or pharmacist.

Where to inject

Use a different injection site each week

The best area is the outer upper thigh. Alternate between the left and right thigh.

Note the injection site each week.

Thigh with a red circular area highlighted indicating the injection site

  • Avonex is injected into a muscle,the best area is the outer upper thighas shown in the diagram above. Injection into the buttocks is not recommended.
  • Use a different injection site each week.This involves less risk of skin or muscle irritation.
  • Do not useareas of skin with bruises, pain, or infection, or if there is an open wound.
  1. Preparation
  1. Take an Avonex Pen from the refrigerator

Check that the container contains an Avonex Pen, a needle, and a pen protector.

Do not shake Avonex Pen.

Check the expiration date on the Avonex Pen label.

Do not use it if it is expired.

  1. Let Avonex Pen warm up

Leave it at room temperature for half an hour.

This makes the injection more comfortable than using it directly from the refrigerator.

Tip:Do not use external heat sources such as hot water to warm up Avonex Pen.

  1. Wash your handswith water and soap and dry them.
  1. Prepare alcohol swabs and gauzes(not provided) if you need them.
  1. Find a clean and stable surfaceto place the necessary material for the injection.
  • Avonex Pen preparation

Hands holding and operating a purple and white auto-injector device with a transparent container

1 Remove the tamper-evident cap

Make sure the tamper-evident cap is intact and has not been opened.If it appears to have been opened, do not use that Avonex Pen.

  • Hold Avonex Pen so that the tamper-evident cap faces upwards.
  • Bend the tamper-evident cap at a right angle to release it.
  • Do not touch the exposed glass tip.

Tips: Put the pen on the table before starting with step 2.

Injection preparation with applicator device showing steps before and after plunger rotation

2 Attach the needle

  • Avonex Pen is designed to work only with the provided needle
  • Remove the wrapperfrom the base of the needle protector.
  • Attach the needle by pressing it onto the glass tip of the pen. Keep the pen upright.
  • Do not remove the needle protector.
  • Carefully turn the needle clockwise until it is firmly attached, otherwise, there may be leaks. You may not receive a complete dose if there are leaks.

Tips: The needle protector will automatically release during the next step 3.

Hands holding an auto-injector before and after use with an arrow indicating the action

3 Extend the injector protector

  • Hold the pen body firmly with one hand. Point the needle protector away from you and anyone else.
  • With the other hand and with a quick motion, lift the injector screen (notched area) above the needleuntil the needle is fully covered.
  • The plastic needle protector will release.

Tips: Do not pressthe blue activation button at the same time.

Pregnancy test showing a positive result line within a red frame and a blue control window

4 Check that the injector screen is correctly extended

  • Check that the injector screen is fully extended. A small rectangular area will be visible next to the oval viewing window. It is the safety lock.

Medicine cartridge with blue and white plunger highlighted within a red frame on a white background

5 Check the liquid

  • Look through the oval viewing window. The liquid should be clear and colorless.

If the solution is cloudy, has color, or contains floating particles, do not use this pen.

Air bubbles are normal.

  • Using Avonex Pen

Leg and arm showing injection sites with a red circular mark indicating the area to inject

1 Clean the injection site

If necessary, use an alcohol swab to clean the skin at the chosen injection site. Let the skin dry.

Tips: The best area is the upper outer thigh.

Hand injecting with syringe in arm, showing safety devices closed and released with an arrow indicating direction

2 Place Avonex Pen on the skin

  • Hold the pen body firmly with one hand, forming a right angle with the injection site. Make sure the pen windows are visible.

Tips: Be careful not to press the blue activation button too soon.

  • Press the pen body firmly against the skin to release the safety lock.
  • Check that the safety lock is released. The small rectangular window will disappear. Avonex Pen is ready to inject.

Tips: Continue holding the pen firmly against the skin.

Hand holding syringe injecting into thigh at a 90-degree angle, arrow indicates direction of injection, text indicates 10 seconds

  1. Administer the injection
  • Press the blue activation button with your thumb to start the injection.

You will hear a "click" that indicates the injection process has started. Do not remove the pen from the skin.

  • Continue holding the pen against the skin and count slowly up to 10 seconds.
  • After 10 seconds, pull the pen to remove the needle from the injection site.
  • Press on the injection site for a few seconds. If there is any blood at the site, clean it.

Auto-injector device with elongated blue button and yellow area highlighted within a red frame

  1. Confirm the injection

administration

  • Check the circular viewing window.When the full dose has been administered, the window will appear yellow.
  • Do not reuse Avonex Pen. It is for single use.

Auto-injector device with inserted cartridge, hands holding and pressing the device, arrow indicating direction, and used cartridge in a yellow container

5 Disposal

  • Place the pen protector on a flat and stable surface

Tips: Do not hold the pen protector.You may suffer a needlestick injury.

  • Insert the needle directly into the pen protector.
  • Press firmlyuntil you hear a "click" to seal the needle. You may need to use both hands. Once the pen is sealed, there is no risk of injury.
  • Dispose of the waste properly. Your doctor, nurse, or pharmacist will provide instructions on how to dispose of the used Avonex Pen, for example, in a sharps container.