Background pattern

Apregia 75 mg capsulas duras efg

About the medicine

About the medication

Introduction

Label: informationfortheuser

Apregia75mghardEFGcapsules

pregabalina

Readthelabelcarefullybeforestartingtotakethismedicine,becauseitcontainsimportantinformationforyou.

Keepthislabel,asyoumayneedtorefertoitagain.

Ifyouhaveanyquestions,consultyourdoctororpharmacist.

Thismedicinehasbeenprescribedonlyforyou,andyoushouldnotgiveittootherswhomayhavethesamesymptomsasyou,asitmayharmthem.

Ifyouexperienceadverseeffects,consultyourdoctororpharmacist,eveniftheyarenotlistedinthislabel.Seesection4.

Labelcontents

1.WhatisApregiaandwhatisitusedfor

2.WhatyouneedtoknowbeforestartingtotakeApregia

3.HowtotakeApregia

4.Adverseeffects

5.StorageofApregia

6.Contentsofthepackagingandadditionalinformation

1. What is Apregia and what is it used for

Apregiabelongstoagroupofmedicinesthatareusedfortreatmentofepilepsy, neuropathic painandgeneralizedanxietydisorder(TAG)inadults.

Peripheral and central neuropathic pain:Pregabalinaisusedfortreatmentofchronic pain caused by nerve damage. There are various diseases that can cause peripheral neuropathic pain, such as diabetes or herpes. The sensation of pain could be described as heat, burning, pulsating pain, stabbing pain, acute pain, spasms, continuous pain, tingling, numbness and pins and needles sensation. Peripheral and central neuropathic pain could also be associated with mood changes, sleep disturbances, fatigue (tiredness) and may affect physical and social activity and overall quality of life.

Epilepsy:Pregabalinaisusedintreatmentofcertainclassesofepilepsy(partial seizureswithorwithoutsecondary generalization)inadults.Yourdoctorwillprescribepregabalinatotreatepilepsywhenyourcurrenttreatmentdoesnotcontrolthedisease.Youmusttakepregabalinainadditiontoyourcurrenttreatment.Pregabalinashouldnotbeadministeredalone,butshouldalwaysbeusedincombinationwithotherantiepilepticmedicines.

Generalized anxiety disorder:Pregabalinaisusedintreatmentofgeneralized anxiety disorder(TAG).ThesymptomsofTAGareexcessiveandprolongedanxietyandworrythataredifficulttocontrol.TAGmayalsoproducerestlessnessorsensationofexcitementornervousness,feelfatigued(tired)easily,havedifficultyconcentratingorstayingwiththemindblank,irritability,muscletensionorsleepdisturbance.Thisisdifferentfromdailylifestressandtensions.

2. What you need to know before starting to take Apregia

Do not take Apregia

If you are allergic to pregabalin or any of the other ingredients in this medicine (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting to take Apregia.

  • Some patients treated with pregabalin have reported symptoms that suggest an allergic reaction. These symptoms include swelling of the face, lips, tongue, and throat, as well as the appearance of a widespread skin rash. If you experience any of these symptoms, you should seek medical attention immediately.
  • Severe skin reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported in association with pregabalin treatment. Stop taking pregabalin and seek medical attention immediately if you notice any of the symptoms related to these severe skin reactions described in section 4.
  • Pregabalin has been associated with dizziness and somnolence, which may increase the risk of accidental injuries (falls) in elderly patients. Therefore, you should be cautious until you become familiar with the effects the medicine may have.
  • Pregabalin may cause blurred vision, loss of vision, or other changes in vision, many of which are transient. If you experience any alteration in your vision, you should inform your doctor immediately.
  • Patients with diabetes who gain weight while taking pregabalin may need to change their diabetes medication.
  • Certain adverse effects, such as somnolence, may be more frequent since patients with spinal cord injury may be taking other medications for treatment, for example, pain or spasticity (tense or rigid muscles), with similar adverse effects to pregabalin, so the intensity of these effects may increase when taken together.
  • Cardiac insufficiency has been reported in some patients treated with pregabalin. Most of them were elderly patients with cardiovascular diseases. Before using this medicine, you should inform your doctor if you have a history of heart disease.
  • Renal insufficiency has been reported in some patients treated with pregabalin. If during pregabalin treatment you notice a decrease in your ability to urinate, you should inform your doctor, as interrupting treatment may improve this situation.
  • Some patients treated with antiepileptic drugs such as pregabalin have had thoughts of self-harm or suicide or have shown suicidal behavior. If at any time you experience these thoughts or have shown such behavior, contact your doctor as soon as possible.
  • Pregabalin taken with other medications that may cause constipation (such as some types of pain medications) may lead to gastrointestinal problems (e.g., constipation and intestinal blockage or paralysis). Inform your doctor if you experience constipation, especially if you are prone to this problem.
  • Before taking this medicine, inform your doctor if you have ever abused or had dependence on alcohol, prescription medications, or illegal drugs; it may mean you have a higher risk of becoming dependent on pregabalin.
  • Convulsions have been reported during or shortly after pregabalin treatment. If you experience convulsions, contact your doctor immediately.
  • Reduced cerebral function (encephalopathy) has been reported in some patients taking pregabalin and who had other diseases. Inform your doctor if you have a history of any serious disease, including liver or kidney disease.
  • Difficulty breathing has been reported. If you have respiratory system disorders, kidney insufficiency, or are over 65 years old, your doctor may prescribe a different dose. Contact your doctor if you experience breathing problems or shallow breathing.

Dependence

Some people may become dependent on pregabalin (need to continue taking the medicine). They may experience withdrawal effects when they stop using pregabalin (see section 3 “How to take Apregia” and “If you interrupt treatment with Apregia”). If you are concerned that you may become dependent on pregabalin, it is essential to consult your doctor.

If you notice any of the following signs while taking pregabalin, it could be a sign that you have become dependent:

- You need to take the medicine for a longer period than recommended by your doctor.

- You feel the need to take a higher dose than recommended.

- You are using the medicine for reasons other than those prescribed.

- You have made repeated and unsuccessful attempts to stop or control the use of the medicine.

- When you stop taking the medicine, you experience discomfort and feel better once you take the medicine again.

If you notice any of these signs, talk to your doctor to analyze the best assistance plan for you, including when it is appropriate to stop treatment and how to do it safely.

Children and adolescents

The safety and efficacy of pregabalin have not been established in children and adolescents (under 18 years old), so pregabalin should not be used in this age group.

Other medicines and Apregia

Inform your doctor or pharmacist if you are taking, have recently taken, or may need to take any other medicine.

Pregabalin and certain medicines may interact with each other. When pregabalin is taken with certain medicines that have a sedative effect (including opioids), these effects may be potentiated, and may lead to respiratory insufficiency, coma, and death. The degree of dizziness, somnolence, and decreased concentration may increase if pregabalin is taken with other medicines that contain:

  • Oxycodone (used as an analgesic).
  • Lorazepam (used to treat anxiety).
  • Alcohol.

Pregabalin can be taken with oral contraceptives.

Taking Apregia with food, drinks, and alcohol

The pregabalin capsules can be taken with or without food.

It is recommended not to drink alcohol during pregabalin treatment.

Pregnancy and breastfeeding

Do not take pregabalin during pregnancy or lactation, unless your doctor has told you to. Using pregabalin during the first 3 months of pregnancy may cause congenital anomalies in the fetus that require medical treatment. In a study that reviewed data from women in Nordic countries who took pregabalin during the first 3 months of pregnancy, 6 out of 100 babies had such congenital anomalies. This contrasts with 4 out of 100 babies born to women not treated with pregabalin in the study. Facial abnormalities (cleft palate), eye abnormalities, nervous system abnormalities (including the brain), kidney abnormalities, and genital abnormalities have been reported.

Use a reliable contraceptive method in fertile women. If you are pregnant or breastfeeding, believe you may be pregnant, or intend to become pregnant, consult your doctor or pharmacist before using this medicine.

Driving and operating machinery

Pregabalin may cause dizziness, somnolence, and decreased concentration. Do not drive, operate heavy machinery, or engage in other potentially hazardous activities until you know if this medicine affects your ability to perform these activities.

3. How to take Apregia

Followexactlytheadministrationinstructionsforthismedicationindicatedbyyourdoctor.Incaseofdoubt,consultyourdoctororpharmacistagain.Donottakemoremedicationthanprescribed.

Yourdoctorwilldeterminewhatdoseisadequateforyou.

Apregiaisavailableexclusivelyfororaluse.

Peripheral and central neuropathic pain, epilepsy, or generalized anxiety disorder:

  • Takethenumberofcapsulesindicatedbyyourdoctor.
  • Thedose,whichhasbeenadjustedforyouandyourcondition,willgenerallybebetween150mgand600mgperday.
  • Yourdoctorwillinformyoutotakepregabalinatwiceorthreetimesaday.Iftwiceaday,takepregabalinaonceinthemorningandonceintheevening,approximatelyatthesametimeeveryday.Ifthreetimesaday,takepregabalinainthemorning,atmiddayandintheevening,approximatelyatthesametimeeveryday.

Ifyouestimatethattheactionofpregabalinaistoostrongorweak,informyourdoctororpharmacist.

Ifyouareanelderlypatient(over65yearsold),takepregabalinanormally,exceptifyouhavekidneyproblems.

Yourdoctormayprescribeadifferentdosageordoseifyouhavekidneyproblems.

Swallowthecapsulewholewithwater.

Continuetakingpregabalinauntilyourdoctortellsyoutostoptakingit.

If you take more Apregia than you should:

Incaseofoverdoseoraccidentalingestion,consultyourdoctororpharmacistimmediatelyorvisitthenearestemergencyservice.Bringthepackageorbottleofcapsuleswithyou.YoucanalsocalltheToxicologicalInformationService,phone915620420,indicatingthemedicationandtheamountingested.

AsaresultofhavingtakenmoreApregiathanyoushouldhave,youmayfeeldrowsy,confused,agitated,orrestless.Clinicalreportshavealsoincludedseizuresandlossofconsciousness(coma).

If you forget to take Apregia:

Itisimportanttotakethecapsulesofpregabalinaregularlyatthesametimeeveryday.Ifyouforgettotakeadose,takeitassoonasyourememberwithoutdelayingthenextdose.Continuewiththenextdoseattheusualtime.Donottakeadoubledosetocompensateforthemisseddoses.

If you interrupt the treatment with Apregia:

Donotstoptakingpregabalinasuddenly.Ifyouwanttostoptakingpregabalina,talktoyourdoctorfirst.Hewilltellyouhowtodoit.Ifyouaregoingtostopthetreatment,itshouldbedonegraduallyoveraminimumofoneweek.

Oncethetreatmentwithpregabalinaisfinishedintheshortandlongterm,youshouldknowthatyoumayexperiencecertainadverseeffects,calledwithdrawaleffects.Theseeffectsincludesleepproblems,headache,nausea,anxietysensations,diarrhea,flu-likesymptoms,seizures,nervousness,depression,thoughtsofself-harmorsuicide,pain,sweating,anddizziness.Theseeffectsmayappearwithgreaterfrequencyorseverityifyouhavebeentakingpregabalinaforalongerperiodoftime.Ifyouexperiencewithdrawaleffects,visityourdoctor.

Ifyouhaveanyotherdoubtsabouttheuseofthismedication,askyourdoctororpharmacist.

4. Possible Adverse Effects

Likeallmedicines,thismedicinecancausesideeffects,althoughnoteveryonewillexperiencethem.

Verycommon:canaffectmorethan1in10people

  • Dizziness, drowsiness, headache.

Common:canaffectupto1in10people

  • Increasedappetite.
  • Feelingofeuphoria,confusion,disorientation,decreasedlibido,irritability.
  • Alterationofattention,clumsiness,difficultywithmovement,declineinmemory,memoryloss,shakiness,difficultyspeaking,tingling,numbness,sedation,drowsiness,insomnia,fatigue,abnormalfeeling.
  • Blurredvision,doublevision.
  • Dizziness,balanceproblems,falls.
  • Drymouth,constipation,vomiting,flatulence,diarrhea,nausea,swollenabdomen.
  • Difficultywitherection.
  • Swellingofthebodyincludingtheextremities.
  • Feelingofintoxication,abnormalgait.
  • Weightgain.
  • Musclecramp,jointpain,backpain,painintheextremities.
  • Throatpain.

Uncommon:canaffectupto1in100people

  • Lossofappetite,weightloss,lowbloodsugar,highbloodsugar.
  • Changeinself-perception,anxiety,depression,agitation,moodswings,difficultyfindingwords,hallucinations,strangedreams,anxietyattacks,apathy,aggressiveness,elevatedmood,mentaldecline,difficultythinking,increasedlibido,sexualproblemsincludinginabilitytoachieveorgasm,delayedejaculation.
  • Changesinvision,abnormaleyemovements,changesinvisionincludingtunnelvision,flashesoflight,spasmodicmovements,diminishedreflexes,hyperactivity,dizzinesswhenstanding,sensitiveskin,lossoftaste,burningfeeling,shakinesswhenmoving,diminishedconsciousness,lossofconsciousness,syncope,increasedsensitivitytonoise,generalmalaise.
  • Eyedryness,swolleneyes,eyepain,fatiguedeyes,tearfuleyes,eyeirritation.
  • Changesinheartrate,increasedheartrate,lowbloodpressure,highbloodpressure,changesinheartrate,heartfailure.
  • Flushes,hotflashes.
  • Difficultybreathing,drynose,stuffynose.
  • Increasedsalivaproduction,burning,numbnessaroundthemouth.
  • Sweating,eruption,chills,fever.
  • Musclespasms,swollenjoints,musclerigidity,painincludingmusclepain,neckpain.
  • Breastpain.
  • Difficultyorpainwhenurinating,inabilitytoholdurine.
  • Weakness,thirst,oppressioninthechest.
  • Changesinbloodtestresultsandliverfunctiontests(elevatedcreatininephosphokinaseinblood,alanineaminotransferaseelevated,aspartateaminotransferaseelevated,decreasedplateletcount,neutropenia,elevatedcreatinineinblood,decreasedpotassiuminblood).
  • Hypersensitivity,swollenface,itching,urticaria,runnynose,nasalbleeding,cough,snoring.
  • Painfulmenstruation.
  • Feelingofcoldnessinhandsandfeet.

Rare:canaffectupto1in1000people

  • Alteredsenseofsmell,oscillatingvision,disturbanceofdepthperception,glare,lossofvision.
  • Dilatedpupils,strabismus.
  • Coldsweat,throatconstriction,swollentongue.
  • Pancreatitis.
  • Difficultyswallowing.
  • Slowedorreducedmovementofthebody.
  • Difficultywritingcorrectly.
  • Fluidaccumulationintheabdominalarea.
  • Fluidinthelungs.
  • Convulsions.
  • Changesintheelectrocardiogram(ECG)correspondingtoheartratealterations.
  • Muscledamage.
  • Milksecretion,abnormalbreastgrowth,enlargedbreastsinmen.
  • Menstrualcycledisruption.
  • Renalinsufficiency,reducedurineoutput,urineretention.
  • Decreasedwhitebloodcellcount.
  • Inappropriatebehavior,suicidalbehavior,suicidalthoughts.
  • Allergicreactionsthatmayincludedifficultybreathing,inflammationoftheeyes(keratitis),andasevereskinreactioncharacterizedbyflatredpatchesthatarenotelevated,orroundorcoin-shapedpatchesonthechest,oftenwithcentralvesicles,skinshedding,mouthulcers,throatulcers,nasalulcers,genitalulcers,andeyeulcers.Thesesevereskinreactionsmaybeprecededbyfeverandflu-likesymptoms(Stevens-Johnsonsyndrome,toxicepidermalnecrolysis).
  • Jaundice(yellowskinandeyes).
  • Parkinsonism,symptomssimilartoParkinson'sdisease,suchasshakiness,bradykinesia(decreasedabilitytomove),andmusclerigidity.

Veryrare:canaffectupto1in10,000people

  • Liverfailure.
  • Hepatitis(inflammationoftheliver).

Frequencynotknown:cannotbeestimatedfromavailabledata

  • Becomingdependentonpregabalin(“drugdependence”).

Onceyouhavefinishedashort-termtreatmentwithpregabalin,youshouldknowthatyoumayexperiencecertainsideeffects,calledwithdrawaleffects(seeIfyoustoptakingApregia”).

Ifyouexperienceswellinginthefaceoronthetongue,orifyourskinturnsredandyougetblisterorshedding,youshouldimmediatelyseekmedicalhelp.

Certainsideeffects,suchasdrowsiness,maybemorecommonsincepatientswithspinalcordinjurymaybetakingothermedicinestotreat,forexample,painorspasticity(muscletensionorrigidity),withsideeffectssimilartopregabalinsothattheintensityofthesesideeffectsmayincreasewhentakentogether.

Thefollowingadversereactionhasbeenreportedinpost-marketingexperience:difficultybreathing,shallowbreathing.

Reportingofadversereactions

Sincerinteanydroguserofpregabalinanyyourhavehadanyothermedicinestotatreattreatmentsandreportthemanyyourhavehadanyothermedicinesthatyouhavenoticedintheprescriptionandresponsibilitytoyourhealthandyourphysicianonceantoyourhealthandonceantoyourhealthandonceanyourhealthandonceantoyourhealthandyourhealthandonceantoyourhealthandyourhealthandonceantoyourhealthandyourhealthandonceantoyourhealthandyourhealthandonceantoyourhealthandyourhealthandonceantoyourhealthandyourhealthandonceantoyourh5. Conservation of Apregia

Keepthismedicationoutofsightandoutofreachofchildren.

Donotusethismedicationaftertheexpirationdatethatappearsonthecontainerafter CAD.Theexpirationdateisthelastdayofthemonthindicated.

This medication does not require special storage conditions.

Do not dispose of medications through the drains or trash. Dispose of the containers and medications you no longer need at the SIGRE collection point at the pharmacy. Ask your pharmacist how to dispose of the containers and medications you no longer need. In this way, you will help protect the environment.

6. Content of the container and additional information

CompositionofApregia

Theactiveingredientispregabalina.Eachhardcapsulecontains75mgofpregabalina.

Theothercomponentsare:pregelatinizedstarch(frommaize),talco(E553b),dióxidodetitanio(E171),gelatina(E441),óxidodehierroamarillo(E172),tintanegradeimpresión-shellac(E904),óxidodehierronegro(E172)andpropilenglicol(E1520).

Appearance of the product and content of the container

Hardcapsuleswiththebodyandcapofyellowish-browncolor.Thecapofthecapsulehasblackprint«P75».Thecontentofthecapsuleisawhiteornearlywhitepowder.Thelengthofthecapsuleis13.8–14.8mm.

Apregiaispresentedinblisterpackscontaining56hardcapsules.

Holder of the marketing authorization and responsible for manufacturing

Holder of the marketing authorization

KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia

Responsible for manufacturing

KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia

TAD Pharma GmbH, Heinz-Lohmann-Straße 5, 27472 Cuxhaven, Germany

You can request more information about this medicine by contacting the local representative of the holder of the marketing authorization:

KRKA Pharmaceutical, S.L., C/ Anabel Segura 10, Pta. Baja, Oficina 1, 28108 Alcobendas, Madrid, Spain

Date of the last review of this leaflet:January 2024

ThedetailledinformationaboutthismedicineisavailableonthewebsiteoftheSpanishAgencyofMedicinesandMedicalDevices(AEMPS) http://www.aemps.gob.es/.

Country of registration
Active substance
Prescription required
Yes
Composition
Propilenglicol (TRAZAS mg mg)
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.

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