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REYATAZ 200 mg HARD CAPSULES

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About the medicine

How to use REYATAZ 200 mg HARD CAPSULES

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Contents of the leaflet

  1. Introduction
  2. What is REYATAZ and what is it used for
  3. What you need to know before you take REYATAZ
  4. How to take REYATAZ
  5. Possible Adverse Effects
  6. Storage of REYATAZ
  7. Package Contents and Additional Information

Introduction

Package Leaflet: Information for the User

REYATAZ200mg hard capsules

atazanavir

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack and other information

  1. What is REYATAZ and what is it used for
  2. What you need to know before you take REYATAZ
  3. How to take REYATAZ
  4. Possible side effects
  5. Storing REYATAZ
  6. Contents of the pack and other information

1. What is REYATAZ and what is it used for

REYATAZ is an antiviral medicine (also known as an antiretroviral).It belongs to a group of medicines called protease inhibitors. These medicines control HIV infection by blocking a protein that the virus needs to multiply. It works by reducing the amount of HIV in your body and this, in turn, strengthens your immune system. This reduces the risk of developing diseases associated with HIV infection.

REYATAZ capsules can be used by adults and children from 6 years of age and older. Your doctor has prescribed REYATAZ because you are infected with HIV, which causes Acquired Immune Deficiency Syndrome (AIDS). It is usually used in combination with other anti-HIV medicines. Your doctor will decide which combination of these medicines is best for you with REYATAZ.

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2. What you need to know before you take REYATAZ

Do not take REYATAZ

  • if you are allergicto atazanavir or any of the other ingredients of this medicine (listed in section 6)
  • if you have moderate to severe liver problems.Your doctor will assess the severity of your liver disease before deciding if you can take REYATAZ
  • if you are taking any of these medicines:see also Other medicines and REYATAZ
  • rifampicin (an antibiotic used to treat tuberculosis)
  • astemizole or terfenadine (often used to treat allergic symptoms, these medicines may be available without a prescription); cisapride (used to treat stomach reflux, sometimes called heartburn); pimozide (used to treat schizophrenia); quinidine or bepridil (used to correct heart rhythm); ergotamine, dihydroergotamine, ergonovine, methylergonovine (used to treat headaches); and alfuzosin (used to treat enlarged prostate)
  • quetiapine (used to treat schizophrenia, bipolar disorder, and major depressive disorder); lurasidone (used to treat schizophrenia)
  • medicines containing St. John's Wort (Hypericum perforatum, a medicinal plant)
  • triazolam and midazolam oral (given by mouth) (used to induce sleep and/or relieve anxiety)
  • lomitapide, simvastatin, and lovastatin (used to lower blood cholesterol)
  • medicines containing grazoprevir, including the fixed-dose combination of elbasvir/grazoprevir and the fixed-dose combination of glecaprevir/pibrentasvir (used to treat chronic hepatitis C infection)
  • apalutamide (used to treat prostate cancer)

Do not take sildenafil with REYATAZ when sildenafil is used to treat pulmonary arterial hypertension. Sildenafil is also used to treat erectile dysfunction. Inform your doctor if you are using sildenafil to treat erectile dysfunction.

Inform your doctor immediately if you are in any of these situations.

Warnings and precautions

REYATAZ is not a cure for HIV infection.You may continue to develop infections or other illnesses associated with HIV infection.

Some people will need special monitoring before or during treatment with REYATAZ. Consult your doctor or pharmacist before starting REYATAZ and make sure to inform your doctor:

  • if you have hepatitis B or C
  • if you develop signs or symptoms of gallstones (pain in the right side of your stomach)
  • if you have hemophilia type A or B
  • if you need to undergo hemodialysis

REYATAZ may affect how your kidneys work.

There have been reports of kidney stones in patients treated with REYATAZ. If you experience signs or symptoms of kidney stones (side pain, blood in the urine, pain when urinating), please inform your doctor immediately.

In some patients with advanced HIV infection (AIDS) and a history of opportunistic infections, signs and symptoms of inflammation of previous infections may appear soon after starting anti-HIV treatment. It is believed that these symptoms are due to an improvement in the body's immune response, allowing it to fight infections that were present without apparent symptoms. If you notice any symptoms of infection, please inform your doctor immediately. In addition to opportunistic infections, autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may also appear after you start taking medicines to treat your HIV infection. Autoimmune disorders may appear many months after starting treatment. If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness starting in the hands and feet and moving up to the body, palpitations, tremors, or hyperactivity, please inform your doctor immediately to receive the necessary treatment.

Some patients receiving combination antiretroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone). Among the many risk factors for developing this disease are the duration of combination antiretroviral therapy, the use of corticosteroids, alcohol consumption, severe immunodepression, and high body mass index. The symptoms of osteonecrosis are stiffness in the joints, pain, and discomfort (especially in the hip, knee, and shoulder) and difficulty moving. If you notice any of these symptoms, please inform your doctor.

Hyperbilirubinemia (increased bilirubin levels in the blood) has occurred in patients receiving REYATAZ. The signs may be a slightly yellowish tone of the skin or eyes. If you notice any of these symptoms, please inform your doctor.

Severe skin rash, including Stevens-Johnson syndrome, has been reported in patients treated with REYATAZ. Inform your doctor immediately if you develop a rash.

If you notice a change in the way your heart beats (changes in heart rhythm), please inform your doctor. Children receiving REYATAZ may require their heart to be monitored. Your doctor will decide this.

Children

Do not give this medicine to childrenunder 3 months of age and weighing less than 5 kg. The use of REYATAZ has not been studied in children under 3 months of age and weighing less than 5 kg due to the risk of serious complications.

Other medicines and REYATAZ

Do not take REYATAZ with certain medicines.These are listed under the heading Do not take REYATAZ, at the beginning of Section 2.

There are other medicines that should not be taken with REYATAZ. Inform your doctor if you are taking, have recently taken, or might take any other medicines. It is especially important that you mention the use of the following:

  • other medicines for the treatment of HIV infection (e.g., indinavir, nevirapine, and efavirenz)
  • sofosbuvir/velpatasvir/voxilaprevir (used to treat hepatitis C)
  • sildenafil, vardenafil, or tadalafil (used by men to treat impotence (erectile dysfunction)
  • certain medicines used to treat diseases related to stomach acid (e.g., antacids that should be administered 1 hour before taking REYATAZ or 2 hours after taking REYATAZ, H2 blockers such as famotidine, and proton pump inhibitors such as omeprazol)
  • medicines to lower blood pressure, reduce heart rate, or correct heart rhythm (amiodarone, diltiazem, systemic lidocaine, verapamil)
  • atorvastatin, pravastatin, and fluvastatin (used to lower blood cholesterol)
  • salmeterol (used to treat asthma)
  • cyclosporine, tacrolimus, and sirolimus (medicines to reduce the effects of the body's immune system)
  • certain antibiotics (rifabutin, clarithromycin)
  • ketoconazole, itraconazole, and voriconazole (antifungals)
  • apixaban, dabigatran, edoxaban, rivaroxaban, warfarin, clopidogrel, prasugrel, and ticagrelor (used to reduce blood clots)
  • carbamazepine, phenytoin, phenobarbital, and lamotrigine (antiepileptics)
  • encorafenib, ivosidenib, and irinotecan (used to treat cancer)
  • elagolix (gonadotropin-releasing hormone receptor antagonists, used to treat severe endometriosis pain)
  • fostamatinib (used to treat chronic immune thrombocytopenia)
  • sedative agents (e.g., midazolam administered by injection)
  • buprenorphine (used to treat opioid addiction and pain)
  • corticosteroids (all routes of administration; including dexamethasone)

Some medicines may interact with ritonavir, a medicine that is given with REYATAZ. It is important that you inform your doctor if you are using an inhaled or nasal corticosteroid (given through the nose), including fluticasone or budesonide (given to treat allergic symptoms or asthma).

Taking REYATAZ with food and drinks

It is important that you take REYATAZ with food (a meal or snack) as this helps the absorption of the medicine.

Pregnancy and breastfeeding

If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.

Atazanavir, the active substance of REYATAZ, is excreted in breast milk. Patients must not breastfeed while taking REYATAZ.

It is not recommendedthat HIV-positive women breastfeed their babies because HIV infection can be transmitted to the baby through breast milk.

If you are breastfeeding or thinking of breastfeeding, you must consultyour doctor as soon as possible.

Driving and using machines

If you feel dizzy or drowsy, do not drive or use machines, and contact your doctor immediately.

REYATAZ contains lactose.

If your doctor has told you that you have an intolerance to some sugars (e.g., lactose), consult your doctor before taking this medicine.

3. How to take REYATAZ

Follow exactly the instructions for administration of this medicine given by your doctor. In case of doubt, consult your doctor again. This way, you can be sure that the treatment is totally effective and reduces the risk of the virus developing resistance to the treatment.

The recommended dose of REYATAZ capsules for adults is 300mg together with 100mg of ritonavir once a day and with food,in combination with other anti-HIV medicines. Your doctor may adjust the dose of REYATAZ according to your anti-HIV treatment.

For children (from 6 to less than 18years of age), your doctor will decide the correct dose based on your child's weight.The dose of REYATAZ capsules for children is calculated by body weight and taken once a day with food and 100 mg of ritonavir as shown below:

Body Weight

(kg)

Dose of REYATAZ once a day

(mg)

Dose of ritonavir* once a day

(mg)

15 to less than 35

200

100

35 or more

300

100

*Ritonavir capsules, tablets, or oral solution may be used.

REYATAZ is also available as an oral powder for use in children from 3 months of age and weighing at least 5 kg. It is recommended to switch from REYATAZ oral powder to REYATAZ capsules as soon as patients are able to swallow the capsules properly.

When switching between the oral powder and capsules, a dose change may be necessary. Your doctor will decide the correct dose based on your child's weight.

There are no dose recommendations for REYATAZ in pediatric patients under 3 months of age.

Take REYATAZ capsules with food(a meal or snack). Swallow the capsules whole. Do not open the capsules.

If you take more REYATAZ than you should

If you or your child take too much REYATAZ, the skin and/or eyes may turn yellow (jaundice) and irregular heartbeats (prolonged QTc) may occur.

If you or your child have accidentally taken more REYATAZ capsules than your doctor recommended, contact your doctor immediately or go to the nearest hospital for consultation.

If you forget to take REYATAZ

If you have missed a dose, take it as soon as possible with some food and then take the next scheduled dose at the usual time. If it is almost time for the next dose, do not take the missed dose. Wait and take the next dose at the usual time. Do not take a double dose to make up for missed doses.

If you stop taking REYATAZ

Do not stop taking REYATAZ before consulting your doctor.

If you have any further questions on the use of this medicine, ask your doctor.

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4. Possible Adverse Effects

Like all medicines, this medicine can cause adverse effects, although not all people suffer from them. During HIV infection treatment, it is not always easy to identify the adverse effects caused by REYATAZ, by any other medicine you are taking, or by the HIV infection itself. Inform your doctor of any change you notice in your state of health.

During HIV treatment, there may be an increase in weight and glucose and lipid levels in the blood. This may be partly related to the recovery of health and lifestyle, and in the case of blood lipids, sometimes with HIV medicines themselves. Your doctor will monitor these changes.

Inform your doctor immediately if you develop any of the following serious adverse effects:

  • Skin rash, itching that can occasionally be severe has been reported. The rash usually disappears within 2 weeks without changing your treatment with REYATAZ. Severe rash associated with other symptoms that can be severe may develop. Discontinue treatment with REYATAZ and inform your doctor immediately if you develop a severe rash or a rash with symptoms similar to the flu, blisters, fever, mouth sores, muscle or joint pain, swelling in the face, eye inflammation that causes redness (conjunctivitis), painful, hot, or red lumps (nodules).
  • Frequent yellowing of the skin or the white part of the eyes caused by high bilirubin levels in the blood has been reported. This adverse effect is usually not dangerous in adults and children over 3 months of age; but it could be a symptom of a serious problem. If your skin or the white part of your eyes turns yellow, inform your doctor immediately.
  • Changes in the way your heart beats (changes in heart rhythm) can occasionally occur. Inform your doctor immediately if you feel dizzy, faint, or if you suddenly faint. These can be symptoms of a serious heart problem.
  • Liver problems can occur infrequently. Your doctor must perform blood tests before starting treatment with REYATAZ and during treatment. If you have liver problems, including hepatitis B or C infection, you may experience worsening of your liver problems. Inform your doctor immediately if your urine turns dark (tea-colored), you have itching, your skin or the white part of your eyes turns yellow, you have pain around the stomach, pale stools, or nausea.
  • Bile duct problems can occur infrequently in people taking REYATAZ. Symptoms of bile duct problems may include pain in the right or upper middle part of the stomach, nausea, vomiting, fever, or yellowing of the skin or the white part of the eyes.
  • REYATAZ may affect the way your kidneys function.
  • Kidney stones can occur infrequently in people taking REYATAZ. Inform your doctor immediately if you have symptoms of kidney stones, which may include pain in the lower back or lower stomach, blood in the urine, or pain when urinating.

Other adverse effects reported in patients treated with REYATAZ are the following:

Frequent (may affect up to 1 in 10 patients):

  • headache
  • vomiting, diarrhea, abdominal pain (stomach discomfort), nausea, dyspepsia (indigestion)
  • fatigue (extreme tiredness)

Infrequent (may affect up to 1 in 100 patients):

  • peripheral neuropathy (numbness, weakness, tingling, or pain in the arms and legs)
  • hypersensitivity (allergic reaction)
  • asthenia (unusual or excessive weakness)
  • weight loss, weight gain, anorexia (loss of appetite), increased appetite
  • depression, anxiety, sleep disturbance
  • disorientation, amnesia (memory loss), dizziness, somnolence (drowsiness), abnormal dreams
  • syncope (fainting), hypertension (high blood pressure)
  • dyspnea (breathing difficulties)
  • pancreatitis (inflammation of the pancreas), gastritis (inflammation of the stomach), aphthous stomatitis (mouth ulcers and cold sores), dysgeusia (altered sense of taste), flatulence (gas), dry mouth, abdominal distension
  • angioedema (severe swelling of the skin and other tissues, usually the lips or eyes)
  • alopecia (abnormal hair loss or thinning), pruritus (itching)
  • muscle atrophy (muscle contraction), arthralgia (joint pain), myalgia (muscle pain)
  • interstitial nephritis (inflammation of the kidney), hematuria (blood in the urine), proteinuria (excess protein in the urine), polyuria (increased frequency of urination)
  • gynecomastia (breast enlargement in men)
  • chest pain, malaise (feeling generally unwell), fever
  • insomnia (difficulty sleeping)

Rare (may affect up to 1 in 1,000 patients):

  • gait disturbance (abnormal walking)
  • edema (swelling)
  • hepatosplenomegaly (enlargement of the liver and spleen)
  • myopathy (muscle pain, muscle weakness, loss of muscle tone not caused by exercise)
  • kidney pain

Reporting of Adverse Effects

If you experience any adverse effects, consult your doctor or nurse, even if they are possible adverse effects not listed in this leaflet. You can also report them directly through the national reporting system included in Appendix V. By reporting adverse effects, you can help provide more information on the safety of this medicine.

5. Storage of REYATAZ

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiration date stated on the label, carton, or blister. The expiration date is the last day of the month indicated.

Do not store above 25°C.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Package Contents and Additional Information

Composition of REYATAZ

  • The active ingredient is atazanavir. Each capsule contains 200 mg of atazanavir (as sulfate).
  • The other ingredients are crospovidone, lactose monohydrate, and magnesium stearate. The capsule shell and printing ink contain gelatin, shellac, ammonium hydroxide, simethicone, propylene glycol, indigo carmine (E132), and titanium dioxide (E171).

Appearance and Package Contents of the Product

Each REYATAZ 200 mg capsule contains 200 mg of atazanavir.

The REYATAZ 200 mg capsule is a blue opaque capsule printed with white ink on one half "BMS 200 mg" and on the other "3631".

REYATAZ 200 mg hard capsules are presented in bottles containing 60 capsules. Each carton contains one or three bottles with 60 hard capsules.

REYATAZ 200 mg hard capsules are also presented in blister strips packaged in cartons containing 60 capsules.

Not all pack sizes may be marketed.

Marketing Authorization Holder

Bristol-Myers Squibb Pharma EEIG

Plaza 254

Blanchardstown Corporate Park 2

Dublin 15, D15 T867

Ireland

Manufacturer

CATALENT ANAGNI S.R.L.

Loc. Fontana del Ceraso snc

Strada Provinciale 12 Casilina, 41

03012 Anagni (FR)

Italy

Swords Laboratories Unlimited Company T/A Bristol-Myers Squibb Pharmaceutical Operations, External Manufacturing

Plaza 254

Blanchardstown Corporate Park 2

Dublin 15, D15 T867

Ireland

Date of the Last Revision of this Leaflet:

Other Sources of Information

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

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Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.
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€55
5.0 (29)
Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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€60
2

Frequently Asked Questions

Is a prescription required for REYATAZ 200 mg HARD CAPSULES?
REYATAZ 200 mg HARD CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in REYATAZ 200 mg HARD CAPSULES?
The active ingredient in REYATAZ 200 mg HARD CAPSULES is atazanavir. This information helps identify medicines with the same composition but different brand names.
Who manufactures REYATAZ 200 mg HARD CAPSULES?
REYATAZ 200 mg HARD CAPSULES is manufactured by Bristol-Myers Squibb Pharma Eeig. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of REYATAZ 200 mg HARD CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether REYATAZ 200 mg HARD CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to REYATAZ 200 mg HARD CAPSULES?
Other medicines with the same active substance (atazanavir) include ATAZANAVIR KRKA 150 mg HARD CAPSULES, ATAZANAVIR KRKA 200 mg HARD CAPSULES, ATAZANAVIR KRKA 300 mg HARD CAPSULES. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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