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RELIF 1000 mg DISPERSIBLE TABLETS

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About the medicine

How to use RELIF 1000 mg DISPERSIBLE TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Relif 1000 mg Dispersible Tablets

nabumetone

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet

  1. What is Relif and what is it used for
  2. What you need to know before you take Relif
  3. How to take Relif
  4. Possible side effects
  5. Storage of Relif
  1. Contents of the pack and further information

1. What is Relif and what is it used for

Relif belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs) with high anti-inflammatory activity and analgesic and antipyretic properties.

Relif is indicated in adults for the treatment of inflammatory processes, such as osteoarthritis and rheumatoid arthritis and periarticular disorders.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you start taking Relif

It is important that you use the smallest dose that relieves-controls the pain and you should not take this medicine for longer than necessary to control your symptoms.

Do not take Relif:

  • If you are allergic to nabumetone or any of the other ingredients of this medicine (listed in section 6).
  • If you have experienced asthma, itching or other types of allergic reactions after taking acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs).
  • If you have a severe liver disease.
  • If you have had or have a stomach or duodenal ulcer or have suffered a perforation of the digestive tract.
  • If you are in the third trimester of pregnancy or during breastfeeding.
  • If you have severe heart failure, or a cerebrovascular problem (stroke or cerebral hemorrhage) or other bleeding.

Warnings and precautions

Consult your doctor or pharmacist before starting to take nabumetone:

  • If you are taking other anti-inflammatory medicines.
  • If you are an elderly person, or have had ulcers, gastrointestinal bleeding or perforation, as your doctor may prescribe a stomach protector for you.
  • If you are taking medicines that alter blood coagulation, such as oral anticoagulants, corticosteroids, antidepressants (selective serotonin reuptake inhibitors) and antiplatelet agents of the type of acetylsalicylic acid and clopidogrel.
  • If you have Crohn's disease or ulcerative colitis, as medicines of the type of Relif may worsen these conditions.
  • If you have a bleeding or ulcer during treatment with nabumetona, stop the medication immediately.
  • If you have or have had a heart disorder, cerebrovascular disorder or have high blood pressure.
  • If you have edema (fluid retention).
  • It is possible that serious skin reactions may occur with this medicine (skin erythema, mucosal lesions and other signs of hypersensitivity). In this case, stop the medication with nabumetona immediately.
  • If you are a woman of childbearing age or are trying to become pregnant.
  • If acetylsalicylic acid or other anti-inflammatory drugs cause you asthma, itching or other types of allergic reactions. Your doctor will monitor the first dose of nabumetona.
  • If you have systemic lupus erythematosus and mixed connective tissue disease (chronic diseases that affect the immune system), as aseptic meningitis (inflammation of the meninges not caused by bacteria) may occur.
  • If you have kidney or liver disease, it is possible that your doctor may need to perform regular checks. Your doctor will indicate the frequency of these checks and if necessary the interruption of treatment.

Non-steroidal anti-inflammatory drugs, including nabumetone, may mask the symptoms or signs of an infection (fever, pain and inflammation).

If you experience vision problems during treatment with nabumetona, consult your doctor, you may need an ophthalmological examination.

Side effects can be minimized by taking the lowest effective dose and for the shortest possible time to control symptoms.

Children and adolescents

This medicine is not recommended for children or adolescents.

Other medicines and Relif

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

The following medicines may interfere and should not be taken with nabumetona without first consulting your doctor:

  • Medicines that alter blood coagulation, such as corticosteroids, oral anticoagulants of the warfarin type, or antiplatelet agents of the type of acetylsalicylic acid.
  • Medicines that may increase the risk of bleeding, such as corticosteroids and selective serotonin reuptake inhibitor antidepressants, bisphosphonates (to prevent osteoporosis), pentoxifylline (to treat intermittent claudication), sulfinpyrazone (to treat gout) and alcohol.

In general, nabumetone may also interact with other medicines, such as:

  • Methotrexate (to treat cancer and inflammatory diseases).
  • Digoxin and other cardiac glycosides (to treat heart disorders).
  • Lithium (antidepressant).

(Your doctor may adjust the doses of these medicines).

  • Diuretics (increase urine elimination).
  • Antihypertensives (to treat high blood pressure).
  • Sulfonamides (to treat some bacterial infections).
  • Sulfonylureas (to treat diabetes).
  • Hydantoins (antiepileptic).
  • Cyclosporin (to prevent organ rejection).
  • Mifepristone (for abortion).
  • Probenecid (to treat gout).
  • Quinolone antibiotics.

The use of nabumetone at the same time as another non-steroidal anti-inflammatory drug is not recommended.

However, other commonly used medicines such as paracetamol, acetylsalicylic acid, cimetidine, aluminum hydroxide antacids do not interfere with nabumetona.

Taking Relif with food, drinks and alcohol

If you drink alcohol while taking this medicine, you may be more likely to experience gastrointestinal side effects.

Medicine questions

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Discuss your symptoms and treatment with a doctor online.

Pregnancy, breastfeeding and fertility

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Because the administration of medicines of the type of nabumetona has been associated with an increased risk of congenital anomalies/abortions, it is not recommended to administer it during the first and second trimester of pregnancy unless it is strictly necessary. In these cases, the dose and duration will be limited to the minimum possible.

In the third trimester, the administration of nabumetona is contraindicated, as it may harm the fetus or cause problems during delivery. It may cause kidney and heart problems in the fetus. It may affect your tendency to bleed and that of your baby and make delivery delayed or prolonged more than expected. You should not take nabumetona during the first 6 months of pregnancy unless it is absolutely necessary and your doctor advises you to do so. If you need treatment during this period or while trying to become pregnant, you should use the lowest dose for the shortest possible time. If you take it for more than a few days from the 20th week of pregnancy, nabumetona may cause kidney problems in your unborn baby/fetus that may lead to low levels of amniotic fluid surrounding the baby (oligohydramnios) or narrowing of a blood vessel (ductus arteriosus) in the baby's heart. If you need treatment for more than a few days, your doctor may recommend additional monitoring.

It is not known if nabumetona is excreted in breast milk, however, its active metabolite is excreted in milk in animals. Due to the possible risk of serious adverse reactions in the breastfed child, a decision should be made to either discontinue breastfeeding or discontinue/discontinue treatment, taking into account the benefit of breastfeeding for the child and the benefit of treatment for the mother.

Women of childbearing age should be aware that medicines of the type of nabumetona have been associated with a decrease in fertility, so their use is not recommended in women who are trying to become pregnant.

Driving and using machines

Patients who experience dizziness and confusion after taking nabumetona should not drive vehicles, operate hazardous machinery and avoid situations that require special alertness.

Relif contains sodium and glucose

This medicine contains less than 1 mmol of sodium (23 mg) per tablet; this is, essentially "sodium-free".

This medicine contains glucose (from corn maltodextrin). If your doctor has told you that you have an intolerance to some sugars, consult with him before taking this medicine.

3. How to take Relif

Follow exactly the administration instructions of this medicine indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.

The recommended dose is:

Adults:

1 tablet (1000 mg) per day, orally. The tablets can be taken with or without food. In those cases where the doctor considers it appropriate, the dose may be increased up to 1500 mg or 2000 mg, which may be taken in a single dose or divided into two doses.

Do not exceed the dose of 2000 mg (2 tablets) per day.

Use in children and adolescents:

This medicine is not recommended for children or adolescents.

Elderly patients:

The total daily dose should not exceed 1000 mg. The initial dose should be 500 mg.

Kidney problems:

Generally, it is not necessary to adjust the dose in patients with kidney problems.

Method of administration:

Oral.

The Relif tablets should be dissolved in a little water before administration.

Your doctor will indicate the duration of your treatment with Relif. Do not stop treatment before.

Remember to take your medicine.

If you take more Relif than you should

Symptoms such as nausea, vomiting, stomach pain, gastrointestinal bleeding, rarely diarrhea, disorientation, excitement, coma, somnolence, dizziness and occasionally convulsions may appear. In case of severe poisoning, acute kidney failure and liver damage may occur.

In case of overdose or accidental ingestion, consult the Toxicological Information Service. Phone 91 5620420. However, if the amount is significant, go to the doctor without delay or to the emergency service of the nearest hospital and take this leaflet with you.

If you forget to take Relif

Do not take a double dose to make up for forgotten doses.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The most frequent side effects that occur with medicines like nabumetone are gastrointestinal: peptic ulcers, gastrointestinal bleeding, perforations (in some cases fatal), especially in elderly people. Nausea, vomiting, diarrhea, flatulence, constipation, heartburn, abdominal pain, blood in stools, oral aphthae, worsening of ulcerative colitis and Crohn's disease have also been observed. Less frequently, gastritis has been observed.

If you experience any of these adverse reactions, inform your doctor and he will assess the convenience of stopping or continuing treatment.

The usual side effects in terms of frequency are the following:

Frequent(affect up to 1 in 10 people):

Tinnitus or ear disorders. Increased blood pressure. Diarrhea, constipation, heartburn, stomach mucosa inflammation, nausea, abdominal pain, flatulence. Skin rash and itching. Edema.

Uncommon(affect up to 1 in 100 people):

Confusion, nervousness, insomnia. Somnolence, dizziness, headache, paresthesia (tingling sensation in limbs). Abnormal vision, eye disorders. Difficulty breathing and respiratory disorders, nosebleeds. Duodenal ulcer, gastrointestinal bleeding, gastric ulcer, gastrointestinal disorders, black stools, vomiting, stomatitis (inflammation of the mouth mucosa), dry mouth. Sensitivity to light, itching, sweating. Myopathy (muscle disease). Urinary tract disorders. Feeling of tiredness, fatigue. Elevated liver function tests.

Rare(affect up to 1 in 10,000 people):

Decreased platelets. Allergic reactions. Interstitial pneumonitis (inflammation of the lungs). Jaundice (yellowing of the skin), liver failure. Bullous skin reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, pseudoporphyria, erythema multiforme, angioedema (skin swelling), alopecia. Nephrotic syndrome (kidney inflammation), kidney failure. Menorrhagia (abundant menstrual bleeding).

Frequency not known(cannot be estimated from the available data):

Anemia (lack of blood due to insufficient production of red blood cells or premature destruction of them). Hallucinations. Aseptic meningitis (with symptoms such as neck stiffness, headache, nausea, vomiting, fever, or disorientation).

Edema, arterial hypertension and heart failure have been reported in association with treatment with NSAIDs. Additionally, if NSAIDs are taken in high doses and for a long time, the risk of atherothrombotic events (such as myocardial infarction or stroke) may increase.

Generalized rash, elevated body temperature, elevated liver enzymes, blood abnormalities (eosinophilia), enlarged lymph nodes and involvement of other body organs (drug reaction with eosinophilia and systemic symptoms, also known as DRESS or drug hypersensitivity syndrome). Stop using Relif if you experience these symptoms and contact your doctor or seek immediate medical attention. See also section 2.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if it is possible side effects that are not listed in this leaflet. You can also report them directly through the Spanish Medicines Monitoring System: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Relif

Keep the blister pack in the outer packaging to protect it from light and moisture. Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the packaging after CAD or EXP. The expiry date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Dispose of the packaging and any unused medicine in the SIGRE collection point at the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Contents of the pack and further information

Composition of Relif

The active substance is nabumetone.

Each dispersible tablet contains 1000 mg of nabumetone.

The other ingredients are: sodium saccharin, sodium croscarmellose, povidone, sodium lauryl sulfate, peppermint flavor, vanilla flavor (contains corn maltodextrin), magnesium stearate, microcrystalline cellulose.

Appearance of the product and packaging contents

Relif is presented in the form of dispersible tablets. Each pack contains a blister pack with 20 dispersible tablets.

Marketing authorization holder:

Viatris Healthcare Limited

Damastown Industrial Park

Mulhuddart, Dublin 15

Dublin

Ireland

Manufacturer:

Haupt Pharma Wülfing GmbH

Bethelner Landstraße 18

31028 Gronau/Leine, Niedersachen

Germany

You can request more information about this medicine by contacting the local representative of the marketing authorization holder:

Viatris Pharmaceuticals, S.L.

C/ General Aranaz, 86

28027 - Madrid

Spain

Date of the last revision of this leaflet:February 2023

Other sources of information

Detailed information about this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) https://www.aemps.gob.es/

Online doctors for RELIF 1000 mg DISPERSIBLE TABLETS

Discuss questions about RELIF 1000 mg DISPERSIBLE TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Chikeluo Okeke

General medicine 4 years exp.

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

He provides online consultations covering symptom assessment, prevention, and long-term management of chronic conditions, helping patients understand what is happening and decide on appropriate next steps.

Common reasons for consultation:

  • General internal medicine concerns and initial health assessment.
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Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

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Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

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Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
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If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Doctor

Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

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  •  Musculoskeletal system (MSK)
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  •  Abdomen and pelvis
  •  Soft tissues

Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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Frequently Asked Questions

Is a prescription required for RELIF 1000 mg DISPERSIBLE TABLETS?
RELIF 1000 mg DISPERSIBLE TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in RELIF 1000 mg DISPERSIBLE TABLETS?
The active ingredient in RELIF 1000 mg DISPERSIBLE TABLETS is nabumetone. This information helps identify medicines with the same composition but different brand names.
How much does RELIF 1000 mg DISPERSIBLE TABLETS cost in pharmacies?
The average pharmacy price for RELIF 1000 mg DISPERSIBLE TABLETS is around 10.82 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures RELIF 1000 mg DISPERSIBLE TABLETS?
RELIF 1000 mg DISPERSIBLE TABLETS is manufactured by Viatris Healthcare Limited. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of RELIF 1000 mg DISPERSIBLE TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether RELIF 1000 mg DISPERSIBLE TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to RELIF 1000 mg DISPERSIBLE TABLETS?
Other medicines with the same active substance (nabumetone) include ACENAM 1250 mg EFFERVSCENT TABLETS, CARTISORB 1500 mg POWDER FOR ORAL SOLUTION, CONDRODIN 400 HARD CAPSULES. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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