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MECOLVIX 500 MG SUPPOSITORIES

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About the medicine

How to use MECOLVIX 500 MG SUPPOSITORIES

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the Patient

Mecolvix 500 mg Suppositories

mesalazine

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Mecolvix and what is it used for
  2. What you need to know before you use Mecolvix
  3. How to use Mecolvix
  4. Possible side effects
  5. Storage of Mecolvix
  6. Contents of the pack and other information

1. What is Mecolvix and what is it used for

Mecolvixcontains the active substance mesalazine, which is an anti-inflammatory active substance for the treatment of ulcerative colitis in adults.

Mecolvixis indicated for:

  • Distal ulcerative colitis (proctitis), an inflammatory disease of the last region of the colon, for example, the rectum.
  • Treatment of mild or moderate acute exacerbations;
  • Maintenance of remission.
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you use Mecolvix

Do not useMecolvix

  • if you are allergic to mesalazine or any of the other ingredients of this medicine (listed in section 6)
  • if you are allergic to acetylsalicylic acid or any other salicylate
  • if you have severe kidney and/or liver impairment.

Warnings and precautions

Consult your doctor or pharmacist before starting to use Mecolvix

  • if you are or plan to become pregnant
  • if you are breast-feeding
  • if you have liver or kidney problems
  • if you have any lung disease, for example, asthma
  • if you have been allergic to sulfasalazine in the past
  • if you have a stomach or intestinal ulcer
  • if you have previously had an inflammation of the heart (which could be a consequence of a heart infection)
  • if you have ever had a severe skin rash or skin peeling, blisters or ulcers in the mouth after using mesalazine.

If you experience severe headache or recurrent headache, vision changes or ringing or buzzing in the ears, contact your doctor immediately.

In case of appearance of any allergic manifestation (e.g., skin rash, itching) or cramps, abdominal pain, severe headache, and fever during the course of treatment, do not use this medicine anymore and inform your doctor immediately.

Before and during treatment, your doctor may want to perform regular blood and urine tests to check the functioning of the liver, kidneys, blood, and lungs.

Kidney stones may occur with the use of mesalazine. The symptoms include pain in the sides of the abdomen and blood in the urine. Make sure to drink a sufficient amount of liquid during treatment with mesalazine.

Mesalazine may cause a discoloration of the urine to a reddish-brown color after contact with sodium hypochlorite bleach in the toilet water. This is a chemical reaction between mesalazine and bleach and is harmless.

Severe skin rashes, such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SSJ), and toxic epidermal necrolysis (TEN), have been observed with mesalazine treatment. Stop taking mesalazine and seek medical attention immediately if you observe any of the symptoms related to these severe skin reactions described in section 4.

Children and adolescents

The information on safety in the use of this medicine in children and adolescents is limited.

Do not administer to children under 5 years of age.

Other medicines andMecolvix

In general, you can continue treatment with other medicines while using Mecolvix. However, inform your doctor or pharmacist if you are using, have recently used, or may need to use any other medicine, including those obtained without a prescription.

Mecolvixmay interact with some medicines if administered at the same time.

In particular:

  • medicines to lower blood sugar (antidiabetics)
  • medicines to lower blood pressure (antihypertensives/diuretics)
  • medicines for the treatment or prevention of gout attacks
  • medicines to prevent blood clotting (anticoagulants)
  • medicines to reduce the activity of the immune system (e.g., azathioprine, 6-mercaptopurine, or thioguanine)
  • medicines to treat pain and inflammation (anti-inflammatory)
  • mesalazine may delay the excretion of methotrexate

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

There is limited experience with the use of mesalazine during pregnancy and breast-feeding. The newborn may develop allergic reactions after breast-feeding, for example, diarrhea. If the newborn develops diarrhea, breast-feeding should be discontinued.

The use of Mecolvixis not recommended in pregnant or breast-feeding women unless your doctor advises you otherwise.

Driving and using machines

Mecolvixhas no or negligible influence on the ability to drive and use machines.

3. How to use Mecolvix

Follow the instructions for administration of this medicine exactly as prescribed by your doctor or pharmacist. If you are in doubt, consult your doctor or pharmacist before using this medicine.

Your doctor may adjust the dose depending on your characteristics and the characteristics of your disease. The recommended dose in adults is:

  • Acute phase treatment: one suppository two or three times a day (corresponding to a daily dose of 1000-1500 mg of mesalazine).
  • Remission maintenance: one suppository one or two times a day (corresponding to a daily dose of 500-1000 mg of mesalazine).

Method of administration:

This medicine can only be used rectally, so it must be inserted through the anus. It must not be taken orally.

It is recommended to go to the bathroom and empty the intestine before using the suppository.

It is advisable to insert the suppository while lying on your left side and remain in this position for approximately 1 hour.

The suppositories should be inserted deeply into the anus and should be kept in the rectum for 1 to 3 hours to increase efficacy.

Use in children and adolescents

The administration of Mecolvixis not recommended in children and adolescents under 18 years of age due to the lack of data on its safety and efficacy. Do not administer to children under 5 years of age.

Use in elderly patients

The use of Mecolvixin elderly patients should be done with caution and always limited to those patients with normal renal function.

If you use moreMecolvixthan you should

If you have used more Mecolvixthan you should, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: 915620420, indicating the medicine and the amount used. It is recommended to bring the packaging and the leaflet of the medicine to the healthcare professional.

If you forget to useMecolvix

Do not use a double dose to make up for forgotten doses.

It is important that you use Mecolvixevery day, even when you do not have symptoms of ulcerative colitis. Continue treatment as prescribed by your doctor.

If you stop usingMecolvix

Do not stop treatment without consulting your doctor first.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

All medicines can cause allergic reactions, although serious allergic reactions are very rare. If you get any of the following symptoms after using this medicine, stop using this medicine and contact your doctor immediately:

  • Allergic skin rash;
  • fever;
  • difficulty breathing.

If you experience fever or irritation of the throat or mouth, stop using this medicine and contact your doctor immediately. These symptoms may be due, very rarely, to a decrease in the number of white blood cells in the blood (a condition called agranulocytosis).

Severe side effects

Stop taking mesalazine and seek medical attention immediately if you get any of the following symptoms:

  • red patches, or circular or coin-shaped patches on the chest, often with central blisters, skin peeling, ulcers in the mouth, throat, nose, genitals, and eyes, generalized rash, fever, and swollen lymph nodes. These severe skin rashes are often preceded by fever or flu-like symptoms.
    • if you experience severe headache or recurrent headache, vision changes, or ringing or buzzing in the ears. These could be symptoms of increased pressure inside your skull (idiopathic intracranial hypertension).

The following side effects have also been reported in patients using mesalazine:

Rare side effects (may affect up to 1 in 1,000 people)

  • abdominal pain, diarrhea, flatulence, nausea, and vomiting;
  • headache, dizziness;
  • chest pain, difficulty breathing, or swollen limbs due to an effect on the heart;
  • increased sensitivity of the skin to sunlight and ultraviolet light (photosensitivity)

Very rare side effects (may affect less than 1 in 10,000 people)

  • kidney problems, sometimes with swollen limbs or side pain;
  • severe abdominal pain due to acute pancreatitis;
  • worsening of colitis symptoms;
  • fever, sore throat, or nausea due to changes in blood count;
  • difficulty breathing, cough, wheezing, spots on lung X-ray due to allergic and/or inflammatory conditions in the lungs;
  • diarrhea and severe abdominal pain due to an allergic reaction to the medicine in the intestine;
  • skin rash or skin inflammation;
  • muscle and joint pain;
  • jaundice or abdominal pain due to liver or biliary disorders;
  • hair loss and development of baldness;
  • erythema multiforme;
  • numbness and tingling of the fingers and toes (peripheral neuropathy)
  • reversible decrease in semen production;
  • blood count disorders.

Side effects of unknown frequency (cannot be estimated from the available data).

  1. Kidney stones and associated kidney pain (see also section 2).

Photosensitivity

More severe reactions have been reported in patients with pre-existing skin conditions, such as atopic dermatitis and atopic eczema.

If these symptoms continue or become more severe, consult your doctor.

Reporting of side effects:

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly to the Spanish Medicines and Healthcare Products Agency (AEMPS) through the website: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Mecolvix

Do not store above 30°C. Do not refrigerate or freeze.

Keep this medicine out of the sight and reach of children.

Do not use this medicineafter the expiry date which is stated on the packaging and blister after EXP. The expiry date is the last day of the month stated.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and other information

Composition ofMecolvix

  • The active substance is mesalazine. Each suppository contains 500 mg of mesalazine
  • The other ingredients are: semi-synthetic solid glycerides.

Appearance of the product and contents of the pack

Mecolvixis presented in the form of torpedo-shaped suppositories, grayish-white to slightly reddish-violet in color.

Mecolvixis available in packs of 12, 24, 30, 60, or 100 suppositories. Not all pack sizes may be marketed.

Marketing authorization holder

Faes Farma, S.A.

Autonomia Etorbidea, 10

48940 Leioa (Bizkaia)

Spain

Manufacturer

Faes Farma Portugal, S.A

Rua Elias Garcia, 28

2700-327 Amadora

Portugal

This medicine is authorized in the Member States of the European Economic Area under the following names:

Spain: Mecolvix 500 mg suppositories

France: Mesalazine Mayoly 500 mg suppositories

Ireland: Galtasa 500 mg suppositories

Romania: Azzavix 500 mg suppositories

Czech Republic: Azzavix

Hungary: Salcrozine 500 mg rectal suppositories

Date of last revision of this leaflet: July 2022

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) http://www.aemps.gob.es/

Online doctors for MECOLVIX 500 MG SUPPOSITORIES

Discuss questions about MECOLVIX 500 MG SUPPOSITORIES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Chikeluo Okeke

General medicine 4 years exp.

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

He provides online consultations covering symptom assessment, prevention, and long-term management of chronic conditions, helping patients understand what is happening and decide on appropriate next steps.

Common reasons for consultation:

  • General internal medicine concerns and initial health assessment.
  • Acute symptoms such as fever, cough, infections, pain, or weakness.
  • Chronic conditions and treatment adjustment.
  • Blood pressure issues, fatigue, metabolic concerns.
  • Preventive consultations and routine check-ups.
  • Interpretation of laboratory results and medical reports.
  • Medical advice for patients receiving care online.

Dr Okeke is known for his clear communication, calm approach, and cultural awareness. He listens carefully, explains medical decisions in a structured way, and supports patients in making informed choices about their health.

Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Doctor

Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Doctor

Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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€55
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Doctor

Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

  •  Neuroimaging
  •  Musculoskeletal system (MSK)
  •  Angiography
  •  Abdomen and pelvis
  •  Soft tissues

Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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Frequently Asked Questions

Is a prescription required for MECOLVIX 500 MG SUPPOSITORIES?
MECOLVIX 500 MG SUPPOSITORIES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in MECOLVIX 500 MG SUPPOSITORIES?
The active ingredient in MECOLVIX 500 MG SUPPOSITORIES is mesalazine. This information helps identify medicines with the same composition but different brand names.
Who manufactures MECOLVIX 500 MG SUPPOSITORIES?
MECOLVIX 500 MG SUPPOSITORIES is manufactured by Faes Farma S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of MECOLVIX 500 MG SUPPOSITORIES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether MECOLVIX 500 MG SUPPOSITORIES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to MECOLVIX 500 MG SUPPOSITORIES?
Other medicines with the same active substance (mesalazine) include ASACOL 1 G SUPPOSITORIES, ASACOL 1600 mg GASTRO-RESISTANT TABLETS, ASACOL 400 mg GASTRO-RESISTANT TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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