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MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS

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About the medicine

How to use MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Patient Information Leaflet

Mecolvix 1000 mg Gastro-Resistant Tablets

mesalazine

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What Mecluvix 1000 mg gastro-resistant tablets are and what they are used for
  2. What you need to know before you take Mecluvix 1000 mg gastro-resistant tablets
  3. How to take Mecluvix 1000 mg gastro-resistant tablets
  4. Possible side effects
  5. Storage of Mecluvix 1000 mg gastro-resistant tablets
  6. Contents of the pack and other information

1. What Mecluvix 1000 mg gastro-resistant tablets are and what they are used for

Mecolvix gastro-resistant tablets contain 1000 mg of the active substance mesalazine (also known as 5-aminosalicylic acid), which belongs to a group of medicines called intestinal anti-inflammatory agents.

Mecolvix is indicated for the treatment of ulcerative colitis, an inflammatory disease of the intestine.

Doctor consultation

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2. What you need to know before you take Mecluvix 1000 mg gastro-resistant tablets

Do not take Mecluvix

  • if you are allergic to mesalazine or any of the other ingredients of this medicine (listed in section 6)
  • if you are allergic to acetylsalicylic acid or any other salicylate
  • if you have a medical condition that may make you prone to bleeding
  • if you have severe kidney and/or liver impairment

Warnings and precautions

Consult your doctor before starting treatment with Mecluvix

  • if you are or plan to become pregnant
  • if you are breast-feeding
  • if you have liver or kidney problems
  • if you suffer from any lung disease, such as asthma
  • if you have had an allergy to sulfasalazine in the past
  • if you have a stomach or intestinal ulcer
  • if you have had inflammation of the heart (which could be a consequence of a heart infection)
  • if you have ever suffered from a severe skin rash, peeling, or blisters in the mouth after using mesalazine.

In case of appearance of any allergic manifestation (e.g. skin rash, itching) or cramps, abdominal pain, severe headache, and fever during the course of treatment, do not take more tablets and inform your doctor immediately.

Before and during treatment, your doctor may want to perform regular blood and urine tests to check the functioning of your liver, kidneys, blood, and lungs.

Kidney stones may occur with the use of mesalazine. The symptoms include pain in the sides of the abdomen and the presence of blood in the urine. Make sure to drink a sufficient amount of liquid during treatment with mesalazine.

Severe skin rashes, such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SSJ), and toxic epidermal necrolysis (TEN), have been observed with mesalazine treatment. Stop taking mesalazine and seek medical attention immediately if you observe any of the symptoms related to these severe skin reactions described in section 4.

Mesalazine may cause a discoloration of the urine to a reddish-brown color after contact with sodium hypochlorite bleach in the toilet water. This is a chemical reaction between mesalazine and bleach and is harmless.

Children and adolescents

The information on safety in the use of this medicine in children and adolescents is limited.

Do not administer to children under 5 years of age.

Other medicines and Mecluvix 1000 mg gastro-resistant tablets

In general, you can continue treatment with other medicines while taking Mecluvix. However, inform your doctor or pharmacist if you are using, have recently used, or may need to use any other medicine, including those obtained without a prescription.

Mecolvix may interact with some medicines if taken at the same time.

In particular:

  • medicines to lower blood sugar levels (antidiabetics)
  • medicines to lower blood pressure (antihypertensives/diuretics)
  • medicines for the treatment or prevention of gout attacks
  • medicines that help with bowel movements (laxatives containing lactulose)
  • medicines to prevent blood clotting (anticoagulants)
  • medicines to reduce the activity of the immune system (e.g., azathioprine, 6-mercaptopurine, or thioguanine)
  • medicines to treat pain and inflammation (anti-inflammatory agents)

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

There is limited experience with the use of mesalazine during pregnancy and breast-feeding. The newborn may develop allergic reactions after breast-feeding, such as diarrhea. If the newborn develops diarrhea, breast-feeding should be discontinued.

The use of Mecluvix is not recommended during pregnancy or breast-feeding unless your doctor advises you otherwise.

Driving and using machines

No adverse effects of Mecluvix on the ability to drive or use machines have been described.

Mecolvix 1000 mg gastro-resistant tablets contain sodium

This medicine contains 98 mg of sodium (the main component of table/cooking salt) in each gastro-resistant tablet. This is equivalent to 5% of the maximum daily recommended sodium intake for an adult.

Consult your doctor or pharmacist if you need to take 4 or more gastro-resistant tablets daily for a prolonged period, especially if you have been advised to follow a low-salt diet.

3. How to take Mecluvix 1000 mg gastro-resistant tablets

Follow exactly the administration instructions of this medicine indicated by your doctor. If in doubt, consult your doctor or pharmacist again.

Your doctor will indicate the duration of your treatment with this medicine. Do not stop treatment before, even if you feel better, as symptoms may return if treatment is stopped too soon.

Strictly follow the treatment according to your doctor's instructions, both in the acute inflammatory phase and in the maintenance time established.

The recommended dose in adults is:

To treat an acute episode of colitis,your doctor will normally prescribe a dose between 1.5 (one 1000 mg tablet and one 500 mg tablet) and 4 grams (four 1000 mg tablets) of mesalazine per day, which can be administered in one or several doses.

To help prevent further episodes,your doctor may prescribe a dose between 1.5 (one 1000 mg tablet and one 500 mg tablet) and 3 grams (three 1000 mg tablets) of mesalazine per day, which can be administered in one or several doses.

Mecolvix gastro-resistant tablets should be taken orally.

The tablets should be taken before meals and should be swallowed whole with the help of liquid. They should not be broken, chewed, or crushed.

In both cases, it may be necessary to use the 500 mg tablets of Mecluvix to provide the dose that best suits you.

Use in children and adolescents

The administration of Mecluvix is not recommended for children and adolescents under 18 years of age due to the lack of data on its safety and efficacy. Do not administer to children under 5 years of age.

Use in the elderly

The use of Mecluvix in elderly patients should be done with caution and limited to those patients with normal renal function.

If you take more Mecluvix 1000 mg gastro-resistant tablets than you should

Consult your doctor if you have taken more than prescribed. In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount taken. It is recommended to take the package and the leaflet of the medicine to the healthcare professional.

Consult your doctor if you have taken more than prescribed.

If you forget to take Mecluvix 1000 mg gastro-resistant tablets

Do not take a double dose to make up for the forgotten dose.

If you stop taking Mecluvix 1000 mg gastro-resistant tablets

It is important that you take Mecluvix gastro-resistant tablets every day, even when you do not have symptoms of ulcerative colitis. Always finish the treatment that has been prescribed to you.

If you have any other questions about the use of this medicine, ask your doctor or pharmacist.

Medicine questions

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4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

All medicines can cause allergic reactions, although severe allergic reactions are very rare. If you present any of these symptoms after using this medicine, stop using this medicine and contact your doctor immediately:

  • Allergic skin rash;
  • fever;
  • difficulty breathing.

If you experience fever or irritation of the throat or mouth, stop using this medicine and contact your doctor immediately. These symptoms may be due, very rarely, to a decrease in the number of white blood cells in the blood (a condition called agranulocytosis).

Severe side effects:

Stop taking mesalazine and seek medical attention immediately if you present any of the following symptoms:

  • reddish patches, or circular or coin-shaped patches on the chest, often with central blisters, peeling of the skin, ulcers in the mouth, throat, nose, genitals, and eyes, generalized rash, fever, and enlargement of the lymph nodes. These severe skin rashes are often preceded by fever or flu-like symptoms.
  • if you experience severe headache or recurrent headache, vision changes, or ringing or buzzing in the ears. These could be symptoms of increased pressure inside your skull (idiopathic intracranial hypertension).

The following side effects have also been reported in patients using mesalazine:

Rare side effects(may affect up to 1 in 1,000 patients)

  • abdominal pain, diarrhea, flatulence, nausea, and vomiting;
  • headache, dizziness;
  • chest pain, difficulty breathing, or swollen limbs due to an effect on the heart;
  • increased sensitivity of the skin to sunlight and ultraviolet light (photosensitivity)

Very rare side effects(may affect less than 1 in 10,000 patients)

  • kidney problems, sometimes with swelling of the limbs or pain in the side;
  • severe abdominal pain due to acute pancreatitis;
  • worsening of colitis symptoms;
  • fever, sore throat, or nausea due to changes in blood count;
  • difficulty breathing, cough, wheezing, spots on the lung X-ray due to allergic and/or inflammatory conditions in the lungs;
  • diarrhea and severe abdominal pain due to an allergic reaction to the medicine at the intestinal level;
  • skin rash or inflammation;
  • muscle and joint pain;
  • jaundice or abdominal pain due to liver or biliary disorders;
  • hair loss and development of baldness;
  • erythema multiforme;
  • numbness and tingling of the fingers and toes (peripheral neuropathy)
  • reversible decrease in semen production;
  • blood count disorders.

Side effects of unknown frequency(cannot be estimated from the available data).

  • kidney stones and associated kidney pain (see also section 2).

severe skin reactions: drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SSJ), and toxic epidermal necrolysis (TEN).

  • increased pressure inside the skull (idiopathic intracranial hypertension)

Photosensitivity

More severe reactions have been reported in patients with pre-existing skin conditions, such as atopic dermatitis and atopic eczema.

If these symptoms continue or become more severe, consult your doctor.

Reporting of side effects:

If you experience any side effect, consult your doctor or pharmacist, even if it is possible that the side effects are not listed in this leaflet. You can also report them directly through the Spanish Medicines Monitoring System: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Mecluvix 1000 mg gastro-resistant tablets

Keep this medicine out of the sight and reach of children.

This medicine does not require special storage conditions.

Do not use this medicine after the expiry date which is stated on the package after EXP. The expiry date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Place the packages and medicines you no longer need in the SIGRE collection point at the pharmacy. If in doubt, ask your pharmacist how to dispose of packages and medicines you no longer need. This will help protect the environment.

6. Contents of the pack and other information

Composition of Mecluvix 1000 mg gastro-resistant tablets

  • Each gastro-resistant tablet contains 1000 mg of mesalazine.
  • The other ingredients are anhydrous sodium carbonate, glycine, povidone, microcrystalline cellulose, sodium croscarmellose, anhydrous colloidal silica, calcium stearate, ethyl acrylate and methyl acrylate copolymer (1:1) dispersion 30%, methacrylic acid and methyl methacrylate copolymer (1:1), methacrylic acid and methyl methacrylate copolymer (1:2), dibutyl sebacate, talc, titanium dioxide (E-171), macrogol, yellow iron oxide (E-172), and red iron oxide (E-172).

Appearance of the product and contents of the pack

The tablets are oblong, with a homogeneous orange coating.

This medicine is marketed in PVC/PVDC-Aluminum blisters packaged in cardboard boxes containing 60 or 100 tablets.

Not all pack sizes may be marketed.

Marketing authorization holder

Faes Farma, S.A.

Autonomia Etorbidea, 10

48940 Leioa (Bizkaia)

Spain

Manufacturer

Faes Farma, S.A.

Maximo Agirre Kalea, 14

48940 Leioa (Bizkaia)

Spain

Date of last revision of this leaflet: January 2023

Online doctors for MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS

Discuss questions about MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Chikeluo Okeke

General medicine 4 years exp.

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

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Common reasons for consultation:

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Dr Okeke is known for his clear communication, calm approach, and cultural awareness. He listens carefully, explains medical decisions in a structured way, and supports patients in making informed choices about their health.

Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

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Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
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  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
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  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

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  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
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Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
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  • Member of the German Society of Surgeons (BDC).
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Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

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  •  Musculoskeletal system (MSK)
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  •  Abdomen and pelvis
  •  Soft tissues

Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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Frequently Asked Questions

Is a prescription required for MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS?
MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS?
The active ingredient in MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS is mesalazine. This information helps identify medicines with the same composition but different brand names.
Who manufactures MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS?
MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS is manufactured by Faes Farma S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to MECOLVIX 1000 mg GASTRO-RESISTANT TABLETS?
Other medicines with the same active substance (mesalazine) include ASACOL 1 G SUPPOSITORIES, ASACOL 1600 mg GASTRO-RESISTANT TABLETS, ASACOL 400 mg GASTRO-RESISTANT TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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