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LYFNUA 45 mg FILM-COATED TABLETS

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About the medicine

How to use LYFNUA 45 mg FILM-COATED TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the Patient

Lyfnua 45mg film-coated tablets

gefapixant

This medicinal product is subject to additional monitoring, which will allow for quick identification of new safety information. You can help by reporting any side effects you may get. See the end of section 4 for how to report side effects.

Read all of this leaflet carefully before you start taking this medicine, because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Lyfnua and what is it used for
  2. What you need to know before you take Lyfnua
  3. How to take Lyfnua
  4. Possible side effects
  5. Storage of Lyfnua
  6. Contents of the pack and other information

1. What is Lyfnua and what is it used for

Lyfnua contains the active substance gefapixant.

Lyfnua is a medicine used in adults for chronic cough (cough that lasts for more than 8 weeks) and:

  • the cough does not go away even after using other medicines or
  • the reason for the cough is unknown.

The active substance of Lyfnua, gefapixant, blocks the action of the nerves that cause abnormal coughing.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Lyfnua

Do not take Lyfnua

  • if you are allergicto gefapixant or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Tell your doctor or pharmacist before you start taking and while you are taking Lyfnua if:

  • you are allergicto medicines that contain sulfonamide
  • you have sleep apnea- where your breathing stops and starts again while you sleep
  • you develop an acute infection of the lung/lower respiratory system (e.g. pneumonia or bronchitis)
  • you notice a change in the taste of things, loss of tasteor less ability to taste, which continues even after stopping Lyfnua.

Children and adolescents

Do not give this medicine to children and adolescents under 18 years of age. This is because it has not been studied in this age group.

Other medicines and Lyfnua

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

Pregnancy and breastfeeding

It is not known if Lyfnua can harm the fetus. Therefore, it is best to avoid using Lyfnua if you are pregnant.

If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Animal studies have shown that Lyfnua can pass into breast milk. A risk to the baby cannot be excluded. You and your doctor must decide whether to take Lyfnua or to breastfeed.

Driving and using machines

You may feel dizzy after taking Lyfnua. If this happens, do not drive or use tools or machines until you feel better.

Lyfnua contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per tablet; this is essentially “sodium-free”.

3. How to take Lyfnua

Always take this medicine exactly as your doctor or pharmacist has told you. If you are not sure, check with your doctor or pharmacist.

How much to take

The recommended dose of Lyfnua is:

  • one 45 mg tablet twice a day.

Adults with kidney problems

Your doctor may change the amount and frequency you take Lyfnua if:

  • you have severe kidney failure and are not on dialysis.

How to take it

Swallow the tablet whole. Do not break, crush or chew the tablet.

You can take the tablet with or without food.

If you take more Lyfnua than you should

If you take too much Lyfnua, contact a doctor or pharmacist immediately.

If you forget to take Lyfnua

If you miss a dose, skip that dose and take the next dose at the scheduled time.

Do not take a double dose to make up for forgotten doses.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Possible side effects are:

Very common (may affect more than 1 in 10 people)

  • change in the taste of things (such as metallic, bitter or salty taste)
  • having less taste
  • loss of taste

Common(may affect up to 1 in 10 people)

  • feeling sick (nausea)
  • taste different from what it used to be
  • cough (worsening, increase)
  • dry mouth
  • upper respiratory tract infection (an infection in the upper part of the respiratory tract, which includes the nose and throat)
  • diarrhea
  • pain in the mouth or throat
  • having less appetite than usual
  • feeling dizzy
  • pain in the upper abdomen (stomach)
  • indigestion
  • unusual sensations in the mouth (e.g. tingling or itching sensation)
  • loss of sensation in the mouth
  • increased saliva production
  • insomnia (difficulty sleeping)
  • headache

Uncommon(may affect up to 1 in 100 people)

  • kidney stones, in the urine or in the kidney

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Lyfnua

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the blister and carton after “EXP”. The expiry date refers to the last day of the month shown.

This medicine does not require any special storage conditions.

Do not use this medicine if you notice that the packaging is damaged or shows signs of tampering.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and other information

What Lyfnua contains

The active substance is gefapixant. Each film-coated tablet contains 45 mg of gefapixant (as citrate).

The other ingredients are silica (colloidal anhydrous) (E 551), crospovidone (E 1202), hypromellose (E 464), magnesium stearate (E 470b), mannitol (E 421), microcrystalline cellulose (E 460), sodium fumarate and stearic acid. The film coating contains the following ingredients: hypromellose (E 464), titanium dioxide (E 171), triacetin (E 1518) and red iron oxide (E 172). The tablets are polished with carnauba wax (E 903).

Appearance and packaging

Lyfnua is a pink, round and convex tablet, engraved with “777” on one side and smooth on the other.

Lyfnua is available in white, opaque PVC/PE/PVdC blisters with a push-through lid, in pack sizes of 28, 56 and 98 film-coated tablets, and in multipacks containing 196 (2 packs of 98) film-coated tablets.

Not all pack sizes may be marketed.

Marketing authorisation holder and manufacturer

Merck Sharp & Dohme B.V.

Waarderweg 39

2031 BN Haarlem

Netherlands

For further information on this medicine, contact the local representative of the marketing authorisation holder:

Belgium

MSD Belgium

Tel: +32(0)27766211

[email protected]

Lithuania

UAB Merck Sharp & Dohme

Tel: +370 5 2780 247

[email protected]

Text in Bulgarian language showing company name Merck Sharp & Dohme Bulgaria, phone number and email address

Luxembourg

MSD Belgium

Tel: +32(0)27766211

[email protected]

Czech Republic

Merck Sharp & Dohme s.r.o.

Tel: +420 233 010 111

[email protected]

Hungary

MSD Pharma Hungary Kft.

Tel: +36 1 888 5300

[email protected]

Denmark

MSD Danmark ApS

Tel: +45 4482 4000

[email protected]

Malta

Merck Sharp & Dohme Cyprus Limited

Tel: 8007 4433 (+356 99917558)

[email protected]

Germany

MSD Sharp & Dohme GmbH

Tel: +49 (0) 89 20 300 4500

[email protected]

Netherlands

Merck Sharp & Dohme B.V.

Tel: 0800 9999000

(+31 23 5153153)

[email protected]

Estonia

Merck Sharp & Dohme OÜ

Tel: +372 614 4200

[email protected]

Norway

MSD (Norge) AS

Tel: +47 32 20 73 00

[email protected]

Greece

MSD Α.Φ.Ε.Ε.

Tel: +30 210 98 97 300

[email protected]

Austria

Merck Sharp & Dohme Ges.m.b.H.

Tel: +43 (0) 1 26 044

[email protected]

Spain

Merck Sharp & Dohme de España, S.A.

Tel: +34 91 321 06 00

[email protected]

Poland

MSD Polska Sp. z o.o.

Tel: +48 22 549 51 00

[email protected]

France

MSD France

Tel: +33 (0) 1 80 46 40 40

Portugal

Merck Sharp & Dohme, Lda

Tel: +351 21 4465700

[email protected]

Croatia

Merck Sharp & Dohme d.o.o.

Tel: +385 1 6611 333

[email protected]

Romania

Merck Sharp & Dohme Romania S.R.L.

Tel: +40 21 529 29 00

[email protected]

Ireland

Merck Sharp & Dohme Ireland (Human Health) Limited

Tel: +353 (0)1 2998700

[email protected]

Slovenia

Merck Sharp & Dohme, inovativna zdravila d.o.o.

Tel: +386 1 520 4201

[email protected]

Iceland

Vistor ehf.

Tel: +354 535 7000

Slovakia

Merck Sharp & Dohme, s. r. o.

Tel: +421 2 58282010

[email protected]

Italy

MSD Italia S.r.l.

Tel: 800 23 99 89 (+39 06 361911)

[email protected]

Finland

MSD Finland Oy

Tel: +358 (0)9 804 650

[email protected]

Cyprus

Merck Sharp & Dohme Cyprus Limited

Tel: 800 00 673 (+357 22866700)

[email protected]

Sweden

Merck Sharp & Dohme (Sweden) AB

Tel: +46 77 5700488

[email protected]

Latvia

SIA Merck Sharp & Dohme Latvija

Tel: +371 67025300

[email protected]

Date of last revision of this leaflet:

Detailed information on this medicine is available on the European Medicines Agency website: https://www.ema.europa.eu

Online doctors for LYFNUA 45 mg FILM-COATED TABLETS

Discuss questions about LYFNUA 45 mg FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Tarek Agami

General medicine 11 years exp.

Dr. Tarek Agami is a general practitioner registered in both Portugal and Israel, with broad experience in family and preventive medicine. He offers online consultations for adults and children, providing personalised support for primary care needs, chronic disease management, and everyday health concerns.

Dr. Agami received clinical training and worked in leading medical institutions in Israel (Kaplan Medical Center, Barzilai Medical Center, Wolfson Medical Center) and Portugal (European Healthcare City, Viscura Internacional, Hospital Dr. José Maria Grande, Hospital Vila Franca de Xira). His approach combines international medical standards with individualised attention to each patient.

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Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

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Nuno Tavares Lopes

Family medicine 18 years exp.

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

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Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

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Anastasiia Shalko

Family medicine 13 years exp.

Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.

Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

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Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

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Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance.

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Frequently Asked Questions

Is a prescription required for LYFNUA 45 mg FILM-COATED TABLETS?
LYFNUA 45 mg FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in LYFNUA 45 mg FILM-COATED TABLETS?
The active ingredient in LYFNUA 45 mg FILM-COATED TABLETS is gefapixant. This information helps identify medicines with the same composition but different brand names.
Who manufactures LYFNUA 45 mg FILM-COATED TABLETS?
LYFNUA 45 mg FILM-COATED TABLETS is manufactured by Merck Sharp & Dohme B.V.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of LYFNUA 45 mg FILM-COATED TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether LYFNUA 45 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to LYFNUA 45 mg FILM-COATED TABLETS?
Other medicines with the same active substance (gefapixant) include ANGITUSS 6mg/mL SYRUP, BISOLVON CALMATOS 2.13 mg/ml ORAL SOLUTION, BRONCHOSTOP NITE ORAL SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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