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HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen

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About the medicine

How to use HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Humalog KwikPen 100 units/ml solution for injection in a pre-filled pen

insulin lispro

Each KwikPen delivers 1 to 60 units in increments of 1 unit.

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

Keep this leaflet. You may need to read it again.

  • Keep this leaflet. You may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What Humalog KwikPen is and what it is used for
  2. What you need to know before you use Humalog KwikPen
  3. How to use Humalog KwikPen
  4. Possible side effects
  5. Storing Humalog KwikPen
  6. Contents of the pack and other information

1. What Humalog KwikPen is and what it is used for

Humalog KwikPen is used to treat diabetes. It works more quickly than normal human insulin because the insulin molecule has been changed slightly.

You have diabetes if your pancreas does not make enough insulin to control the level of glucose in your blood. Humalog is a substitute for your own insulin and is used to control glucose levels in the long term. It acts quickly and has a shorter duration of action (between 2 to 5 hours) compared to soluble insulin. Normally, Humalog is given shortly before a meal.

Your doctor may tell you to use Humalog KwikPen as well as a longer-acting insulin. Each of these insulins has its own patient information leaflet to tell you how to use it. Do not change your insulin unless your doctor has told you to.

Humalog can be used in adults and children.

The KwikPen is a pre-filled pen containing 3 ml (300 units, 100 units/ml) of insulin lispro. One KwikPen contains multiple doses of insulin. The KwikPen is designed to deliver a single dose of 1 to 60 units of insulin. The number of units is shown in the dose window, always check this before you give the injection.You can give yourself one dose at a time or, if your doctor has prescribed more than one dose at a time, you can give the total dose as several injections.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you use Humalog KwikPen

Do not use Humalog KwikPen

  • If you think you are experiencing the start of a hypoglycaemic attack (low blood sugar). Further in this leaflet, it tells you how to deal with a mild hypoglycaemic attack (see Section 3: If you use more Humalog than you need).
  • If you are allergic to insulin lispro or any of the other ingredients of this medicine (listed in Section 6).

Warnings and precautions

  • Always check the name and type of insulin you use to make sure it is the right one for you.
  • If your blood glucose levels are well controlled with your current insulin, you may not feel the warning symptoms of a hypoglycaemic attack as much. You must be careful to check your blood glucose levels regularly.
  • Some patients who have had hypoglycaemic attacks after switching from animal insulin to human insulin have reported that the early warning symptoms were less pronounced or different.
  • If you answer “yes” to any of the following questions, tell your doctor, pharmacist or diabetes educator:
  • Have you recently become ill?
  • Do you have problems with your liver or kidneys?
  • Are you doing more exercise than usual?
  • The amount of insulin you need may change if you drink alcohol.
  • If you are going abroad, tell your doctor, pharmacist or diabetes educator.
  • Some patients with long-standing type 2 diabetes and heart disease or previous stroke who were treated with pioglitazone and insulin developed heart failure.
  • Do not use this pen without proper instruction from your doctor or diabetes educator.

Other medicines and Humalog KwikPen

Your insulin needs may change if you are taking:

  • oral contraceptives,
  • corticosteroids,
  • thyroid hormone replacement therapy,
  • oral hypoglycaemics,
  • acetylsalicylic acid,
  • sulfa antibiotics,
  • octreotide,
  • beta-2 stimulants (such as ritodrine, salbutamol or terbutaline),
  • beta-blockers, or
  • certain antidepressants (monoamine oxidase inhibitors or selective serotonin reuptake inhibitors),
  • danazol,
    • certain angiotensin-converting enzyme (ACE) inhibitors (such as captopril, enalapril),

and

  • angiotensin II receptor blockers.

Tell your doctor if you are using, have recently used or might use any other medicines.

Pregnancy and breast-feeding

Are you pregnant or breast-feeding, thinking of becoming pregnant or planning to breast-feed? Your insulin needs may change during pregnancy or while you are breast-feeding. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Driving and using machines

Your ability to concentrate or react may be reduced if you have hypoglycaemia (low blood sugar). Keep this possible problem in mind in all situations where you might put yourself and others at risk (such as driving a car or operating machinery). You should contact your doctor for advice on driving if:

  • you have frequent episodes of hypoglycaemia
  • you have difficulty recognising the warning signs of hypoglycaemia

Humalog KwikPen contains sodium

This medicine contains less than 1 mmol sodium (23 mg) per dose, i.e. it is essentially “sodium-free”.

3. How to use Humalog KwikPen

Follow the instructions for using Humalog KwikPen as instructed by your doctor.

Dose

  • Humalog should be given shortly before meals.

If you need to, you can give yourself a dose shortly after a meal.

Preparing Humalog KwikPen

  • Humalog is already dissolved in water, so you do not need to mix it.

Injecting Humalog

  • Inject Humalog under your skin as you have been instructed by your doctor or diabetes educator.

After the injection

  • After injecting, remove the needle from the pen and put the cap back on the pen.

Further injections

  • Always use a new needle for each injection.
  • Before each injection, check the pen for any air bubbles and remove them.

Using Humalog in an insulin infusion pump

Humalog KwikPen is only suitable for injection under the skin. If you need to use an insulin infusion pump, you should use a different type of insulin.

If you use more Humalog than you need

If you use more Humalog than you need, you may experience hypoglycaemia (low blood sugar).

If you forget to use Humalog

If you forget to use Humalog, you may experience hyperglycaemia (high blood sugar).

Three simple measuresto prevent hypoglycaemia or hyperglycaemia are:

  • Always carry spare insulin and needles with you.
  • Always carry something to show you are diabetic.
  • Always carry some sugar with you.
Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Systemic allergic reactions are rare (affecting less than 1 in 1,000 people). These symptoms include:

  • redness and swelling of the face, lips, tongue or throat
  • difficulty breathing
  • abnormal heart rhythms
  • fall in blood pressure

If you think you are having this type of reaction, contact your doctor immediately.

Local allergic reactions are common (affecting less than 1 in 10 people). Some people get redness, swelling or itching at the injection site. This usually clears up in a few days.

Lipodystrophy (thickening or thinning of the skin) is uncommon (affecting less than 1 in 100 people). If you notice your skin thickening or pitting at the injection site, tell your doctor.

Swelling of the feet, ankles, and hands due to retention of fluid (oedema) has been reported, particularly at the start of treatment or during dose escalation.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet.

Common problems of diabetes

  • Hypoglycaemia

Hypoglycaemia means that your blood sugar is too low.

This can be caused by:

  • too much Humalog or other insulin
  • missing a meal or delaying a meal
  • exercising more than usual
  • being sick (vomiting) or having a fever

Alcohol and some medicines can affect your blood sugar levels.

The first symptoms of a hypoglycaemic attack, which can come on suddenly, are:

  • shakiness, sweating, feeling very anxious
  • fast heart beat
  • palpitations

Until you are confident that you can recognise the warning signs of a hypoglycaemic attack, you should avoid situations (such as driving a car) where you or others would be put at risk if you had a hypoglycaemic attack.

  • Hyperglycaemia and diabetic ketoacidosis

Hyperglycaemia means that your blood sugar is too high.

This can be caused by:

  • not using enough Humalog or other insulin
  • using less insulin than your doctor has prescribed
  • exercising less than usual
  • eating more carbohydrates than usual

Hyperglycaemia can lead to diabetic ketoacidosis. The first symptoms of diabetic ketoacidosis usually develop gradually, over a few hours or days.

They include:

  • feeling sick (nausea), being sick (vomiting)
  • dry mouth, thirst, urinating more than usual
  • flushed face, feeling very tired

Severe symptoms are heavy breathing and a rapid pulse. Get medical help immediately.

5. Storage of Humalog KwikPen

Before first use, store Humalog KwikPen in the refrigerator (between 2°C and 8°C). Do not freeze.

Keep your Humalog KwikPen in use at room temperature (below 30°C) and discard it after 28 days. Do not leave it near any heat source or in the sun. Do not store the KwikPen pen you are using in the refrigerator. The KwikPen pen should not be stored with the needle attached.

Keep this medicine out of sight and reach of children.

Do not use this medicine after the expiration date shown on the label and on the

packaging. The expiration date is the last day of the month indicated.

Do not use this medicine if you notice it has color or if it contains solid particles. Onlyuse it if its appearance is like that of water. Check that this is the case before administering each injection.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of the packaging and medicines you no longer need. This will help protect the environment.

6. Package contents and additional information

Composition of Humalog KwikPen 100 units/ml solution for injection

  • The active substance is insulin lispro. Insulin lispro is manufactured in the laboratory by a process of "recombinant DNA technology". It is a modified form of human insulin and, therefore, differs from other human insulins and animal-derived insulins. Insulin lispro is closely related to human insulin, which is a natural hormone produced by the pancreas.
  • The other components are m-cresol, glycerol, disodium phosphate heptahydrate, zinc oxide, and water for injections. Sodium hydroxide or hydrochloric acid may have been used to adjust the acidity.

Appearance of the product and package contents

Humalog KwikPen 100 units/ml solution for injection is a sterile, transparent, colorless, aqueous solution and contains 100 units of insulin lispro in each milliliter of solution for injection (100 units/ml). Each Humalog KwikPen contains 300 units (3 milliliters). Humalog KwikPen is presented in a package of 5 pre-filled pens or in a multipack consisting of 2 packages of 5 pre-filled pens. Not all presentations may be marketed. The Humalog 100 units/ml contained in your pre-filled pen is the same as the Humalog 100 units/ml presented in separate Humalog 100 units/ml cartridges. The KwikPen simply contains a cartridge inside. When the pre-filled pen is empty, it cannot be reused.

Marketing authorization holder and manufacturer

Humalog KwikPen 100 units/ml solution for injection is manufactured by:

  • Lilly France, S.A.S., Rue du Colonel Lilly, 67640 Fegersheim, France,
  • Eli Lilly Italia S.p.A., Via Gramsci 731-733, 50019 Sesto Fiorentino, (FI) Italy.

The marketing authorization holder is Eli Lilly Nederland B.V., Papendorpseweg 83, 3528 BJ Utrecht, Netherlands.

You can request more information about this medicine by contacting the local representative of the marketing authorization holder:

Belgique/België/Belgien

Eli Lilly Benelux S.A./N.V.

Tél/Tel: + 32-(0)2 548 84 84

Lietuva

Eli Lilly Lietuva

Tel. +370 (5) 2649600

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?? "??? ???? ?????????" ?.?. - ????????

???. + 359 2 491 41 40

Luxembourg/Luxemburg

Eli Lilly Benelux S.A./N.V.

Tél/Tel: + 32-(0)2 548 84 84

Ceská republika

ELI LILLY CR, s.r.o.

Tel: + 420 234 664 111

Magyarország

Lilly Hungária Kft.

Tel: + 36 1 328 5100

Danmark

Eli Lilly Danmark A/S

Tlf: +45 45 26 6000

Malta

Charles de Giorgio Ltd.

Tel: + 356 25600 500

Deutschland

Lilly Deutschland GmbH

Tel. + 49-(0) 6172 273 2222

Nederland

Eli Lilly Nederland B.V.

Tel: + 31-(0) 30 60 25 800

162

Eesti

Eli Lilly Nederland B.V.

Tel: +372 6817 280

Norge

Eli Lilly Norge A.S.

Tlf: + 47 22 88 18 00

Ελλ?δα

ΦΑΡΜΑΣΕΡΒ-ΛΙΛΛΥ Α.Ε.Β.Ε.

Τηλ: +30 210 629 4600

Österreich

Eli Lilly Ges. m.b.H.

Tel: + 43-(0) 1 711 780

España

Lilly S.A.

Tel: + 34-91 663 50 00

Polska

Eli Lilly Polska Sp. z o.o.

Tel: +48 22 440 33 00

France

Lilly France S.A.S.

Tél: +33-(0) 1 55 49 34 34

Portugal

Lilly Portugal - Produtos Farmacêuticos, Lda

Tel: + 351-21-4126600

Hrvatska

Eli Lilly Hrvatska d.o.o.

Tel: +385 1 2350 999

România

Eli Lilly România S.R.L.

Tel: + 40 21 4023000

Ireland

Eli Lilly and Company (Ireland) Limited

Tel: + 353-(0) 1 661 4377

Slovenija

Eli Lilly farmacevtska družba, d.o.o.

Tel: +386 (0) 1 580 00 10

Ísland

Icepharma hf.

Sími + 354 540 8000

Slovenská republika

Eli Lilly Slovakia s.r.o.

Tel: + 421 220 663 111

Italia

Eli Lilly Italia S.p.A.

Tel: + 39- 055 42571

Suomi/Finland

Oy Eli Lilly Finland Ab

Puh/Tel: + 358-(0) 9 85 45 250

Κ?προς

Phadisco Ltd

Τηλ: +357 22 715000

Sverige

Eli Lilly Sweden AB

Tel: + 46-(0) 8 7378800

Latvija

Eli Lilly (Suisse) S.A Parstavnieciba Latvija

Tel: +371 67364000

United Kingdom

Eli Lilly and Company Limited

Tel: + 44-(0) 1256 315000

Date of last revision of this leaflet:

USER MANUAL

The text of the user manual is included at the end.

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

Online doctors for HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen

Discuss questions about HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

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Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Doctor

Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Frequently Asked Questions

Is a prescription required for HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen?
HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen?
The active ingredient in HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen is insulin lispro. This information helps identify medicines with the same composition but different brand names.
How much does HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen cost in pharmacies?
The average pharmacy price for HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen is around 93.95 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen?
HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen is manufactured by Eli Lilly Nederland B.V.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to HUMALOG KWIKPEN 200 Units/mL Injectable Solution in a Pre-filled Pen?
Other medicines with the same active substance (insulin lispro) include HUMALOG 100 U/ml INJECTABLE SOLUTION IN VIALS, HUMALOG JUNIOR KWIKPEN 100 Units/mL Injectable Solution in Pre-filled Pen, HUMALOG KWIKPEN 100 U/ml, INJECTABLE SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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