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ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION

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About the medicine

How to use ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Esmeron 10 mg/ml solution for injection and infusion

Rocuronium, bromide

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.

Contents of the package leaflet

  1. What is Esmeron and what is it used for
  2. What you need to know before you use Esmeron
  3. How to use Esmeron
  4. Possible side effects
  5. Storage of Esmeron
  6. Contents of the pack and further information

1. What is Esmeron and what is it used for

Esmeron belongs to a group of medicines called muscle relaxants. Muscle relaxants are used in general anesthesia for surgical operations to relax the muscles completely. This makes the operation easier for the surgeon. Normally, nerves send messages to the muscles through impulses. Esmeron works by blocking these impulses, causing the muscles to relax. Since the muscles needed for breathing also relax, you will need help breathing (artificial respiration) during and after the operation until you can breathe on your own. The effect of the muscle relaxant is regularly monitored during the operation, and if necessary, more medication will be administered. The effects disappear at the end of the operation, and then you can start breathing on your own. Sometimes, another medication is given to speed up this process. Esmeron can also be used in the Intensive Care Unit to keep the muscles relaxed.

This medicine is for hospital use only.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you use Esmeron

Do not use Esmeron:

  • if you are allergic to rocuronium, bromide ions, or any of the other components of this medicine (listed in section 6).

Warnings and precautions

Your medical history may affect how Esmeron is administered to you.

Tell your anesthesiologist if you have had or currently have any of the following diseases:

  • allergy to muscle relaxants
  • kidney disease
  • heart disease
  • edema (fluid retention, for example, in the calves)
  • liver or bile duct disease, or liver function disorders
  • diseases that affect the nerves and muscles.

Also, inform your anesthesiologist if you have had:

  • a history of malignant hyperthermia (sudden fever with palpitations, rapid breathing, and muscle stiffness, pain, and/or weakness).

Certain medical conditions may affect how Esmeron works. For example, if you have any of these conditions, your anesthesiologist will take them into account when deciding the correct dose of Esmeron:

  • low potassium levels in the blood
  • high magnesium levels in the blood
  • low calcium levels in the blood
  • low protein levels in the blood
  • dehydration
  • too much acid in the blood
  • too much carbon dioxide in the blood
  • poor overall health
  • overweight
  • burns.

Children/elderly patients

Esmeron can be used in children and adolescents (from birth to 17 years) and elderly patients, but your anesthesiologist will evaluate your medical history first.

Using Esmeron with other medicines

Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines.

Other medicines may affect the effects of Esmeron or vice versa. If you take (or think you might take) any of the following medicines, you should inform your doctor.

The following medicines may increasethe effect of Esmeron:

  • certain anesthetics
  • prolonged use of corticosteroids with Esmeron for a long time in the Intensive Care Unit (anti-inflammatory medications)
  • certain medications for bacterial infections (antibiotics)
  • certain medications for bipolar disorder (such as lithium)
  • certain medications for heart disease or high blood pressure (quinidine, calcium antagonists, beta-blockers)
  • certain medications for malaria (quinine)
  • medications that increase urine production, such as diuretics
  • magnesium salts
  • local anesthetics (lidocaine, bupivacaine)
  • use of medications for epilepsy during an operation (phenytoin).

The following medicines may decreasethe effect of Esmeron:

  • prolonged use of medications for epilepsy: phenytoin and carbamazepine
  • medications for pancreatitis, blood coagulation disorders, or acute blood loss (protease inhibitors: gabexate, ulinastatin).

The following medicines have a variable effecton Esmeron:

  • other muscle relaxants.

Esmeron may affect the effects of the following medicines:

  • may increase the effect of local anesthetics (such as lidocaine).

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you might be pregnant, or plan to become pregnant, consult your doctor before Esmeron is administered to you.

Breastfeeding should be stopped 6 hours after the use of this medicine.

Driving and using machines

Your doctor will inform you when you can drive and use potentially hazardous machines safely after the administration of Esmeron.

Esmeron contains sodium

This medicine contains less than 23 mg of sodium (1 mmol) per vial; it is essentially "sodium-free".

3. How to use Esmeron

Your doctor will adjust the dose to your needs. You will be given Esmeron before or during the operation. The recommended dose is 0.6 mg per kilogram of body weight, and the effect lasts for 30 to 40 minutes. During the operation, the activity of Esmeron will be monitored. If necessary, you will be given more doses, which will depend on various factors, such as possible interactions with other medicines, the expected duration of the operation, your age, or your state of health.

Your doctor will administer Esmeron to you, either by intravenous injection or by continuous infusion.

If you use more Esmeron than you should

The medical staff will be monitoring the operation, and it is unlikely that you will be given too much Esmeron. However, if this happens, artificial respiration will be maintained until you are able to breathe on your own.

Your doctor may speed up your recovery by giving you a medication that counteracts the effects of the muscle relaxant.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Rare or uncommon (at least 1 in 10,000 patients)

  • increased heart rate (tachycardia)
  • decreased blood pressure (hypotension)
  • increased or decreased effect of Esmeron
  • pain at the injection site
  • prolonged muscle relaxant effect of Esmeron.

Very rare (less than 1 in 10,000 patients)

  • allergic reactions such as changes in blood pressure and heart rate, and shock due to low blood circulation
  • chest pressure due to muscle spasms in the airways (bronchospasm)
  • skin disorders (such as edema, redness, rash, or hives)
  • muscle weakness or paralysis
  • chronic muscle disorder, usually observed after the concomitant administration of Esmeron and corticosteroids (anti-inflammatory medications) in critically ill patients in the Intensive Care Unit (steroid myopathy).

Frequency not known (cannot be estimated from the available data)

  • dilated pupils (mydriasis) or fixed pupils that do not change size with light or other stimuli
  • severe allergic spasm of the coronary blood vessels (Kounis syndrome) that causes chest pain (angina) or heart attack (myocardial infarction).

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Esmeron

Keep this medicine out of the sight and reach of children.

Esmeron is only available in hospitals.

Store in a refrigerator (between 2°C and 8°C). Keep in the original packaging to protect from light.

The product can be stored outside the refrigerator at a temperature of up to 30°C for a maximum of 3 months. The product can be put in and taken out of the refrigerator at any time during the 36-month validity period, but the total storage time outside the refrigerator must not exceed 3 months. The storage period must not exceed the expiry date stated on the packaging.

Do not use this medicine after the expiry date stated on the packaging. The expiry date is the last day of the month indicated.

Disposal of unused medicine and all materials that have come into contact with it will be carried out in accordance with local regulations.

6. Contents of the pack and further information

Composition of Esmeron

  • The active substance is rocuronium bromide. Each ml of solution contains 10 mg of rocuronium bromide.
  • The other ingredients are sodium acetate, sodium chloride, acetic acid, and water for injections. 1 ml of Esmeron contains 1.64 mg of sodium.

Appearance of the product and pack contents

Esmeron is a clear solution for injection and infusion that contains 10 mg/ml of rocuronium bromide. Esmeron is presented in 5 ml vials that contain 50 mg of rocuronium bromide, in packs of 10 vials.

Marketing authorization holder and manufacturer

Marketing authorization holder

Schering-Plough, S.A.; C/ Josefa Valcárcel, 42; 28027 Madrid; Spain

Manufacturer

N.V. Organon; Kloosterstraat 6; 5349 BH Oss; Netherlands

Merck Sharp & Dohme B.V.; Waarderweg 39; 2031 BN Haarlem; Netherlands

Local representative:

Merck Sharp & Dohme of Spain, S.A.; C/ Josefa Valcárcel, 42; 28027 Madrid; Spain.

Tel.: 91 3210600

Date of last revision of this leaflet:12/2022.

Detailed and up-to-date information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) (http://www.aemps.gob.es/)

Online doctors for ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION

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Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
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  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
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  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

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  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

He provides online consultations covering symptom assessment, prevention, and long-term management of chronic conditions, helping patients understand what is happening and decide on appropriate next steps.

Common reasons for consultation:

  • General internal medicine concerns and initial health assessment.
  • Acute symptoms such as fever, cough, infections, pain, or weakness.
  • Chronic conditions and treatment adjustment.
  • Blood pressure issues, fatigue, metabolic concerns.
  • Preventive consultations and routine check-ups.
  • Interpretation of laboratory results and medical reports.
  • Medical advice for patients receiving care online.

Dr Okeke is known for his clear communication, calm approach, and cultural awareness. He listens carefully, explains medical decisions in a structured way, and supports patients in making informed choices about their health.

Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

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His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
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  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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Bulat Garipov

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Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

  •  Neuroimaging
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Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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Frequently Asked Questions

Is a prescription required for ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION?
ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION?
The active ingredient in ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION is rocuronium bromide. This information helps identify medicines with the same composition but different brand names.
Who manufactures ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION?
ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION is manufactured by Schering Plough S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION?
Other medicines with the same active substance (rocuronium bromide) include ROCURONIUM AGUETTANT 10 mg/mL Injectable Solution in Pre-filled Syringe, ROCURONIUM B. BRAUN 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION, ROCURONIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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