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EPIVIR 300 MG FILM-COATED TABLETS

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About the medicine

How to use EPIVIR 300 MG FILM-COATED TABLETS

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Epivir 300mg film-coated tablets

lamivudine

Read all of this leaflet carefully before you start taking this medicine, because it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What Epivir is and what it is used for
  2. What you need to know before you take Epivir
  3. How to take Epivir
  4. Possible side effects
  5. Storing Epivir
  6. Contents of the pack and other information

1. What Epivir is and what it is used for

Epivir is used in the treatment of HIV (Human Immunodeficiency Virus) infection in adults and children.

The active substance of Epivir is lamivudine. Epivir is a type of medicine known as an antiretroviral. It belongs to a group of medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).

Epivir does not completely cure HIV infection; it reduces the amount of virus in the body and keeps it at a low level. It also increases the number of CD4 cells in the blood. CD4 cells are a type of white blood cell that plays an important role in helping your body fight infection.

Not everyone responds to treatment with Epivir in the same way. Your doctor will monitor the effectiveness of your treatment.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Epivir

Do not take Epivir

  • if you are allergicto lamivudine or any of the other ingredients of this medicine (listed in section 6).

Consult your doctorif you think this applies to you.

Be cautious with Epivir

Some people who take Epivir or other combination treatments for HIV infection have a higher risk of serious side effects. You need to know that there is a higher risk:

  • if you have ever had liver disease, including hepatitis B or C (if you have hepatitis B, do not stop taking Epivir without your doctor's advice, as it may worsen)
  • if you are overweight(especially if you are a woman)
  • if you have kidney disease, your dose may need to be adjusted.

Consult your doctorif any of these apply to you. You may need additional tests, including blood tests, while taking this medicine. See section 4 for more information.

Be aware of important symptoms

Some people who take HIV medicines develop other conditions, which can be serious. You need to know what signs and symptoms to look out for while taking Epivir.

Read the information on "Other possible side effects of combination HIV therapy" in section 4 of this leaflet.

Other medicines and Epivir

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including herbal medicines and those bought without a prescription.

Remember to tell your doctor or pharmacist if you start taking a new medicine while taking Epivir.

The following medicines must not be used with Epivir:

  • medicines (usually liquids) that contain sorbitol and other polyalcohols (such as xylitol, mannitol, lactitol, or maltitol), if taken regularly
  • other medicines that contain lamivudine (used to treat HIV infectionor hepatitis B virus infection)
  • emtricitabine (used to treat HIV infection)
  • high doses of co-trimoxazole(a combination of trimethoprim and sulfamethoxazole), an antibiotic
  • cladribine (used to treat hairy cell leukemia).

Tell your doctorif you are being treated with any of these medicines.

Pregnancy

If you are pregnant, if you become pregnant, or if you are planning to become pregnant, talk to your doctor about the risks and benefits of taking Epivir for both you and your baby.

Epivir and similar medicines may cause side effects in babies during pregnancy. If you have been taking Epivirduring your pregnancy, your doctor may ask you to have regular blood tests and other diagnostic tests to monitor your baby's development. In children whose mothers took NRTIs during pregnancy, the benefit of protection against HIV was greater than the risk of side effects.

Breast-feeding

It is not recommendedthat women with HIV breast-feed their babies because HIV infection can be passed to the baby through breast milk.

A small amount of the components of Epivir may also pass into breast milk.

If you are breast-feeding or thinking of breast-feeding, you should consult your doctor as soon as possible.

Driving and using machines

Epivir is unlikely to affect your ability to drive or use machines.

Epivir contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per dose; this is essentially "sodium-free".

3. How to take Epivir

Follow exactly the instructions for administration of this medicine given by your doctor or pharmacist. If you are unsure, consult your doctor or pharmacist again.

Swallow the Epivir tablets with a little water. Epivir can be taken with or without food.

If you cannot swallow the tablets whole, you can break them and mix them with a small amount of food or liquid; take the whole dose immediately.

Stay in regular contact with your doctor

Epivir helps control your condition. You will need to take it every day to prevent your condition from getting worse. You may develop other infections and illnesses associated with HIV infection.

Stay in touch with your doctor and do not stop taking Epivirwithout talking to your doctor first.

How much to take

Adults, adolescents, and children weighing at least 25 kg:

The usual dose is one 300 mg tablet once a day.

Epivir is also available in 150 mg tablets for the treatment of children from 3 months of age with a weight of less than 25 kg.

It is also available as an oral solution for the treatment of children over 3 months and for patients who cannot swallow tablets or who need a lower dose than usual.

If you have kidney problems, your dose may need to be adjusted.

Consult your doctorif this applies to you.

If you take more Epivir than you should

If you take more Epivir than you should, tell your doctor or pharmacist, or contact the nearest hospital emergency department for more information. If possible, show them the Epivir packaging.

If you forget to take Epivir

If you forget to take a dose, take it as soon as you remember and then continue with your usual treatment schedule.

Do not take a double dose to make up for forgotten doses.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

During treatment for HIV, there may be an increase in weight and levels of glucose and lipids in the blood. This may be partly due to recovery of health and lifestyle, and in the case of lipids in the blood, sometimes to HIV medicines themselves. Your doctor will monitor these changes.

As with all medicines, this medicine can cause side effects, although not everybody gets them.

When you are being treated for HIV, it can be difficult to distinguish between a side effect of Epivir or other medicines you are taking, or if it is due to the HIV disease itself. Therefore, it is very important that you inform your doctor about any change in your health.

In addition to the side effects listed below for Epivir, other conditions can develop during combination HIV therapy.

It is important that you read the information under the heading "Other possible side effects of combination HIV therapy".

Common side effects

May affect up to 1 in 10people:

  • headache
  • feeling sick (nausea)
  • vomiting
  • diarrhea
  • stomach pain
  • fatigue, lack of energy
  • fever (high temperature)
  • feeling unwell
  • muscle pain and discomfort
  • joint pain
  • difficulty sleeping (insomnia)
  • cough
  • irritated or runny nose
  • skin rash
  • hair loss (alopecia).

Uncommon side effects

May affect up to 1 in 100people:

The uncommon side effects that may appear in blood tests are:

  • a decrease in the number of cells involved in blood clotting (thrombocytopenia)
  • low red blood cell count (anemia)or low white blood cell count (neutropenia)
  • an increase in liver enzyme levels.

Rare side effects

May affect up to 1 in 1,000people:

  • severe allergic reaction that causes swelling of the face, tongue, or throat, which can cause difficulty swallowing or breathing
  • inflammation of the pancreas (pancreatitis)
  • muscle tissue breakdown
  • inflammation (hepatitis).

A rare side effect that may appear in blood tests is:

  • an increase in an enzyme called amylase.

Very rare side effects

May affect up to 1 in 10,000people:

  • lactic acidosis (excess lactic acid in the blood)
  • tingling or numbness of the arms, legs, hands, or feet.

A very rare side effect that may appear in blood tests is:

  • failure of the bone marrow to produce new red blood cells (pure red cell aplasia).

If you experience side effects

Tell your doctor or pharmacistif you think any of the side effects you are experiencing are serious or if you notice any side effects not listed in this leaflet.

Other possible side effects of combination HIV therapy

Combination treatments like Epivir can cause other conditions to develop during HIV treatment.

Worsening of old infections

People with advanced HIV infection (AIDS) have weakened immune systems and are more likely to develop serious infections (opportunistic infections). When these people start treatment, they may find that old, hidden infections become active again, causing signs and symptoms of inflammation. These symptoms are probably due to an improvement in the body's immune response, which allows it to fight off these infections.

In addition to these opportunistic infections, autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) can also occur after you start taking medicines for your HIV infection. Autoimmune disorders can occur many months after starting treatment. If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness in the hands and feet that spreads to the body, palpitations, tremors, or hyperactivity, please inform your doctor immediately to receive the necessary treatment.

If you notice any symptoms of infection while taking Epivir

Tell your doctor immediately. Do not take any other medicine for the infection without your doctor's advice.

You may have problems with your bones

Some people who receive combination HIV therapy may develop a bone disease called osteonecrosis. In this disease, part of the bone tissue dies due to a reduction in blood supply to the bone. People are more likely to develop this disease:

  • if they have been taking combination therapy for a long time
  • if they are also taking anti-inflammatory medicines called corticosteroids
  • if they drink alcohol
  • if their immune system is severely weakened
  • if they are overweight.

Signs of osteonecrosis include:

  • stiffness in the joints
  • pain and discomfort (especially in the hips, knees, or shoulders)
  • difficulty moving.

If you notice any of these symptoms:

Tell your doctor.

Reporting side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing Epivir

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date stated on the carton.

Do not store Epivir above 30°C.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Container contents and additional information

Composition of Epivir

The active ingredient is lamivudine.

The other components are:

  • Core of the tablet: microcrystalline cellulose, sodium carboxymethyl starch (gluten-free), magnesium stearate
    • Coating of the tablet: hypromellose, titanium dioxide, black iron oxide (E172), macrogol, polysorbate 80.

Appearance of Epivir and container contents

Epivir 300 mg film-coated tablets are supplied in white polyethylene bottles or blisters containing 30 tablets. The tablets are gray, rhomboid in shape, and have the code "GXEJ7" engraved on one face.

Marketing authorization holder and manufacturer

Manufacturer

Marketing authorization holder

Delpharm Poznan Spólka Akcyjna

ul. Grunwaldzka 189

60-322 Poznan

Poland

ViiV Healthcare BV

Van Asch van Wijckstraat 55H

3811 LP Amersfoort

Netherlands

You can request more information about this medicinal product by contacting the local representative of the marketing authorization holder:

Belgium

ViiV Healthcare srl/bv

Tel: + 32 (0)10 85 65 00

Lithuania

ViiV Healthcare BV

Tel: + 370 80000334

Bulgaria

ViiV Healthcare BV

Tel: + 359 80018205

Luxembourg

ViiV Healthcare srl/bv

Belgium

Tel: + 32 (0)10 85 65 00

Czech Republic

GlaxoSmithKline s.r.o.

Tel: + 420 222 001 111

[email protected]

Hungary

ViiV Healthcare BV

Tel: + 36 80088309

Denmark

GlaxoSmithKline Pharma A/S

Tlf: + 45 36 35 91 00

[email protected]

Malta

ViiV Healthcare BV

Tel: + 356 80065004

Germany

ViiV Healthcare GmbH

Tel: + 49 (0)89 203 0038-10

[email protected]

Netherlands

ViiV Healthcare BV

Tel: + 31 (0) 33 2081199

Estonia

ViiV Healthcare BV

Tel: + 372 8002640

Norway

GlaxoSmithKline AS

Tlf: + 47 22 70 20 00

Greece

GlaxoSmithKline Μονοπρ?σωπη A.E.B.E.

Tel: + 30 210 68 82 100

Austria

GlaxoSmithKline Pharma GmbH

Tel: + 43 (0)1 97075 0

[email protected]

Spain

Laboratorios ViiV Healthcare, S.L.

Tel: + 34 900 923 501

[email protected]

Poland

GSK Services Sp. z o.o.

Tel: + 48 (0)22 576 9000

France

ViiV Healthcare SAS

Tel: + 33 (0)1 39 17 6969

[email protected]

Portugal

VIIVHIV HEALTHCARE, UNIPESSOAL, LDA.

Tel: + 351 21 094 08 01

[email protected]

Croatia

ViiV Healthcare BV

Tel: +385 800787089

Romania

ViiV Healthcare BV

Tel: + 40 800672524

Ireland

GlaxoSmithKline (Ireland) Limited

Tel: + 353 (0)1 4955000

Slovenia

ViiV Healthcare BV

Tel: + 386 80688869

Iceland

Vistor hf.

Tel: +354 535 7000

Slovak Republic

ViiV Healthcare BV

Tel: + 421 800500589

Italy

ViiV Healthcare S.r.l.

Tel: + 39 (0)45 7741600

Finland

GlaxoSmithKline Oy

Tel: + 358 (0)10 30 30 30

Cyprus

ViiV Healthcare BV

Tel: + 357 80070017

Sweden

GlaxoSmithKline AB

Tel: + 46 (0)8 638 93 00

[email protected]

Latvia

ViiV Healthcare BV

Tel: + 371 80205045

United Kingdom (Northern Ireland)

ViiV Healthcare BV Limited

Tel: + 44 (0)800 221441

[email protected]

Date of the last revision of this leaflet:{MM/AAAA}.

Detailed information on this medicinal product is available on the European Medicines Agency website: http://www.ema.europa.eu

Online doctors for EPIVIR 300 MG FILM-COATED TABLETS

Discuss questions about EPIVIR 300 MG FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

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Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

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Additional care areas:

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Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

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Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
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Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Frequently Asked Questions

Is a prescription required for EPIVIR 300 MG FILM-COATED TABLETS?
EPIVIR 300 MG FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in EPIVIR 300 MG FILM-COATED TABLETS?
The active ingredient in EPIVIR 300 MG FILM-COATED TABLETS is lamivudine. This information helps identify medicines with the same composition but different brand names.
Who manufactures EPIVIR 300 MG FILM-COATED TABLETS?
EPIVIR 300 MG FILM-COATED TABLETS is manufactured by Viiv Healthcare B.V.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of EPIVIR 300 MG FILM-COATED TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether EPIVIR 300 MG FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to EPIVIR 300 MG FILM-COATED TABLETS?
Other medicines with the same active substance (lamivudine) include EPIVIR 10 mg/mL ORAL SOLUTION, EPIVIR 150 MG FILM-COATED TABLETS, EPIVIR 150 MG FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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