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DENVAR 400 mg CAPSULES

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use DENVAR 400 mg CAPSULES

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Denvar 400 mg Hard Capsules

cefixime

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the package leaflet:

  1. What is Denvar and what is it used for
  2. What you need to know before you take Denvar
  3. How to take Denvar
  4. Possible side effects
  5. Storage of Denvar
  6. Contents of the pack and further information

1. What is Denvar and what is it used for

Denvar contains a substance called cefixime, which belongs to the group of antibiotics known as "cephalosporins" and is used to treat infections caused by bacteria.

Antibiotics are used to treat bacterial infections and are not effective against viral infections such as the flu or the common cold.

It is important that you follow the instructions regarding dosage, administration interval, and treatment duration as indicated by your doctor.

Do not store or reuse this medication. If you have any leftover antibiotic after completing treatment, return it to the pharmacy for proper disposal. Do not throw away medications via wastewater or trash.

Denvar is used to treat:

1.- Ear, nose, and throat infections: acute sinusitis.

2.- Lower respiratory tract infections: acute bronchitis and exacerbations of chronic bronchitis.

3.- Urinary tract infections: uncomplicated acute pyelonephritis.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Denvar

Do not take Denvar

  • If you are allergic to cefixime, other cephalosporins or cefamicins, or any of the other components of this medication (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting to take Denvar:

In case of allergy to other beta-lactam antibiotics (e.g., penicillin), a possible cross-allergic reaction with cefixime should be considered. Special caution is required in patients who have experienced an anaphylactic reaction to penicillins. The appearance of any allergic manifestation requires the suspension of treatment.

Treatment with cefixime may increase the risk of developing antibiotic-resistant bacteria.

Some cephalosporin antibiotics can cause seizures, especially in patients with renal insufficiency when the dose has not been reduced. If seizures occur, stop taking this medication and contact your doctor immediately.

Children

It is not recommended to administer to premature infants, newborns, and infants under 6 months.

Other medications and Denvar

Taking cefixime with some of the following medications may alter the effect of both cefixime and the other medication:

  • diuretic medications (such as etacrynic acid or furosemide) or medications that can be harmful to the kidneys (certain antibiotics, colistin, polymyxin, chloramphenicol)
  • medications that act on blood vessels (such as nifedipine)
  • medications to control blood coagulation (coumarins)

Inform your doctor or pharmacist if you are taking, have recently taken, or may need to take any other medication.

Interference with laboratory tests:

Denvar may give false positive reactions in urine tests for ketones and glucose, and a false positive reaction in the direct Coombs test (a diagnostic test for some types of anemia).

Using Denvar with food and drinks

Denvar can be taken with food.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medication.

Since there is not enough information about the possible negative effects of Denvar during pregnancy, it is only recommended to take Denvar during pregnancy if your doctor prescribes it after assessing the benefit-risk ratio.

Cefixime has not been detected in breast milk.

Treatment with Denvar during breastfeeding is not recommended unless your doctor prescribes it after assessing the benefit-risk ratio. Your doctor will decide whether to continue breastfeeding and treatment with cefixime.

Driving and using machines

Based on current experience, Denvar does not affect the ability to drive and use machines. However, some side effects may affect concentration and reaction, so this should be taken into account in situations where concentration and reaction are important, such as driving and using machines.

3. How to take Denvar

Follow the instructions for administration of this medication exactly as indicated by your doctor. If you are unsure, consult your doctor or pharmacist again.

Unless your doctor has given you different instructions, follow these instructions:

The recommended daily dose for adults and children over 12 years is 1 capsule of 400 mg/24 hours, for 10 days.

Denvar is administered orally. The capsules should be swallowed without chewing and with a little liquid.

Patients with renal problems

In case of renal insufficiency with a creatinine clearance ≥20 ml/minute, it is not necessary to modify the dose; if the clearance is lower, the dose should be reduced by half. In patients undergoing hemodialysis, the dosage of cefixime should not exceed 200 mg/day.

Patients with liver problems

In patients with liver insufficiency, the fact that cefixime is not metabolized in the liver allows the administration of the medication without the need to modify the dose.

Patients of advanced age

It is not necessary to change the dose for patients of advanced age if kidney function is normal.

If you think the effect of Denvar is too strong or too weak, tell your doctor or pharmacist.

If you take more Denvar than you should

Consult your doctor or pharmacist immediately.

Given the low toxicity of cefixime, it is unlikely that accidental massive ingestion will lead to a poisoning syndrome. If this occurs, gastric lavage and symptomatic treatment are recommended. In case of significant allergic manifestations, treatment should be symptomatic: adrenaline, corticosteroids, antihistamines.

In case of overdose or accidental ingestion, call the Toxicology Information Service, phone 91 562 04 20, indicating the medication and the amount ingested.

If you forget to take Denvar

Do not take a double dose to make up for forgotten doses, wait for the next dose and continue treatment as usual.

If you stop taking Denvar

Your doctor will indicate the duration of your treatment with Denvar. Do not stop treatment before, as you may experience the symptoms you had before treatment again.

If you have any other questions about the use of this medication, ask your doctor or pharmacist.

Medicine questions

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4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following side effects may occur:

Common (may affect up to 1 in 10 people):

Diarrhea, soft stools.

Uncommon (may affect up to 1 in 100 people):

Nausea, vomiting, indigestion, abdominal pain, urticaria, skin redness, rash, exanthema, headache, reversible increases in liver enzymes in blood.

Rare (may affect up to 1 in 1,000 people):

Lack of appetite, flatulence, itching, mucosal inflammation, dizziness, fever, hypersensitivity reactions such as flushing, palpitations, difficulty breathing, decreased blood pressure, facial edema, transient increase in urea concentration in blood, resistance to pathogens, predisposition to superinfections by fungi and resistant bacteria in case of prolonged administration, blood disorders (eosinophilia, increase in a type of blood cell).

Very rare (may affect up to 1 in 10,000 people):

Colitis, toxic skin disorders (Stevens-Johnson syndrome, erythema multiforme), blood disorders (leukopenia, agranulocytosis, pancytopenia, thrombocytopenia, coagulation disorders, anemia, and other changes in blood count), transient hyperactivity, anaphylactic shock, serum sickness-like reactions (e.g., joint pain and inflammation, muscle pain, urticaria, etc.), hepatitis, yellowing of the skin, kidney disorders.

Frequency not known (cannot be estimated from available data):

DRESS syndrome (drug reaction with eosinophilia and systemic symptoms), granulocytopenia (reduction in granulocyte white blood cell count), increase in bilirubin in blood (which can cause yellowing of the skin), acute kidney failure including tubulointerstitial nephritis (a type of kidney inflammation).

An increased predisposition to seizures cannot be ruled out.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if it is possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Medicines and Healthcare Products Agency's website: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medication.

5. Storage of Denvar

Keep this medication out of the sight and reach of children.

Do not use this medication after the expiry date which is stated on the packaging after CAD. The expiry date is the last day of the month indicated.

Store below 30°C. Store in the original packaging.

Medicines should not be disposed of via wastewater or household waste. Return the packaging and any unused medication to the pharmacy for proper disposal. If you are unsure, ask your pharmacist how to dispose of the packaging and any unused medication. This will help protect the environment.

6. Contents of the pack and further information

Composition of Denvar

  • The active substance is cefixime. Each hard capsule contains 400 mg of cefixime (as trihydrate).
  • The other ingredients are calcium carboxymethylcellulose, magnesium stearate, anhydrous colloidal silica, and polyoxyl 40 stearate. Capsule components: gelatin, quinoline yellow (E 104), titanium dioxide (E 171), erythrosine (E 127), and gray printing ink (containing Shellac, titanium dioxide (E 171), black iron oxide (E 172), propylene glycol, ammonium hydroxide, and simethicone).

Appearance of the product and pack contents

Denvar is presented in the form of hard orange capsules. Each pack contains 10 hard capsules.

Marketing authorization holder

Merck, S.L.

María de Molina, 40

28006 Madrid

Spain

Manufacturer

Merck, S.L.

Merck Industrial Park

08100 Mollet del Vallés (Barcelona)

Spain

Date of last revision of this leaflet:06/2022

Detailed and updated information on this medication is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) http://www.aemps.gob.es

Online doctors for DENVAR 400 mg CAPSULES

Discuss questions about DENVAR 400 mg CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance.

His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation.

Patients commonly consult Dr Daniel Cichi for:

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.
Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.
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€55
0.0 (0)
Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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€58
5.0 (25)
Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Camera Book a video appointment
€70
5.0 (760)
Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

Camera Book a video appointment
€55

Frequently Asked Questions

Is a prescription required for DENVAR 400 mg CAPSULES?
DENVAR 400 mg CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in DENVAR 400 mg CAPSULES?
The active ingredient in DENVAR 400 mg CAPSULES is cefixime. This information helps identify medicines with the same composition but different brand names.
How much does DENVAR 400 mg CAPSULES cost in pharmacies?
The average pharmacy price for DENVAR 400 mg CAPSULES is around 11.47 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures DENVAR 400 mg CAPSULES?
DENVAR 400 mg CAPSULES is manufactured by Merck S.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of DENVAR 400 mg CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether DENVAR 400 mg CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to DENVAR 400 mg CAPSULES?
Other medicines with the same active substance (cefixime) include CEFIXIME CODAL 400 mg FILM-COATED TABLETS, CEFIXIME MABO 200 mg FILM-COATED TABLETS, CEFIXIME MABO 400 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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