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CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION

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About the medicine

How to use CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: information for the user

Cloxacillin Normon 500 mg powder for injectable solution and for perfusion EFG

cloxacillin sodium

Read the entire leaflet carefully before starting to use the medicine, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any doubts, consult your doctor, pharmacist, or nurse.
  • This medicine has been prescribed to you only, and you should not give it to others,

even if they have the same symptoms as you, as it may harm them.

  • If you experience side effects, consult your doctor, pharmacist, or nurse, even if it is a side effect not listed in this leaflet. See section 4.

Contents of the leaflet:

  1. What is Cloxacillin Normon and what is it used for
  2. What you need to know before taking Cloxacillin Normon
  3. How to use Cloxacillin Normon
  4. Possible side effects
  5. Storage of Cloxacillin Normon
  6. Package contents and additional information

1. What is Cloxacillin Normon and what is it used for

Cloxacillin Normon 500 mg is presented in a vial with powder for injectable solution.

Cloxacillin Normon is indicated for the treatment of the following infections caused by sensitive germs:

  • Infections of the skin and soft tissues.
  • Mastitis (inflammation of the mammary gland).
  • Osteoarticular infections such as septic arthritis (inflammation of joints due to infection) and osteomyelitis (bone inflammation due to infection).
  • Sepsis (generalized infection).
  • Endocarditis (inflammation of certain parts of the heart).
  • Meningitis (inflammation of the meninges).

Informative text on the correct use of antibiotics and their proper elimination after treatment

Doctor consultation

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2. What you need to know before taking Cloxacillin Normon

Do not use Cloxacillin Normon

If you are allergic (hypersensitive) to penicillins or other beta-lactams or to any of the other components of Cloxacillin Normon.

Warnings and precautions

  • If you are allergic to cephalosporins, as there may be a cross-allergic reaction.
  • In newborns with jaundice (evidenced by yellow color of the skin).
  • If you have renal dysfunction (kidney damage), due to the risk of neurotoxicity (nerve damage).
  • If you have restricted sodium intake, as each gram of Cloxacillin Normon 500 mg powder and solvent for injectable solution contains 50 mg.

This medicine may interfere with the analytical determination of serum aspartate aminotransferase (AST) concentration, glucose determination in urine, protein determination in urine and plasma, and Coombs test.

Other medicines and Cloxacillin Normon

Tell your doctor or pharmacist if you are using or have recently used other medicines, including those purchased without a prescription.

Some drugs may influence the action of others.

Cloxacillin Normon interacts with the following drugs:

  • Bacteriostatic antibiotics (chloramphenicol, tetracycline, erythromycin, or sulfonamides): may decrease their action.
  • Probenecid: decreases the elimination of cloxacillin.

Pregnancy and lactation

Consult your doctor or pharmacist before using a medicine.

Pregnancy

The use of Cloxacillin Normon in pregnant women should only be considered when the potential benefits outweigh the potential risks associated with treatment.

Lactation

Cloxacillin Normon is excreted in breast milk. Its use during lactation will be carried out with caution.

Driving and using machines

There is no evidence of effects on the ability to drive vehicles or use hazardous machinery.

Important information about some of the components of Cloxacillin Normon

This medicine contains 26.4 mg of sodium (main component of table salt/kitchen salt) in each vial. This is equivalent to 1.35% of the maximum recommended daily sodium intake for an adult.

3. How to use Cloxacillin Normon

Follow the administration instructions of Cloxacillin Normon indicated by your doctor. Consult your doctor, pharmacist, or nurse if you have doubts.

Remember to use your medicine. Your doctor will indicate the duration of your treatment with cloxacillin. Do not suspend treatment before. If you think the action of this medicine is too strong or weak, tell your doctor, pharmacist, or nurse.

Cloxacillin Normon is administered intravenously or intramuscularly.

The doctor will decide which posology is suitable for each type of pathology.

Adults and children over 12 years:the recommended dose in adults is 500 mg to 1 g every 6-8 hours. These doses are guidelines and may be increased when the severity of the process requires it.

Children over 2 years:the recommended dose is 12.5-25 mg/kg of body weight every 6-8 hours.

Children under 2 years:the recommended dose is 6.25-12.5 mg/kg of body weight every 6 hours.

If you use more Cloxacillin Normon than you should

Consult your doctor or pharmacist immediately. In case of overdose or accidental administration, consult the Toxicology Information Service (Tel. 91 562 04 20), indicating the product and the amount administered.

If you forget to take Cloxacillin Normon

Do not take a double dose to make up for forgotten doses.

If you interrupt treatment with Cloxacillin Normon

If you have any other doubts about the use of this product, ask your doctor, pharmacist, or nurse.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, Cloxacillin Normon can cause side effects, although not everyone gets them:

  • Hypersensitivity reactions:skin disorders, interstitial nephritis (kidney inflammation). Rarely, other reactions such as angioneurotic edema (extensive swelling of the face), anaphylaxis (unusual or exaggerated allergic reaction with hypotension and bronchospasm that makes breathing difficult), and serum sickness (allergic reaction to serum) have been reported.
  • Gastrointestinal tract disorders:diarrhea, nausea, and vomiting, which are usually mild and transient and do not require treatment suspension. Persistence of diarrhea should raise the possibility of pseudomembranous colitis.
  • Blood disorders:rare cases of neutropenia (decrease in white blood cell count) and platelet dysfunction have been reported.
  • Central nervous system disorders:at very high doses, convulsions may appear. Liver function disorders:jaundice (evidenced by yellow color of the skin) and hepatitis. Local reactions:cases of phlebitis (venous inflammation) may occur.
  • Other adverse reactions:oral candidiasis.

Reporting of side effects

If you experience any side effects, consult your doctor or pharmacist, even if it is a possible side effect not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medicine.

5. Storage of Cloxacillin Normon

Keep this medicine out of the sight and reach of children. Store in the original packaging.

Do not use Cloxacillin Normon after the expiration date stated on the packaging after CAD. The expiration date is the last day of the month indicated.

After reconstitution, the physical-chemical stability of the reconstituted product with water for injectable preparations has been demonstrated for up to 6 hours at 25°C and 72 hours at 2-8°C. The physical-chemical stability of the diluted solution with sodium chloride 9 mg/ml (0.9%) for injection or glucose 50 mg/ml (5%) in bags or vials for perfusion has been demonstrated for up to 6 hours at 25°C or 48 hours at 2-8°C. From a microbiological point of view, the product must be used immediately. If not used immediately, the storage times and conditions prior to use are the responsibility of the user and should not normally exceed 24 hours at 2-8°C, unless the dilution/reconstitution has taken place in controlled and validated aseptic conditions.

Do not use this medicine if you observe the presence of particles or if the reconstituted solution is turbid.

Medicines should not be thrown away through wastewater or household waste. Deposit the packaging and medicines you no longer need in the SIGRE Point of the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and medicines you no longer need. This way, you will help protect the environment.

6. Package contents and additional information

Composition of Cloxacillin Normon

The active ingredient is cloxacillin sodium. Each vial contains 500 mg of cloxacillin sodium.

Appearance of the product and package contents

Cloxacillin Normon 500 mg is presented as a powder for injectable solution, with each package containing a vial.

Marketing authorization holder and manufacturer

LABORATORIOS NORMON, S.A.

Ronda de Valdecarrizo, 6 – 28760 Tres Cantos – Madrid (Spain)

OTHER PRESENTATIONS

Cloxacillin Normon 1 g powder for injectable solution and for perfusion EFG.

Date of the last revision of this leaflet: February 2024

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

THIS INFORMATION IS INTENDED ONLY FOR HEALTHCARE PROFESSIONALS

Information for the doctor

In case of overdose, symptomatic and maintenance treatment should be carried out. Peritoneal dialysis or hemodialysis is not effective.

Precautions in parenteral administration

Intravenous administration:The vial is reconstituted with 10 ml of water for injectable preparations. Inject slowly over 3-4 minutes.

For administration in continuous perfusion, the reconstituted powder in 10 mL of water for injectable preparations will be removed from the vial and added to a 100 mL bag of sodium chloride 9 mg/ml (0.9%) or glucose 50 mg/ml (5%) for perfusion in the hospital.

Intramuscular administration:The vial is reconstituted with 3.5 ml of water for injectable preparations.

Cloxacillin sodium should not be used in solutions containing protein hydrolysates, lipid suspensions, amino acids, blood, or serum. It is compatible with most commonly used intravenous solutions (physiological serum or glucose).

The mixture of cloxacillin and aminoglycosides can cause substantial mutual inactivation, so they should not be mixed in the same container for administration.

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Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

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Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

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Dmytro Horobets

Family medicine 7 years exp.

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

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Svetlana Kolomeeva

Cardiology 18 years exp.

Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

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Alexander Nazarchuk

Allergology 7 years exp.

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

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Frequently Asked Questions

Is a prescription required for CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION?
CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION?
The active ingredient in CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION is cloxacillin. This information helps identify medicines with the same composition but different brand names.
Who manufactures CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION?
CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION is manufactured by Laboratorios Normon S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to CLOXACILLIN NORMON 500 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION?
Other medicines with the same active substance (cloxacillin) include ANACLOSIL 1000 mg powder for injectable solution and for infusion, ANACLOSIL 500 mg CAPSULES, ANACLOSIL 500 mg powder for injectable solution and for infusion. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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