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ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe

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About the medicine

How to use ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

ATROPINE AGUETTANT 0.2mg/ml, Solution for Injection in Pre-filled Syringe

Atropine, sulfate

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

The name of this medicine is Atropine Aguettant 0.2 mg/ml Solution for Injection in Pre-filled Syringe, it will be referred to as Atropine Aguettant throughout this leaflet.

Contents of the pack

  1. What is Atropine Aguettant and what it is used for
  2. What you need to know before you use Atropine Aguettant
  3. How to use Atropine Aguettant
  4. Possible side effects
  5. Storage of Atropine Aguettant
  6. Contents of the pack and other information

1. What is Atropine Aguettant and what it is used for

Atropine belongs to a class of medicines called anticholinergics. An anticholinergic is a substance that blocks the neurotransmitter acetylcholine in the central and peripheral nervous system. It is used in emergency situations, when the heart beats too slowly, as an antidote for cases of poisoning by organophosphorus insecticides or nerve gas, for example, and for cases of poisoning by mushrooms.

It can be used as part of the pre-medication before general anesthesia. It can also be used to prevent the side effects of other drugs used to counteract the effects of muscle relaxants after surgery.

Atropine Aguettant 0.2 mg/ml Solution for Injection in Pre-filled Syringe is used to treat adults only.

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2. What you need to know before you use Atropine Aguettant

Do not use Atropine Aguettant:

  • if you are allergic (hypersensitive) to atropine or any of the other ingredients of this medicine (listed in section 6);
  • if you have urinary problems;
  • if you have high pressure in the eye (glaucoma);
  • if you suffer from esophageal disease (esophageal achalasia), intestinal blockage (paralytic ileus) or a form of acute colonic distension (toxic megacolon).

These contraindications do not apply in cases of potentially life-threatening emergencies.

Warnings and precautions

Consult your doctor before starting to use Atropine Aguettant if you suffer from:

  • hyperthyroidism;
  • prostate disease;
  • heart failure;
  • liver or kidney disease;
  • certain heart diseases;
  • stomach disease, such as pyloric stenosis;
  • chronic bronchitis;
  • fever;
  • if you are an elderly person;
  • severe myasthenia (severe muscle weakness);
  • heartburn (reflux).

Using Atropine Aguettant with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines:

  • tricyclic antidepressants;
  • certain antihistamines;
  • medicines for Parkinson's disease;
  • phenothiazine, clozapine or neuroleptic drugs (for mental illnesses);
  • quinidine or disopyramide (for heart diseases);
  • antispasmodics (for irritable bowel syndrome).

Pregnancy and breast-feeding

Pregnancy

Limited data on the use of atropine in pregnant women indicate that there are no adverse effects on pregnancy or fetal health. Atropine crosses the placenta. Intravenous administration of atropine during pregnancy or at term may cause a faster heart rate in the fetus and mother. This medicine should only be administered during pregnancy after careful consideration of the benefits and risks of treatment.

Breast-feeding

Small amounts of atropine may pass into breast milk and have effects on the infant. Atropine may inhibit milk production. Your doctor will weigh the benefit of breast-feeding against the benefit of treatment. If treatment is decided, breast-feeding should be interrupted. However, if breast-feeding is continued during treatment, your doctor will perform additional tests on the infant.

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

Driving and using machines

The injection of atropine can cause confusion or blurred vision. You should not drive or operate machinery after receiving an injection.

Atropine Aguettant contains sodium

This medicine contains less than 23 mg (1 mmol) of sodium per dose, so it is essentially "sodium-free".

3. How to use Atropine Aguettant

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Your doctor will decide the correct dose for you and how and when the injection will be administered.

The recommended dose is:

As pre-medication before anesthesia

Adults: 0.3-0.6 mg intravenously immediately before induction of anesthesia or 0.3-0.6 mg intramuscularly, 30-60 minutes before anesthesia.

To counteract the effects of muscle relaxants:

Adults: 0.6-1.2 mg intravenously with neostigmine.

In case of low heart rate, heart block or cardiac arrest:

Adults:

  • Sinus bradycardia (low pulse rate): 0.5 mg intravenously, every 2-5 minutes until the desired heart rate is achieved.
  • AV block (blockage of the transmission of contraction between the atrium and ventricle): 0.5 mg intravenously, every 3-5 minutes (maximum 3 mg).

As an antidote for organophosphate poisoning (insecticides or nerve gas), anticholinesterases or poisoning by muscarinic mushrooms:

Adults: 0.5-2 mg depending on the characteristics and response of the patient, may be repeated after 5 minutes and subsequently as required.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

This injection will be administered by a doctor or nurse, so it is unlikely that you will receive an overdose of atropine. If you think you have been given too much atropine, feel that your heart is beating very fast, breathe rapidly, have a high fever, feel restless, confused, have hallucinations or lose coordination, you should inform the person who administered the injection.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Side effects depend on the dose you receive and usually disappear with the interruption of treatment.

Rarely, an allergic reaction may occur. This can cause skin rashes, intense itching, skin peeling, swelling of the face (especially around the lips and eyes), throat tightness and difficulty breathing or swallowing, fever, dehydration, shock and fainting. All these are very serious side effects. Tell your doctor immediately if you experience any of these side effects. You may need urgent medical attention.

Very common side effects (may affect more than 1 in 10 people)

  • visual disturbances (pupil dilation, difficulty focusing, blurred vision, light intolerance);
  • reduced bronchial secretion;
  • dry mouth (difficulty swallowing and speaking, feeling of thirst);
  • constipation and heartburn (reflux);
  • reduced gastric acid secretion;
  • loss of taste;
  • nausea;
  • vomiting;
  • feeling of bloating;
  • lack of sweating;
  • dry skin;
  • rash;
  • eruption.

Common side effects (may affect up to 1 in 10 people)

  • excitement (especially with higher doses);
  • loss of coordination (especially with higher doses);
  • confusion (especially with higher doses);
  • hallucinations (especially with higher doses),
  • excessive temperature;
  • certain heart disorders (fast heart rate, irregular heart rate, temporary slowing of heart rate);
  • flushing;
  • difficulty urinating.

Uncommon side effects (may affect up to 1 in 100 people)

  • psychotic reactions.

Rare side effects (may affect up to 1 in 1,000 people)

  • allergic reactions;
  • seizures (convulsions);
  • drowsiness.

Very rare side effects (may affect up to 1 in 10,000 people)

  • severe allergic reaction;
  • irregular heart rate, including ventricular fibrillation;
  • chest pain;
  • peak in blood pressure.

Frequency not known (cannot be estimated from the available data)

  • headache;
  • restlessness;
  • unstable gait and balance problems;
  • insomnia.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. You can also report side effects directly via the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Atropine Aguettant

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton, syringe and blister. The expiry date is the last day of the month stated.

This medicine does not require any special storage conditions.

Do not use this medicine if you notice visible signs of deterioration.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and other information

Composition of Atropine Aguettant

  • The active substance is Atropine sulfate:

Each ml of solution for injection contains 0.2 mg of atropine sulfate monohydrate, which is equivalent to 0.17 mg of atropine.

Each 5 ml syringe contains 1 mg of atropine sulfate monohydrate, which is equivalent to 0.83 mg of atropine.

  • The other ingredients are:

Sodium chloride, concentrated hydrochloric acid (for pH adjustment), water for injections.

Appearance of the product Atropine Aguettant and contents of the pack.

This medicine is a clear and colorless solution for injection in a sterile pre-filled syringe of polypropylene of 5 ml.

Boxes of 1, 5, 10, 12 and 20 syringes.

Not all pack sizes may be marketed.

Marketing authorisation holder and manufacturer

Marketing authorisation holder:

Laboratoire AGUETTANT

1, rue Alexander Fleming

69007 Lyon

FRANCE

Manufacturer:

Laboratoire AGUETTANT

1, rue Alexander

Fleming 69007 LYON

France

Laboratoire AGUETTANT

Lieu-dit “Chantecaille ”

07340 CHAMPAGNE

France

Date of last revision of this leaflet: December 2021

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS). http//www.aemps.gob.es

This information is intended only for healthcare professionals:

The pre-filled syringe is intended for single patient use. Discard the syringe after use. Do not reuse.

The content of the unopened and intact blister is sterile and should not be opened until it is to be used.

The product should be visually inspected for particles and discoloration before administration. Only the clear, colorless solution without particles or precipitates should be used.

The product should not be used if the security seal of the syringe (plastic cover on the tip cap) is broken.

The outer surface of the syringe is sterile until the blister is opened.

  1. Remove the pre-filled syringe from the sterile blister.

Hand holding a syringe with a needle inserted, showing the plunger with numerical marks and the grip with fingers

  1. Push the plunger to release the stopper.

Needle inserted into the skin at a 45-degree angle, showing the entry and path under the epidermis

  1. Twist the tip cap to remove it and break the seal.

Needle connected to a white cylinder with numbers and an arrow pointing down to the left

  1. Check that the syringe seal (plastic cover on the tip cap and seal under the tip cap) has been completely removed. If not, replace the cap and twist it again.

Hand holding a transparent syringe with liquid and black plunger vertically

  1. Remove the air by gently pushing the plunger.
  1. Connect the syringe to the vascular access device or needle.

Push the plunger to inject the necessary volume.

The needle size required to use with the syringe is 23-20 gauge for intravenous administration and 23-21 gauge for intramuscular administration.

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Anastasiia Shalko

Family medicine 13 years exp.

Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

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Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

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Joao Silva

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Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

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Daniel Cichi

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Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

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Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

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If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Frequently Asked Questions

Is a prescription required for ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe?
ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe?
The active ingredient in ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe is atropine. This information helps identify medicines with the same composition but different brand names.
Who manufactures ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe?
ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe is manufactured by Laboratoire Aguettant. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to ATROPINE Aguettant 0.2 mg/ml Injectable Solution in Pre-filled Syringe?
Other medicines with the same active substance (atropine) include ATROPINE ACCORD 0.1 mg/mL Injectable Solution in Pre-filled Syringe, ATROPINE Aguettant 0.1 mg/ml Injectable Solution in Pre-filled Syringe, ATROPINE NORIDEM 1 mg/mL INJECTABLE SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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