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ATERINA 25 mg SOFT GEL CAPSULES

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About the medicine

How to use ATERINA 25 mg SOFT GEL CAPSULES

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the Patient

Aterina 25 mg Soft Capsules

Sulodexide

Read the entire package leaflet carefully before starting to take this medication, as it contains important information for you.

  • Keep this package leaflet, as you may need to read it again.
  • If you have any questions, consult your doctor or pharmacist.
  • This medication has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are side effects not listed in this package leaflet. See section 4.

Contents of the Package Leaflet

  1. What Aterina Capsules are and what they are used for
  2. What you need to know before taking Aterina Capsules
  3. How to take Aterina Capsules
  4. Possible side effects
  5. Storage of Aterina Capsules
  6. Package Contents and Additional Information
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1. What Aterina Capsules are and what they are used for

Aterina Capsules contain sulodexide, which belongs to the group of medications called antithrombotics, used to prevent and treat blood clots (thrombi) that can form in blood vessels.

Aterina Capsules are indicated in adults for:

  • Treatment of chronic venous insufficiency (when veins weaken and blood pooling occurs, associated with swelling, heaviness, and pain in the legs).

Due to its antithrombotic effect, Aterina Capsules improve blood circulation and alleviate symptoms associated with chronic venous insufficiency.

  • Treatment of chronic venous ulcers
  • Treatment of symptoms of intermittent claudication in occlusive peripheral arterial disease (stage II).

2. What you need to know before taking Aterina Capsules

Do not take Aterina Capsules

  • if you are allergic to the active substance (sulodexide) or to any of the other components of this medication (listed in section 6), to heparin or heparinoids (medications that decrease blood coagulation),
  • if you have a risk of bleeding or suffer from hemorrhagic diseases.

Warnings and Precautions

Consult your doctor or pharmacist before starting to take Aterina Capsules.

Medicine questions

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Children and Adolescents

The safety and efficacy of Aterina in children and adolescents under 18 years of age have not been established. No data are available.

Other Medications and Aterina

Inform your doctor or pharmacist if you are taking, have recently taken, or may need to take any other medication.

Aterina Capsules may increase the anticoagulant effect of heparin-based medications and other oral anticoagulants if taken simultaneously (see Warnings and Precautions section).

Taking Aterina Capsules with Food and Drinks

No information is available on interactions with food or drinks.

Pregnancy, Breastfeeding, and Fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

Pregnancy

As a precaution, it is recommended to avoid using Aterina Capsules during pregnancy.

Breastfeeding

Aterina Capsules should not be taken during breastfeeding.

Fertility

Studies in animals do not indicate direct or indirect harmful effects on male and female fertility.

Driving and Using Machines

This medication does not affect or has negligible effects on the ability to drive and use machines.

Aterina Capsules contain sodium ethyl para-hydroxybenzoate (E 215), sodium propyl para-hydroxybenzoate, and sodium.

Aterina Capsules may cause allergic reactions (possibly delayed) because they contain sodium ethyl para-hydroxybenzoate (E 215) and sodium propyl para-hydroxybenzoate.

This medication contains less than 1 mmol (23 mg) of sodium per capsule; it is essentially "sodium-free".

3. How to Take Aterina Capsules

Follow the administration instructions for this medication exactly as indicated by your doctor or pharmacist. If in doubt, consult your doctor or pharmacist again.

Treatment of chronic venous insufficiency:

The recommended dose is one 25 mg capsule twice a day (2 capsules a day) for 3 months and medical reevaluation.

Chronic venous ulcers:

Treatment is recommended to start with 60 mg per day by parenteral route (ampoules) for 15-20 days and continue with the oral formulation taking 1 capsule of 25 mg twice a day (2 capsules a day), which may be increased up to a maximum of 2 capsules of 25 mg twice a day (4 capsules a day). The recommended treatment duration is 2-3 months and medical reevaluation.

Symptomatic treatment of intermittent claudication in occlusive peripheral arterial disease (stage II):

Treatment is recommended to start with 60 mg per day by parenteral route (ampoules) for 15-20 days and continue with the oral formulation taking 1 capsule of 25 mg twice a day (2 capsules a day), which may be increased up to a maximum of 2 capsules of 25 mg twice a day (4 capsules a day). The recommended treatment duration is 6 months and medical reevaluation.

Aterina Capsules should be taken orally with liquid and separated from meals.

Use in Children and Adolescents

The safety and efficacy of Aterina in children and adolescents have not been established due to the lack of data.

Patients with Hepatic Problems

The use of Aterina Capsules is not recommended in patients with hepatic disorders since there are no data on the safety and efficacy of the medication in these patients.

If You Take More Aterina Capsules Than You Should

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately, or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medication and the amount taken.

If you take more Aterina Capsules than recommended, you may increase the risk of bleeding. If bleeding occurs, go to the nearest emergency service.

If You Forget to Take Aterina Capsules

In case of a missed dose, take another as soon as possible, then follow the usual schedule. However, if it is close to the time for the next dose, do not take the missed dose and wait until the next one.

Do not take a double dose to make up for missed doses.

If You Interrupt Treatment with Aterina Capsules

If you have any other questions about the use of this medication, ask your doctor or pharmacist.

4. Possible Side Effects

Like all medications, this medication can cause side effects, although not everyone will experience them.

Aterina Capsules are usually well tolerated. The following side effects have been observed:

Common Side Effects(may affect up to 1 in 10 people):

  • dizziness (feeling of spinning),
  • diarrhea,
  • upper abdominal pain,
  • skin rash.

Uncommon Side Effects(may affect up to 1 in 100 people):

  • loss of consciousness,
  • headache,
  • stomach bleeding,
  • pruritic rash
  • itching, redness, and dryness of the skin,
  • swelling, especially of ankles and feet.

Side Effects of Unknown Frequency(cannot be estimated from available data):

  • anemia,
  • disorder of blood protein metabolism,
  • perception disorders,
  • seizures,
  • tremors,
  • visual impairment,
  • palpitations,
  • hot flashes,
  • nosebleeds,
  • coughing up blood (hemoptysis),
  • asthma,
  • black-colored stools due to gastrointestinal bleeding,
  • vomiting,
  • gas,
  • indigestion,
  • nausea,
  • abdominal discomfort,
  • potentially life-threatening reaction with symptoms similar to flu and painful rash affecting the skin, mouth, eyes, and genitals (Stevens-Johnson syndrome),
  • rapid swelling under the skin,
  • redness of the skin,
  • purple spots with bruising (purpura),
  • blood extravasation under the skin (ecchymosis),
  • papule,
  • itching,
  • difficulty emptying the bladder,
  • pain while urinating,
  • loss of bladder control,
  • more frequent menstrual periods,
  • swelling of the genitals,
  • redness of the skin around the genitals,
  • chest pain,
  • pain,
  • fever.

Reporting Side Effects

If you experience any side effects, consult your doctor or pharmacist, even if they are possible side effects not listed in this package leaflet. You can also report them directly through the Spanish Medication Surveillance System for Human Use: https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Aterina Capsules

Keep this medication out of sight and reach of children.

Do not use this medication after the expiration date stated on the package after CAD. The expiration date is the last day of the month indicated.

Do not store above 30 ºC.

Medications should not be disposed of through wastewater or household waste. Deposit the packaging and medications you no longer need at the SIGRE point in your pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and medications you no longer need. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Angileptol Mint Flavor

Each tablet contains:

  • The active ingredients:

Chlorhexidine dihydrochloride, 5 mg

Benzocaine, 4 mg

Enoxolone, 3 mg

  • The other components (excipients) are: sorbitol (E420), acesulfame potassium (E950), magnesium stearate, and mint flavor

Appearance of the Product and Package Contents

Angileptol are sucking tablets, white, round, and with the Greek letter σ on one face.

They come in packages containing 15 and 30 sucking tablets.

Other Presentations

Angileptol Mint-Eucalyptus Flavor

Angileptol Honey-Lemon Flavor

Marketing Authorization Holder

Alfasigma España S.L.

C/ Aribau 195, 4º

08021 Barcelona, Spain

Manufacturer

Pharmaloop, S.L.

Polígono Industrial Azque C/Bolivia, 15

28806 Alcalá de Henares (Madrid), Spain

or

Alfasigma, S.p.A.

Via Pontina, Km 30,400

00071 Pomezia (Rome), Italy

Date of the Last Revision of this Package Leaflet:September 2021

Other Sources of Information

Detailed information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

Online doctors for ATERINA 25 mg SOFT GEL CAPSULES

Discuss questions about ATERINA 25 mg SOFT GEL CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Chikeluo Okeke

General medicine 4 years exp.

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

He provides online consultations covering symptom assessment, prevention, and long-term management of chronic conditions, helping patients understand what is happening and decide on appropriate next steps.

Common reasons for consultation:

  • General internal medicine concerns and initial health assessment.
  • Acute symptoms such as fever, cough, infections, pain, or weakness.
  • Chronic conditions and treatment adjustment.
  • Blood pressure issues, fatigue, metabolic concerns.
  • Preventive consultations and routine check-ups.
  • Interpretation of laboratory results and medical reports.
  • Medical advice for patients receiving care online.

Dr Okeke is known for his clear communication, calm approach, and cultural awareness. He listens carefully, explains medical decisions in a structured way, and supports patients in making informed choices about their health.

Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

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Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

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  •  Musculoskeletal system (MSK)
  •  Angiography
  •  Abdomen and pelvis
  •  Soft tissues

Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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Frequently Asked Questions

Is a prescription required for ATERINA 25 mg SOFT GEL CAPSULES?
ATERINA 25 mg SOFT GEL CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in ATERINA 25 mg SOFT GEL CAPSULES?
The active ingredient in ATERINA 25 mg SOFT GEL CAPSULES is sulodexide. This information helps identify medicines with the same composition but different brand names.
Who manufactures ATERINA 25 mg SOFT GEL CAPSULES?
ATERINA 25 mg SOFT GEL CAPSULES is manufactured by Alfasigma Espana S.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of ATERINA 25 mg SOFT GEL CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ATERINA 25 mg SOFT GEL CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to ATERINA 25 mg SOFT GEL CAPSULES?
Other medicines with the same active substance (sulodexide) include ATERINA 15 mg SOFT GEL CAPSULES, ATERINA 60 mg/2 mL INJECTABLE SOLUTION, ATENATIV 1000 IU POWDER AND SOLVENT FOR SOLUTION FOR INFUSION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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