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AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS

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About the medicine

How to use AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Amoxicillin/Clavulanic Acid Normon500 mg/125 mg Powder for Oral Suspension in Sachets EFG

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
    • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Contents of the pack:

  1. What Amoxicillin/Clavulanic Acid Normon is and what it is used for
  2. What you need to know before you take Amoxicillin/Clavulanic Acid Normon
  3. How to take Amoxicillin/Clavulanic Acid Normon
  4. Possible side effects
  5. Storage of Amoxicillin/Clavulanic Acid Normon
  6. Contents of the pack and other information

1. What Amoxicillin/Clavulanic Acid Normon is and what it is used for

Amoxicillin/Clavulanic Acid Normon is an antibiotic that eliminates the bacteria that cause infections. It contains two different active substances called amoxicillin and clavulanic acid. Amoxicillin belongs to a group of medicines known as "penicillins" which can sometimes lose their effectiveness (become inactivated). The other component (clavulanic acid) prevents this from happening.

Antibiotics are used to treat bacterial infections and are not effective against viral infections such as the flu or the common cold. It is essential to follow the instructions regarding dosage, administration interval, and treatment duration indicated by your doctor. Do not store or reuse this medicine. If you have any leftover antibiotic after completing the treatment, return it to the pharmacy for proper disposal. Do not throw away medicines via wastewater or household waste.

Amoxicillin/Clavulanic Acid Normon is used in adults and children to treat the following infections:

  • Middle ear and sinus infections
  • Respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections, including dental infections
  • Bone and joint infections.
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Amoxicillin/Clavulanic Acid Normon

Do not takeAmoxicillin/Clavulanic Acid Normonif:

  • you are allergic to amoxicillin, clavulanic acid, or any of the other ingredients of this medicine (listed in section 6);
  • you have ever had a severe allergic reaction (hypersensitivity) to any other antibiotic. This could include a skin rash or swelling of the face or throat;
  • you have ever had liver problems or jaundice (yellowing of the skin) when taking an antibiotic.

Do not takeAmoxicillin/Clavulanic Acid Normonif any of the above applies to you. If you are not sure, consult your doctor or pharmacist before starting treatment with Amoxicillin/Clavulanic Acid Normon.

Warnings and precautions

Consult your doctor or pharmacist before taking this medicine if:

  • you have infectious mononucleosis
  • you are receiving treatment for liver or kidney problems
  • you do not urinate regularly.

If you are unsure whether any of the above symptoms affect you, inform your doctor or pharmacist before taking Amoxicillin/Clavulanic Acid Normon.

In some cases, your doctor may investigate the type of bacteria causing your infection. Depending on the results, you may be prescribed a different formulation of Amoxicillin/Clavulanic Acid or another medicine.

Symptoms to be aware of

Amoxicillin/Clavulanic Acid Normon can worsen certain existing conditions or cause severe side effects. These include allergic reactions, seizures, and inflammation of the large intestine. You should be aware of certain symptoms while taking Amoxicillin/Clavulanic Acid Normon to reduce the risk of problems. See "Symptoms to be aware of" in section 4.

Blood and urine tests

If you are having blood tests (such as red blood cell status or liver function studies) or urine tests (to check glucose levels), inform your doctor or nurse that you are taking Amoxicillin/Clavulanic Acid Normon. This is because Amoxicillin/Clavulanic Acid Normon may alter the results of these types of tests.

Other medicines and Amoxicillin/Clavulanic Acid Normon

Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines.

If you are taking allopurinol (used for gout) with Amoxicillin/Clavulanic Acid Normon, you may be more likely to suffer a skin allergic reaction.

If you are taking probenecid (used for gout), your doctor may adjust the dose of Amoxicillin/Clavulanic Acid Normon. Concomitant use of probenecid may reduce the excretion of amoxicillin and is not recommended.

If you are taking anticoagulants (such as warfarin) with Amoxicillin/Clavulanic Acid Normon, more blood tests will be needed.

Amoxicillin/Clavulanic Acid Normon may affect the action of methotrexate (a medicine used to treat cancer and severe psoriasis). Penicillins may reduce the excretion of methotrexate and cause a potential increase in side effects.

Amoxicillin/Clavulanic Acid Normon may affect how mycophenolate mofetil (a medicine used to prevent organ rejection in transplant patients) works.

Pregnancy and breastfeeding

If you are pregnant, breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using any medicine.

Driving and using machines

Amoxicillin/Clavulanic Acid Normon may have side effects that could affect your ability to drive or use machines. Do not drive or operate machinery unless you are feeling well.

Important information about some of the ingredients of Amoxicillin/Clavulanic Acid Normon 500 mg/125 mg Powder for Oral Suspension in Sachets EFG

Amoxicillin/Clavulanic Acid Normon contains sucrose

If your doctor has told you that you have an intolerance to some sugars, consult them before taking this medicine.

Amoxicillin/Clavulanic Acid Normon contains sodium benzoate

This medicine contains 8 mg of sodium benzoate in each sachet. Sodium benzoate may increase the risk of jaundice (yellowing of the skin and eyes) in newborns (up to 4 weeks of age).

Amoxicillin/Clavulanic Acid Normon contains sodium

This medicine contains less than 23 mg of sodium (1 mmol) per dose; this is essentially "sodium-free".

3. How to take Amoxicillin/Clavulanic Acid Normon

Follow the instructions for administration of this medicine exactly as indicated by your doctor or pharmacist. If you are unsure, consult your doctor or pharmacist again.

Adults and children over 40 kg

The recommended dose is:

• 1 sachet administered three times a day.

Children under 40 kg

Amoxicillin/Clavulanic Acid Normon 500 mg/125 mg Powder for Oral Suspension in Sachets EFG is not recommended.

Patients with kidney and liver problems

  • If you have kidney problems, your dose may be changed. Your doctor may choose a different formulation or another medicine.
  • If you have liver problems, you will have more frequent blood tests to check how your liver is working.

How to take Amoxicillin/Clavulanic Acid Normon

  • Just before taking Amoxicillin/Clavulanic Acid Normon, open the sachet and mix the contents in half a glass of water.
  • Take it at the start of meals or a while before.
  • Space out the doses during the day, at least 4 hours apart. Do not take 2 doses in 1 hour.
  • Do not take this medicine for more than 2 weeks. If you are still feeling unwell, consult your doctor.

If you take more Amoxicillin/Clavulanic Acid Normon than you should

If you take too much Amoxicillin/Clavulanic Acid Normon, you may experience symptoms such as stomach upset (nausea, vomiting, or diarrhea) or seizures. Consult your doctor as soon as possible. Take the pack with you to show the doctor.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, telephone 91 562 04 20, indicating the medicine and the amount taken.

If you forget to take Amoxicillin/Clavulanic Acid Normon

If you forget to take a dose, take it as soon as you remember. Do not take the next dose too soon, wait at least 4 hours before taking the next dose. Do not take a double dose to make up for forgotten doses.

If you stop taking Amoxicillin/Clavulanic Acid Normon

Continue taking this medicine until you finish the treatment, even if you feel better. You need to take the full treatment to cure the infection. If you do not, the bacteria that survive may cause you to become infected again.

If you have any further questions about the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, Amoxicillin/Clavulanic Acid Normon can cause side effects, although not everybody gets them. The side effects described below may occur when taking this medicine.

Symptoms to be aware of

Allergic reactions:

  • skin rash;
  • inflammation of blood vessels (vasculitis) that can appear as red or purple spots on the skin but can affect other parts of the body;
  • fever, joint pain, swollen glands in the neck, armpits, or groin;
  • swelling sometimes of the face or throat (angioedema), which can cause difficulty breathing;
  • collapse,
  • chest pain in the context of allergic reactions, which can be a symptom of an allergy-induced heart attack (Kounis syndrome).
    • Contact your doctor immediatelyif you experience any of these symptoms. Stop takingAmoxicillin/Clavulanic Acid Normon.

Inflammation of the large intestine

Inflammation of the large intestine, which causes watery diarrhea, usually with blood and mucus, stomach pain, and/or fever.

Acute pancreatitis

If you have severe and persistent stomach pain, this could be a sign of acute pancreatitis.

Drug-induced enterocolitis syndrome (DIES):

DIES has been reported mainly in children who receive amoxicillin. It is a certain type of allergic reaction with the main symptom of repeated vomiting (1-4 hours after taking the medicine). Other symptoms may include abdominal pain, lethargy, diarrhea, and low blood pressure.

  • Contact your doctor immediately if you experience any of these symptoms.

Very common side effects

May affect more than 1 in 10 people

  • diarrhea (in adults).

Common side effects

May affect up to 1 in 10 people

  • thrush (candida - fungal infection of the vagina, mouth, or mucous membranes);
  • nausea, especially when taking high doses;
  • vomiting;
  • diarrhea (in children).

Uncommon side effects

May affect up to 1 in 100 people

  • skin rash, itching;
  • pruritic rash increased (urticarial habon);
  • indigestion
  • dizziness
  • headache.

Uncommon side effects that may appear in blood tests:

  • Increased levels of certain substances (enzymes) produced by the liver.

Rare side effects

May affect up to 1 in 1,000 people

  • skin rash that can form blisters, which look like small targets (central dark spot surrounded by a paler area, with a dark ring around the edge - erythema multiforme).
  • If you have anyof these symptoms, consult your doctor urgently

Rare side effects that may appear in blood tests:

  • low count of cells involved in blood clotting;
  • low count of white blood cells.

Frequency not known

Frequency cannot be estimated from the available data.

  • Allergic reactions (see above).
  • Inflammation of the large intestine (see above).
  • Inflammation of the protective membrane surrounding the brain and spinal cord (aseptic meningitis).
  • Severe skin reactions:
  • Widespread rash with blisters and peeling of the skin, particularly around the mouth, nose, eyes, and genitals (Stevens-Johnson syndrome), and in its most severe form, causing widespread peeling of the skin (more than 30% of the body surface - toxic epidermal necrolysis).
  • Generalized red rash with small blisters containing pus (exfoliative dermatitis).
  • Red exfoliative rash, with bumps under the skin and hives (pustular exanthematous).
  • Flu-like symptoms with skin rash, fever, gland inflammation, and abnormal blood test results (such as increased white blood cells (eosinophilia) and elevated liver enzymes) (Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)).
  • Contact a doctor immediately if you have any of these symptoms.
  • Inflammation of the liver (hepatitis).
  • Jaundice, caused by increased bilirubin in the blood (a substance produced by the liver) that can make the skin and whites of the eyes turn yellow.
  • Inflammation of the kidney ducts.
  • Delayed blood clotting.
  • Hyperactivity.
  • Seizures (in patients taking high doses of Amoxicillin/Clavulanic Acid or with kidney problems).
  • Black hairy tongue.
  • Stained teeth (in children), which usually disappears with brushing.
  • Rash with blisters arranged in a circle with a central crust or like a string of pearls (linear IgA disease)
  • Inflammation of the membranes surrounding the brain and spinal cord (aseptic meningitis).

Side effects that may appear in blood or urine tests:

  • Significant reduction in the number of white blood cells.
  • Low red blood cell count (hemolytic anemia).
  • Crystals in the urine that cause acute kidney injury.

Reporting of side effects:

If you experience any side effects, consult your doctor or pharmacist, even if it is possible side effects not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Amoxicillin/Clavulanic Acid Normon

Do not store above 25°C.

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date that appears on the packaging after EXP. The expiry date is the last day of the month indicated.

Do not use Amoxicillin/Clavulanic Acid Normon if the sachets are broken or damaged.

Medicines should not be disposed of via wastewater or household waste. Place the packaging and any unused medicines in the SIGRE collection point at the pharmacy. If you are unsure, ask your pharmacist how to dispose of packaging and medicines you no longer need. This will help protect the environment.

6. Container Content and Additional Information

Composition ofAmoxicillin/Clavulanic Acid Normon500 mg/125 mg powder for oral suspension in EFG sachets

The active ingredients are amoxicillin and clavulanic acid. Each sachet contains 500 mg of amoxicillin (as amoxicillin trihydrate) and 125 mg of clavulanic acid (as potassium clavulanate).

The other components (excipients) are: anhydrous citric acid (E-330), anhydrous sodium citrate (E-331), colloidal silica, microcrystalline cellulose (E-460i) and sodium carboxymethylcellulose (E-466), xanthan gum (E-415), sodium benzoate (E-211), sucrose, and orange essence.

Appearance of the Product and Container Content

Amoxicillin/Clavulanic Acid Normon 500 mg/125 mg is presented in sachets containing powder for oral suspension. The sachets contain a white or slightly creamy powder with a characteristic odor.

Each container contains 30 and 500 sachets.

Marketing Authorization Holder and Manufacturer

LABORATORIOS NORMON, S.A.

Ronda de Valdecarrizo, 6 – 28760 Tres Cantos – Madrid (Spain)

Date of the Last Revision of this Leaflet:April 2023

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Instructions for Reconstitution

Pour the contents of the sachet into a glass.

Add a small amount of water and mix well.

Take immediately.

Detailed and updated information on this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

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Frequently Asked Questions

Is a prescription required for AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS?
AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS?
The active ingredient in AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS is amoxicillin and beta-lactamase inhibitor. This information helps identify medicines with the same composition but different brand names.
How much does AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS cost in pharmacies?
The average pharmacy price for AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS is around 5.84 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS?
AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS is manufactured by Laboratorios Normon S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to AMOXICILLIN/CLAVULANIC ACID NORMON 500 mg/125 mg ORAL SUSPENSION POWDER IN SACHETS?
Other medicines with the same active substance (amoxicillin and beta-lactamase inhibitor) include AMOXICILLIN / CLAVULANIC ACID SANDOZ 250 mg/62.5 mg/5 ml ORAL SUSPENSION POWDER, AMOXICILLIN CLAVULANATE POWDER FOR SOLUTION FOR INFUSION 2000 mg/200 mg, AMOXICILLIN CLAVULANATE SUN 500 mg/125 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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