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AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS

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About the medicine

How to use AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

PATIENT INFORMATION LEAFLET

Amoxicillin/Clavulanic Acid ArdineClav 500 mg/125 mg film-coated tablets

Read all of this leaflet carefully before you start taking this medicine.

-Keep this leaflet, you may need to read it again. If you have any further questions, ask your doctor or pharmacist.

-This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.

-If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Contents of the pack

  1. What is Amoxicillin/Clavulanic Acid ArdineClav and what is it used for
  2. Before taking Amoxicillin/Clavulanic Acid ArdineClav
  3. How to take Amoxicillin/Clavulanic Acid ArdineClav
  4. Possible side effects
  5. Storage of Amoxicillin/Clavulanic Acid ArdineClav
  6. Further information

1. What is Amoxicillin/Clavulanic Acid ArdineClav and what is it used for

Amoxicillin/Clavulanic Acid ArdineClav is an antibiotic that eliminates the bacteria that cause infections. It contains two different active substances called amoxicillin and clavulanic acid. Amoxicillin belongs to a group of medicines known as "penicillins" which can sometimes lose their effectiveness (become inactivated). The other component (clavulanic acid) prevents this from happening.

Antibiotics are used to treat bacterial infections and are not effective against viral infections such as the flu or the common cold.

It is essential to follow the instructions regarding dosage, administration interval, and treatment duration as indicated by your doctor.

Do not store or reuse this medication. If you have any leftover antibiotic after completing the treatment, return it to the pharmacy for proper disposal. Do not dispose of medications through the drain or in the trash.

Amoxicillin/Clavulanic Acid ArdineClav is used in adults and children to treat the following infections:

  • Middle ear and sinus infections
  • Respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections, including dental infections
  • Bone and joint infections
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. Before taking Amoxicillin/Clavulanic Acid ArdineClav

Do not take Amoxicillin/Clavulanic Acid ArdineClav:

  • if you are allergic (hypersensitive) to amoxicillin, clavulanic acid, or any of the other ingredients of Amoxicillin/Clavulanic Acid ArdineClav (see section 6)
  • if you have ever had a severe allergic reaction (hypersensitivity) to any other antibiotic. This could include skin rash or swelling of the face or neck
  • if you have ever had liver problems or jaundice (yellowing of the skin) when taking an antibiotic.

Do not take Amoxicillin/Clavulanic Acid ArdineClav if you are included in any of the above points.If you are unsure, consult your doctor or pharmacist before starting treatment with Amoxicillin/Clavulanic Acid ArdineClav.

Be cautious with Amoxicillin/Clavulanic Acid ArdineClav

Tell your doctor or pharmacist before taking this medicine if:

  • you have infectious mononucleosis
  • you are receiving treatment for liver or kidney problems
  • you do not urinate regularly.

If you are unsure whether any of the above symptoms affect you, inform your doctor or pharmacist before taking Amoxicillin/Clavulanic Acid ArdineClav.

In some cases, your doctor may investigate the type of bacteria causing your infection. Depending on the results, you may be prescribed a different formulation of Amoxicillin/Clavulanic Acid or another medication.

Symptoms to be aware of

Amoxicillin/Clavulanic Acid ArdineClav can worsen certain existing conditions or cause serious side effects. These include allergic reactions, seizures, and inflammation of the large intestine. You should be aware of certain symptoms while taking Amoxicillin/Clavulanic Acid ArdineClav to reduce the risk of problems. See "Symptoms to be aware of" in section 4.

Blood and urine tests

If you are having blood tests (such as red blood cell studies or liver function tests) or urine tests (to check glucose levels), inform your doctor or nurse that you are taking Amoxicillin/Clavulanic Acid ArdineClav. This is because Amoxicillin/Clavulanic Acid ArdineClav can alter the results of these types of tests.

Use of other medications

Tell your doctor or pharmacist if you are using or have recently used other medications, including those obtained without a prescription and herbal medicines.

If you are taking allopurinol (used for gout) with Amoxicillin/Clavulanic Acid ArdineClav, you may be more likely to experience an allergic skin reaction.

If you are taking probenecid (used to treat gout), your doctor may adjust the dose of Amoxicillin/Clavulanic Acid ArdineClav. Concomitant use of probenecid may reduce the excretion of amoxicillin and is not recommended.

If you are taking anticoagulants (such as warfarin) with Amoxicillin/Clavulanic Acid ArdineClav, more blood tests will be needed.

Amoxicillin/Clavulanic Acid ArdineClav may affect the action of methotrexate (a medication used to treat cancer and severe psoriasis or rheumatic diseases). Penicillins can reduce the excretion of methotrexate and cause a potential increase in side effects.

Pregnancy and breastfeeding

If you are pregnant, think you may be pregnant, or are breastfeeding, consult your doctor or pharmacist.

Consult your doctor or pharmacist before using any medication.

Driving and using machines

Amoxicillin/Clavulanic Acid ArdineClav can have side effects and symptoms that may make you unfit to drive.

Do not drive or operate machinery unless you feel well.

3. How to take Amoxicillin/Clavulanic Acid ArdineClav

Follow the instructions for administration of Amoxicillin/Clavulanic Acid ArdineClav exactly as indicated by your doctor. Consult your doctor or pharmacist if you have any doubts.

Adults and children over 40 kg

The usual dose is:

•1 tablet administered three times a day

Children under 40 kg

It is preferable to treat children under 6 years old with the oral suspension of Amoxicillin/Clavulanic Acid ArdineClav or sachets.

Ask your doctor or pharmacist for advice when administering Amoxicillin/Clavulanic Acid ArdineClav tablets to children who weigh less than 40 kg.

Patients with kidney and liver problems

  • If you have kidney problems, your dose may be changed. Your doctor may choose a different formulation or another medication.
  • If you have liver problems, you will have more frequent blood tests to check how your liver is working.

How to take Amoxicillin/Clavulanic Acid ArdineClav

  • Swallow the tablets whole with a glass of water at the start of meals or a little before.
  • Space out the doses during the day, at least 4 hours apart. Do not take 2 doses in 1 hour.
  • Do not take Amoxicillin/Clavulanic Acid ArdineClav for more than 2 weeks. If you are still feeling unwell, consult your doctor.

If you take more Amoxicillin/Clavulanic Acid ArdineClav than you should

If you take too much Amoxicillin/Clavulanic Acid ArdineClav, you may experience symptoms such as stomach upset (nausea, vomiting, or diarrhea) or seizures. Consult your doctor as soon as possible. Bring the package with you to show the doctor.

You can also call the Toxicology Information Service, phone 91 562 04 20, indicating the medication and the amount taken.

If you forget to take Amoxicillin/Clavulanic Acid ArdineClav

If you forget to take a dose, take it as soon as you remember. Do not take the next dose too soon, wait at least 4 hours before taking the next dose.

If you stop taking Amoxicillin/Clavulanic Acid ArdineClav

Continue taking Amoxicillin/Clavulanic Acid ArdineClav until you finish the treatment, even if you feel better. You need to take the complete treatment to cure the infection. If you do not, the surviving bacteria may cause the infection to return.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, Amoxicillin/Clavulanic Acid ArdineClav can cause side effects, although not everybody gets them. The side effects described below may occur when taking this medication.

Symptoms to be aware of

Allergic reactions

  • skin rash
  • inflammation of blood vessels (vasculitis) that can appear as red or purple spots on the skin, but can affect other parts of the body
  • fever, joint pain, swollen glands in the neck, armpits, or groin
  • swelling, sometimes of the face or mouth (angioedema), which can cause difficulty breathing
  • collapse

Contact a doctor immediatelyif you experience any of these symptoms. Stop taking Amoxicillin/Clavulanic Acid ArdineClav.

Inflammation of the large intestine

Inflammation of the large intestine, which causes watery diarrhea, usually with blood and mucus, stomach pain, and/or fever.

Contact your doctor as soon as possiblefor advice if you have these symptoms.

Very common side effects

May affect more than 1 in 10 patients

  • diarrhea (in adults).

Common side effects

May affect up to 1 in 10 patients

  • thrush (candida - fungal infection in the vagina, mouth, or mucous membranes)
  • nausea, especially when taking high doses; if this happens, take Amoxicillin/Clavulanic Acid ArdineClav before meals
  • vomiting
  • diarrhea (in children).

Uncommon side effects

May affect up to 1 in 100 patients

  • skin rash, itching
  • increased itching (urticarial)
  • indigestion
  • dizziness
  • headache.

Uncommon side effects that may appear in your blood or urine tests:

  • increase in some substances (enzymes) produced by the liver.

Rare side effects

May affect up to 1 in 1,000 patients

  • skin rash that can form blisters, which look like small targets (central dark spot surrounded by a paler area, with a dark ring around the edge - erythema multiforme)

Rare side effects that may appear in your blood tests:

  • low count of cells involved in blood clotting
  • low count of white blood cells

Other side effects

Other side effects that have occurred in a very small number of patients and whose frequency is not known:

  • Allergic reactions (see above)
  • Inflammation of the large intestine (see above)
  • Inflammation of the membrane that surrounds the brain and spinal cord (aseptic meningitis)
  • Severe skin reactions:
  • widespread rash with blisters and peeling of the skin, particularly around the mouth, nose, eyes, and genitals (Stevens-Johnson syndrome), and in its most severe form, causing widespread peeling of the skin (more than 30% of the body surface - toxic epidermal necrolysis)
  • widespread rash with small blisters containing pus (bullous exfoliative dermatitis)
  • red rash with bumps under the skin and blisters (pustular exanthematous)
  • flu-like symptoms with skin rash, fever, swollen glands, and abnormal blood test results (such as increased white blood cells (eosinophilia) and elevated liver enzymes) (drug reaction with eosinophilia and systemic symptoms (DRESS)).
  • Chest pain in the context of allergic reactions, which can be a symptom of allergy-induced myocardial infarction (Kounis syndrome).
  • Drug-induced enterocolitis syndrome (DIES): DIES has been reported mainly in children who receive amoxicillin. It is a certain type of allergic reaction with the main symptom of repeated vomiting (1-4 hours after taking the medication). Other symptoms may include abdominal pain, lethargy, diarrhea, and low blood pressure.
  • Crystals in the urine that cause acute kidney injury
  • Rash with blisters arranged in a circle with a central crust or like a string of pearls (linear IgA disease)
  • Inflammation of the membranes that surround the brain and spinal cord (aseptic meningitis)
  • Acute inflammation of the pancreas (acute pancreatitis).

If you have severe and persistent stomach pain, this could be a sign of acute pancreatitis.

  • Contact a doctor immediately if you have any of these symptoms.
  • inflammation of the liver (hepatitis)
  • jaundice, caused by increased bilirubin in the blood (a substance produced by the liver) that can make the skin and the whites of the eyes turn yellow
  • inflammation of the kidney ducts
  • delayed blood clotting
  • hyperactivity
  • seizures (in patients taking high doses of Amoxicillin/Clavulanic Acid or with kidney problems)
  • black hairy tongue
  • stained teeth (in children), which usually disappears with brushing.

Side effects that may appear in your blood or urine tests:

  • significant reduction in the number of white blood cells
  • low count of red blood cells (hemolytic anemia)
  • crystals in the urine.

Reporting of side effects

If you experience any side effects, consult your doctor, pharmacist, or nurse, even if it is a possible side effect not listed in this leaflet. You can also report them directly through the Spanish Medicines Surveillance System for Human Use: http://www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medication.

5. Storage of Amoxicillin/Clavulanic Acid ArdineClav

Do not store above 25°C.

Keep in the original packaging to protect from moisture.

Keep out of the reach and sight of children.

Do not use Amoxicillin/Clavulanic Acid ArdineClav after the expiration date stated on the packaging. The expiration date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Deposit the packaging and any unused medication in the pharmacy's SIGRE collection point. If in doubt, ask your pharmacist how to dispose of the packaging and any unused medication. This will help protect the environment.

6. Further information

Composition of Amoxicillin/Clavulanic Acid ArdineClav 500 mg/125 mg film-coated tablets

The active substances are amoxicillin and clavulanic acid. Each tablet contains:

Amoxicillin (as amoxicillin trihydrate) 500 mg

Clavulanic acid (as potassium clavulanate) 125 mg

The other ingredients (excipients) are: colloidal anhydrous silica, magnesium stearate, sodium starch glycolate (type A) (derived from potato starch), and microcrystalline cellulose 112.

Coating: Opadry Oy-S-7300 (hypromellose (hydroxypropylmethylcellulose (E464)), macrogol (polyethylene glycol) 4000 (E1521), macrogol (polyethylene glycol) 6000 (E1521), and titanium dioxide (E-171)), dimethicone 500, and purified water.

Appearance of the product and packaging contents

White, film-coated, elongated tablets with a score line and engraved with A/C.

Packaging containing 30 or 500 film-coated tablets.

Marketing authorization holder and manufacturer

Holder:

Laboratorio REIG JOFRE, S.A.

Gran Capitan 10, 08970 Sant Joan Despí (Barcelona), Spain

Manufacturer:

Laboratorio REIG JOFRE, S.A.

C/Jarama 111, Pol Industrial

45007 Toledo, Spain

This leaflet was last revised in January 2023.

Detailed and updated information on this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

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General surgery 12 years exp.

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Alexander Nazarchuk

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Frequently Asked Questions

Is a prescription required for AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS?
AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS?
The active ingredient in AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS is amoxicillin and beta-lactamase inhibitor. This information helps identify medicines with the same composition but different brand names.
How much does AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS cost in pharmacies?
The average pharmacy price for AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS is around 5.84 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS?
AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS is manufactured by Laboratorio Reig Jofre, S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to AMOXICILLIN/CLAVULANIC ACID ARDINECLAV 500/125 mg FILM-COATED TABLETS?
Other medicines with the same active substance (amoxicillin and beta-lactamase inhibitor) include AMOXICILLIN / CLAVULANIC ACID SANDOZ 250 mg/62.5 mg/5 ml ORAL SUSPENSION POWDER, AMOXICILLIN CLAVULANATE POWDER FOR SOLUTION FOR INFUSION 2000 mg/200 mg, AMOXICILLIN CLAVULANATE SUN 500 mg/125 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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