Mpox (monkeypox)
Mpox is a viral infection that until recently was called monkeypox. The name was an accident of history: monkeys simply happened to be the first animals the…
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Mpox is a viral infection that until recently was called monkeypox. The name was an accident of history: monkeys simply happened to be the first animals the virus was spotted in, while its natural home is small African rodents. Between people it moves differently — by close bodily contact — so it does not circulate like flu but more like an infection tied to intimacy. It causes fever and a very characteristic rash, and in most adults it settles on its own within two to four weeks. What makes it dangerous is the exceptions: small children, pregnant women and people with weakened immunity have a hard time of it, and a lesion on the eye can cost sight. This page is about recognising mpox, what to do in the first few days, and when to stop waiting.
How it starts and what the rash looks like
Between catching it and the first signs there are usually five days to three weeks, most often about a week. The start resembles any viral illness: fever, headache, aching muscles and lower back, chills, a flattening tiredness. There is one detail that sets it apart from measles and chickenpox — clearly swollen glands in the neck, under the jaw, in the groin or the armpits.
One to five days later the rash appears, and it goes through stages: a flat spot, then a firm bump, then a blister filled with clear fluid, then a pustule with a dented centre and finally a scab that stays for several days and drops off. The lesions tend to hurt rather than itch. One important feature: within a single patch of skin they are all roughly the same age, turning into blisters together and drying together. In chickenpox fresh spots sit beside old scabs, and that is one of the main differences.
They can come up anywhere, including the palms and the soles, where almost no childhood rash appears. The mouth and tongue are often involved, which makes eating and swallowing painful. If the infection was passed on during sex, the first lesions may be only on the genitals or around the anus, sometimes just one or two ulcers, and there may be no general rash at all.
Involvement of the rectum deserves a separate mention: severe anal pain, a constant false urge to open the bowels, discharge and blood. It is a common and thoroughly miserable form, and a regular reason for admission to hospital purely to get the pain under control. The whole illness lasts two to four weeks. A person stays infectious until every scab has fallen off and new skin has formed underneath.
How it is passed on
The main route is direct skin-to-skin and mucosa-to-mucosa contact: hugging, kissing, massage, sex of any kind. The virus sits in blister fluid, in pus and in scabs, so touching the lesions passes it on, and so does touching the bedding, towels, clothing, crockery or sex toys of someone who has it. A long face-to-face conversation with someone who has mouth ulcers can also end in infection, but that takes closeness and time: mpox does not drift across a room.
A condom lowers the risk without removing it, because it does not cover all the skin that touches. The virus is also found in semen, which is why using condoms for about twelve weeks after recovery is advised.
The third route is from animals, and it applies only in those parts of Africa where the virus lives permanently: a rodent bite or scratch, butchering a carcass, eating bushmeat that has not been cooked through. After coming back from there it is worth keeping an eye on yourself for three weeks.
Pregnancy is a chapter of its own: the virus crosses the placenta and can cause loss of the pregnancy and congenital infection in the baby. Any suspicion of contact means seeing a doctor without delay.
What it is mistaken for
Almost anything that produces blisters and sores. Chickenpox — the difference lies in the age of the lesions and in the swollen glands. Herpes — herpes makes a cluster of small blisters in one spot and keeps returning to the same place, while mpox scatters more widely and comes with fever and glands. Syphilis — its ulcer is painless and feels firm, which is why a syphilis test is always done when the picture looks like this. Scabies, an infected hair follicle, an ordinary boil. And finally a drug reaction.
Deciding by eye is a poor idea: the more it resembles something familiar, the easier it is to get it wrong. All of these are treated differently, and some of them go on being passed to partners for as long as they go unrecognised.
How the diagnosis is confirmed
The diagnosis comes from the laboratory, not from looking. A swab is taken from a lesion — fluid from a blister, a scraping from the base of an ulcer, or a scab that has come away — and sent for PCR. That test finds the virus itself, and it is the one that answers the question. A throat or rectal swab is added if there are few lesions but symptoms are there.
It is just as useful to know what does not make the diagnosis. An ordinary blood count will show inflammation and say nothing about the cause. Antibody testing is no good as a diagnostic test: antibodies appear late and do not tell infection apart from a past smallpox vaccination. Asking for "a blood test for monkeypox" leads nowhere; what is needed is the swab from the skin.
While you are there, it is worth being checked for other sexually transmitted infections: they travel together, and half of them clear within a week once found.
When help is needed urgently
For most people mpox is got through at home. But there are signs that mean not waiting and calling an ambulance; across Europe the single emergency number is 112:
- lesions on the eyelid or on the eye itself, eye pain, discomfort in bright light, worsening vision — the cornea scars quickly and permanently;
- severe headache, confusion, fits, a stiff neck;
- difficulty breathing, or being unable to swallow even water;
- abdominal pain, vomiting that will not stop, signs of dehydration;
- spreading redness, swelling and heat around the lesions, pus, red streaks up the skin — that is a bacterial infection on top;
- severe rectal pain, inability to pass urine or to open the bowels.
Same-day advice, though without an ambulance, is needed if the rash appears in a baby, in a pregnant woman, in someone with untreated HIV, after a transplant or while taking medicines that damp down immunity. In these groups the illness is a good deal more serious and they should be followed from the start.
What the treatment is
There is as yet no specific medicine that reliably shortens the illness: antivirals are used in hospital for severe disease and within trials, and their benefit is not fully proven. The mainstay is supportive care, and it deals with the main problem, which is pain.
Pain is treated with paracetamol and, where needed, anti-inflammatory painkillers. Ibuprofen and its relatives do not suit everyone: with a stomach ulcer, kidney disease, high blood pressure, in late pregnancy and alongside anticoagulants they are taken only with a doctor's agreement. For mouth ulcers, rinses and anaesthetic gels help; for the rectum, sitz baths, stool softeners and pain relief that sometimes has to be worked out on a ward.
The skin is kept clean and dry, and lesions are neither scratched nor burst: that is how scars are left and bacteria get in. A weeping scab is covered with a dry dressing. Hands are washed after every contact with the rash and the eyes are left alone — the easiest way to get the virus onto your own cornea is with your own fingers.
How not to pass it on, and how to stay clear of it
Until the rash has healed, a person is infectious. For that stretch it is better to sleep separately, not to share towels, bedding or crockery, to wash clothes separately and without shaking them out, and to cover the lesions with clothing or a dressing when leaving the room. Sex and any intimate contact are put off until healing is complete, and condoms are used for a further twelve weeks. Pets, rodents above all, are best kept at a distance too: the virus can move to them.
Vaccination is worth discussing in advance. Modern smallpox vaccines also protect against mpox, and they are offered to people at high risk of catching it and to those who have already been in contact with a case. In the second situation speed is what counts: the sooner after the contact the vaccine is given, the more it does, and the sensible window is the first few days. Who is offered it free of charge is decided differently in each country, so that question belongs to a doctor rather than to the internet.
Online consultation
A rash is precisely the sort of problem where a remote appointment earns its keep. What the doctor needs is a photograph in good light and the account: when it started, which came first, the fever or the spots, where the first lesions appeared, whether there are ulcers in the mouth, whether the glands are up, and whether the past three weeks brought new partners, contact with a case or a trip abroad. From that the main things get settled: whether this looks like mpox, where to go for the swab, whether other infections should be ruled out at the same time, and what to do about the pain today.
A part of the conversation of its own is how not to infect the household: what to wash, what to clean with, where to sleep, how long this will go on and when normal life can resume. Here a calm, detailed answer is worth more than an examination.
The limits are worth naming honestly. A swab cannot be taken through a screen and the diagnosis cannot be confirmed online; the doctor will say where to go. And with eye pain, confusion, difficulty breathing or an inability to drink, what is needed is an ambulance rather than an appointment.
This material is for information only and does not replace medical advice.
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Discuss your symptoms and possible next steps for Mpox (monkeypox) with a doctor online.
