Первичный билиарный холангит
Первичный билиарный холангит – это хроническое аутоиммунное заболевание печени, при котором постепенно разрушаются мелкие желчные протоки, что может приводить к холестазу и фиброзу печени.
На этой странице
- Symptoms of PBC
- How PBC is diagnosed
- Causes of PBC
- How PBC is treated
- Complications of PBC
- Symptoms Primary biliary cholangitis (primary biliary cirrhosis)
- Advanced PBC
- Treatment Primary biliary cholangitis (primary biliary cirrhosis)
- Self-help
- Avoid certain medicines
- Ursodeoxycholic acid
- Obeticholic acid
- Elafibranor
- Treating itchiness
- Alternative treatments for itching
- Managing fatigue
- Treating dry mouth and eyes
- Liver transplant
Лекарства, которые могут применяться при Первичный билиарный холангит
Информация приведена только в справочных целях. Перед приемом любых лекарств проконсультируйтесь с врачом.
Форма выпуска и дозировка: ТАБЛЕТКА, 300 мгДействующее вещество: урсодезоксихолевая кислотаПроизводитель лекарства: Glenmark Arzneimittel GmbhОтпускается по рецептуФорма выпуска и дозировка: ТАБЛЕТКА, 450 мгДействующее вещество: урсодезоксихолевая кислотаПроизводитель лекарства: Glenmark Arzneimittel GmbhОтпускается по рецептуФорма выпуска и дозировка: КАПСУЛА, 500 мгДействующее вещество: урсодезоксихолевая кислотаПроизводитель лекарства: Laboratorio Estedi S.L.Отпускается по рецепту
Primary biliary cholangitis (PBC, often referred to as primary biliary cirrhosis) is a type of liver disease that can get gradually worse over time. Without treatment, it may eventually lead to liver failure.
Symptoms of PBC
PBC does not always cause symptoms, but some people may experience:
- bone and joint aches
- fatigue (extreme tiredness)
- itchy skin
- dry eyes and mouth
- pain or discomfort in the upper right side of their tummy
Read more about the symptoms of PBC
How PBC is diagnosed
Many people are only diagnosed with PBC after having a routine blood test for another reason. PBC can usually be diagnosed just using blood tests.
Once PBC is diagnosed, you'll also need an ultrasound scan to help rule out other problems with your bile ducts and assess your liver.
A liver biopsy is occasionally recommended to assess your liver and help doctors decide on the best treatment.
This involves safely removing a small sample of liver tissue so it can be studied under a microscope.
Causes of PBC
Bile is a liquid produced inside the liver that's used to help digest fats, absorb certain vitamins and remove waste products from the body. It passes out of the liver through small tubes called bile ducts.
In PBC, the immune system (the body's natural defence against infection and illness) mistakenly attacks the bile ducts.
It's not clear why this happens, but it's thought to be caused by a combination of subtle differences in how the immune system works.
The bile ducts become damaged and injured, causing bile to build up in the liver. This further damages the liver and may lead to scarring (cirrhosis).
How PBC is treated
PBC is a progressive condition, which means the damage to the liver can steadily get worse over time.
The rate at which PBC progresses varies between individuals. Sometimes, it can take decades.
Without treatment, the liver can become so badly damaged that it no longer works properly. This is known as liver failure and can be fatal.
Current treatments such as ursodeoxycholic acid and obeticholic acid can help slow down liver damage caused by PBC.
Other medicines can help relieve the itchiness associated with PBC. Occasionally, if the liver is severely damaged, a liver transplant may be needed.
Read more about treating PBC
Complications of PBC
If PBC is not treated or reaches an advanced stage, there may be other problems including:
- osteoporosis – a condition in which the bones become weak and brittle
- portal hypertension – increased blood pressure inside the blood vessels in your abdomen
- ascites – a build-up of fluid in your abdomen (stomach) and around your intestines
- vitamin deficiencies – including vitamins A, D, E and K
- a slightly increased risk of developing liver cancer
Symptoms Primary biliary cholangitis (primary biliary cirrhosis)
Most people are only diagnosed with PBC after having a routine blood test for another reason. Some people have symptoms early on and some may develop them later.
People who have symptoms may experience:
- bone or joint aches
- fatigue – this is a common symptom (but not always caused by PBC) and can have a significant impact on your daily activities
- itchy skin – this can be widespread or only affect a single area; it may be worse at night, when in contact with fabrics, when warm, or during pregnancy
- dry eyes and mouth
- feeling very sleepy during the day
- pain or discomfort in the upper right side of the tummy
Symptoms can range from mild to severe, and this is not always related to the degree of liver damage you have.
Some people with PBC have severe symptoms but their liver is not severely damaged, while others may have significant liver damage but no symptoms or only mild ones.
If you have PBC, you may also have symptoms of another condition, such as an underactive thyroid (hypothyroidism).
Advanced PBC
Medicine can usually help delay liver damage caused by PBC.
But as the liver slowly becomes more scarred and damaged (eventually leading to cirrhosis), you may have additional symptoms.
These can include:
- yellowing of the whites of the eyes and the skin (jaundice), although this may be less noticeable on brown or black skin
- a build-up of fluid in the legs, ankles and feet (oedema)
- build-up of fluid in your tummy that can make you look heavily pregnant (ascites)
- the formation of small fatty deposits on the skin, usually around your eyes (xanthelasmata)
- dark urine and pale stools
- a tendency to bleed and bruise more easily
- problems with memory and concentration
Read more about the symptoms of cirrhosis
Treatment Primary biliary cholangitis (primary biliary cirrhosis)
The aim of treatment for PBC is to slow down the liver damage and reduce your symptoms.
Self-help
All types of liver disease, including PBC, can be helped by following some general health advice.
You should:
- stop smoking
- eat a balanced diet
- stop drinking alcohol, or only drink a small amount, depending on how much liver damage you have
Following this advice could:
- help prevent PBC getting worse
- mean all the treatments for PBC are available to you if you need them – for example, a liver transplant
Avoid certain medicines
The damage to your liver can affect its ability to process certain medicines.
This means you may need to avoid certain medicines – for example, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen.
Ask your doctor about any medicines you should avoid. Tell a pharmacist or any healthcare professional treating you that you have PBC.
Ursodeoxycholic acid
Ursodeoxycholic acid (UDCA) is the main treatment for PBC.
It can help delay liver damage in most people, particularly if you start taking it in the early stages of the condition. But it does not improve symptoms such as fatigue.
Once you start taking UDCA, it's likely you'll need to take it for the rest of your life.
You may need regular blood tests to monitor your liver function, and you'll be assessed after a year to see if you've responded to UDCA. If not, you may need additional treatment.
Side effects
Side effects of UDCA can include diarrhoea and feeling and being sick.
Obeticholic acid
Obeticholic acid (OCA) is a treatment that works by improving bile flow and reducing inflammation.
It may be offered as an option for treating PBC, either:
- in combination with UDCA – if UDCA is not working well enough
- on its own – for people who cannot take UDCA
People who may need OCA will first need to be assessed by a specialist team with experience in treating PBC.
Side effects
A possible side effect of OCA is itching. If itching is a problem, your dose may be lowered or you may be offered medicine to treat the itching.
If you have very advanced liver disease, you may be prescribed a lower dose of OCA.
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Elafibranor
Elafibranor is a treatment that works by reducing the amount of bile acid you produce. It also makes the bile acid you produce less damaging to your liver.
It may be offered as an option for treating PBC, either:
- in combination with UDCA – if UDCA is not working well enough
- on its own – for people who cannot take UDCA
Side effects
Side effects of elafibranor can include constipation, diarrhoea, headaches and feeling and being sick.
Treating itchiness
Colestyramine (previously called cholestyramine) is a medicine widely used to treat the itchiness associated with PBC.
It usually comes in sachets as a powder that can be dissolved in water or fruit juice. It's a good idea to take the powder with fruit juice because it has an unpleasant taste.
You may need to take colestyramine for a few days before your symptoms begin to improve.
If you're taking UDCA as well as colestyramine, you should avoid taking them at the same time because colestyramine will affect how your body absorbs UDCA.
You should take UDCA at least 1 hour before colestyramine, or 4 to 6 hours afterwards.
This also applies to any other medicines you're taking. A GP can give you further advice about this.
Constipation is a common side effect of colestyramine, although this usually improves once your body gets used to the medicine. Other side effects can include bloating and headache.
If you're taking colestyramine long term, it may affect your body's ability to absorb vitamins A, D and K and folic acid from food. Taking additional vitamin supplements may be beneficial.
A GP can advise you about whether you would benefit from taking vitamin supplements.
Alternative treatments for itching
See a GP if your itchiness does not improve after taking colestyramine.
Alternative medicines are available, such as an antibiotic called rifampicin and a medicine called naltrexone.
These are usually only prescribed by the specialist that looks after your PBC – for example, a gastroenterologist or hepatologist (liver specialist).
Regularly using moisturisers to stop your skin becoming dry may also help reduce itchiness.
Managing fatigue
No medicines are currently available to specifically treat fatigue associated with PBC.
A GP may want to rule out and treat any other possible causes for your tiredness, such as iron deficiency anaemia (a lack of red blood cells), sleep apnoea, or depression.
You should try to exercise whenever possible, but you may need to pace yourself and limit your daily activities to a manageable level.
Adjusting your daily routine around fatigue (which is often worse later in the day) can make a big difference to your quality of life.
If you have difficulty sleeping (insomnia), sleep hygiene measures may help. These include avoiding caffeine, nicotine and alcohol late at night, and ensuring you have a comfortable sleeping environment.
Treating dry mouth and eyes
If you have a dry mouth and eyes, a GP may recommend eyedrops containing "artificial tears" or saliva substitute products.
You should take care of your teeth and gums and visit a dentist regularly because having a dry mouth can increase your risk of tooth decay.
Liver transplant
A liver transplant may be recommended if it's thought the liver damage may eventually put your life at risk.
Planning for a liver transplant often begins before significant damage to the liver has taken place. This is because the waiting time for a liver transplant may be longer than 3 months for adults, so it's important your specialist doctor considers assessment and listing for transplantation as soon as possible.
Having a liver transplant will cure the itchiness and other symptoms, but you may still have fatigue.
Like all organ transplants, liver transplants carry a risk of complications. Your immune system may reject a donated liver, which could be life threatening.
Medicines that suppress the immune system are very effective at preventing this, but they need to be taken for life to reduce this risk.
Most people live more than 10 years after having a liver transplant.
But having a liver transplant does not always completely cure PBC. Some people who have a liver transplant for PBC develop the condition in their new liver. This is known as recurrent PBC.
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