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PROPOFOL FARMUNION

PROPOFOL FARMUNION

Ask a doctor about a prescription for PROPOFOL FARMUNION

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Doctor

Svetlana Kolomeeva

Cardiology18 years of experience

Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use PROPOFOL FARMUNION

INSTRUCTIONS for medical use of the medicinal product ALLERGODIL®(ALLERGODIL®)

Composition

active substance: azelastine hydrochloride; 1 ml of solution contains azelastine hydrochloride 1 mg; excipients: hypromellose, disodium edetate, anhydrous citric acid, sodium hydrogen phosphate, dodecahydrate, sodium chloride, purified water.

Pharmaceutical form

Nasal spray, dosed.

Main physical and chemical properties

Transparent colorless solution.

Pharmacotherapeutic group

Agents used in diseases of the nasal cavity. Antiallergic agents, excluding corticosteroids. ATC code R01A C03.

Pharmacological properties

Pharmacodynamics

Azelastine hydrochloride is an H1-receptor antagonist and, as a result, is an antiallergic substance with a relatively long half-life (t1/2 @ 20 hours).

In addition, in vivo studies in guinea pigs have shown that when used in therapeutic doses for humans, azelastine hydrochloride inhibits bronchial spasm caused by leukotrienes and platelet-activating factor (PAF) inhibitors.

Due to these properties, in animal experiments, azelastine hydrochloride is also able to inhibit inflammation in the airways caused by hypersensitivity reactions. The significance of the findings obtained in animal studies has not been clarified regarding the therapeutic application of the drug in humans.

Pharmacokinetics

Azelastine hydrochloride is quickly and almost completely absorbed after oral administration and is mainly distributed in peripheral organs, primarily in the lungs, skin, muscles, liver, and kidneys, and to a minor extent in the brain. Dose-dependent linear kinetics have been demonstrated. Azelastine hydrochloride and its metabolites are excreted approximately 75% with feces and approximately 25% by the kidneys. The most important metabolic pathways are hydroxylation of the ring, N-demethylation, and oxidative opening of the azepine ring.

In patients with allergic rhinitis, the steady-state average concentration of azelastine hydrochloride in plasma, observed 2 hours after administration of the total daily dose of 0.56 mg of azelastine hydrochloride (1 spray in each nostril 2 times a day), was approximately 0.65 ng/ml, but this did not lead to clinically significant systemic side effects.

As a result of the dose-dependent linear effect, an increase in average plasma levels can be expected with an increase in the daily dose.

Clinical characteristics

Indications

Symptomatic treatment of seasonal allergic rhinitis (hay fever) and non-seasonal (perennial) allergic rhinitis.

Contraindications

Increased sensitivity to the active substance, ethylenediaminetetraacetic acid (EDTA), or to any other component of the drug.

The drug is contraindicated in children under 6 years of age.

Interaction with other medicinal products and other types of interactions

So far, no interaction with other drugs has been detected.

Special warnings and precautions for use

None.

Use during pregnancy or breastfeeding

Clinical data on the use of azelastine hydrochloride in women during pregnancy or breastfeeding are absent. Studies in animals with high oral doses of azelastine led to embryo death, delayed development, and skeletal defects.

Therefore, it is not recommended to use the drug during pregnancy or breastfeeding.

Ability to influence the reaction rate when driving vehicles or operating other mechanisms

When using the drug, in individual cases, increased fatigue, exhaustion, fatigue, dizziness, or weakness may occur, which can also be caused by the disease itself. In these cases, the reaction rate when driving a vehicle or working with other mechanisms may be reduced. Special attention should be paid to the fact that these symptoms can be exacerbated by the simultaneous use of alcohol and other drugs that negatively affect the reaction rate.

Method of administration and dosage

For nasal use.

Unless otherwise prescribed, the spray should be administered 1 dose in each nostril 2 times a day (in the morning and evening; corresponds to a daily dose of azelastine hydrochloride 0.56 mg/day).

When using the spray, the head should be kept straight.

The duration of therapy depends on the type, severity, and development of symptoms and is determined by the doctor individually.

The drug can be used for long-term therapy.

Children

Can be used in children from 6 years of age.

Overdose

There is no experience with the use of toxic doses of azelastine hydrochloride in humans. In case of overdose or intoxication, central nervous system disorders are expected based on the results of experiments on animals. Treatment of these disorders should be symptomatic. There is no known antidote.

Side effects

Side effects that may occur during the use of azelastine hydrochloride are classified according to the following frequency: very often (≥ 1/10), often (≥ 1/100 – < 1/10), uncommon (≥ 1/1000 – <1/100), rare (≥ 1/10000 – < 1/1000), very rare (< 1/10000), unknown (cannot be determined from available data).

From the immune system: very rare – hypersensitivity reactions.

From the nervous system: often – dysgeusia (in case of incorrect use (head thrown back) may cause symptoms of a bitter taste in the mouth, which can cause nausea); very rare – dizziness.

From the respiratory system: uncommon – irritation of the nasal mucosa with inflammation after spraying (such as burning and itching), sneezing, and nasal bleeding.

From the gastrointestinal tract: rare – nausea.

General disorders: very rare – increased fatigue (feeling of fatigue and exhaustion), dizziness or weakness, which can also be caused by the disease itself.

From the skin: very rare – rash, itching, urticaria.

Also, reports of drowsiness, headache, and dry mouth have been reported in some patients.

Shelf life

3 years.

After opening the bottle, the drug should be used within 6 months.

Storage conditions

Store at a temperature not exceeding 25 °C. Do not cool. The drug should be stored in a place inaccessible to children.

Packaging

10 ml in a bottle with a screwed-on sprayer; 1 bottle in a cardboard box.

Release category

Without a prescription.

Manufacturer

Madaus GmbH / Madaus GmbH.

Location of the manufacturer and its address

Lutticher Strasse 5, 53842 Troisdorf, Germany / Lutticher Strasse 5, 53842 Troisdorf, Germany.

Alternatives to PROPOFOL FARMUNION in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to PROPOFOL FARMUNION in España

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Online doctors for PROPOFOL FARMUNION

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for PROPOFOL FARMUNION – subject to medical assessment and local rules.

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If you’re struggling with chronic pain, migraines, nerve disorders, or sleep problems, Dr. Agapova offers professional guidance to restore your well-being.

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Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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