Background pattern
XERMELO 250 mg FILM-COATED TABLETS

XERMELO 250 mg FILM-COATED TABLETS

Ask a doctor about a prescription for XERMELO 250 mg FILM-COATED TABLETS

5.0(32)
Doctor

Nuno Tavares Lopes

Family medicine17 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC. He offers online consultations in Portuguese, English, and Spanish — combining global expertise with a patient-centred, evidence-based approach.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.
CameraBook a video appointment
€59
Today14:55
Today15:15
Today15:35
Today15:55
Today16:15
More times
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use XERMELO 250 mg FILM-COATED TABLETS

Introduction

Package Leaflet: Information for the Patient

Xermelo 250 mg film-coated tablets

telotristat ethyl

This medicinal product is subject to additional monitoring, which will allow for the quick identification of new safety information. You can help by reporting any side effects you may get. The last section of section 4 will tell you how to report side effects.

Read all of this leaflet carefully before you start taking this medicine, because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Xermelo and what is it used for
  2. What you need to know before you take Xermelo
  3. How to take Xermelo
  4. Possible side effects
  5. Storage of Xermelo
  6. Contents of the pack and other information

1. What is Xermelo and what is it used for

What is Xermelo

This medicine contains the active substance telotristat ethyl.

What Xermelo is used for

This medicine is used in adults with a condition called “carcinoid syndrome”, which occurs when a tumour, called a “neuroendocrine tumour”, releases a substance called serotonin into the bloodstream.

Your doctor will prescribe this medicine to you if your diarrhoea is not well controlled with injections of other medicines called “somatostatin analogues” (lanreotide or octreotide). You should continue to receive injections of these other medicines while you are taking Xermelo.

How Xermelo works

When the tumour releases too much serotonin into the bloodstream, you may get diarrhoea.

This medicine works by reducing the amount of serotonin produced by the tumour and reducing diarrhoea.

2. What you need to know before you take Xermelo

Do not take Xermelo:

  • If you are allergic to telotristat or any of the other ingredients of this medicine

(listed in section 6).

Warnings and precautions

Talk to your doctor or pharmacist before taking Xermelo:

  • If you have liver problems. This is because this medicine has not been studied in patients with severe liver problems. Your doctor will decide if you need to reduce your daily dose of Xermelo. Your doctor will also monitor your liver.
  • If you have kidney problems. This is because this medicine has not been fully studied

in patients with kidney problems.

Looking for side effects

Tell your doctor immediately if you get any of the following signs and symptoms that your liver may not be working properly:

  • Feeling or being sick (nausea or unexplained vomiting), unusually dark urine, yellow skin or eyes, pain in the right upper side of your stomach.

Your doctor will do blood tests to check how your liver is working and will decide if you should keep taking this medicine.

Talk to your doctor or pharmacist:

  • If you feel unenthusiastic, depressed or if you have no interest or pleasure in doing your usual activities, while taking this medicine.
  • If you get signs of constipation, because telotristat reduces the number of bowel movements.

Tests

  • Your doctor may do blood tests before you start taking this medicine and while you are taking it. This is to check that your liver is working normally.

Children and adolescents

This medicine is not recommended for patients under 18 years of age, because it has not been studied in this age group.

Other medicines and Xermelo

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This is because Xermelo may affect the way other medicines work or other medicines may affect the way Xermelo works. This might mean that your doctor needs to change the doses of your medicines. You should tell your doctor about all medicines, including:

  • Medicines for diarrhoea. Both Xermelo and these types of medicines reduce the number of bowel movements and, when taken together, may cause severe constipation. Your doctor may need to change the dose of your medicines.
  • Medicines used to treat epilepsy, such as valproic acid.
  • Medicines used to treat neuroendocrine tumours, such as sunitinib or everolimus.
  • Medicines used to treat depression, such as bupropion or sertraline.
  • Medicines used to prevent transplant rejection, such as cyclosporin.
  • Medicines used to lower cholesterol levels, such as simvastatin.
  • Oral contraceptives, such as ethinylestradiol.
  • Medicines used to treat high blood pressure, such as amlodipine.
  • Octreotide. If you need treatment with subcutaneous injections of octreotide, you should receive the injection at least 30 minutes after taking Xermelo.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Do not take this medicine if you are pregnant or think you might be pregnant. It is not known how telotristat may affect the baby.

Women must use effective contraceptive methods during treatment with this medicine.

Do not breast-feed while taking Xermelo, because this medicine may pass into the breast milk.

Driving and using machines

Telotristat may have a small effect on your ability to drive or use machines or tools. If you feel tired, wait until you feel better before driving or using machines or tools.

Xermelo contains lactose

Xermelo contains lactose (a type of sugar). If your doctor has told you that you have an intolerance to some sugars, talk to them before taking this medicine.

3. How to take Xermelo

Always take this medicine exactly as your doctor or pharmacist has told you. If you are not sure, check with your doctor or pharmacist.

How much to take

The recommended dose is one tablet (250 mg) three times a day. The maximum dose of Xermelo is 750 mg in 24 hours.

Your doctor will decide how long you should take Xermelo.

If you have liver problems, your doctor will decide if you need to reduce your daily dose of Xermelo.

How to take this medicine

  • Always take this medicine with a meal or with some food.
  • You should continue to receive injections of somatostatin analogues (lanreotide or octreotide) while you are taking Xermelo.

If you take more Xermelo than you should

You may feel or be sick, get diarrhoea or stomach pain. Talk to a doctor. Take the medicine pack with you.

If you forget to take Xermelo

If you forget to take a dose, take the next dose when it is due, skipping the missed dose. Do not take a double dose to make up for a forgotten dose.

If you stop taking Xermelo

Do not stop taking Xermelo without talking to your doctor.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Tell your doctor immediately if you get any of the following side effects:

  • Feeling or being sick, unusually dark urine, yellow skin or eyes, pain in the upper right side of your stomach. These may be signs that your liver is not working properly. This may be shown by changes in your blood test results, such as increased liver enzymes: gamma-glutamyl transferase (very common, may affect more than 1 in 10 people), transaminases and alkaline phosphatase in the blood (common, may affect up to 1 in 10 people).

Other side effects

Tell your doctor, pharmacist or nurse if you get any of the following side effects:

Very common side effects:

  • Stomach pain (abdominal pain)
  • Feeling tired or weak (fatigue)

Common side effects:

  • Wind
  • Fever
  • Headache
  • Constipation
  • Bloated stomach
  • Loss of appetite
  • Swelling (fluid build-up in the body)

Tell your doctor, pharmacist or nurse if you get any of the side effects listed above.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Xermelo

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. The expiry date refers to the last day of that month.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help to protect the environment.

6. Contents of the pack and other information

What Xermelo contains

  • The active substance is telotristat ethyl. Each tablet contains telotristat ethyl equivalent to 250 mg of telotristat ethyl.
  • The other ingredients are: anhydrous lactose (see section 2 “Xermelo contains lactose”), hydroxypropylcellulose, sodium croscarmellose, magnesium stearate, silica, colloidal anhydrous, polyvinyl alcohol (partially hydrolysed) (E1203), titanium dioxide (E171), macrogol 3350 (E1521) and talc (E553b).

Appearance and packaging

The tablets are white to off-white, film-coated and oval. Each tablet is approximately 17 mm long and 7.5 mm wide and has “T-E” engraved on one side and “250” on the other. The tablets are packaged in aluminium-PVC/PCTFE/PVC blisters. The blisters are packaged in a cardboard box.

Packs of 90 and 180 tablets. Not all pack sizes may be marketed.

Marketing authorisation holder

SERB SAS

40 Avenue George V

75008 Paris

France

Manufacturer

Beaufour Ipsen Industrie Rue Ethé Virton

28100 Dreux France

Date of last revision of this leaflet:

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu. There are also links to other web sites about rare diseases and orphan medicines.

Alternatives to XERMELO 250 mg FILM-COATED TABLETS in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to XERMELO 250 mg FILM-COATED TABLETS in Ukraine

Dosage form: flowers, 50 g in a pack
Manufacturer: TOV "Ternofarm
Prescription not required
Dosage form: flowers, 40 g or 50 g
Manufacturer: AT "Lubnifarm
Prescription not required
Dosage form: flowers, 40 g or 50 g
Prescription not required
Dosage form: flowers, 30 g or 40 g, or 50 g, or 75 g
Manufacturer: PrAT "Liktravi
Prescription not required
Dosage form: suppositories, 0.3 g in 5 suppositories per strip
Manufacturer: PAT "Monfarm
Prescription not required
Dosage form: suppositories, 0.35 g
Prescription not required

Online doctors for XERMELO 250 mg FILM-COATED TABLETS

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for XERMELO 250 mg FILM-COATED TABLETS – subject to medical assessment and local rules.

0.0(0)
Doctor

Abdullah Alhasan

General medicine10 years of experience

Dr. Abdullah Alhasan is a physician specialising in cardiology and general medicine, with international clinical experience and a commitment to evidence-based care. He offers online consultations for adults, focusing on both acute symptoms and long-term health management.

Main areas of consultation:

  • Chest pain, shortness of breath, heart palpitations, high blood pressure
  • Hypertension control and cardiovascular disease prevention
  • Interpretation of ECG, blood tests, and Holter monitor results
  • Management of heart failure and coronary artery disease
  • General medical issues: infections, fever, fatigue, gastrointestinal symptoms
  • Guidance on diagnostics, treatment plans, and medication adjustments
Dr. Alhasan’s approach is based on thorough assessment, clear communication, and personalised care – helping patients understand their health and make informed decisions about their treatment.
CameraBook a video appointment
€69
Today14:55
Today15:10
Today15:25
Today15:40
Today15:55
More times
5.0(32)
Doctor

Nuno Tavares Lopes

Family medicine17 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC. He offers online consultations in Portuguese, English, and Spanish — combining global expertise with a patient-centred, evidence-based approach.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.
CameraBook a video appointment
€59
Today14:55
Today15:15
Today15:35
Today15:55
Today16:15
More times
5.0(10)
Doctor

Duarte Meneses

Family medicine4 years of experience

Dr. Duarte Meneses is a licensed family medicine and general practice doctor based in Portugal, with additional expertise in occupational health. He provides online consultations for adults, offering medical support for both acute symptoms and chronic health conditions.

  • Common symptoms such as fever, sore throat, cough, fatigue, or digestive issues
  • Chronic conditions including hypertension, diabetes, high cholesterol, and thyroid problems
  • Mental health concerns such as stress, sleep issues, anxiety, and burnout
  • Preventive care: health check-ups, lifestyle advice, and follow-up for existing conditions
  • Work-related health questions, sick leave documentation, and medical guidance for returning to work
Dr. Meneses graduated from the University of Beira Interior and has years of experience working with diverse patient populations. He is fluent in Portuguese, English, Spanish, and French.

His approach is friendly, clear, and focused on delivering practical medical advice tailored to each patient’s needs.

CameraBook a video appointment
€65
Today14:55
Today15:20
Today15:45
Today16:10
Today16:35
More times
5.0(1)
Doctor

Ngozi Precious Okwuosa

General medicine5 years of experience

Dr. Ngozi Precious Okwuosa is a Primary Care Physician with over 5 years of clinical experience in Hungary, Sweden, and Nigeria. A graduate of the University of Szeged (cum laude), she offers online consultations for adults in the areas of internal medicine, women’s health, and postoperative care.

Key areas of consultation:

  • Preventive and family medicine
  • Women’s health, including gynaecology and obstetrics
  • Chronic disease management: hypertension, diabetes, and more
  • Mental health support, anxiety, and counselling
  • Postoperative care and lab test interpretation
She has conducted research on the genetic background of stroke and is skilled in communicating with patients from diverse cultural backgrounds. Her approach combines clinical expertise with empathy and clear communication.
CameraBook a video appointment
€60
Today14:55
Today15:45
Today16:35
Today17:25
Today18:15
More times
5.0(18)
Doctor

Sergio Correa

General medicine7 years of experience

Dr. Sergio Correa is a licensed general practitioner, aesthetic medicine specialist, and trichologist with experience in emergency care and preventive health. He offers online consultations in English and Spanish, supporting adult patients with a wide range of medical concerns – from acute symptoms to chronic condition management.

His areas of focus include:

  • General and urgent care: fever, fatigue, infections, digestive issues, respiratory symptoms, and other common concerns
  • Chronic condition support: hypertension, high cholesterol, diabetes, thyroid issues
  • Aesthetic medicine and dermatology: acne, skin ageing, hyperpigmentation, personalised skincare guidance
  • Trichology: hair loss, scalp conditions, treatment strategies for men and women
  • Preventive care: health check-ups, lifestyle advice, second opinions

Dr. Correa combines medical knowledge with an aesthetic and holistic approach to help patients improve both health and quality of life.

CameraBook a video appointment
€40
Today15:10
Today16:10
November 413:00
November 414:00
November 415:00
More times
0.0(0)
Doctor

Antonio Cayatte

General medicine43 years of experience

Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic.

His clinical background includes:

  • assessment of sudden or unclear symptoms
  • ongoing care for chronic conditions
  • follow-up after hospital discharge
  • interpretation of test results
  • medical support while abroad
Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association.

Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

CameraBook a video appointment
€60
Today15:40
Today16:10
Today16:40
Today17:10
Today17:40
More times
5.0(131)
Doctor

Andrei Popov

General medicine6 years of experience

Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

He specialises in diagnosing and treating pain conditions that affect quality of life, including:

  • Chronic pain lasting more than 3 months.
  • Migraines and recurring headaches.
  • Neck, back, lower back, and joint pain.
  • Post-traumatic pain following injury or surgery.
  • Nerve-related pain, fibromyalgia, and neuralgia.
In addition to pain management, Dr. Popov helps patients with:
  • Respiratory infections (colds, bronchitis, pneumonia).
  • High blood pressure and metabolic conditions such as diabetes.
  • Preventive care and routine health check-ups.

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

CameraBook a video appointment
€59
Today16:00
Today16:30
Today17:00
Today17:30
Today18:00
More times
5.0(16)
Doctor

Taisiya Minorskaya

Family medicine12 years of experience

Dr Taisiya Minorskaya is a family medicine doctor with an official licence to practise in Spain and over 12 years of clinical experience. She provides online consultations for adults and children, combining evidence-based medicine with a personalised, modern European approach.

She helps with:

  • Viral infections and cold symptoms (flu, sore throat, cough, runny nose)
  • Review and adjustment of antibiotics
  • Skin rashes and allergic reactions
  • Chronic condition flare-ups, high blood pressure, headaches, fatigue
  • Lab and test interpretation
  • Medication review and adaptation to European standards
  • Patient navigation: what tests are needed, which specialists to see, when an in-person visit is required
Dr Minorskaya also specialises in the diagnosis and management of gastrointestinal conditions, including bloating, abdominal pain, chronic nausea, IBS, and SIBO. She supports patients with unexplained physical symptoms that may be linked to somatisation or stress, helping them find relief and improve quality of life.

She offers care for people undergoing GLP-1 therapy (Ozempic, Mounjaro, and others) for weight management. Her support follows Spanish clinical guidelines, from treatment planning and side effect counselling to regular follow-ups and coordination with private or public healthcare providers.

CameraBook a video appointment
€65
Today16:40
Today17:10
Today17:40
November 515:00
November 515:30
More times
5.0(14)
Doctor

Jonathan Marshall Ben Ami

Family medicine8 years of experience

Dr. Jonathan Marshall Ben Ami is a licensed family medicine doctor in Spain. He provides comprehensive care for adults and children, combining general medicine with emergency care expertise to address both acute and chronic health concerns.

Dr. Ben Ami offers expert diagnosis, treatment, and follow-up for:

  • Respiratory infections (cold, flu, bronchitis, pneumonia).
  • ENT conditions such as sinusitis, ear infections, and tonsillitis.
  • Digestive issues including gastritis, acid reflux, and irritable bowel syndrome (IBS).
  • Urinary tract infections and other common infections.
  • Management of chronic diseases: high blood pressure, diabetes, thyroid disorders.
  • Acute conditions requiring urgent medical attention.
  • Headaches, migraines, and minor injuries.
  • Wound care, health check-ups, and ongoing prescriptions.

With a patient-focused and evidence-based approach, Dr. Ben Ami supports individuals at all stages of life — offering clear medical guidance, timely interventions, and continuity of care.

CameraBook a video appointment
€55
Today16:40
Today17:25
Today18:10
November 415:00
November 415:45
More times
5.0(38)
Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

CameraBook a video appointment
€54
Today16:40
Today17:20
Today18:00
Today18:40
Today19:20
More times

Get updates and exclusive offers

Be the first to know about new services, marketplace updates, and subscriber-only promos.

Follow us on social media
FacebookInstagram
Logo
Oladoctor
Find a doctor
Doctors by specialty
Services
Choose language
© 2025 Oladoctor. All rights reserved.
VisaMastercardStripe