OZEMPIC 1 mg SOLUTION FOR INJECTION IN PRE-FILLED PEN

Instructions for Use of Ozempic 1 mg Solution for Injection in Pre-filled Pen

Read these instructions carefullybefore using your Ozempic pre-filled pen.

Ask your doctor, nurse, or pharmacist to show you how to inject Ozempic correctly.

Start by checking the pen to make sure it contains Ozempic 1 mgand then look at the following pictures to familiarize yourself with the different parts of the pen and needle.

If you are blind or have poor eyesight and cannot read the dose counter on the pen, do not use this pen without help.Ask someone who can see well and is familiar with the Ozempic pre-filled pen to help you.

Your pen is a pre-filled dose counter pen. It contains 4 mg of semaglutide and you can only select doses of 1 mg. A new pen contains four doses of 1 mg.

Use the table on the carton to keep track of how many injections you have taken and when you took them.

The pen is designed to be used with NovoFine Plus disposable needles, 30G, 31G, and 32G, up to 8 mm in length.

The package includes NovoFine Plus needles.

Important Information

Pay special attention to these notes, as they are important for the safe use of the pen.

1. Preparing the pen with a new needle

• Check the name and color of your pen's label to make sure it contains Ozempic 1 mg. This is especially important if you use more than one type of injectable medication. Using the wrong medication could be harmful to your health.
• Remove the pen cap.

• Check that the solution in the pen is clear and colorless. Look through the pen window. If the solution appears cloudy or colored, do not use the pen.

• Take a new needle.

Check that the paper tab and outer cap of the needle are not damaged, which could affect the sterility. If you notice any damage, use a new needle.

• Remove the paper tab.

Make sure to attach the needle correctly.

• Put the needle straight onto the pen.
• Screw it on until it is tight.

The needle is covered by two caps. You must remove both caps.If you forget to remove both caps, you will notinject solution.

• Remove the outer needle cap and set it aside for later. You will need it after the injection to safely remove the needle from the pen.

• Remove the inner needle cap and discard it. If you try to put it back on, you could accidentally stick yourself with the needle.

A drop of solution may appear on the tip of the needle. This is normal, but you must still check the flow if it is a new pen and you are using it for the first time. See step 2 "Checking the flow with each new pen".

Do not put a new needleon the pen until you are ready to take the injection.

Always use a new needle for each injection.

This can help prevent needles from becoming clogged, contamination, infection, and inaccurate dosing.

Never use a bent or damaged needle.

1. Checking the flow with each new pen

• If the pen is already in use, go to step 3, "Selecting the dose". Check the flow only before the first injection with each new pen.

• Turn the dose selector until the flow check symbol () is just after the '0'. Make sure the flow check symbol is aligned with the dose marker.

• Hold the pen with the needle pointing upwards.

Press and hold the dose buttonuntil the dose counter returns to '0'. The '0' must be aligned with the dose marker.

A drop of solution should appear on the tip of the needle.

It is possible that a small drop remains on the tip of the needle, but it will not be injected.

If no drop appears,repeat step 2 "Checking the flow with each new pen" up to 6 times. If still no drop is seen, change the needle and repeat step 2 "Checking the flow with each new pen" one more time.

Discard the pen and use a new one if, despite this, no drop of solution appears.

Always make sure a drop appearson the tip of the needle before using a new pen for the first time. This ensures that the solution flows.

If no drop appears, you will notinject medication, even though the dose counter moves. This may indicate that the needle is clogged or damaged.

If you do not check the flow before the first injection with each new pen, you may not receive the prescribed dose or achieve the intended effect of Ozempic.

1. Selecting the dose

• Turn the dose selector until 1 mg is selected.

Continue turning until the dose counter stops and shows 1 mg.

Only the dose counter and dose marker will show that 1 mg has been selected.

You can only select 1 mg per dose. When your pen contains less than 1 mg, the dose counter will stop before showing 1.

The dose selector clicks differently when turned forward, backward, or past 1 mg. Do not count the clicks of the pen.

Always use the dose counter and dose markerto see that you have selected 1 mg.

Do not count the clicks of the pen.

Only select 1 mg doseswith the dose selector. 1 mg must be exactly aligned with the dose marker to ensure you receive the correct dose.

How much solution is left

• To see how much solution is left, use the dose counter: turn the dose selector until the dose counter stops.

If it shows 1, there is at least 1 mgleft in the pen.

If the dose counter stops before 1 mg, there is not enough solution for a full 1 mg dose.

If there is not enough solution in the pen for a full dose, do not use it. Instead, use a new Ozempic pen.

1. Injecting the dose

• Insert the needle under the skin as your doctor or nurse has shown you.
• Make sure you can see the dose counter. Do not cover it with your fingers. This could interrupt the injection.

• Press and hold the dose button. Watch while the dose counter returns to '0'. The '0' must be aligned with the dose marker. You may hear or feel a click.

• Continue to press the dose button while keeping the needle under the skin.

• Count slowly to 6 while keeping the dose button pressed.
• If you withdraw the needle too early, you may see solution coming out of the needle tip. In this case, you may not have received a full dose.

• Remove the needle from the skin. You can then release the dose button.

If blood appears at the injection site, press lightly.

A drop of solution may appear on the tip of the needle after the injection. This is normal and does not affect your dose.

• Always check the dose counterto see how many mg you inject. Hold the dose button down until the dose counter returns to '0'.

How to tell if the needle is clogged or damaged

• If the '0' does not appear on the dose counter after continuously pressing the dose button, you may have used a clogged or damaged needle.
• In this case, you will not have received any medication, even though the dose counter moved.

What to do if the needle is clogged

Change the needle as described in step 5 "After the injection" and repeat all the steps from step 1 "Preparing the pen with a new needle". Make sure to select the full dose you need.

Never touch the dose counterduring the injection. This could interrupt the injection.

1. After the injection

Always discard the needleafter each injection to ensure that injections are administered correctly and to prevent needles from becoming clogged. If the needle is clogged, you will notinject any medication.

• Put the needle tip into its outer cap, placed on a flat surface, without touching the needle or the outer cap.

• When the needle is covered, carefully press the outer cap of the needle down to the end.
• Unscrew the needle and carefully discard it according to the instructions of your doctor, nurse, pharmacist, or local authorities.

• Put the pen cap back on the pen after each use to protect the solution from light.

When the pen is empty, discard it withoutthe needle attached, following the instructions of your doctor, nurse, pharmacist, or local authorities.

Never try to put the inner cap back on the needle.You could stick yourself with the needle.

Always remove the needlefrom the pen immediately after each injection.

This can help prevent needles from becoming clogged, contamination, infection, loss of solution, and inaccurate dosing.

Other Important Information

• Always keep the pen and needles out of the sight and reach of other people, especially children.
• Never share the pen or needles with other people.
• People caring for patients must be careful when handling used needles to avoid accidental needlestick injuries and infections.

Maintenance of Your Pen

Treat the pen with care. Rough handling or misuse can cause inaccurate dosing. If this happens, you may not achieve the intended effect of this medication.

• Do not leave the pen in a car or other places where it can get too hot or too cold.
• Do not inject Ozempic that has been frozen. If you do, you may not achieve the intended effect of this medication.
• Do not inject Ozempic that has been exposed to direct sunlight. If you do, you may not achieve the intended effect of this medication.
• Do not expose the pen to dust, dirt, or liquids.
• Do not wash, wet, or lubricate the pen. It can be cleaned with a damp cloth and a mild detergent.
• Make sure the pen does not fall or hit hard surfaces. If you drop the pen or suspect it has a problem, put a new needle on and check the flow before injecting.
• Do not try to refill the pen. Once empty, it must be discarded.
• Do not attempt to repair the pen or take it apart.

Instructions for Use of Ozempic 1 mg Solution for Injection in Pre-filled Pen

Read these instructions carefullybefore using your Ozempic pre-filled pen. Ask your doctor, nurse, or pharmacist to show you how to inject Ozempic correctly.

Start by checking the pen to make sure it contains Ozempic 1 mgand then look at the following pictures to familiarize yourself with the different parts of the pen and needle.

If you are blind or have poor eyesight and cannot read the dose counter on the pen, do not use this pen without help.Ask someone who can see well and is familiar with the Ozempic pre-filled pen to help you.

Your pen is a pre-filled dose counter pen. It contains 8 mg of semaglutide and you can only select doses of 1 mg. A new pen contains eight doses of 1 mg.

After you have injected the prescribed doses, there will still be solution left in the pen. The pen must be discarded.

Use the table on the carton to keep track of how many injections you have taken and when you took them.

The pen is designed to be used with NovoFine Plus disposable needles, 30G, 31G, and 32G, up to 8 mm in length.

The package includes NovoFine Plus needles.

Important Information

Pay special attention to these notes, as they are important for the safe use of the pen.

Pay special attention to these notes, as they are important for the safe use of the pen.

1. Preparing the pen with a new needle

• Check the name and color of the label on your pen to ensure it contains Ozempic 1 mg. This is especially important if you use more than one type of injectable medication. Using the wrong medication could be harmful to your health.
• Remove the cap from the pen.

• Check that the solution in the pen is clear and colorless. Look through the pen window. If the solution appears cloudy or discolored, do not use the pen.

• Take a new needle.

Check that the paper tab and the outer cap of the needle are not damaged in a way that could affect sterility. If you notice any damage, use a new needle.

• Remove the paper tab.

Make sure to place the needle correctly.

• Place the needle straight into the pen.
• Tighten it until it is secure.

The needle is covered by two caps. You must remove both caps.If you forget to remove both caps, youwill notinject the solution.

• Remove the outer cap of the needle and set it aside for later. You will need it after the injection to safely remove the needle from the pen.

• Remove the inner cap of the needle and discard it. If you try to put it back on, you may accidentally prick yourself with the needle.

A drop of solution may appear at the tip of the needle. This is normal, but you should still check the flow if it is a new pen and you are using it for the first time. See step 2 "Checking the flow with each new pen".

Do not put a new needleon the pen until you are ready to give the injection.

Always use a new needlefor each injection.

This can help prevent needles from becoming clogged, contamination, infection, and inaccurate dosing.

Never use a bent or damaged needle.

1. Checking the flow with each new pen

• If the pen is already in use, go to step 3, "Selecting the dose". Check the flow only before the first injection with each new pen.

• Turn the dose selector until the flow check symbol () is just after the '0'. Make sure the flow check symbol is aligned with the dose marker.

• Hold the pen with the needle pointing up.

Press and hold the buttonuntil the dose counter returns to '0'. The '0' must be aligned with the dose marker.

A drop of solution should appear at the tip of the needle.

It is possible that a small drop will remain at the tip of the needle, but it will not be injected.

If no drop appears,repeat step 2 "Checking the flow with each new pen" up to 6 times. If still no drop appears, change the needle and repeat step 2 "Checking the flow with each new pen" one more time.

Discard the pen and use a new one if, despite this, no drop of solution appears.

Always make sure a drop appearsat the tip of the needle before using a new pen for the first time. This ensures that the solution is flowing.

If no drop appears, youwill notinject the medication, even if the dose counter moves. This may indicate that the needle is clogged or damaged.

If you do not check the flow before the first injection with each new pen, you may not receive the prescribed dose or achieve the intended effect of Ozempic.

1. Selecting the dose

• Turn the dose selector until 1 mg is selected.

Continue turning until the dose counter stops and shows 1 mg.

Only the dose counter and the dose marker will show that 1 mg has been selected.

You can only select 1 mg per dose. When your pen contains less than 1 mg, the dose counter will stop before showing 1.

The dose selector makes a different click when turned forward, backward, or past 1 mg. Do not count the clicks of the pen.

Always use the dose counter and the dose marker to check that you have selected 1mg.

Do not count the clicks of the pen.

Only select 1mg doses with the dose selector.1 mg must be exactly aligned with the dose marker to ensure you receive the correct dose.

How much solution is left

• To find out how much solution is left, use the dose counter: turn the dose selector until the dose counter stops.

If it shows 1, there is at least 1mgleft in the pen.

If the dose counter stops before 1mg,there is not enough solution for a full 1 mg dose.

If there is not enough solution in the pen for a full dose, do not use it. Instead, use a new Ozempic pen.

1. Injecting the dose

• Insert the needle under the skin as your doctor or nurse has taught you.
• Make sure you can see the dose counter. Do not cover it with your fingers. This could interrupt the injection.

• Press and hold the button. Watch as the dose counter returns to '0'. The '0' must be aligned with the dose marker. You may hear or feel a click.

• Continue to press the button while keeping the needle under the skin.

• Count slowly to 6 while keeping the button pressed.

• If you withdraw the needle too early, you may see solution coming out of the needle tip. In this case, you will not have administered the full dose.

• Withdraw the needle from the skin. You can then release the button.

If blood appears at the injection site, press lightly.

A drop of solution may appear at the tip of the needle after the injection. This is normal and does not affect your dose.

• Always check the dose counterto see how many mg you are injecting. Keep the button pressed until the dose counter returns to '0'.

How to tell if the needle is clogged or damaged

• If the '0' does not appear on the dose counter after continuously pressing the button, you may have used a clogged or damaged needle.
• In this case, you will not have received any medication, even if the dose counter has moved from the original dose you set.

What to do if the needle is clogged

Change the needle as described in step 5 "After the injection" and repeat all the steps from step 1 "Preparing the pen with a new needle". Make sure to select the full dose you need.

Never touch the dose counter during the injection.This can interrupt the injection.

1. After the injection

Always discard the needle after each injectionto ensure that injections are administered correctly and to prevent needles from becoming clogged. If the needle is clogged, youwill notinject any medication.

• Insert the tip of the needle into its outer cap, which is placed on a flat surface, without touching the needle or the outer cap.

• When the needle is protected, carefully press the outer cap of the needle down to the bottom.
• Unscrew the needle and discard it carefully according to the instructions of your doctor, nurse, pharmacist, or local authorities.

• Put the cap back on the pen after each use to protect the solution from light.

When the pen is empty, discard it withoutthe needle attached, following the instructions of your doctor, nurse, pharmacist, or local authorities.

Never try to put the inner cap back on the needle.You may prick yourself with the needle.

Always remove the needle from the pen immediately after each injection.

This can help prevent needles from becoming clogged, contamination, infection, loss of solution, and inaccurate dosing.

Other important information

• Always keep the pen and needles out of sight and reach of other people, especially children.
• Never share the pen or needles with other people.
• People caring for patients should be very careful when handling used needles to avoid accidental needlestick injuries and infections.

Maintenance of your pen

Treat the pen with care. Rough handling or misuse can cause inaccurate dosing. If this happens, you may not achieve the intended effect of this medication.

• Do not leave the pen in a car or other places where it can become too hot or too cold.
• Do not inject Ozempic that has been frozen. If you do, you may not achieve the intended effect of this medication.
• Do not inject Ozempic that has been exposed to direct sunlight. If you do, you may not achieve the intended effect of this medication.
• Do not expose the pen to dust, dirt, or liquids.
• Do not wash, wet, or lubricate the pen. It can be cleaned with a damp cloth and a mild detergent.
• Make sure the pen does not fall or hit hard surfaces. If you drop the pen or suspect it may have a problem, put a new needle on and check the flow before injecting.
• Do not try to refill the pen. Once empty, it must be discarded.
• Do not attempt to repair the pen or take it apart.