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Tussicom 400

Tussicom 400

Ask a doctor about a prescription for Tussicom 400

5.0(6)
Doctor

Tarek Agami

General medicine10 years of experience

Dr. Tarek Agami is a general practitioner registered in both Portugal and Israel, with broad experience in family and preventive medicine. He offers online consultations for adults and children, providing personalised support for primary care needs, chronic disease management, and everyday health concerns.

Dr. Agami received clinical training and worked in leading medical institutions in Israel (Kaplan Medical Center, Barzilai Medical Center, Wolfson Medical Center) and Portugal (European Healthcare City, Viscura Internacional, Hospital Dr. José Maria Grande, Hospital Vila Franca de Xira). His approach combines international medical standards with individualised attention to each patient.

Main areas of consultation:

  • Diagnosis and treatment of acute and chronic conditions (high blood pressure, diabetes, respiratory infections, cardiovascular symptoms)
  • Evaluation of symptoms and guidance on further diagnostic testing
  • Preventive check-ups and regular health monitoring
  • Medical support during travel or after relocation
  • Treatment adjustments and lifestyle recommendations based on your personal history
Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

Dr. Agami is committed to evidence-based, patient-centred care, ensuring that each person receives trusted medical support tailored to their health goals.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Tussicom 400

Package Leaflet: Information for the User

TUSSICOM 200, 200 mg/5 g, Powder for Solution

Acetylcysteine

TUSSICOM 400, 400 mg/5 g, Powder for Solution

Acetylcysteine

TUSSICOM 600, 600 mg/5 g, Powder for Solution

Acetylcysteine
{logo of the marketing authorization holder}

Read the package leaflet carefully before taking the medicine, as it contains important information for the patient.

  • Keep this package leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you experience any side effects, including those not listed in this package leaflet, tell your doctor or pharmacist. See section 4.

Package Leaflet Contents

  • 1. What is Tussicom and what is it used for
  • 2. Important information before taking Tussicom
  • 3. How to take Tussicom
  • 4. Possible side effects
  • 5. How to store Tussicom
  • 6. Package contents and other information

1. What is Tussicom and what is it used for

Tussicom contains acetylcysteine, which is a derivative of the natural amino acid L-cysteine. The medicine
reduces the viscosity of respiratory tract secretions, making it easier to cough them up and improving
breathing and relieving a nagging cough.
The medicine is used to treat respiratory diseases with thick bronchial secretions that require thinning and in cystic fibrosis.

2. Important information before taking Tussicom

When not to take Tussicom

  • if you are allergic to acetylcysteine or any of the other ingredients of this medicine (listed in section 6);
  • in children under 2 years of age.

Warnings and precautions

Taking acetylcysteine may cause an increase in the volume of bronchial secretions.
Particular caution should be exercised when taking the medicine:

  • in patients with asthma; if bronchospasm occurs and persists, the medicine should be discontinued;
  • in patients with gastric and duodenal ulcer disease, especially when other medicines that irritate the mucous membrane of the digestive tract are used at the same time;
  • in elderly patients;
  • in patients with severe respiratory failure.

Acetylcysteine should not be given to patients with reduced ability to cough, unless respiratory physiotherapy is provided during treatment.
If any new skin or mucous membrane changes occur during acetylcysteine treatment (symptoms of severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis), you should consult a doctor immediately and discontinue acetylcysteine treatment (see section 4).

Tussicom and other medicines

Tell your doctor about all medicines you are taking or have recently taken, as well as those that are available without a prescription.
Acetylcysteine should not be taken at the same time as antibiotics (erythromycin, tetracyclines, amoxicillin); a 2-hour interval should be maintained between taking the medicines.
Do not give cough suppressants at the same time as acetylcysteine.
Acetylcysteine may enhance the vasodilating effect of nitroglycerin. Caution should be exercised when taking these medicines together.
Activated charcoal may reduce the effect of acetylcysteine due to reduced absorption.
Acetylcysteine may affect the results of laboratory tests, such as salicylate analysis by colorimetry. You should inform your doctor and medical staff that you are taking this medicine.

Pregnancy and breastfeeding

Before taking any medicine, consult your doctor.
Do not take the medicine during pregnancy and breastfeeding, unless necessary.

Driving and using machines

There is no available data on the effect of acetylcysteine on the ability to drive and use machines.

Tussicom contains sugar

1 sachet of Tussicom 200 contains 4.759 g of sugar – approximately 0.4 bread units per sachet.
1 sachet of Tussicom 400 contains 4.575 g of sugar – approximately 0.4 bread units per sachet.
1 sachet of Tussicom 600 contains 4.370 g of sugar – approximately 0.4 bread units per sachet.
This should be taken into account in patients with diabetes. If you have previously been diagnosed with intolerance to some sugars, you should consult your doctor before taking this medicine.

Tussicom 400 contains quinoline yellow

The medicine may cause allergic reactions.

Tussicom 600 contains cochineal red

The medicine may cause allergic reactions.

3. How to take Tussicom

Always take this medicine exactly as your doctor has told you. If you are not sure, ask your doctor or pharmacist.

Dosage

The usual dose of Tussicom:

  • in adults and children over 14 years - up to 600 mg of acetylcysteine per day;
  • in children from 6 to 14 years - up to 400 mg of acetylcysteine per day;
  • in children from 2 to 6 years - up to 300 mg of acetylcysteine per day.

Recommended dosage in cystic fibrosis:

  • in children over 6 years - up to 600 mg of acetylcysteine per day;
  • in children from 2 to 6 years - up to 400 mg of acetylcysteine per day.

Method of administration

The contents of the sachet should be dissolved in a glass of water and taken immediately after dissolution. The contents of the sachets should not be divided.
Caution:
Avoid contact between the solution and metals and rubber.

Taking a higher dose of Tussicom than recommended

Overdose of the medicine may cause excessive liquefaction of mucopurulent secretions, especially in patients with inadequate cough reflex, in whom mechanical aspiration of secretions from the bronchi may be necessary. Additionally, overdose of the medicine may also lead to gastrointestinal symptoms such as nausea, vomiting, and diarrhea.
If you suspect an overdose, seek medical attention immediately.

Missing a dose of Tussicom

If you miss a dose, do not take a double dose, just take the next dose at the recommended time.
If you have any further questions about taking this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Uncommon (may affect up to 1 in 100 people)

  • hypersensitivity, which may occur in the form of bronchospasm, dyspnea, itching, urticaria, skin rash; severe allergic reaction called "angioedema" with symptoms including: swelling of the throat and tongue, swelling around the eyes and mouth, difficulty breathing and swallowing, tachycardia,
  • headache,
  • tinnitus,
  • stomatitis, abdominal pain, nausea, vomiting, diarrhea,
  • fever,
  • low blood pressure.

Rare (may affect up to 1 in 1,000 people)

  • indigestion.

Very rare (may affect up to 1 in 10,000 people)

  • severe allergic reactions (anaphylactic shock, anaphylactic and/or pseudoanaphylactic reactions). Anaphylactic shock is a severe, life-threatening allergic reaction, with symptoms including: dyspnea, swelling of the larynx and throat, itching and redness of the skin, headache, feeling of "pressure", dizziness, significant weakness up to loss of consciousness. In severe cases, anaphylactic shock can be life-threatening.
  • bleeding,
  • in the initial period of treatment: bronchospasm, excessive mucus production, irritating cough,
  • Stevens-Johnson syndrome (widespread rash with blisters and peeling skin, mainly in the mouth, eyes, nose, and genital areas), toxic epidermal necrolysis.

Frequency not known (frequency cannot be estimated from the available data)

  • vasodilation and sudden flushing of the face after taking high doses,
  • facial edema.

Reporting side effects

If you experience any side effects, including those not listed in this package leaflet, tell your doctor or pharmacist, or nurse. Side effects can be reported directly to the Department of Drug Safety Monitoring of the Office for Registration of Medicinal Products, Medical Devices and Biocidal Products:
Aleje Jerozolimskie 181C
02-222 Warsaw
Phone: +48 22 49 21 301
Fax: +48 22 49 21 309
Website: https://smz.ezdrowie.gov.pl
Side effects can also be reported to the marketing authorization holder.
By reporting side effects, you can help provide more information on the safety of this medicine.

5. How to store Tussicom

There are no special precautions for storage.
Keep the medicine out of the sight and reach of children.
Do not use this medicine after the expiry date stated on the packaging. The expiry date refers to the last day of the month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

6. Package contents and other information

What Tussicom 200 contains

  • The active substance is acetylcysteine. Each sachet contains 200 mg of acetylcysteine.
  • The other ingredients are: sugar, beta-carotene 2.5%, flavor and aroma enhancer, orange.

What Tussicom 400 contains

  • The active substance is acetylcysteine. Each sachet contains 400 mg of acetylcysteine.
  • The other ingredients are: sugar, flavor and aroma enhancer, lemon, quinoline yellow.

What Tussicom 600 contains

  • The active substance is acetylcysteine. Each sachet contains 600 mg of acetylcysteine.
  • The other ingredients are: sugar, colloidal silica, flavor and aroma enhancer, raspberry, flavor and aroma enhancer, orange, and cochineal red.

What Tussicom looks like and contents of the pack

Tussicom 200 is a light orange powder with an orange flavor and aroma, in sachets. Each sachet contains 5 g of powder. The carton box contains 20 sachets.
Tussicom 400 is a light yellow powder with a lemon flavor and aroma, in sachets. Each sachet contains 5 g of powder. The carton box contains 20 sachets.
Tussicom 600 is a light pink powder with a fruity flavor and aroma, in sachets. Each sachet contains 5 g of powder. The carton box contains 20 sachets.

Marketing authorization holder and manufacturer

Marketing authorization holder:
Sanofi-Aventis Sp. z o.o.
Bonifraterska 17 Street
00-203 Warsaw
Manufacturer:
Opella Healthcare Poland Sp. z o.o.
Rzeszów Branch
Lubelska 52 Street
35-233 Rzeszów
To obtain more detailed information, please contact:
Sanofi-Aventis Sp. z o.o.
Bonifraterska 17 Street
00-203 Warsaw
phone: (22) 280 00 00
Date of last revision of the package leaflet:March 2022

Alternatives to Tussicom 400 in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to Tussicom 400 in Spain

Dosage form: EFFERVESCENT TABLET, 600 mg
Active substance: acetylcysteine
Manufacturer: Kern Pharma S.L.
Prescription not required
Dosage form: ORAL SOLUTION/SUSPENSION, 600 mg
Active substance: acetylcysteine
Prescription required
Dosage form: EFFERVESCENT TABLET, 600 mg
Active substance: acetylcysteine
Prescription required
Dosage form: ORAL SOLUTION/SUSPENSION, 200 mg
Active substance: acetylcysteine
Prescription required
Dosage form: EFFERVESCENT TABLET, 200 mg
Active substance: acetylcysteine
Prescription required
Dosage form: EFFERVESCENT TABLET, 600 mg
Active substance: acetylcysteine
Manufacturer: Kern Pharma S.L.
Prescription not required

Alternative to Tussicom 400 in Ukraine

Dosage form: tablets, 600 mg
Active substance: acetylcysteine
Manufacturer: E-Farma Trento S.P.A.
Prescription not required
Dosage form: powder, 600 mg, 3.0 g in sachets
Active substance: acetylcysteine
Manufacturer: AT "Farmak
Prescription not required
Dosage form: powder, 200mg/1g in sachet
Active substance: acetylcysteine
Manufacturer: AT "Farmak
Prescription not required
Dosage form: powder, 100mg/0.5g
Active substance: acetylcysteine
Manufacturer: AT "Farmak
Prescription not required
Dosage form: tablets, 600 mg
Active substance: acetylcysteine
Manufacturer: KUSUM HELTHKER PVT LTD
Prescription not required
Dosage form: granules, 600mg
Active substance: acetylcysteine
Manufacturer: KUSUM HELTHKER PVT LTD
Prescription not required

Online doctors for Tussicom 400

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for Tussicom 400 – subject to medical assessment and local rules.

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In addition to pain management, Dr. Popov helps patients with:
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Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

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Dr. Agami received clinical training and worked in leading medical institutions in Israel (Kaplan Medical Center, Barzilai Medical Center, Wolfson Medical Center) and Portugal (European Healthcare City, Viscura Internacional, Hospital Dr. José Maria Grande, Hospital Vila Franca de Xira). His approach combines international medical standards with individualised attention to each patient.

Main areas of consultation:

  • Diagnosis and treatment of acute and chronic conditions (high blood pressure, diabetes, respiratory infections, cardiovascular symptoms)
  • Evaluation of symptoms and guidance on further diagnostic testing
  • Preventive check-ups and regular health monitoring
  • Medical support during travel or after relocation
  • Treatment adjustments and lifestyle recommendations based on your personal history
Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

Dr. Agami is committed to evidence-based, patient-centred care, ensuring that each person receives trusted medical support tailored to their health goals.

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Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.

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