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Hepa-mezh

Hepa-mezh

Ask a doctor about a prescription for Hepa-mezh

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Doctor

Marta Reguero Capilla

Allergology7 years of experience

Dr Marta Reguero Capilla is an allergist and immunologist who works with both adults and children. She specialises in the diagnosis, treatment, and ongoing management of allergic and immune-related conditions through online consultations.

In her practice, Dr Reguero Capilla helps patients understand the causes of their symptoms, review test results, and choose appropriate treatment or monitoring strategies. Her consultations are suitable both for first-time assessments and for follow-up care over time.

Patients commonly consult Dr Marta Reguero Capilla for:

  • allergic rhinitis, seasonal allergies, and perennial allergy symptoms;
  • allergic conditions in adults and children;
  • bronchial asthma and allergy-related respiratory symptoms;
  • urticaria (acute and chronic) and angioedema;
  • food allergies and reactions to foods, additives, or medications;
  • atopic dermatitis, allergic rashes, and persistent itching;
  • unexplained or recurrent allergic reactions;
  • interpretation of laboratory tests, allergy testing, and immunology results;
  • immune system concerns, frequent infections, and reduced immune response;
  • ongoing medical follow-up and treatment adjustment.
Dr Reguero Capilla works in a structured and attentive manner, explaining medical decisions clearly and helping patients make informed choices about their own health or their child’s care.

When clinically appropriate, she may provide recommendations for further tests or referrals that patients can use within Spanish medical networks, including Sanitas and DKV, in accordance with the terms and conditions of those services.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Hepa-mezh

Package Leaflet: Information for the Patient

Warning! Keep the leaflet. Information on the immediate packaging in a foreign language.

Hepa-Merz, 5 g/10 ml, Concentrate for Solution for Infusion

Ornithine aspartate

Read the leaflet carefully before using the medicine, as it contains important information for the patient.

  • Keep this leaflet, so you can read it again if you need to.
  • If you have any doubts, consult your doctor or pharmacist.
  • This medicine has been prescribed specifically for you. Do not pass it on to others. The medicine may harm another person, even if their symptoms are the same.
  • If the patient experiences any side effects, including any side effects not listed in this leaflet, they should tell their doctor, pharmacist, or nurse. See section 4.

Table of Contents of the Leaflet

  • 1. What is Hepa-Merz and what is it used for
  • 2. Important information before using Hepa-Merz
  • 3. How to use Hepa-Merz
  • 4. Possible side effects
  • 5. How to store Hepa-Merz
  • 6. Package contents and other information

1. What is Hepa-Merz and what is it used for

Hepa-Merz is a medicine that stimulates the removal of ammonia from the body by increasing urea synthesis in the liver. Hepa-Merz also supports the removal of ammonia from tissues other than the liver. Hepa-Merz is used to treat liver encephalopathy in the course of acute and chronic liver diseases, such as steatosis, cirrhosis, and hyperammonemia.

2. Important information before using Hepa-Merz

When not to use Hepa-Merz

Do not use Hepa-Merz in patients with the following disorders:

  • hypersensitivity to L-ornithine L-aspartate;
  • severe renal impairment (serum creatinine above 3 mg/100 ml);
  • disorders of amino acid metabolism involved in the urea cycle, e.g., due to enzymatic defects.

Warnings and precautions

Before starting to use Hepa-Merz, discuss it with your doctor or pharmacist. When using high doses of the medicine, monitor the urea concentration in the serum and urine. In cases of severe liver dysfunction, the infusion rate should be adjusted individually to avoid gastrointestinal disorders, such as nausea and vomiting.

Children

There are no data on the use of Hepa-Merz in children.

Hepa-Merz and other medicines

Tell your doctor about all medicines you are currently taking or have recently taken, as well as any medicines you plan to take. There are no known interactions between Hepa-Merz and other medicines.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to have a child, consult your doctor before using this medicine. PregnancyThere are insufficient studies on the safety of using Hepa-Merz during pregnancy, so it should be avoided during pregnancy. However, if the use of the medicine in a pregnant woman is necessary, the doctor should weigh the potential benefits against the risks before making a decision. BreastfeedingIt is not known whether L-ornithine L-aspartate (the active substance of Hepa-Merz) passes into breast milk. Avoid using the medicine during breastfeeding. However, if the use of the medicine in a breastfeeding woman is necessary, the doctor should weigh the potential benefits against the risks before making a decision.

Driving and using machines

The ability to drive and use machines may be reduced due to the disease being treated with Hepa-Merz.

3. How to use Hepa-Merz

Dosage:

Always use this medicine exactly as your doctor has told you. If you are unsure, consult your doctor or pharmacist. Usually, up to 20 g (4 ampoules) per day is administered. In pre-coma and coma states, up to 40 g (8 ampoules) per day, depending on the patient's condition. If you feel that the effect of the medicine is too strong or too weak, contact your doctor or pharmacist.

Method of administration

Intravenous administration. Before administration, dissolve the contents of the ampoule in the infusion fluid. Hepa-Merz can be administered in all commonly used infusion fluids. No incompatibilities have been observed to date. It is recommended to prepare the infusion solution immediately before administration. Due to the risk of vein damage, do not administer more than 6 ampoules in 500 ml of fluid. Infusion rate: maximum 5 g (1 ampoule)/hour. Do not administer intra-arterially.

Using more than the recommended dose of Hepa-Merz

No symptoms of overdose have been observed to date. In case of overdose, symptomatic treatment is used.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Uncommon side effects (less than 1 in 100 people):

nausea.

Rare side effects (less than 1 in 1,000 people):

vomiting.

Frequency not known (cannot be estimated from the available data):

hypersensitivity, allergic reactions (anaphylactic). Nausea and vomiting are usually transient and do not require discontinuation of the medicine. They subside after reducing the dose or infusion rate.

Reporting side effects

If you experience any side effects, including any side effects not listed in this leaflet, tell your doctor, pharmacist, or nurse. Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products: Al. Jerozolimskie 181C, 02-222 Warsaw, tel.: 22 49-21-301, fax: 22 49-21-309, website: https://smz.ezdrowie.gov.pl. By reporting side effects, you can help provide more information on the safety of this medicine.

5. How to store Hepa-Merz

Keep the medicine out of the sight and reach of children. Do not use this medicine after the expiry date stated on the packaging. The expiry date refers to the last day of the month stated. Do not store above 30°C. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Package contents and other information

What Hepa-Merz contains

The active substance is L-ornithine L-aspartate. One ampoule (10 ml) of the concentrate for solution for infusion contains 5 g of L-ornithine L-aspartate. The other ingredient (excipient) is water for injections.

What Hepa-Merz looks like and what the package contains

Hepa-Merz, concentrate for solution for infusion, is a clear solution. The package contains 10 ampoules of 10 ml each. For more detailed information, contact the marketing authorization holder or the parallel importer.

Marketing authorization holder in Bulgaria, the country of export:

Merz Pharmaceuticals GmbH, Eckenheimer Landstr. 100, 60318 Frankfurt am Main, Germany

Manufacturer:

Merz Pharma GmbH & Co. KGaA, Eckenheimer Landstr. 100, 60318 Frankfurt am Main, Germany

Parallel importer:

Delfarma Sp. z o.o., ul. Św. Teresy od Dzieciątka Jezus 111, 91-222 Łódź

Repackaged by:

Delfarma Sp. z o.o., ul. Św. Teresy od Dzieciątka Jezus 111, 91-222 Łódź
Authorization number in Bulgaria, the country of export: 20000705

Parallel import authorization number: 139/23

Date of leaflet approval: 13.07.2023

[Information about the trademark]

  • Country of registration
  • Prescription required
    No
  • Marketing authorisation holder (MAH)
    Merz Pharmaceuticals GmbH
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Alternatives to Hepa-mezh in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to Hepa-mezh in Hiszpania

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Alternative to Hepa-mezh in Ukraina

Dosage form: fruits, 50 g, or 100 g, or 200 g
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Prescription not required
Dosage form: fruits, 50 g, 100 g or 200 g
Prescription not required
Dosage form: lyophilizate, 1 vial (bottle) contains lecithin standard - 320 mg; anthral - 4.2 mg
Manufacturer: TOV "BIOLIK FARMA
Prescription required
Dosage form: capsules, 10 capsules in a blister
Prescription not required
Dosage form: solution, 50mg/ml in 5ml ampoule
Manufacturer: AT "Farmak
Prescription required
Dosage form: capsules, 10 capsules in a blister
Manufacturer: Nabros Farma Pvt. Ltd.
Prescription not required

Online doctors for Hepa-mezh

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for Hepa-mezh – subject to medical assessment and local rules.

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Doctor

Marta Reguero Capilla

Allergology7 years of experience

Dr Marta Reguero Capilla is an allergist and immunologist who works with both adults and children. She specialises in the diagnosis, treatment, and ongoing management of allergic and immune-related conditions through online consultations.

In her practice, Dr Reguero Capilla helps patients understand the causes of their symptoms, review test results, and choose appropriate treatment or monitoring strategies. Her consultations are suitable both for first-time assessments and for follow-up care over time.

Patients commonly consult Dr Marta Reguero Capilla for:

  • allergic rhinitis, seasonal allergies, and perennial allergy symptoms;
  • allergic conditions in adults and children;
  • bronchial asthma and allergy-related respiratory symptoms;
  • urticaria (acute and chronic) and angioedema;
  • food allergies and reactions to foods, additives, or medications;
  • atopic dermatitis, allergic rashes, and persistent itching;
  • unexplained or recurrent allergic reactions;
  • interpretation of laboratory tests, allergy testing, and immunology results;
  • immune system concerns, frequent infections, and reduced immune response;
  • ongoing medical follow-up and treatment adjustment.
Dr Reguero Capilla works in a structured and attentive manner, explaining medical decisions clearly and helping patients make informed choices about their own health or their child’s care.

When clinically appropriate, she may provide recommendations for further tests or referrals that patients can use within Spanish medical networks, including Sanitas and DKV, in accordance with the terms and conditions of those services.

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  • Ongoing care for children with chronic or complex health conditions.
By combining paediatrics with a personalised approach, Dr. Savin ensures professional support that addresses both the physical health and overall well-being of children, while guiding parents at every stage of their child’s growth.
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Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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If you are seeking qualified assistance in diagnosing or treating urological conditions, book an online consultation with Dr. Giorgi Eremeishvili. Get expert support, accurate diagnosis, and a personalized treatment plan from the comfort of your home.

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