HEPA-MERZ 3 g/5 g Granulate

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Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Hepa-mezh 3000

Contents of the leaflet

  1. Package Leaflet: Information for the Patient
  2. Warning! Keep the leaflet. Information on the immediate packaging in a foreign language.
  3. Hepa-Merz 3000 (Hepa-Merz 3 g Granules)
    1. Read the leaflet carefully before taking the medicine, as it contains important information for the patient.
    2. Table of Contents of the Leaflet:
  4. WHAT IS HEPA-MERZ 3000 AND WHAT IS IT USED FOR
  5. IMPORTANT INFORMATION BEFORE TAKING HEPA-MERZ 3000
    1. When not to take Hepa-Merz 3000
    2. Warnings and precautions
    3. Hepa-Merz 3000 and other medicines
    4. Pregnancy and breastfeeding
    5. Driving and using machines
    6. Hepa-Merz 3000 contains orange yellow S (E 110) and fructose.
  6. HOW TO TAKE HEPA-MERZ 3000
    1. Route of administration
    2. Overdose of Hepa-Merz 3000
    3. Missed dose of Hepa-Merz 3000
  7. POSSIBLE SIDE EFFECTS
    1. Uncommon side effects (less than 1 in 100 people):
    2. Rare side effects (less than 1 in 10,000 people):
    3. Reporting side effects
  8. HOW TO STORE HEPA-MERZ 3000
  9. CONTENTS OF THE PACK AND OTHER INFORMATION
    1. What Hepa-Merz 3000 contains
    2. What Hepa-Merz 3000 looks like and what the pack contains
    3. Marketing authorization holder in Austria, the country of export:
    4. Manufacturer:
    5. Parallel importer:
    6. Repackaged by:
    7. Parallel import license number: 16/13 Date of leaflet approval: 13.01.2023

Package Leaflet: Information for the Patient

Warning! Keep the leaflet. Information on the immediate packaging in a foreign language.

Doctor consultation

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Discuss your symptoms and treatment with a doctor online.

Hepa-Merz 3000 (Hepa-Merz 3 g Granules)

3 g/5 g, granules for oral solution preparation
Ornithine aspartate
Hepa-Merz 3000 and Hepa-Merz 3 g Granules are different trade names for the same drug.

Read the leaflet carefully before taking the medicine, as it contains important information for the patient.

This medicine should always be taken exactly as described in the patient leaflet or as directed by a doctor or pharmacist.

  • Keep this leaflet, so you can read it again if you need to.
  • If you need advice or additional information, consult a pharmacist.
  • If the patient experiences any side effects, including any possible side effects not listed in the leaflet, they should inform their doctor, pharmacist, or nurse. See section 4. If there is no improvement or the patient feels worse, they should contact their doctor.

Table of Contents of the Leaflet:

  • 1. What is Hepa-Merz 3000 and what is it used for
  • 2. Important information before taking Hepa-Merz 3000
  • 3. How to take Hepa-Merz 3000
  • 4. Possible side effects
  • 5. How to store Hepa-Merz 3000
  • 6. Contents of the pack and other information

1. WHAT IS HEPA-MERZ 3000 AND WHAT IS IT USED FOR

Hepa-Merz 3000 is used to treat latent and overt hepatic encephalopathy occurring in the course of chronic liver diseases, such as chronic hepatitis, liver cirrhosis.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

2. IMPORTANT INFORMATION BEFORE TAKING HEPA-MERZ 3000

When not to take Hepa-Merz 3000

Do not take Hepa-Merz 3000 if you have the following disorders:

  • hypersensitivity to L-ornithine L-aspartate, orange yellow S (E 110), or any of the other ingredients of the medicine;
  • severe renal impairment (serum creatinine concentration above 3 mg/100 ml);
  • disorders of amino acid metabolism involved in the urea cycle, e.g., due to enzymatic defects;
  • fructose intolerance.

Warnings and precautions

Hepa-Merz 3000 contains a dye – orange yellow S (E 110), which may cause allergic reactions (including asthma symptoms). This type of allergy is particularly common in people allergic to acetylsalicylic acid.
Hepa-Merz 3000 contains fructose (1.13 g in one sachet, which corresponds to 0.11 bread units). This should be taken into account in patients with diabetes.
Long-term use of Hepa-Merz 3000 may cause tooth decay.
Children:
There is no data on the use of the medicine in children.
Before administering the medicine to infants or children, it is necessary to consult a doctor, as there is a possibility of undiagnosed fructose intolerance in the child.

Hepa-Merz 3000 and other medicines

Tell your doctor about all medicines you are taking or have recently taken, as well as any medicines you plan to take.
There are no known interactions between Hepa-Merz 3000 and other medicines.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to have a child, consult your doctor before taking this medicine.
Pregnancy:
There are insufficient studies on the safety of using Hepa-Merz 3000 during pregnancy, so the medicine should be avoided during pregnancy. Hepa-Merz 3000 may be taken by pregnant women only if recommended by a doctor.
Breastfeeding:
It is not known whether L-ornithine L-aspartate (the active substance of Hepa-Merz 3000) passes into breast milk. The medicine should be avoided during breastfeeding. Hepa-Merz 3000 may be taken by breastfeeding women only if recommended by a doctor.

Driving and using machines

The ability to drive vehicles and operate machines may be impaired due to the disease being treated with Hepa-Merz 3000.

Hepa-Merz 3000 contains orange yellow S (E 110) and fructose.

The medicine contains orange yellow S, which may cause allergic reactions.
The medicine contains 1.13 g of fructose in each sachet. The fructose in the medicine may harm teeth.
See the "Warnings and precautions" section.

3. HOW TO TAKE HEPA-MERZ 3000

This medicine should always be taken as directed by your doctor. If you have any doubts, consult your doctor or pharmacist.
The usual dose is 1 or 2 sachets 1 to 3 times a day.
The contents of the sachet should be dissolved in a glass of water. Take during or after a meal.
If you feel that the effect of the medicine is too strong or too weak, contact your doctor or pharmacist.

Route of administration

Oral administration.

Overdose of Hepa-Merz 3000

No symptoms of overdose have been observed with Hepa-Merz 3000 so far.
In case of overdose, symptomatic treatment is used.

Missed dose of Hepa-Merz 3000

Take the next dose at the right time, according to the dosing instructions.
Do not take a double dose to make up for a missed dose. If you have any doubts about taking the medicine, consult your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Uncommon side effects (less than 1 in 100 people):

nausea; vomiting; stomach pain; bloating; diarrhea.

Rare side effects (less than 1 in 10,000 people):

limb pain.
The listed side effects are usually temporary and do not require discontinuation of the medicine.
The excipient – orange yellow S (E 110) may cause allergic reactions.

Reporting side effects

If you experience any side effects, including any side effects not listed in the leaflet, tell your doctor, pharmacist, or nurse. Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products
Al. Jerozolimskie 181C
02-222 Warsaw
Phone: +48 22 49 21 301
Fax: +48 22 49 21 309
Website: https://smz.ezdrowie.gov.pl
Reporting side effects will help gather more information on the safety of the medicine.

5. HOW TO STORE HEPA-MERZ 3000

Keep out of sight and reach of children.
Do not use the medicine after the expiry date stated on the packaging.
The expiry date refers to the last day of the specified month.
Do not store above 25°C.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. CONTENTS OF THE PACK AND OTHER INFORMATION

What Hepa-Merz 3000 contains

The active substance of the medicine is L-ornithine L-aspartate.
1 sachet (5 g granules) contains 3 g of L-ornithine L-aspartate.
Excipients:
citric acid, lemon flavor, orange flavor, sodium saccharin, sodium cyclamate, orange yellow S (E 110), povidon K 25, fructose.

What Hepa-Merz 3000 looks like and what the pack contains

Hepa-Merz 3000 is an orange granule.
The pack contains 10, 30, 50, or 100 sachets.
For more detailed information, contact the marketing authorization holder or parallel importer.

Marketing authorization holder in Austria, the country of export:

Merz Pharma Austria GmbH
Guglgasse 17
AT - 1110 Vienna
Austria

Manufacturer:

Merz Pharma GmbH & Co. KGaA
Eckenheimer Landstraße 100
D-60318 Frankfurt
Germany

Parallel importer:

Delfarma Sp. z o.o.
ul. Św. Teresy od Dzieciątka Jezus 111
91-222 Łódź

Repackaged by:

Delfarma Sp. z o.o.
ul. Św. Teresy od Dzieciątka Jezus 111
91-222 Łódź
Austrian export license number: 1-20706

Parallel import license number: 16/13 Date of leaflet approval: 13.01.2023

[Information about the trademark]

  • Hepa-mezh 3000
  • Country of registration
  • Dosage form
    Granulate, 3 g/5 g
  • ATC code
    A05BA06
  • Active substance
  • Prescription required
    Yes
  • Marketing authorisation holder (MAH)
    Merz Pharma Austria GmbH
  • Alternatives to Hepa-mezh 3000
    Dosage form: Granulate, 3 g/5 g
    Active substance: ornithine oxoglurate
    Prescription required
    Dosage form: Granulate, 3 g/5 g
    Active substance: ornithine oxoglurate
    Prescription required
    Dosage form: Concentrate, 5 g/10 ml
    Active substance: ornithine oxoglurate
    Prescription not required

Online doctors for Hepa-mezh 3000

Discuss questions about Hepa-mezh 3000, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

Family medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

Family medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(2)

Dmytro Horobets

Family medicineEndocrinology7 years of experience

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
  • Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
  • Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
  • Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

Book a video appointment
€71
Doctor
5.0(19)

Nuno Tavares Lopes

Family medicineGeneral medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70

Get Hepa-mezh 3000 Prescription Online

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Tell us your symptoms, history, and what medicine you're requesting.

2

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3

Doctor reviews your case

Usually within 30 minutes. They may ask follow-up questions via chat.

4

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Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for Hepa-mezh 3000?

Hepa-mezh 3000 requires a prescription in Poland. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in Hepa-mezh 3000?

The active ingredient in Hepa-mezh 3000 is ornithine oxoglurate. This information helps identify medicines with the same composition but different brand names.

Who manufactures Hepa-mezh 3000?

Hepa-mezh 3000 is manufactured by Merz Pharma Austria GmbH. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of Hepa-mezh 3000 online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether Hepa-mezh 3000 is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy Hepa-mezh 3000 in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy Hepa-mezh 3000 in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to Hepa-mezh 3000?

Other medicines with the same active substance (ornithine oxoglurate) include Hepa-mezh 3000, Hepa-mezh 3000, Hepa-mezh. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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