This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use Doxium 500

LEAFLET INCLUDED IN THE PACKAGING: INFORMATION FOR THE USER

DOXIUM 500, 500 mg, hard capsules
Calcii dobesilas

Please read carefully the contents of the leaflet before taking the medicine, as it contains important information for the patient.

Please keep this leaflet, so that you can read it again if you need to.
In case of any doubts, you should consult a doctor or pharmacist.
This medicine has been prescribed to you by a doctor and should not be given to others. The medicine may harm another person, even if their symptoms are the same.
If the patient experiences any side effects, including any side effects not listed in this leaflet, they should inform their doctor or pharmacist. See section 4.

Table of contents of the leaflet

1. What is DOXIUM 500 and what is it used for
2. Important information before taking DOXIUM 500
3. How to take DOXIUM 500
4. Possible side effects
5. How to store DOXIUM 500
6. Contents of the packaging and other information

1. WHAT IS DOXIUM 500 AND WHAT IS IT USED FOR

Indications for use of the medicine:
Clinical symptoms of chronic venous insufficiency of the lower limbs (pain, cramps, paresthesia, swelling, skin changes due to blood stasis), mild to moderate non-proliferative diabetic retinopathy, in order to slow down the progression of the disease.

2. IMPORTANT INFORMATION BEFORE TAKING DOXIUM 500

When not to take DOXIUM 500

if the patient is allergic to calcium dobesilate or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Before starting to take DOXIUM 500, the patient should discuss it with their doctor or pharmacist.
In very rare cases, taking DOXIUM 500 may cause agranulocytosis - a disease in which a significant decrease in the number of white blood cells increases the risk of infections. In such a situation, symptoms such as high fever, infections in the mouth (tonsillitis), sore throat, inflammatory changes in the genital and anal areas, and other symptoms that usually indicate the presence of an infection may occur. If such symptoms occur, the patient should stop the treatment and inform their doctor immediately.
DOXIUM 500 may cause severe allergic reactions (anaphylactic reaction or anaphylactic shock) with symptoms such as skin reactions, fever, difficulty breathing, or dizziness. In such a case, the patient should stop the treatment and inform their doctor immediately.
Clean

1.3.1.PL-PL-PL Pg. 1

The patient should also inform their doctor:

if they have kidney disease, especially if dialysis is required, as the dose of the medicine may need to be reduced in such cases.
If the patient is to undergo tests during treatment with DOXIUM 500, laboratory test samples (e.g., blood samples) should be taken before taking the first dose of the medicine to minimize the potential impact of DOXIUM 500 on the test results.

Children and adolescents

The safety and efficacy of DOXIUM 500 in children and adolescents have not been evaluated.

DOXIUM 500 and other medicines

The patient should inform their doctor or pharmacist about all medicines they are currently taking or have recently taken, as well as any medicines they plan to take.
So far, no confirmed cases of interaction between DOXIUM 500 and other medicines have been reported.
DOXIUM 500 may affect the results of laboratory tests for serum creatinine levels.
Therefore, the patient should inform their doctor about all laboratory tests, especially those that will assess kidney function.

Pregnancy, breastfeeding, and fertility

If the patient is pregnant or breastfeeding, thinks they may be pregnant, or plans to have a child, they should consult their doctor or pharmacist before taking this medicine.
Pregnancy
There are no data indicating that DOXIUM 500 has adverse effects on the fetus or embryo; however, this medicine should not be used during pregnancy.
Breastfeeding
After oral administration, the active substance of DOXIUM 500, calcium dobesilate, passes into breast milk in very small amounts. For safety reasons, either the treatment or breastfeeding should be discontinued. In such cases, the patient should consult their doctor.

Driving and using machines

DOXIUM 500 does not affect the ability to drive or use machines.

3. HOW TO TAKE DOXIUM 500

This medicine should always be taken according to the doctor's or pharmacist's recommendations. In case of doubts, the patient should consult their doctor or pharmacist.
Dosage
For adults only
Recommended dose:
Diabetic retinopathy: 1000 to 1500 mg/day (500 mg 2 to 3 times a day)
Chronic venous insufficiency: 500 to 1000 mg/day (500 or 1000 mg once a day).
The dose of the medicine should be determined individually, depending on the severity of symptoms. The duration of treatment depends on the type and course of the disease and usually lasts from several weeks to several months.
Patients with renal impairment
The safety and efficacy of DOXIUM 500 in patients with renal impairment have not been evaluated. The medicine is excreted by the kidneys, so caution should be exercised, and in patients with renal impairment (especially those requiring dialysis), the dose of DOXIUM 500 may be reduced.
Clean

1.3.1.PL-PL-PL Pg. 2

Patients with liver impairment
The safety and efficacy of DOXIUM 500 in patients with liver impairment have not been evaluated, so caution should be exercised.
If the patient feels that the effect of DOXIUM 500 is too strong or too weak, they should consult their doctor or pharmacist.
Method of administration
DOXIUM 500 is taken orally. The capsules should be swallowed whole, without opening them.
To minimize potential stomach discomfort, the capsules of DOXIUM 500 should be taken during or immediately after a meal.

Taking a higher dose of DOXIUM 500 than recommended

No cases of overdose have been reported so far.

Missing a dose of DOXIUM 500

The patient should not take a double dose to make up for a missed capsule.

Stopping treatment with DOXIUM 500

Stopping treatment with DOXIUM 500 before the end of therapy may have an unfavorable effect on its success. The patient should not stop treatment without consulting their doctor.
In case of any further doubts about the use of this medicine, the patient should consult their doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS

Like all medicines, DOXIUM 500 can cause side effects, although not everybody gets them.
Common side effects (may occur in up to 1 in 10 patients)
Abdominal pain, nausea, diarrhea, vomiting, headache, joint pain, muscle pain, increased alanine aminotransferase activity (change in liver function, which can be detected in blood tests)
Uncommon side effects (may occur in up to 1 in 100 patients)
Fever, chills, feeling weak, fatigue, hypersensitivity (rash, allergic dermatitis, itching, urticaria, facial edema; see section "Warnings and precautions")
Very rare side effects (may occur in up to 1 in 10,000 patients)
Significant decrease in the number of certain white blood cells, leading to an increased risk of infection (agranulocytosis; see section "Warnings and precautions"), severe allergic reaction leading to difficulty breathing or dizziness (anaphylactic reaction; see section "Warnings and precautions")
Frequency not known (frequency cannot be estimated from the available data)
Decreased number of white blood cells called neutrophils (neutropenia), decreased number of white blood cells (leukopenia)
These reactions usually resolve spontaneously after stopping treatment.

Reporting side effects

If the patient experiences any side effects, including any side effects not listed in this leaflet, they should inform their doctor or pharmacist. Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products.
Aleje Jerozolimskie 181C
02-222 Warsaw
Website: https://smz.ezdrowie.gov.pl
Reporting side effects can help gather more information on the safety of the medicine.

5. HOW TO STORE DOXIUM 500

The medicine should be stored out of sight and reach of children.
Do not use the medicine after the expiry date stated on the packaging. The expiry date refers to the last day of the given month.
Store in a temperature below 25°C.
Medicines should not be disposed of via wastewater or household waste. The patient should ask their pharmacist how to dispose of medicines that are no longer needed. This will help protect the environment.

6. CONTENTS OF THE PACKAGING AND OTHER INFORMATION

What DOXIUM 500 contains

The active substance of the medicine is calcium dobesilate (Calcii dobesilas).
Each hard capsule contains 500 mg of calcium dobesilate.
The other ingredients are: cornstarch, magnesium stearate.
The ingredients of the capsule shell are: yellow iron oxide (E 172), titanium dioxide (E 171), gelatin, indigo carmine (E 132).

What DOXIUM 500 looks like and contents of the packaging

DOXIUM 500 capsules are opaque, with a yellow body and a dark green cap.
The packaging contains 30 or 60 hard capsules in aluminum foil or PVC/PVDC blisters (10 capsules per blister).
Not all pack sizes may be marketed.

Marketing authorization holder and manufacturer

Marketing authorization holder

OMEDICAMED Unipessoal Lda
Avenida António Augusto de Aguiar nº 19 – 4º
1050-012 Lisboa
Portugal

Manufacturer

FLAVINE PHARMA FRANCE
3 voie d’Allemagne,
13127 Vitrolles, France
Clean

1.3.1.PL-PL-PL Pg. 4

For more detailed information, the patient should contact the local representative of the marketing authorization holder:
GEDEON RICHTER POLSKA Sp. z o.o.
Medical Department
ul. ks. J. Poniatowskiego 5
05-825 Grodzisk Mazowiecki
phone: +48 (22) 755 96 48
[email protected]

Date of last revision of the leaflet: January 2023

Clean

1.3.1.PL-PL-PL Pg. 5

Country of registration
Poland
Active substance
calcium dobesilate
Prescription required
No
Manufacturer
Flavine Pharma France
Importer
Flavine Pharma France
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
Alternatives to Doxium 500
Adproctin
Dosage form: Capsules, 500 mg
Active substance: calcium dobesilate
Manufacturer: Farmaceutyczna Spółdzielnia Pracy "Galena"
Prescription not required
Calcium dobesilate Galena
Dosage form: Tablets, 250 mg
Active substance: calcium dobesilate
Manufacturer: Farmaceutyczna Spółdzielnia Pracy "GALENA"
Prescription required
Calcium dobesilate Hasco
Dosage form: Tablets, 250 mg
Active substance: calcium dobesilate
Prescription required

Alternatives to Doxium 500 in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to Doxium 500 in Spain

DOXIUM FUERTE 500 mg HARD CAPSULES

Dosage form: CAPSULE, 500 mg

Active substance: calcium dobesilate

Manufacturer: Esteve Pharmaceuticals S.A.

Prescription required

FEPARIL 10mg/g + 50mg/g GEL

Dosage form: GEL, 10 mg escin; 50 mg diethylamine salicylate/1 g

Manufacturer: Cooper Consumer Health B.V.

Prescription not required

Online doctors for Doxium 500

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for Doxium 500 – subject to medical assessment and local rules.

0.0(0)

Eteri Tabeshadze

Cardiology32 years of experience

Dr. Eteri Tabeshadze is a cardiologist with the highest qualification category and over 32 years of clinical experience. She also practises functional diagnostics, offering a comprehensive approach to cardiovascular care. Dr. Tabeshadze provides online consultations for adults with a wide range of heart-related conditions, from preventive screenings to acute and chronic disease management.

Areas of expertise include:

Diagnosis and treatment of hypertension, coronary artery disease, and chronic heart failure
Management of arrhythmias and conduction disorders, including paroxysmal events
Emergency care: myocardial infarction, acute left ventricular failure, acute pulmonary heart disease
Post-thromboembolism care and evaluation of cardiomyopathies
Treatment of vegetative dysfunction and autonomic disorders
Interpretation of cardiovascular tests: ECG, Holter monitoring, ambulatory blood pressure monitoring (ABPM), echocardiography (including transesophageal echo), stress echocardiography, exercise testing (VEM, treadmill test)

Dr. Tabeshadze combines extensive diagnostic experience with personalised care. She helps patients understand their cardiovascular health, navigate symptoms and diagnoses, and create tailored treatment plans to improve quality of life and reduce long-term risks.

Book a video appointment

Maryna Kuznetsova

Cardiology16 years of experience

Dr Marina Kuznetsova is an internal medicine doctor and cardiologist with a PhD in medicine. She provides online consultations for adults with chronic and acute conditions, with a strong focus on cardiovascular health. Her approach is based on current clinical guidelines and evidence-based treatment strategies.

Areas of expertise:

dyslipidaemia and lipid metabolism disorders
prevention and management of atherosclerosis
blood pressure monitoring and antihypertensive therapy
arrhythmias: diagnosis, follow-up, and treatment adjustment
cardiovascular care and recovery support after Covid-19

Dr Kuznetsova helps patients manage cardiovascular risk factors, optimise long-term treatment, and gain clarity in complex health situations – all through accessible and structured online care.

Book a video appointment

Nataliia Lifantieva

Cardiology21 years of experience

Dr. Nataliia Lifantieva is a cardiologist and cardiac electrophysiologist with extensive experience in the diagnosis and treatment of arrhythmias. She offers online consultations for patients with chronic cardiovascular conditions, including medication management and post-operative follow-up.

Main areas of expertise:

Diagnosis and treatment of arrhythmias: extrasystole, atrial fibrillation and flutter, supraventricular and ventricular tachycardia
Conduction disorders: AV blocks, sinoatrial block, bradyarrhythmias
ECG and Holter monitor interpretation, including data from smartwatches
Evaluation for interventional treatment: stenting, bypass surgery, valve replacement
Anticoagulant management (e.g., warfarin, DOACs) based on kidney function and clinical context
Perioperative advice on anticoagulant/antiplatelet therapy before dental procedures

Book a video appointment

Anna Biriukova

General medicine5 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
Leg swelling, chronic fatigue, reduced exercise tolerance.
EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
Post-COVID-19 cardiac monitoring and care.

Endocrinology – Diabetes, thyroid, metabolism:

Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
Individual treatment plans including oral medications and insulin therapy.
GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
Metabolic syndrome – obesity, lipid disorders, insulin resistance.

Gastroenterology – Digestive health:

Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).

General internal medicine and preventive care:

Respiratory infections – cough, colds, bronchitis.
Lab test analysis, therapy adjustments, medication management.
Adult vaccinations – planning, contraindications assessment.
Cancer prevention – screening strategies and risk assessment.
Holistic approach – symptom relief, complication prevention, and quality of life improvement.

Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.

Book a video appointment

Liudmyla Boichuk

Family medicine10 years of experience

Dr Liudmyla Boichuk is a family medicine doctor providing diagnosis and treatment for a wide range of acute and chronic conditions in adults and children. She works with respiratory, cardiovascular and digestive system disorders and has extensive experience caring for patients with multiple coexisting conditions, where coordinated, whole-person management is essential.

She treats adults with respiratory illnesses such as pneumonia, COPD and bronchial asthma, as well as cardiovascular conditions including hypertension and ischaemic heart disease. Her practice also covers gastrointestinal complaints and chronic comorbidities that require careful, structured medical supervision.

Dr Boichuk provides care for children from birth, including acute respiratory viral infections, infectious diseases, pneumonia, bronchitis, bronchial obstruction syndromes and allergic reactions. She offers clear, evidence-based guidance to parents and ensures safe follow-up throughout the child’s recovery.

Her work also includes developing personalised immunisation plans and supporting families with long-term preventive care.

Known for her structured clinical approach and clear communication, Dr Liudmyla Boichuk offers patients of all ages comprehensive, reliable and evidence-based medical care.

Book a video appointment

Svetlana Kolomeeva

Cardiology17 years of experience

Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

Patients commonly seek her help for:

High blood pressure, headaches, dizziness, swelling, palpitations.
Diagnosis and management of hypertension, arrhythmias, and tachycardia.
Metabolic syndrome, excess weight, high cholesterol.
Chronic fatigue, insomnia, poor concentration, anxiety.
Respiratory symptoms: colds, flu, sore throat, cough, fever.
Digestive issues: heartburn, bloating, constipation, IBS symptoms.
Chronic conditions: diabetes, thyroid disorders.
Interpretation of lab tests and medical reports, therapy adjustment.
Second opinion and decision-making support.
Cardiovascular disease prevention and metabolic risk reduction.
Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

Book a video appointment

Mar Tabeshadze

Endocrinology10 years of experience

Dr. Mar Tabeshadze is a licensed endocrinologist and general practitioner in Spain. She provides online consultations for adults, offering medical support for a wide range of endocrine conditions and related health concerns.

Diagnostic consultations for suspected endocrine disorders
Management of thyroid conditions, including in pregnant women
Early detection and treatment of type 1 and type 2 diabetes, with personalised therapy plans
Obesity treatment: identifying underlying causes of weight gain, combining medication and non-pharmacological strategies, and long-term support
Diagnosis and treatment of endocrine-related skin, hair, and nail issues
Ongoing care for patients with osteoporosis, pituitary, and adrenal gland disorders

Dr. Tabeshadze takes a patient-centred approach based on evidence-based medicine. Her goal is to help patients achieve hormonal balance, manage chronic conditions effectively, and improve overall well-being through targeted, personalised care.

Book a video appointment

Nataliia Bessolitsyna

Rheumatology25 years of experience

Dr. Nataliia Bessolitsyna is a rheumatologist with extensive clinical experience. She provides online consultations focused on the diagnosis, treatment, and long-term management of joint diseases and systemic autoimmune disorders, following international clinical guidelines and evidence-based medicine.

You can consult Dr. Bessolitsyna about:

Joint pain — acute, chronic, or recurring pain.
Inflammatory arthritis: rheumatoid arthritis, psoriatic arthritis, polyarthritis, gouty arthritis.
Degenerative joint conditions: osteoarthritis, knee and hip arthritis (gonarthrosis, coxarthrosis), nodal polyosteoarthritis.
Periarthritis and spondyloarthritis.
Spinal inflammation: ankylosing spondylitis (Bechterew’s disease).
Systemic autoimmune diseases: lupus, scleroderma, systemic vasculitis.
Osteoporosis and bone fragility.

Dr. Bessolitsyna offers a personalised and structured approach — helping patients identify causes of joint pain, interpret test results, and follow tailored treatment plans. Her consultations focus on early diagnosis, symptom control, complication prevention, and improving long-term quality of life.

With remote access to specialist care, patients can receive expert rheumatology support wherever they are.

Book a video appointment

Alexandra Alexandrova

General medicine8 years of experience

Dr Alexandra Alexandrova is a licensed general medicine doctor in Spain, specialising in trichology, nutrition, and aesthetic medicine. She offers online consultations for adults, combining a therapeutic approach with personalised care for hair, scalp, and overall health.

Areas of expertise:

Hair loss in women and men, postpartum hair loss, androgenetic and telogen effluvium.
Scalp conditions: seborrheic dermatitis, psoriasis, scalp irritation, dandruff.
Chronic conditions: hypertension, diabetes, metabolic disorders.
Online trichology consultation: customised treatment plans, nutritional support, hair growth stimulation.
Hair loss prevention: hormonal imbalance, stress factors, haircare strategies.
Routine health check-ups, prevention of cardiovascular and metabolic diseases.
Personalised nutritional advice to improve hair strength, skin health, and hormonal balance.
Aesthetic medicine: non-invasive strategies to enhance skin quality, tone, and metabolic wellness.

Dr Alexandrova follows an evidence-based and holistic approach: online consultations with a therapist and trichologist on Oladoctor provide professional support for hair, scalp, and overall health — all from the comfort of your home.

Book a video appointment