DOXIUM 500 mg Capsules

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Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Doxium 500

Contents of the leaflet

  1. LEAFLET INCLUDED IN THE PACKAGING: INFORMATION FOR THE USER
    1. Please read carefully the contents of the leaflet before taking the medicine, as it contains important information for the patient.
    2. Table of contents of the leaflet
  2. WHAT IS DOXIUM 500 AND WHAT IS IT USED FOR
  3. IMPORTANT INFORMATION BEFORE TAKING DOXIUM 500
    1. When not to take DOXIUM 500
    2. Warnings and precautions
    3. Children and adolescents
    4. DOXIUM 500 and other medicines
    5. Pregnancy, breastfeeding, and fertility
    6. Driving and using machines
  4. HOW TO TAKE DOXIUM 500
    1. Taking a higher dose of DOXIUM 500 than recommended
    2. Missing a dose of DOXIUM 500
    3. Stopping treatment with DOXIUM 500
  5. POSSIBLE SIDE EFFECTS
    1. Reporting side effects
  6. HOW TO STORE DOXIUM 500
  7. CONTENTS OF THE PACKAGING AND OTHER INFORMATION
    1. What DOXIUM 500 contains
    2. What DOXIUM 500 looks like and contents of the packaging
    3. Marketing authorization holder and manufacturer
    4. Marketing authorization holder
    5. Manufacturer
    6. Date of last revision of the leaflet: January 2023

LEAFLET INCLUDED IN THE PACKAGING: INFORMATION FOR THE USER

DOXIUM 500, 500 mg, hard capsules
Calcii dobesilas

Please read carefully the contents of the leaflet before taking the medicine, as it contains important information for the patient.

  • Please keep this leaflet, so that you can read it again if you need to.
  • In case of any doubts, you should consult a doctor or pharmacist.
  • This medicine has been prescribed to you by a doctor and should not be given to others. The medicine may harm another person, even if their symptoms are the same.
  • If the patient experiences any side effects, including any side effects not listed in this leaflet, they should inform their doctor or pharmacist. See section 4.

Table of contents of the leaflet

  • 1. What is DOXIUM 500 and what is it used for
  • 2. Important information before taking DOXIUM 500
  • 3. How to take DOXIUM 500
  • 4. Possible side effects
  • 5. How to store DOXIUM 500
  • 6. Contents of the packaging and other information

1. WHAT IS DOXIUM 500 AND WHAT IS IT USED FOR

Indications for use of the medicine:
Clinical symptoms of chronic venous insufficiency of the lower limbs (pain, cramps, paresthesia, swelling, skin changes due to blood stasis), mild to moderate non-proliferative diabetic retinopathy, in order to slow down the progression of the disease.

Doctor consultation

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Discuss your symptoms and treatment with a doctor online.

2. IMPORTANT INFORMATION BEFORE TAKING DOXIUM 500

When not to take DOXIUM 500

  • if the patient is allergic to calcium dobesilate or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Before starting to take DOXIUM 500, the patient should discuss it with their doctor or pharmacist.
In very rare cases, taking DOXIUM 500 may cause agranulocytosis - a disease in which a significant decrease in the number of white blood cells increases the risk of infections. In such a situation, symptoms such as high fever, infections in the mouth (tonsillitis), sore throat, inflammatory changes in the genital and anal areas, and other symptoms that usually indicate the presence of an infection may occur. If such symptoms occur, the patient should stop the treatment and inform their doctor immediately.
DOXIUM 500 may cause severe allergic reactions (anaphylactic reaction or anaphylactic shock) with symptoms such as skin reactions, fever, difficulty breathing, or dizziness. In such a case, the patient should stop the treatment and inform their doctor immediately.
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The patient should also inform their doctor:

  • if they have kidney disease, especially if dialysis is required, as the dose of the medicine may need to be reduced in such cases.
  • If the patient is to undergo tests during treatment with DOXIUM 500, laboratory test samples (e.g., blood samples) should be taken before taking the first dose of the medicine to minimize the potential impact of DOXIUM 500 on the test results.

Children and adolescents

The safety and efficacy of DOXIUM 500 in children and adolescents have not been evaluated.

DOXIUM 500 and other medicines

The patient should inform their doctor or pharmacist about all medicines they are currently taking or have recently taken, as well as any medicines they plan to take.
So far, no confirmed cases of interaction between DOXIUM 500 and other medicines have been reported.
DOXIUM 500 may affect the results of laboratory tests for serum creatinine levels.
Therefore, the patient should inform their doctor about all laboratory tests, especially those that will assess kidney function.

Pregnancy, breastfeeding, and fertility

If the patient is pregnant or breastfeeding, thinks they may be pregnant, or plans to have a child, they should consult their doctor or pharmacist before taking this medicine.
Pregnancy
There are no data indicating that DOXIUM 500 has adverse effects on the fetus or embryo; however, this medicine should not be used during pregnancy.
Breastfeeding
After oral administration, the active substance of DOXIUM 500, calcium dobesilate, passes into breast milk in very small amounts. For safety reasons, either the treatment or breastfeeding should be discontinued. In such cases, the patient should consult their doctor.

Driving and using machines

DOXIUM 500 does not affect the ability to drive or use machines.

3. HOW TO TAKE DOXIUM 500

This medicine should always be taken according to the doctor's or pharmacist's recommendations. In case of doubts, the patient should consult their doctor or pharmacist.
Dosage
For adults only
Recommended dose:
Diabetic retinopathy: 1000 to 1500 mg/day (500 mg 2 to 3 times a day)
Chronic venous insufficiency: 500 to 1000 mg/day (500 or 1000 mg once a day).
The dose of the medicine should be determined individually, depending on the severity of symptoms. The duration of treatment depends on the type and course of the disease and usually lasts from several weeks to several months.
Patients with renal impairment
The safety and efficacy of DOXIUM 500 in patients with renal impairment have not been evaluated. The medicine is excreted by the kidneys, so caution should be exercised, and in patients with renal impairment (especially those requiring dialysis), the dose of DOXIUM 500 may be reduced.
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Patients with liver impairment
The safety and efficacy of DOXIUM 500 in patients with liver impairment have not been evaluated, so caution should be exercised.
If the patient feels that the effect of DOXIUM 500 is too strong or too weak, they should consult their doctor or pharmacist.
Method of administration
DOXIUM 500 is taken orally. The capsules should be swallowed whole, without opening them.
To minimize potential stomach discomfort, the capsules of DOXIUM 500 should be taken during or immediately after a meal.

No cases of overdose have been reported so far.

Missing a dose of DOXIUM 500

The patient should not take a double dose to make up for a missed capsule.

Stopping treatment with DOXIUM 500

Stopping treatment with DOXIUM 500 before the end of therapy may have an unfavorable effect on its success. The patient should not stop treatment without consulting their doctor.
In case of any further doubts about the use of this medicine, the patient should consult their doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. POSSIBLE SIDE EFFECTS

Like all medicines, DOXIUM 500 can cause side effects, although not everybody gets them.
Common side effects (may occur in up to 1 in 10 patients)
Abdominal pain, nausea, diarrhea, vomiting, headache, joint pain, muscle pain, increased alanine aminotransferase activity (change in liver function, which can be detected in blood tests)
Uncommon side effects (may occur in up to 1 in 100 patients)
Fever, chills, feeling weak, fatigue, hypersensitivity (rash, allergic dermatitis, itching, urticaria, facial edema; see section "Warnings and precautions")
Very rare side effects (may occur in up to 1 in 10,000 patients)
Significant decrease in the number of certain white blood cells, leading to an increased risk of infection (agranulocytosis; see section "Warnings and precautions"), severe allergic reaction leading to difficulty breathing or dizziness (anaphylactic reaction; see section "Warnings and precautions")
Frequency not known (frequency cannot be estimated from the available data)
Decreased number of white blood cells called neutrophils (neutropenia), decreased number of white blood cells (leukopenia)
These reactions usually resolve spontaneously after stopping treatment.

Reporting side effects

If the patient experiences any side effects, including any side effects not listed in this leaflet, they should inform their doctor or pharmacist. Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products.
Aleje Jerozolimskie 181C
02-222 Warsaw
Website: https://smz.ezdrowie.gov.pl
Reporting side effects can help gather more information on the safety of the medicine.

5. HOW TO STORE DOXIUM 500

The medicine should be stored out of sight and reach of children.
Do not use the medicine after the expiry date stated on the packaging. The expiry date refers to the last day of the given month.
Store in a temperature below 25°C.
Medicines should not be disposed of via wastewater or household waste. The patient should ask their pharmacist how to dispose of medicines that are no longer needed. This will help protect the environment.

6. CONTENTS OF THE PACKAGING AND OTHER INFORMATION

What DOXIUM 500 contains

The active substance of the medicine is calcium dobesilate (Calcii dobesilas).
Each hard capsule contains 500 mg of calcium dobesilate.
The other ingredients are: cornstarch, magnesium stearate.
The ingredients of the capsule shell are: yellow iron oxide (E 172), titanium dioxide (E 171), gelatin, indigo carmine (E 132).

What DOXIUM 500 looks like and contents of the packaging

DOXIUM 500 capsules are opaque, with a yellow body and a dark green cap.
The packaging contains 30 or 60 hard capsules in aluminum foil or PVC/PVDC blisters (10 capsules per blister).
Not all pack sizes may be marketed.

Marketing authorization holder and manufacturer

Marketing authorization holder

OMEDICAMED Unipessoal Lda
Avenida António Augusto de Aguiar nº 19 – 4º
1050-012 Lisboa
Portugal

Manufacturer

FLAVINE PHARMA FRANCE
3 voie d’Allemagne,
13127 Vitrolles, France
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For more detailed information, the patient should contact the local representative of the marketing authorization holder:
GEDEON RICHTER POLSKA Sp. z o.o.
Medical Department
ul. ks. J. Poniatowskiego 5
05-825 Grodzisk Mazowiecki
phone: +48 (22) 755 96 48
[email protected]

Date of last revision of the leaflet: January 2023

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Online doctors for Doxium 500

Discuss questions about Doxium 500, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

Family medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

Family medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(2)

Dmytro Horobets

Family medicineEndocrinology7 years of experience

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
  • Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
  • Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
  • Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

Book a video appointment
€71
Doctor
5.0(19)

Nuno Tavares Lopes

Family medicineGeneral medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70

Get Doxium 500 Prescription Online

1

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Tell us your symptoms, history, and what medicine you're requesting.

2

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3

Doctor reviews your case

Usually within 30 minutes. They may ask follow-up questions via chat.

4

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Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for Doxium 500?

Doxium 500 does not require a prescription in Poland. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in Doxium 500?

The active ingredient in Doxium 500 is calcium dobesilate. This information helps identify medicines with the same composition but different brand names.

Who manufactures Doxium 500?

Doxium 500 is manufactured by Flavine Pharma France. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of Doxium 500 online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether Doxium 500 is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy Doxium 500 in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy Doxium 500 in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to Doxium 500?

Other medicines with the same active substance (calcium dobesilate) include Adproctin, Calcium dobesilate Galena, Calcium dobesilate Hasco. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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