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Darunavir Sinoptis

Darunavir Sinoptis

Ask a doctor about a prescription for Darunavir Sinoptis

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Nuno Tavares Lopes

Family medicine17 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC. He offers online consultations in Portuguese, English, and Spanish — combining global expertise with a patient-centred, evidence-based approach.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Darunavir Sinoptis

Package Leaflet: Information for the User

Darunavir Synoptis, 400 mg, Film-Coated Tablets

Darunavir Synoptis, 800 mg, Film-Coated Tablets

Darunavir

Read all of this leaflet carefully before taking this medicine.

  • Keep this leaflet. You may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse.
  • This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you experience any side effects, talk to your doctor, pharmacist, or nurse. See section 4.

Contents of the Pack

  • 1. What Darunavir Synoptis is and what it is used for
  • 2. Important information before taking Darunavir Synoptis
  • 3. How to take Darunavir Synoptis
  • 4. Possible side effects
  • 5. How to store Darunavir Synoptis
  • 6. Contents of the pack and other information

1. What Darunavir Synoptis is and what it is used for

What Darunavir Synoptis is

Darunavir Synoptis contains the active substance darunavir. Darunavir Synoptis is an antiretroviral medicine used to treat HIV infection.

What Darunavir Synoptis is used for

Darunavir Synoptis 400 mg and 800 mg film-coated tablets are used to treat adults and children from 3 years of age and at least 40 kg body weight who are infected with HIV.

  • who have not taken any antiretroviral medicines before,
  • and for some patients who have taken other antiretroviral medicines in the past (as determined by their doctor).

Darunavir Synoptis should be taken in combination with other HIV medicines and a small dose of cobicistat or ritonavir.

2. Important information before taking Darunavir Synoptis

When not to take Darunavir Synoptis

  • if you are allergic to darunavir or any of the other ingredients of this medicine,
  • if you have severe liver problems.

Do not take Darunavir Synoptis with the following medicines

Tell your doctor if you are taking any of these medicines:

Medicine NameUse of Medicine
AwanafilTreatment of erectile dysfunction
Astemizole or terfenadineTreatment of allergy symptoms
Triazolam and oral midazolamSedative and anxiolytic effects
CisaprideTreatment of certain stomach disorders
Colchicine (in patients with renal and/or hepatic impairment)Treatment of gout or familial Mediterranean fever
Lurasidone, pimozide, quetiapine, or sertindoleTreatment of psychiatric disorders
Ergot derivatives (e.g., ergotamine, dihydroergotamine, ergometrine, and methylergonovine)Treatment of migraine and other types of headaches
Amiodarone, bepridil, dronedarone, ivabradine, quinidine, and ranolazineTreatment of certain heart conditions, such as arrhythmias
Lovastatin, simvastatin, and lomitapideTreatment of high cholesterol
RifampicinTreatment of certain infections, such as tuberculosis
Lopinavir/ritonavir combinationAntiretroviral medicine for HIV infection
Elbasvir/grazoprevirTreatment of hepatitis C infection
AlfuzosinTreatment of enlarged prostate
SildenafilTreatment of pulmonary arterial hypertension
Dabigatran, ticagrelorPrevention of blood clots in patients with a history of heart attack
NaloxegolTreatment of opioid-induced constipation
DapoxetineTreatment of premature ejaculation
DomperidoneTreatment of nausea and vomiting

During treatment with Darunavir Synoptis, you must not take any of the following medicines:

Warnings and precautions

Before taking Darunavir Synoptis, tell your doctor if:

  • you have ever had liver problems,
  • you have diabetes,
  • you notice any signs of infection (e.g., swollen lymph nodes, fever),
  • you have hemophilia,
  • you are allergic to sulfonamides,
  • you have musculoskeletal disorders.

Elderly patients

Darunavir Synoptis has only been used in a small number of patients aged 65 and over.

Children and adolescents

Darunavir Synoptis 400 mg and 800 mg film-coated tablets are not intended for children below 3 years of age or weighing less than 40 kg.

Interactions with other medicines

Tell your doctor or pharmacist about all the medicines you are taking or have recently taken.

Darunavir Synoptis with food and drink

See section 3 "How to take Darunavir Synoptis".

Pregnancy and breastfeeding

Do not take Darunavir Synoptis with ritonavir during pregnancy or while breastfeeding without consulting your doctor.

Driving and using machines

Do not drive or operate machines if you experience dizziness while taking Darunavir Synoptis.

Darunavir Synoptis contains lactose

This medicine contains lactose. If you have been told that you have an intolerance to some sugars, contact your doctor before taking this medicine.

Darunavir Synoptis 400 mg film-coated tablets contain sunset yellow FCF (E 110)

This may cause allergic reactions.

3. How to take Darunavir Synoptis

Always take this medicine exactly as your doctor or pharmacist has told you.

Dosing in children from 3 years of age and at least 40 kg body weight who have not taken antiretroviral medicines before

  • The recommended dose is 800 mg (two 400 mg tablets or one 800 mg tablet) once daily with 100 mg ritonavir.

Dosing in children from 3 years of age and at least 40 kg body weight who have taken antiretroviral medicines before

The dose is:

  • 800 mg Darunavir Synoptis (two 400 mg tablets or one 800 mg tablet) once daily with 100 mg ritonavir, or
  • 600 mg darunavir with 100 mg ritonavir twice daily.

Discuss with your doctor which dose is right for you.

Dosing in adults who have not taken antiretroviral medicines before

The typical dose is 800 mg (two 400 mg tablets or one 800 mg tablet) once daily.

Dosing in adults who have taken antiretroviral medicines before

The dose is:

  • 800 mg Darunavir Synoptis (two 400 mg tablets or one 800 mg tablet) once daily with 150 mg cobicistat or 100 mg ritonavir, or
  • 600 mg darunavir with 100 mg ritonavir twice daily.

Discuss with your doctor which dose is right for you.

How to take Darunavir Synoptis

  • Take the dose at the same time every day.
  • Take Darunavir Synoptis with food.
  • Swallow the tablets with water or milk.

Opening the child-resistant cap

Hand opening the child-resistant cap on the bottle, arrows indicating the direction of rotation 1 and 2

The plastic bottle has a child-resistant cap. To open it, press the plastic cap while turning it counterclockwise.

If you take more Darunavir Synoptis than you should

Contact your doctor or pharmacist immediately.

If you forget to take Darunavir Synoptis

If you notice you have missed a dose within 12 hours, take the missed dose as soon as possible. If you notice you have missed a dose after 12 hours, skip the missed dose and take the next dose at the usual time.

Do not stop taking Darunavir Synoptis without talking to your doctor

Even if you feel better, do not stop taking Darunavir Synoptis without talking to your doctor.

4. Possible side effects

During HIV treatment, weight and levels of blood fats and sugar may increase.

Common side effects

  • Diarrhea.

Uncommon side effects

  • Nausea, vomiting, abdominal pain, indigestion, bloating.

Rare side effects

  • Severe skin reactions, including DRESS syndrome.

5. How to store Darunavir Synoptis

Keep this medicine out of the sight and reach of children.

What Darunavir Synoptis contains

  • The active substance is darunavir.

Each film-coated tablet contains 400 mg or 800 mg of darunavir.

What Darunavir Synoptis looks like and contents of the pack

Darunavir Synoptis 400 mg film-coated tablets are orange, oval tablets with "400" engraved on one side.

Darunavir Synoptis 800 mg film-coated tablets are dark red, oval tablets with "800" engraved on one side.

The pack contains a bottle with a child-resistant cap and a desiccant.

Marketing authorization holder and manufacturer

Marketing authorization holder: Synoptis Pharma Sp. z o.o.

Manufacturer: Pharmathen S.A.

Revision date of the leaflet

04/2020

Alternatives to Darunavir Sinoptis in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to Darunavir Sinoptis in Spain

Dosage form: TABLET, 75 mg
Active substance: darunavir
Prescription required
Dosage form: TABLET, 150 mg
Active substance: darunavir
Prescription required
Dosage form: TABLET, 800 mg
Active substance: darunavir
Prescription required
Dosage form: TABLET, 600 mg
Active substance: darunavir
Prescription required
Dosage form: TABLET, 400 mg
Active substance: darunavir
Prescription required
Dosage form: TABLET, 400 mg
Active substance: darunavir
Prescription required

Alternative to Darunavir Sinoptis in Ukraine

Dosage form: tablets, 800mg, 30 tablets
Active substance: darunavir
Manufacturer: KRKA, d.d., Novo mesto
Prescription required
Dosage form: tablets, 600 mg
Active substance: darunavir
Manufacturer: Getero Labz Limited
Prescription required
Dosage form: tablets, 400 mg
Active substance: darunavir
Manufacturer: Getero Labz Limited
Prescription required

Online doctors for Darunavir Sinoptis

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for Darunavir Sinoptis – subject to medical assessment and local rules.

5.0(31)
Doctor

Nuno Tavares Lopes

Family medicine17 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC. He offers online consultations in Portuguese, English, and Spanish — combining global expertise with a patient-centred, evidence-based approach.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.
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  • Work-related health questions, sick leave documentation, and medical guidance for returning to work
Dr. Meneses graduated from the University of Beira Interior and has years of experience working with diverse patient populations. He is fluent in Portuguese, English, Spanish, and French.

His approach is friendly, clear, and focused on delivering practical medical advice tailored to each patient’s needs.

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  • Mental health support, anxiety, and counselling
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Dr. Alhasan’s approach is based on thorough assessment, clear communication, and personalised care – helping patients understand their health and make informed decisions about their treatment.
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  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
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Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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With a patient-focused and evidence-based approach, Dr. Ben Ami supports individuals at all stages of life — offering clear medical guidance, timely interventions, and continuity of care.

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