Aspargin

Leaflet attached to the packaging: patient information

Aspargin

17 mg of magnesium ions + 54 mg of potassium ions, tablets

Magnesium hydroaspartate + Potassium hydroaspartate

Read the leaflet carefully before taking the medicine, as it contains important information for the patient.

This medicine should always be taken exactly as described in this patient leaflet or as directed by a doctor or pharmacist.

• Keep this leaflet, so you can read it again if you need to.
• If you need advice or additional information, consult a pharmacist.
• If the patient experiences any side effects, including those not listed in this leaflet, they should tell their doctor or pharmacist. See section 4.
• If there is no improvement after 30 days or the patient feels worse, they should contact their doctor.

Table of contents of the leaflet

• 1. What is Aspargin and what is it used for
• 2. Important information before taking Aspargin
• 3. How to take Aspargin
• 4. Possible side effects
• 5. How to store Aspargin
• 6. Contents of the packaging and other information

1. What is Aspargin and what is it used for

Aspargin is a medicine containing magnesium and potassium. It contains a well-absorbed mixture of magnesium and potassium salts of aspartic acid, an important building block of the body.
Magnesiumis an activator of many enzymes, it participates in the production and transport of energy in the body. It is necessary for the functioning of the heart muscle, nervous system, smooth muscle of blood vessels, and striated muscles. Magnesium deficiency increases the risk of coronary heart disease, heart attack, and arrhythmias. Symptoms of magnesium deficiency are:

• hyperexcitability,
• difficulty concentrating and sleeping,
• increased susceptibility to stress,
• muscle disorders manifested by tremors, cramps, and tics.

Potassiumparticipates in the functioning of the nervous system and cardiovascular system, as well as in neuromuscular conduction. Potassium deficiency poses a risk to the proper functioning of:

• the nervous system, nerve conduction, and neuromuscular conduction (movement, heart function, functioning of other internal organs),
• the system transporting various substances to and from the body's cells (nutrition, respiration, and excretion),
• the circulatory and excretory system in regulating water and electrolyte balance (responsible for maintaining proper blood pressure and acidity).

Aspartic acidparticipates in the transmission of stimuli in the central nervous system.

Indications for use:

Aspargin is used to supplement magnesium and potassium deficiencies:

• in heart function disorders caused by magnesium and potassium deficiencies;
• prophylactically in ischemic heart disease and the risk of heart attack;
• supportively in patients after a heart attack (during the recovery period);
• after infectious diseases or surgical procedures that have reduced magnesium and potassium levels;
• with prolonged use of cardiac glycosides and diuretics (e.g., thiazides, furosemide).

If there is no improvement after 30 days or the patient feels worse, they should consult their doctor.

2. Important information before taking Aspargin

When not to take Aspargin

• if the patient is allergic to magnesium aspartate, potassium aspartate (active substances), or any of the other ingredients of this medicine (listed in section 6);
• if the patient has hypermagnesemia (excess magnesium in the blood);
• if the patient has hyperkalemia (excess potassium in the blood);
• if the patient has severe kidney failure (creatinine clearance less than 30 ml/minute);
• if the patient has urinary tract infections (bladder, kidneys);
• if the patient has heart function disorders (feeling of too slow, too fast, or irregular heartbeat);
• if the patient has myasthenia gravis(a rare disease characterized by muscle weakness);
• if the patient has significant hypotension.

Warnings and precautions

Before starting to take Aspargin, the patient should discuss it with their doctor or pharmacist.
Caution should be exercised if:

• the patient has acute dehydration,
• the patient has undergone extensive tissue destruction (e.g., burns to large areas of the body),
• the patient is taking other potassium-containing medicines,
• the patient has stomach ulcers,
• the patient has previously been diagnosed with intolerance to certain sugars.

During long-term use and in the event of diarrhea, as well as in patients treated with cardiac glycosides, potassium and magnesium levels in the blood serum should be monitored, and if necessary, also in erythrocytes (the doctor will prescribe the relevant tests).
The medicine should not be administered without the doctor's knowledge in cancer patients.

Aspargin and other medicines

The patient should tell their doctor or pharmacist about all medicines they are currently taking or have recently taken, as well as any medicines they plan to take.
Aspargin should not be taken at the same time as the following medicines:

• tetracycline antibiotics, as magnesium salts reduce the absorption of these antibiotics; a minimum 3-hour interval should be maintained between the administration of these medicines;
• oral anticoagulants derived from coumarin, fluoroquinolones, fluorine, as magnesium compounds reduce their absorption;
• medicines and dietary supplements containing phosphates, calcium, and iron, as they reduce magnesium absorption from the gastrointestinal tract;
• atropine or hyoscine, as the risk of intestinal ulcers increases, which may occur when taking potassium salts orally.

Cardiac glycosides (heart medicines) used in combination with potassium can lead to arrhythmias.
Diuretics (amiloride, spironolactone, triamterene) and angiotensin-converting enzyme inhibitors (medicines used in cardiovascular diseases, e.g., captopril and enalapril) cause an increase in potassium levels in the blood.
Aminoglycoside antibiotics, loop diuretics, cisplatin, cyclosporine, mitramycin, amphotericin B, and mineralocorticosteroids enhance magnesium excretion.
Cortisone reduces the effects of potassium. The potassium contained in the medicine reduces the absorption of vitamin B.

Taking Aspargin with food and drink

The medicine should be taken after a meal, with a glass of water. Magnesium absorption decreases in the presence of phosphates, calcium, lipids, and phytates in the diet.

Pregnancy, breastfeeding, and fertility

If the patient is pregnant or breastfeeding, thinks they may be pregnant, or plans to have a child, they should consult their doctor or pharmacist before taking this medicine.

Driving and using machines

The medicine, when taken as directed, does not affect the ability to drive vehicles, operate machinery, or physical and mental performance.

Aspargin contains sugar

One tablet contains 53 mg of sucrose. If the patient has previously been diagnosed with intolerance to certain sugars, they should consult their doctor before taking the medicine.

Aspargin contains sodium

The medicine contains less than 1 mmol (23 mg) of sodium per tablet, which means the medicine is considered "sodium-free".

3. How to take Aspargin

This medicine should always be taken exactly as described in this patient leaflet or as directed by a doctor or pharmacist. If in doubt, the patient should consult their doctor or pharmacist.
Usually, the medicine is taken as described below.

Adults and adolescents over 12 years of age:

The recommended dose is 1 to 2 tablets 2 to 3 times a day, after a meal, which is 2 to 6 tablets per day in 2 or 3 divided doses.
The medicine should be taken after a meal, with a glass of water.
The medicine should not be taken by children under 12 years of age.
Patient with kidney or liver function disorders
Aspargin should not be taken by patients with severe kidney or liver function disorders due to the risk of hypermagnesemia or hyperkalemia.
Elderly patients
There is no need to change the way the medicine is taken or the dosage in patients over 65 years of age.
If the patient feels that the effect of Aspargin is too strong or too weak, they should consult their doctor.

Taking a higher dose of Aspargin than recommended

In the event of taking a higher dose of the medicine than recommended, the patient should immediately consult their doctor or pharmacist.
Symptoms of overdose: atrioventricular conduction disorders, respiratory disorders, decreased blood pressure, seizures, muscle weakness, feeling of fatigue, drooping eyelids.

Missing a dose of Aspargin

A double dose should not be taken to make up for a missed dose.

Stopping the use of Aspargin

In case of any further doubts about the use of this medicine, the patient should consult their doctor or pharmacist.

4. Possible side effects

Like all medicines, Aspargin can cause side effects, although not everybody gets them.
Uncommon(occurring in less than 1 in 100 treated patients): abdominal pain, nausea, diarrhea, constipation, vomiting, which usually resolve on their own.
Rare side effects(occurring in less than 1 in 1,000 treated patients): atrioventricular conduction disorders (heart function disorders), muscle weakness, skin redness.
Rarely, especially in patients with kidney function disorders: hyperkalemia.
Very rare side effects(occurring in less than 1 in 10,000 treated patients): insomnia.

Reporting side effects

If any side effects occur, including those not listed in this leaflet, the patient should tell their doctor, pharmacist, or nurse. Side effects can be reported directly to the Department of Monitoring of Adverse Reactions to Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products:
Al. Jerozolimskie 181C
02-222 Warsaw
phone: 22 49 21 301
fax: 22 49 21 309
Website: https://smz.ezdrowie.gov.pl.
Side effects can also be reported to the marketing authorization holder.
Reporting side effects will help gather more information on the safety of the medicine.

5. How to store Aspargin

The medicine should be stored out of sight and reach of children.
The medicine should not be taken after the expiry date stated on the packaging after: EXP.
The expiry date refers to the last day of the specified month.
Store in a temperature below 25°C.
Store in the original packaging to protect from moisture.
Medicines should not be disposed of via wastewater or household waste. The patient should ask their pharmacist how to dispose of medicines that are no longer needed. This will help protect the environment.

6. Contents of the packaging and other information

What Aspargin contains

• The active substances of the medicine are: magnesium aspartate and potassium aspartate. 1 tablet contains 17 mg of magnesium ions in the form of 250 mg of magnesium aspartate; 54 mg of potassium ions in the form of 250 mg of potassium aspartate.
• The excipients are: potato starch, sodium carboxymethyl starch, sucrose, magnesium stearate, talc.

What Aspargin looks like and contents of the packaging

Aspargin is an oral tablet.
Available packaging:
Tablets in blisters, in a cardboard box:
25 tablets – 1 blister of 25 tablets.
50 tablets – 2 blisters of 25 tablets.
75 tablets – 3 blisters of 25 tablets.
Not all pack sizes may be marketed.

Marketing authorization holder and manufacturer

Pharmaceutical Cooperative FILOFARM
ul. Pułaskiego 39
85-619 Bydgoszcz
To obtain more detailed information about this medicine, the patient should contact the representative of the marketing authorization holder.
Pharmaceutical Cooperative Filofarm
ul. Pułaskiego 39, 85-619 Bydgoszcz
Phone: (52) 342 67 88
Information for the blind and visually impaired: the content of the Aspargin leaflet is available in the Audio Leaflet system under the nationwide free phone number 800 706 848.

Date of last revision of the leaflet: