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DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

Show original

Contents of the leaflet

  1. Introduction
  2. What is Ditralia and what is it used for
  3. What you need to know before you take Ditralia
  4. How to take Ditralia
  5. Possible side effects
  6. Storing Ditralia
  7. Contents of the pack and other information

Introduction

Package Leaflet: Information for the User

Ditralia 25000 IUorodispersible films

colecalciferol (vitamin D3)

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Ditralia and what is it used for
  2. What you need to know before you take Ditralia
  3. How to take Ditralia
  4. Possible side effects
  5. Storing Ditralia
  6. Contents of the pack and other information

1. What is Ditralia and what is it used for

Ditralia contains colecalciferol (vitamin D3). The main function of vitamin D is to ensure proper intestinal absorption of calcium and to promote adequate mineralization of bones.

Ditralia is indicated for the initial treatment of clinically relevant vitamin D deficiency in adults.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Ditralia

Do not take Ditralia

  • if you are allergic to colecalciferol or any of the other ingredients of this medicine (listed in section 6)
  • if you have a particular sensitivity to vitamin D (tissue damage in various organs caused by vitamin D overdose) (hypervitaminosis D)
  • if you have high levels of calcium in the blood
  • if you have high levels of calcium in the urine, especially if you have kidney stones
  • if you have calcium deposits in the kidneys (nephrocalcinosis)
  • if you have severely reduced kidney function (severe renal insufficiency)

If you are in any of the above situations, consult your doctor or pharmacist before taking Ditralia.

Warnings and precautions

Consult your doctor or pharmacist before taking Ditralia.

Tell your doctor if you are taking other products that contain vitamin D, such as fortified foods and milk, as vitamin D accumulates in the body and an overdose can cause toxic effects. Ditralia should be used with caution in immobilized patients.

Therefore, it is important not to exceed the recommended dose.

Consult your doctor before taking Ditralia:

  • if you have a high tendency to form kidney stones
  • if you have a parathyroid hormone imbalance (pseudo-hypoparathyroidism)

If you have any of the following conditions, your doctor will monitor your calcium or phosphate levels in the blood, or your calcium levels in the urine:

  • if you have kidney problems
  • if you suffer from "sarcoidosis", an immune system disease that can affect the liver, lungs, skin, or lymph nodes
  • if you are an elderly person being treated with glycosides or diuretics
  • if you are immobilized

Children and adolescents

This medicine is not recommended for children and adolescents under 18 years of age.

Other medicines and Ditralia

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including those obtained without a prescription.

In particular, consult your doctor if you are taking any of the following medicines:

  • thiazide diuretics: your calcium levels in the blood will be regularly monitored
  • corticosteroids ("steroids", e.g., prednisolone or dexamethasone): your vitamin D dose may need to be increased
  • cholestyramine (a medicine to reduce cholesterol) or laxatives (e.g., paraffin oil): reduce vitamin D absorption
  • heart medicines (cardiac glycosides): you will be under medical supervision and your ECG and calcium levels in the blood may be monitored
  • anticonvulsants (for the treatment of epilepsy; e.g., phenytoin), sleeping medicines (e.g., hydantoin, barbiturics), or primidone: reduce the effects of vitamin D
  • rifampicin, isoniazid (antibiotics): may reduce the effectiveness of vitamin D
  • actinomycin (a medicine used to treat some types of cancer) and antifungal agents derived from imidazole (e.g., clotrimazole and ketoconazole, medicines used to treat fungal infections): may reduce the effectiveness of vitamin D
  • products containing high doses of calcium: increase the risk of high calcium levels in the blood
  • products containing magnesium (e.g., antacids): should not be used during treatment with vitamin D due to the risk of high magnesium levels
  • products containing high doses of phosphorus: concomitant use with vitamin D may increase the risk of high phosphate levels in the blood
  • orlistat (a medicine used to treat obesity, including weight loss): may reduce vitamin D absorption. There should be a 2-hour interval (before and after) between the administration of vitamin D and orlistat.

Taking Ditralia with food and drinks

See section 3 "How to take Ditralia".

Pregnancy, breastfeeding, and fertility

During pregnancy and breastfeeding, high doses of this product should not be used, but lower doses. If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking vitamin D. Vitamin D3 passes into breast milk. This should be taken into account when administering additional vitamin D to the infant. There are no data on the effects of vitamin D3 on fertility. However, it is not expected that normal levels of vitamin D will have negative effects on fertility.

Driving and using machines

Ditralia has no or negligible influence on the ability to drive and use machines.

Ditralia contains orange yellow:

Orange yellow (E110), which may cause allergic reactions.

3. How to take Ditralia

Follow exactly the administration instructions of this medicine given by your doctor. If you are not sure, ask your doctor or pharmacist.

Use in adults

Your doctor will supervise the treatment, as the dose and duration of therapy depend on your 25-hydroxycolecalciferol (25(OH)D) level in the blood, the severity of your disease, and your response to treatment.

Recommended dose: 1 orodispersible film of 25,000 IU per week for the first month. After the first month of treatment, your doctor may consider reducing the dose.

Alternatively, national dosage recommendations for the treatment of vitamin D deficiency can be followed.

Use in children and adolescents

Ditralia is not intended for use in children and adolescents under 18 years of age.

Instructions for use

The orodispersible film should be placed in the mouth, on the tongue, and allowed to dissolve before swallowing. It should be taken immediately after removal from the sachet. Ditralia can be taken with or without food.

Important: Do not handle the orodispersible film with wet hands.

  • Take the sachet, locate the arrow symbol on the top of the sachet, and hold it with this side facing up. The sachet is not sealed in this area.

Hand pressing the gray oval applicator with the thumb on a flat surface

  • Gently peel apart the two parts of the sachet.

To do this, hold each part with one hand, using your thumb and index finger.

Hand holding an auto-injector with the tip applied to the skin of the upper right abdomen

  • Carefully pull the two parts of the sachet in opposite directions until they separate.

You will see the orodispersible film placed in one of the separated parts of the sachet.

Hands holding a gray rectangular medical device with a central transparent window

  • Remove the orodispersible film from the sachet with dry fingers and place it in your mouth, directly on the tongue. It will dissolve quickly and can be swallowed easily.

Hand placing a sublingual tablet under the tongue with the mouth slightly open

If you take more Ditralia than you should

If you take an excessive dose of Ditralia, consult your doctor or pharmacist immediately. Excess vitamin D causes an alteration of the calcium cycle in the body. The following symptoms may be experienced: weakness, fatigue, headache, nausea, vomiting, diarrhea (and in later stages, constipation), excessive urine production, urinary calcium, dry mouth, nocturia, intense thirst, loss of appetite, muscle and joint pain, abdominal pain, and arrhythmia.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone 91 562 04 20, indicating the medicine and the amount ingested.

Emergency treatment:

Calcitonin, corticosteroid therapy (which prevents intestinal absorption of calcium), abundant hydration, diuretics to increase calcium content in the urine (furosemide), a low-calcium diet. High levels of calcium in the blood require immediate hospitalization.

If you forget to take Ditralia

Do not take a double dose to make up for forgotten doses.

If you stop taking Ditralia

Do not stop treatment unless you experience side effects. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Stop treatment with Ditralia and consult your doctor immediately

  • If you experience any of the following symptoms, as they may be a sign of an allergic reaction (hypersensitivity):
    • swelling of the face, lips, tongue, or throat
    • difficulty swallowing
    • hives
    • difficulty breathing

Uncommon side effects (may affect up to 1 in 100 people):

  • excess calcium in the blood (hypercalcemia)
  • excess calcium in the urine (hypercalciuria)

Rare side effects (may affect up to 1 in 1,000 people):

  • pruritus, skin rash, and urticaria

Frequency not known (cannot be estimated from the available data):

  • constipation, flatulence, nausea, abdominal pain, diarrhea

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing Ditralia

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date stated on the carton after EXP.

Do not store above 30°C.

Store the product in its original packaging to protect it from light.

Medicines should not be disposed of via wastewater or household waste. Return the containers and any unused medicines to the SIGRE collection point at your pharmacy. If you have any further questions on how to dispose of the containers and any unused medicines, ask your pharmacist. This will help protect the environment.

6. Contents of the pack and other information

Composition of Ditralia

The active substance is colecalciferol. Each film contains 625 micrograms of colecalciferol (vitamin D3), equivalent to 25,000 IU.

The other ingredients (excipients) are refined olive oil, purified water, maltodextrin, hydroxypropylbetadex, copovidone, mannitol (E421), glycerol (E422), polysorbate 80 (E433), mono-linoleate glycerol, titanium dioxide (E171), sucralose (E955), orange flavor*, ascorbic acid (E300), all-rac-alpha-tocopherol (E307), orange yellow (E110).

*contains:

Flavor: orange essential oil, terpene-free orange oil, terpene-free lemon oil, terpene-free mandarin oil, ethyl hexanoate, ethyl 2-methylbutyrate, ethyl butyrate, acetaldehyde

Additives: butylhydroxyanisole (E320), citric acid (E330)

Fillers: maltodextrin, arabic gum (E414)

Appearance and packaging of the product

Ditralia 25,000 IU is a rectangular, flexible, light orange film (15 mm x 30 mm).

The orodispersible film is presented in a pack containing 2 or 4 films for each concentration. Each sachet contains one orodispersible film.

Marketing Authorization Holder:

IBSA Farmaceutici Italia S.r.l.

Via Martiri di Cefalonia 2

26900 Lodi, Italy

Manufacturer:

IBSA Farmaceutici Italia S.r.l

S.S. n. 11 Padana Superiore Km 160

20051 Cassina de’ Pecchi (Mi), Italy

or

Altergon Italia Srl

Zona Industriale

83040 Morra de Sanctis (AV), Italy

You can request more information about this medicine by contacting the local representative of the Marketing Authorization Holder:

Instituto Bioquimico Iberico IBSA S.L.

Avenida Diagonal 605,

Planta 8, Local 1,

08028 Barcelona (Spain)

Date of last revision of this leaflet:

August 2024

Detailed and up-to-date information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

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Frequently Asked Questions

Is a prescription required for DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS?
DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS?
The active ingredient in DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS is colecalciferol. This information helps identify medicines with the same composition but different brand names.
Who manufactures DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS?
DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS is manufactured by Ibsa Farmaceutici Italia S.R.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to DITRALIA 25,000 IU ORALLY DISINTEGRATING TABLETS?
Other medicines with the same active substance (colecalciferol) include ALDEXINA 25,000 IU HARD CAPSULES, ALDEXINA 50,000 IU HARD CAPSULES, BENFEROL CHOQUE 50,000 IU SOFT GEL CAPSULES. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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