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TRINEFRON-ZDOROV'A

TRINEFRON-ZDOROV'A

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Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use TRINEFRON-ZDOROV'A

INSTRUCTIONS for medical use of the medicinal product LOXIDOL (LOXIDOL)

Composition

active substance: meloxicam; 1 ampoule (1.5 ml) of the solution contains meloxicam 15 mg; excipients: meglumine, glycofurol, poloxamer 188, glycine, sodium chloride, sodium hydroxide, water for injections.

Pharmaceutical form

Solution for injections.

Main physical and chemical properties

Light-yellow transparent solution.

Pharmacotherapeutic group

Non-steroidal anti-inflammatory and anti-rheumatic drugs. ATC code M01A C06.

Pharmacological properties

Pharmacodynamics

Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) of the enolic acid class, which exhibits anti-inflammatory, analgesic, and antipyretic effects.

Pharmacokinetics

Absorption: After intramuscular administration, meloxicam is completely absorbed. The relative bioavailability compared to oral administration is almost 100%. Therefore, dose adjustment is not required when switching from intramuscular to oral administration.

Distribution: Meloxicam is strongly bound to plasma proteins, mainly albumin (99%). It penetrates into synovial fluid, where its concentration is half that in plasma.

Metabolism: Meloxicam undergoes extensive biotransformation in the liver.

Excretion: Meloxicam is excreted mainly in the form of metabolites in equal parts with urine and feces.

Clinical characteristics

Indications

Short-term symptomatic treatment of acute attacks of rheumatoid arthritis and ankylosing spondylitis, when other routes of administration cannot be used.

Contraindications

Increased sensitivity to the active substance or to other excipients of the medicinal product;

increased sensitivity to active substances with similar action, such as NSAIDs, acetylsalicylic acid;

meloxicam should not be used in patients who have experienced symptoms of asthma, nasal polyps, angioneurotic edema, or urticaria after taking acetylsalicylic acid or other NSAIDs;

gastrointestinal bleeding or perforation associated with previous NSAID therapy in the anamnesis;

active or recurrent peptic ulcer/bleeding in the anamnesis (two or more separate confirmed cases of ulcer or bleeding);

severe liver insufficiency;

severe renal insufficiency (without dialysis use);

gastrointestinal bleeding, cerebrovascular bleeding in the anamnesis, or other coagulation disorders;

hemostasis disorders or concomitant use of anticoagulants (contraindications related to the route of administration);

severe heart failure;

treatment of perioperative pain in coronary artery bypass grafting (CABG);

III trimester of pregnancy (see section "Use during pregnancy or breastfeeding");

patient age under 18 years.

Interaction with other medicinal products and other types of interactions

Pharmacodynamic interactions

Certain medicinal products or therapeutic groups that may contribute to hyperkalemia: potassium salts, potassium-sparing diuretics, angiotensin-converting enzyme inhibitors (ACE), angiotensin receptor antagonists (ARA) II, NSAIDs, (low-molecular-weight or unfractionated) heparins, cyclosporine, tacrolimus, and trimethoprim

Pharmacokinetic interactions

Lithium: It has been reported that NSAIDs increase the level of lithium in plasma (due to decreased renal excretion of lithium), which can reach toxic levels.

Methotrexate: NSAIDs may decrease the tubular secretion of methotrexate, thereby increasing its concentration in plasma.

Special warnings and precautions for use

Side effects

Side effects can be minimized by using the smallest effective dose of the medicinal product for the shortest period of time necessary to control the disease.

Effect on the gastrointestinal tract

As with the use of other NSAIDs, potentially life-threatening gastrointestinal bleeding, ulcers, or perforation may occur at any time during treatment, with or without previous symptoms or serious gastrointestinal diseases in the anamnesis.

Effect on the cardiovascular system

During the use of the medicinal product, patients with arterial hypertension and/or congestive heart failure from mild to moderate degree in the anamnesis should be closely monitored, as fluid retention and edema have been observed during NSAID treatment.

Effect on the skin

During the use of meloxicam, life-threatening severe skin lesions have been reported: Stevens-Johnson syndrome and toxic epidermal necrolysis.

Ability to influence the reaction rate when driving vehicles or using other mechanisms

There are no special studies on the effect of meloxicam on the ability to drive vehicles or use other mechanisms.

Method of administration and dosage

Dosage

The medicinal product should be used in a dose of 15 mg once a day (1 injection).

Special patient categories

Elderly patients: The recommended dose of the medicinal product for elderly patients is 7.5 mg per day (half an ampoule of 1.5 ml).

Patients at increased risk of side effects: Patients at increased risk of side effects, such as gastrointestinal diseases in the anamnesis or risk factors for cardiovascular diseases, should start using the medicinal product with a dose of 7.5 mg per day (half an ampoule of 1.5 ml).

Overdose

Symptoms of acute NSAID overdose are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive therapy.

Side effects

Study data and epidemiological data suggest that the use of some NSAIDs (especially in high doses and with prolonged treatment) may be associated with a small increased risk of vascular thrombotic events, such as myocardial infarction or stroke.

From the blood and lymphatic system

uncommon – anemia; rare – deviations of blood test parameters from normal (including changes in leukocyte count), leukopenia, thrombocytopenia.

From the immune system

uncommon – allergic reactions, except anaphylactic or anaphylactoid; frequency unknown – anaphylactic shock, anaphylactic reaction, anaphylactoid reaction, including shock.

Use during pregnancy or breastfeeding

Pregnancy

Suppression of prostaglandin synthesis may negatively affect pregnancy and/or embryo/fetal development.

Breastfeeding period

Although there are no specific data on meloxicam, it is known that NSAIDs can penetrate into breast milk.

Storage conditions

Store at a temperature not exceeding 25 °C in the original packaging and out of reach of children.

Incompatibility

Due to possible incompatibility, the medicinal product should not be mixed with other preparations in the same syringe.

Packaging

1.5 ml of solution in a glass ampoule; 3 ampoules in a contour cell package; 1 contour cell package in a cardboard box.

Release category

By prescription.

Manufacturer

PharmaVision San. ve Tic. A.S./PharmaVision San. ve Tic. A.S.

Manufacturer's location and address

Davutpasa Cad. No:145 Zeytinburnu Istanbul, Turkey/Davutpasa Cad. No:145 Zeytinburnu Istanbul, Turkey.

Applicant

LLC "WORLD MEDICINE", Ukraine/ WORLD MEDICINE, LLC, Ukraine.

Online doctors for TRINEFRON-ZDOROV'A

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for TRINEFRON-ZDOROV'A – subject to medical assessment and local rules.

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Doctor

Liudmyla Boichuk

Family medicine10 years of experience

Dr Liudmyla Boichuk is a family medicine doctor providing diagnosis and treatment for a wide range of acute and chronic conditions in adults and children. She works with respiratory, cardiovascular and digestive system disorders and has extensive experience caring for patients with multiple coexisting conditions, where coordinated, whole-person management is essential.

She treats adults with respiratory illnesses such as pneumonia, COPD and bronchial asthma, as well as cardiovascular conditions including hypertension and ischaemic heart disease. Her practice also covers gastrointestinal complaints and chronic comorbidities that require careful, structured medical supervision.

Dr Boichuk provides care for children from birth, including acute respiratory viral infections, infectious diseases, pneumonia, bronchitis, bronchial obstruction syndromes and allergic reactions. She offers clear, evidence-based guidance to parents and ensures safe follow-up throughout the child’s recovery.

Her work also includes developing personalised immunisation plans and supporting families with long-term preventive care.

Known for her structured clinical approach and clear communication, Dr Liudmyla Boichuk offers patients of all ages comprehensive, reliable and evidence-based medical care.

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5.0(39)
Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

CameraBook a video appointment
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Karim BenHarbi

General medicine8 years of experience

Dr. Karim Ben Harbi is a licensed general practitioner based in Italy. He provides online consultations for adults and children, combining international clinical experience with evidence-based medicine. His care approach is focused on accurate diagnosis, preventive care, and personalised health guidance.

Dr. Ben Harbi received his medical degree from Sapienza University in Rome. His training included hands-on experience in diverse settings — tropical medicine, rural healthcare, and urban outpatient practice. He also conducted clinical research in microbiology, exploring the role of the gut microbiome in chronic gastrointestinal issues.

You can consult Dr. Ben Harbi for:

  • General health concerns, prevention, and primary care.
  • Hypertension, type 1 and type 2 diabetes, metabolic issues.
  • Cold, cough, flu, respiratory infections, sore throat, fever.
  • Chronic digestive issues: bloating, gastritis, IBS, microbiome imbalance.
  • Skin rashes, mild allergic reactions, basic dermatological complaints.
  • Medication guidance, treatment adjustments, prescription review.
  • Paediatric concerns — fever, infections, general well-being.
  • Lifestyle optimisation: stress, sleep, weight, and diet counselling.

Dr. Ben Harbi offers reliable, accessible medical support through online consultations, helping patients make informed decisions about their health with a clear, structured, and compassionate approach.

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Ekaterina Agapova

Neurology8 years of experience

Dr. Ekaterina Agapova is a neurologist specialising in the diagnosis and treatment of neurological conditions and chronic pain. She provides online consultations for adults, combining evidence-based medicine with a personalised approach.

She offers expert care for:

  • Headaches and migraines, including tension-type and cluster headaches.
  • Neck and back pain, both acute and chronic.
  • Chronic pain syndromes – fibromyalgia, neuropathic pain, post-traumatic pain.
  • Mononeuropathies – carpal tunnel syndrome, trigeminal neuralgia, facial nerve palsy.
  • Polyneuropathies – diabetic, toxic, and other types.
  • Multiple sclerosis – diagnosis, monitoring, long-term support.
  • Dizziness and coordination disorders.
  • Sleep disturbances – insomnia, daytime sleepiness, fragmented sleep.
  • Anxiety, depression, and stress-related conditions.

Dr. Agapova helps patients manage complex neurological symptoms like pain, numbness, weakness, poor sleep, and emotional distress. Her consultations focus on accurate diagnosis, clear explanation of findings, and tailored treatment plans.

If you’re struggling with chronic pain, migraines, nerve disorders, or sleep problems, Dr. Agapova offers professional guidance to restore your well-being.

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Nataliia Lifantieva

Cardiology21 years of experience

Dr. Nataliia Lifantieva is a cardiologist and cardiac electrophysiologist with extensive experience in the diagnosis and treatment of arrhythmias. She offers online consultations for patients with chronic cardiovascular conditions, including medication management and post-operative follow-up.

Main areas of expertise:

  • Diagnosis and treatment of arrhythmias: extrasystole, atrial fibrillation and flutter, supraventricular and ventricular tachycardia
  • Conduction disorders: AV blocks, sinoatrial block, bradyarrhythmias
  • ECG and Holter monitor interpretation, including data from smartwatches
  • Evaluation for interventional treatment: stenting, bypass surgery, valve replacement
  • Anticoagulant management (e.g., warfarin, DOACs) based on kidney function and clinical context
  • Perioperative advice on anticoagulant/antiplatelet therapy before dental procedures
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Marta Reguero Capilla

Allergology7 years of experience

Dr Marta Reguero Capilla is an allergist and immunologist who works with both adults and children. She specialises in the diagnosis, treatment, and ongoing management of allergic and immune-related conditions through online consultations.

In her practice, Dr Reguero Capilla helps patients understand the causes of their symptoms, review test results, and choose appropriate treatment or monitoring strategies. Her consultations are suitable both for first-time assessments and for follow-up care over time.

Patients commonly consult Dr Marta Reguero Capilla for:

  • allergic rhinitis, seasonal allergies, and perennial allergy symptoms;
  • allergic conditions in adults and children;
  • bronchial asthma and allergy-related respiratory symptoms;
  • urticaria (acute and chronic) and angioedema;
  • food allergies and reactions to foods, additives, or medications;
  • atopic dermatitis, allergic rashes, and persistent itching;
  • unexplained or recurrent allergic reactions;
  • interpretation of laboratory tests, allergy testing, and immunology results;
  • immune system concerns, frequent infections, and reduced immune response;
  • ongoing medical follow-up and treatment adjustment.
Dr Reguero Capilla works in a structured and attentive manner, explaining medical decisions clearly and helping patients make informed choices about their own health or their child’s care.

When clinically appropriate, she may provide recommendations for further tests or referrals that patients can use within Spanish medical networks, including Sanitas and DKV, in accordance with the terms and conditions of those services.

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Nikita Savin

Pediatrics4 years of experience

Dr. Nikita Savin is a paediatrician providing online consultations for children of all ages. He offers comprehensive medical care with a focus on preventive health, proper development, and long-term management of chronic and complex conditions.

His areas of expertise include:

  • Preventive care and vaccination planning, including catch-up schedules for children.
  • Assessment of psychomotor, emotional, and physical development.
  • Diagnosis, treatment planning, and clinical monitoring for paediatric conditions.
  • Nutritional guidance for infants, including the choice of adapted milk formulas tailored to medical needs.
  • Early identification of rare and orphan diseases.
  • Ongoing care for children with chronic or complex health conditions.
By combining paediatrics with a personalised approach, Dr. Savin ensures professional support that addresses both the physical health and overall well-being of children, while guiding parents at every stage of their child’s growth.
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Svetlana Kolomeeva

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Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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Roman Raevskii

General medicine6 years of experience

Dr. Roman Raevskii is a licensed general practitioner in Spain, offering online medical consultations with a strong focus on prevention, early diagnosis, and personalized care. He combines evidence-based clinical expertise with a patient-centered approach to deliver comprehensive support.

Dr. Raevskii provides medical care in the following areas:

  • Diagnosis and management of common conditions: hypertension, diabetes, respiratory and digestive disorders.
  • Oncological consultations: early cancer detection, risk evaluation, and treatment navigation.
  • Supportive care for oncology patients – pain control, symptom relief, and side effect management.
  • Preventive medicine and health screenings.
  • Development of tailored treatment plans based on clinical guidelines.

With a patient-centred approach, Dr. Raevskii helps individuals manage both chronic illnesses and complex oncological cases. His consultations are guided by current medical standards and adapted to each patient’s needs.

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Tetiana Fursenko

Otolaryngology (ENT)4 years of experience

Dr. Tetiana Fursenko is an ENT (ear, nose, and throat) specialist offering online consultations for both adults and children. She focuses on diagnosing and treating conditions of the upper respiratory tract using evidence-based medical guidelines and personalised treatment plans.

Common concerns addressed during consultation:

  • Nasal congestion, runny nose, sinusitis, rhinitis, and hay fever.
  • Ear pain, otitis (middle ear infections), earwax buildup, hearing loss.
  • Sore throat, tonsillitis, pharyngitis, chronic throat irritation.
  • Hoarseness, loss of voice, laryngitis.
  • Allergic rhinitis, sneezing, nasal itching, seasonal allergies.
  • Snoring, mouth breathing, enlarged adenoids.
  • Frequent colds, lingering post-viral symptoms.
  • Foreign objects in the ear or nose.
  • ENT-related check-ups and chronic condition follow-up.

Dr. Fursenko helps patients manage symptoms early, avoid complications, and receive timely treatment. Online ENT consultations are a convenient way to access care for both urgent and recurring conditions — from anywhere.

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