This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use TIVARGIN-N

INSTRUCTIONS for medical use of the medicinal product KLIMAKTOPLAN (KLIMAKTOPLAN®)

Composition

active substances: 1 tablet contains: Cimicifuga D2 25 mg, Ignatia D3 25 mg, Sepia D2 25 mg, Sanguinaria D6 25 mg; auxiliary substances: lactose monohydrate, magnesium stearate, wheat starch.

Pharmaceutical form

Tablets.

Main physical and chemical properties

gray, biconvex tablets with a beveled edge, sometimes slightly speckled.

Pharmacotherapeutic group

Complex homeopathic preparation. Other preparations for the treatment of gynecological diseases. ATC code G02CX.

Pharmacological properties

Klimaktoplan contains four ingredients that determine the effect of the preparation. Cimicifuga affects the hypothalamus, eliminating or weakening hot flashes, nervous excitement, and depression. Sepia regulates the common functions of hormones of the adrenal cortex, sex organs, and pituitary gland. Sepia, like Ignatia, primarily acts on mental reactions, but it also affects flashes of heat, hot flashes, headaches, and a state of weakness. Sanguinaria is particularly effective in hot flashes accompanied by transient flushing and rapid heartbeat, as well as in migraine-type headaches.

Therefore, Klimaktoplan, due to the combination of specific ingredients, treats a complex of symptoms typical of the climacteric period. Thanks to its good tolerability, Klimaktoplan can be taken for a long time.

Clinical characteristics

Indications

Climacteric disorders: hot flashes, increased sweating, feeling of heartbeat, dizziness, itching, internal anxiety, sleep disturbances, depressive state, nervous excitability.

Contraindications

Increased sensitivity to the active substances or to any of the auxiliary substances of the medicinal product.

Interaction with other medicinal products and other types of interactions

Not known to date.

The use of a homeopathic medicinal product does not exclude the use of other medicinal products.

Patients should consult a doctor if they are taking or have recently taken any other medications, including medicinal products that can be purchased without a prescription.

Note. The action of homeopathic medicinal products may vary depending on general negative factors associated with harmful habits (stimulants: for example, coffee or tea, alcohol, smoking).

Special instructions

It is necessary to consult a doctor if the condition has not improved or worsened, or if additional complaints have appeared.

The medicinal product contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency, or glucose-galactose malabsorption syndrome should not use it.

One of the auxiliary substances that make up the preparation is wheat starch. In connection with this, tablets should not be used by patients with increased sensitivity or intolerance to gluten.

Use during pregnancy or breastfeeding

Not used during pregnancy and breastfeeding.

Ability to affect the speed of reaction when driving vehicles or other mechanisms

Does not affect.

Method of administration and dosage

Take 1-2 tablets 3 times a day. The maximum daily dose is 6 tablets. Tablets should be taken 30 minutes before meals or 30 minutes after meals, slowly dissolving in the oral cavity. If necessary, tablets can be dissolved in a small amount of water. In case of improvement, the dosage should be reduced. Klimaktoplan should be used for at least 3 months. Treatment can be extended if necessary.

Children

Not used in children.

Overdose

Overdose has not been observed.

Adverse reactions

When using the preparation, hypersensitivity reactions are possible, menstrual and nasal bleeding may occur, or the frequency of menstrual bleeding may increase.

Note. When using homeopathic medicinal products, a temporary worsening of existing disease symptoms (primary worsening) is possible. In this case, the use of the preparation should be stopped and a doctor should be consulted.

In case of any adverse reactions, you should consult a doctor. This applies to all possible side effects, including those not described in this instruction.

Shelf life

5 years.

Do not use after the expiration date stated on the packaging.

Storage conditions

Store at a temperature not exceeding 25 ºC in a dry, inaccessible place for children.

Packaging

20 tablets in a blister pack; 3 or 5 blister packs in a cardboard box.

Release category

Without a prescription.

Manufacturer

Dr. Gustav Klein GmbH & Co. KG

Location of the manufacturer and address of the place of its activity

Steinenfeld 3, 77736 Zell am Harmersbach, Germany

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

12+ years of clinical experience in university hospitals in Germany and Spain.
International education: Ukraine – Germany – Spain.
Member of the German Society of Surgeons (BDC).
Certified in radiological diagnostics and robotic surgery.
Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

TIVARGIN-N

Nuno Tavares Lopes

Duarte Meneses

Nuno Tavares Lopes

Duarte Meneses

How to use TIVARGIN-N