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BOFEN 400

Ask a doctor about a prescription for BOFEN 400

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Doctor

Anna Biriukova

General medicine5 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use BOFEN 400

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT GLYCERIN MICRO-ENEMAS FOR ADULTS ADYULAX

Composition:

The active substance is glycerin; 1 applicator (7.5 ml) contains glycerin 6.14 ml; the auxiliary substance is purified water.

Pharmaceutical form.

Rectal solution.

Main physical and chemical properties:

A syrupy liquid, transparent, colorless with a characteristic odor, which does not contain foreign inclusions.

Pharmacotherapeutic group.

Laxatives. Glycerin.

ATC code A06A X01.

Pharmacological properties.

Pharmacodynamics.

The active substance of the medicinal product is glycerin, which, after rectal administration, causes a laxative effect due to its ability to lubricate fecal masses and promote the flow of fluid to them, stimulating intestinal contractions.

Pharmacokinetics.

Glycerin promotes bowel emptying within 15-30 minutes to 1 hour after administration of the micro-enema.

Clinical characteristics.

Indications.

For local relief of symptoms of short-term and episodic constipation.

Contraindications.
  • Increased sensitivity to glycerin.
  • Abdominal spasms, colic, nausea, vomiting, or other symptoms of appendicitis.
  • Hemorrhagic rectocolitis.
  • Diarrhea.
  • Anorectal diseases.
  • Ulcerative colitis and inflammatory hemorrhoidal conditions.
  • Abdominal pain.
  • Intestinal obstruction.
  • Acute inflammatory bowel diseases.
  • Children under 12 years of age.
Interaction with other medicinal products and other types of interactions.

No interactions have been reported.

If the patient is taking or has recently taken any medicinal product, it is recommended to consult a doctor.

Special instructions.

In case of blood in the stool, irritation, pain, or lack of improvement in bowel condition, treatment should be stopped and a doctor consulted regarding further use of the medicinal product.

Adyulax should not be used for more than one week, unless the doctor has prescribed otherwise.

Patients with severe diseases, including cardiovascular diseases, can use the medicinal product only under medical supervision.

Glycerin may exacerbate abdominal pain in patients with irritable bowel syndrome. Such patients are recommended to use the preparation with caution.

Prolonged use of the medicinal product should be avoided.

Use during pregnancy or breastfeeding.

Use is possible only when, in the doctor's opinion, the benefit to the woman outweighs the potential risk to the fetus/child.

Ability to affect reaction speed when driving vehicles or operating machinery.

Given the nature of the preparation and its action, no effect on reaction speed is expected.

Method of administration and dosage.

It is necessary to follow the recommendations below, unless the doctor has given other instructions.

This medicinal product is intended only for rectal administration.

Adults and children over 12 years: 1 rectal applicator per day.

Elderly patients: the recommended dose is the same as for adults.

Liver and/or kidney insufficiency: dose adjustment is not necessary.

It is recommended to consult a doctor if the effect of glycerin micro-enemas for adults Adyulax seems too strong or too weak.

Method of administration

At the chosen time of administration, remove the cap that covers the tip of the cannula and, holding the cannula vertically upwards, gently press to allow a few drops of the preparation to moisten the tip of the cannula to facilitate the introduction of the applicator into the rectum.

After introduction into the rectum, express the contents of the applicator and, when it is empty, remove it, continuing to squeeze the walls of the applicator.

Each applicator is filled with an excess of the product, which remains in the applicator after use.

Thus, the amount that enters the rectum during administration is the full dose, and there is no need to empty the applicator completely, which makes it easier to use.

Each applicator contains 1 dose of the medicinal product - it should be discarded after use.

If resistance is felt during administration, administration should be stopped, as it may cause harm.

Therefore, before continuing treatment, it is necessary to consult a doctor to determine the cause of the resistance.

Delay bowel movement as long as possible to allow the medicinal product to take effect.

Duration of treatment

The preparation should not be used for more than one week, unless the doctor has prescribed otherwise.

If symptoms worsen or persist after 7 days of use, a doctor should be consulted.

Children.

This medicinal product is not used in children under 12 years of age.

Overdose.

Misuse and prolonged use of the preparation may cause irritable bowel syndrome (diarrhea or constipation).

Therefore, in case of need for longer use, it is recommended to use it with caution under medical supervision.

In case of overdose or accidental ingestion, a doctor should be consulted.

Adverse reactions.

Local discomfort, irritation, and anal pain, itching may be observed.

Allergic reactions are possible.

A doctor should be consulted if any of these or other adverse reactions not mentioned in the instructions are noticed.

Shelf life.

3 years.

Do not use after the expiration date stated on the packaging.

Storage conditions.

Store at a temperature not exceeding 25 ºC.

Store in a place inaccessible to children.

Packaging.

Rectal solution, 6.14 ml/7.5 ml, 7.5 ml in applicators No. 4 in a cardboard box.

Release category.

Without a prescription.

Manufacturer.

Casen Recordati, S.L.

Location of the manufacturer and address of the place of its activities.

Autovia de Logrono km 13,300, 50180 Utebo, Zaragoza, Spain.

Alternatives to BOFEN 400 in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to BOFEN 400 in Spain

Dosage form: ORAL SOLUTION/SUSPENSION, 100 MG/5 ML
Active substance: ibuprofen
Manufacturer: Laboratorios Ern S.A.
Prescription required
Dosage form: CAPSULE, 400 mg
Active substance: ibuprofen
Prescription not required
Dosage form: ORAL SOLUTION/SUSPENSION, 4%
Active substance: ibuprofen
Prescription required
Dosage form: ORAL SOLUTION/SUSPENSION, 4%
Active substance: ibuprofen
Prescription required
Dosage form: TABLET, 400 mg
Active substance: ibuprofen
Manufacturer: Zentiva K.S.
Prescription required
Dosage form: CAPSULE, 200 mg
Active substance: ibuprofen
Prescription not required

Alternative to BOFEN 400 in Poland

Dosage form: Capsules, 400 mg
Active substance: ibuprofen
Prescription not required
Dosage form: Suspension, 40 mg/ml
Active substance: ibuprofen
Manufacturer: Alkaloid - INT d.o.o.
Prescription not required
Dosage form: Tablets, 400 mg
Active substance: ibuprofen
Marketing authorisation holder (MAH): Reckitt Benckiser Healthcare France
Prescription not required
Dosage form: Suspension, 40 mg/ml
Active substance: ibuprofen
Marketing authorisation holder (MAH): Reckitt Benckiser Deutschland GmbH
Prescription not required
Dosage form: Suspension, 40 mg/ml
Active substance: ibuprofen
Marketing authorisation holder (MAH): Reckitt Benckiser Deutschland GmbH
Prescription not required
Dosage form: Suspension, 40 mg/ml
Active substance: ibuprofen
Marketing authorisation holder (MAH): Reckitt Benckiser Deutschland GmbH
Prescription not required

Online doctors for BOFEN 400

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for BOFEN 400 – subject to medical assessment and local rules.

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Mar Tabeshadze

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Dr. Mar Tabeshadze is a licensed endocrinologist and general practitioner in Spain. She provides online consultations for adults, offering medical support for a wide range of endocrine conditions and related health concerns.

  • Diagnostic consultations for suspected endocrine disorders
  • Management of thyroid conditions, including in pregnant women
  • Early detection and treatment of type 1 and type 2 diabetes, with personalised therapy plans
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Dr. Tabeshadze takes a patient-centred approach based on evidence-based medicine. Her goal is to help patients achieve hormonal balance, manage chronic conditions effectively, and improve overall well-being through targeted, personalised care.
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Anna Biriukova

General medicine5 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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  • dyslipidaemia and lipid metabolism disorders
  • prevention and management of atherosclerosis
  • blood pressure monitoring and antihypertensive therapy
  • arrhythmias: diagnosis, follow-up, and treatment adjustment
  • cardiovascular care and recovery support after Covid-19
Dr Kuznetsova helps patients manage cardiovascular risk factors, optimise long-term treatment, and gain clarity in complex health situations – all through accessible and structured online care.
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His clinical background includes:

  • assessment of sudden or unclear symptoms
  • ongoing care for chronic conditions
  • follow-up after hospital discharge
  • interpretation of test results
  • medical support while abroad
Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association.

Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

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Dr. Ben Harbi received his medical degree from Sapienza University in Rome. His training included hands-on experience in diverse settings — tropical medicine, rural healthcare, and urban outpatient practice. He also conducted clinical research in microbiology, exploring the role of the gut microbiome in chronic gastrointestinal issues.

You can consult Dr. Ben Harbi for:

  • General health concerns, prevention, and primary care.
  • Hypertension, type 1 and type 2 diabetes, metabolic issues.
  • Cold, cough, flu, respiratory infections, sore throat, fever.
  • Chronic digestive issues: bloating, gastritis, IBS, microbiome imbalance.
  • Skin rashes, mild allergic reactions, basic dermatological complaints.
  • Medication guidance, treatment adjustments, prescription review.
  • Paediatric concerns — fever, infections, general well-being.
  • Lifestyle optimisation: stress, sleep, weight, and diet counselling.

Dr. Ben Harbi offers reliable, accessible medical support through online consultations, helping patients make informed decisions about their health with a clear, structured, and compassionate approach.

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Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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Dr. Ben Ami offers expert diagnosis, treatment, and follow-up for:

  • Respiratory infections (cold, flu, bronchitis, pneumonia).
  • ENT conditions such as sinusitis, ear infections, and tonsillitis.
  • Digestive issues including gastritis, acid reflux, and irritable bowel syndrome (IBS).
  • Urinary tract infections and other common infections.
  • Management of chronic diseases: high blood pressure, diabetes, thyroid disorders.
  • Acute conditions requiring urgent medical attention.
  • Headaches, migraines, and minor injuries.
  • Wound care, health check-ups, and ongoing prescriptions.

With a patient-focused and evidence-based approach, Dr. Ben Ami supports individuals at all stages of life — offering clear medical guidance, timely interventions, and continuity of care.

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  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
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Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Dr. Bessolitsyna offers a personalised and structured approach — helping patients identify causes of joint pain, interpret test results, and follow tailored treatment plans. Her consultations focus on early diagnosis, symptom control, complication prevention, and improving long-term quality of life.

With remote access to specialist care, patients can receive expert rheumatology support wherever they are.

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Dr Alexandrova follows an evidence-based and holistic approach: online consultations with a therapist and trichologist on Oladoctor provide professional support for hair, scalp, and overall health — all from the comfort of your home.

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