LOKELMA 5 g ORAL SUSPENSION POWDER
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How to use LOKELMA 5 g ORAL SUSPENSION POWDER
Introduction
Patient Information Leaflet: Information for the Patient
Lokelma 5g oral powder for suspension
Lokelma 10g oral powder for suspension
sodium zirconium cyclosilicate
Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
- Keep this leaflet, you may need to read it again.
- If you have any further questions, ask your doctor, pharmacist, or nurse.
- This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
- If you experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.
Contents of the pack
- What is Lokelma and what is it used for
- What you need to know before you take Lokelma
- How to take Lokelma
- Possible side effects
- Storage of Lokelma
- Contents of the pack and other information
1. What is Lokelma and what is it used for
Lokelma contains the active substance sodium zirconium cyclosilicate.
Lokelma is used to treat high levels of potassium in the blood in adults. Having high levels of potassium in the blood means that there is too much potassium in the blood.
Lokelma reduces high levels of potassium in your body and helps to maintain a normal level. As it passes through your stomach and intestines, Lokelma binds to potassium and both are eliminated from the body in the feces, reducing the amount of potassium in the body.
2. What you need to know before you take Lokelma
Do not take Lokelma:
- If you are allergic to the active substance.
Warnings and precautions
Monitoring
Your doctor or nurse will check your potassium levels in your blood when you start taking this medicine:
- They will make sure you are receiving the correct dose. The dose may be increased or decreased depending on your potassium levels in the blood.
- Treatment may be stopped if your potassium levels in the blood are too low.
- Tell your doctor or nurse if you are taking any medicines that may change your potassium levels in the blood, as it may be necessary to change your dose of Lokelma. These include diuretics (medicines that increase urine production), angiotensin-converting enzyme inhibitors (ACE inhibitors) such as enalapril, angiotensin receptor blockers such as valsartan (medicines for high blood pressure and heart problems), and renin inhibitors such as aliskiren (for high blood pressure).
While you are taking Lokelma, talk to your doctor or nurse if
- you have a heart signaling disorder (prolonged QT interval), as Lokelma reduces potassium levels in the blood, which can affect heart signaling.
- you need to have an X-ray, as Lokelma may affect the interpretation of the results.
- you have sudden or severe abdominal pain, as this may be a sign of a problem that can occur with medicines that work in the gastrointestinal tract.
Children and adolescents
Do not give this medicine to children or adolescents under 18 years old, as the effects of Lokelma in children or adolescents are not known.
Other medicines and Lokelma
Tell your doctor or nurse if you are taking, have recently taken, or might take any other medicines.
Lokelma may affect how certain medicines are absorbed in your digestive tract. If you are taking any of the following medicines, they should be taken 2 hours before or after taking Lokelma, otherwise, they may not work properly.
- tacrolimus (a medicine used to suppress your immune system to prevent organ transplant rejection)
- ketoconazole, itraconazole, and posaconazole (used to treat fungal infections)
- atazanavir, nelfinavir, indinavir, ritonavir, saquinavir, raltegravir, ledipasvir, and rilpivirine (used to treat HIV infection)
- tyrosine kinase inhibitors such as erlotinib, dasatinib, and nilotinib (used to treat cancer)
If any of the above applies to you (or if you are unsure), talk to your doctor, pharmacist, or nurse before taking this medicine.
Pregnancy and breastfeeding
Pregnancy
Do not use this medicine during pregnancy, as there is no information on its use during pregnancy.
Breastfeeding
No effects on newborns/infants are expected since systemic exposure to Lokelma in breastfeeding women is negligible. Lokelma can be used during breastfeeding.
Driving and using machines
This medicine has no or negligible influence on the ability to drive and use machines.
Lokelma contains sodium
This medicine contains approximately 400 mg of sodium (the main component of table salt/cooking salt) in each 5 g dose. This is equivalent to 20% of the maximum recommended daily intake of sodium for an adult.
Talk to your pharmacist or doctor if you need to take Lokelma 5 g or more per day for a prolonged period, especially if you have been advised to follow a low-salt diet (sodium).
3. How to take Lokelma
Follow the instructions for administration of this medicine exactly as told by your doctor. If you are unsure, talk to your doctor again.
How much to take
Initial dose - to reduce high levels of potassium to normal:
- The recommended dose is 10 g taken three times a day.
- The medicine takes one or two days to work.
- Do not take this initial dose for more than three days.
Maintenance dose - to keep potassium levels within the normal range once they have decreased:
- The recommended dose is 5 g taken once a day.
- Your doctor will decide if you need a higher dose (10 g once a day) or a lower dose (5 g every other day).
- Do not take a maintenance dose of more than 10 g once a day.
If you are on hemodialysis:
- Take Lokelma only on non-dialysis days.
- The recommended initial dose is 5 g once a day.
- Your doctor may decide that you need more (up to 15 g once a day).
- Do not take more than 15 g once a day.
How to take this medicine
- Try to take Lokelma at the same time every day.
- You can take this medicine with or without food.
Method of administration
- Open the sachet(s) and pour the powder into a glass with about 45 ml of non-carbonated water.
- Stir well and drink the tasteless liquid immediately.
- The powder does not dissolve and the liquid has a cloudy appearance. The powder will settle quickly to the bottom of the glass. In this case, stir the liquid again and drink it.
- If necessary, rinse the glass with a small amount of water and drink it to take all the medicine.
If you take more Lokelma than you should
If you take more of this medicine than you should, talk to a doctor as soon as possible. Do not take it again until you have talked to a doctor.
If you forget to take Lokelma
- If you forget to take a dose of this medicine, skip the missed dose.
- Take the next dose as usual at the usual time.
- Do not take a double dose to make up for missed doses.
If you stop taking Lokelma
Do not reduce the dose of this medicine or stop taking it without talking to the doctor who prescribed it. If you do, your potassium levels in the blood may increase again.
If you have any further questions on the use of this medicine, ask your doctor, pharmacist, or nurse.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Tell your doctor or nurse if you get any of the following side effects:
Common (may affect up to 1 in 10 people):
- you feel tired, or have muscle weakness or muscle cramps; these could be signs that your potassium levels in the blood have decreased too much. Talk to your doctor immediately if these symptoms get worse.
- you notice swelling in the tissues, which causes unusual or unexpected swelling in some parts of the body (usually the feet and ankles).
- constipation.
Reporting of side effects
If you experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.
5. Storage of Lokelma
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton and on the sachet after EXP. The expiry date is the last day of the month shown.
This medicine does not require any special storage conditions.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.
6. Contents of the pack and other information
What Lokelma contains
The active substance is sodium zirconium cyclosilicate.
Lokelma 5 g oral powder for suspension
Each sachet contains 5 g of sodium zirconium cyclosilicate.
Lokelma 10 g oral powder for suspension
Each sachet contains 10 g of sodium zirconium cyclosilicate.
This medicine does not contain any other ingredients.
Appearance and packaging
The oral powder for suspension is a white to grey powder. It is available in a sachet.
Lokelma 5 g oral powder for suspension
Each sachet contains 5 g of powder.
Lokelma 10 g oral powder for suspension
Each sachet contains 10 g of powder.
The sachets are available in a carton with 3 or 30 sachets.
Not all pack sizes may be marketed.
Marketing authorisation holder
AstraZeneca AB
SE-151 85 Södertälje
Sweden
Manufacturer
AstraZeneca AB
Gärtunavägen
SE-152 57 Södertälje
Sweden
You can get more information on this medicine by contacting the local representative of the marketing authorisation holder:
België/Belgique/Belgien AstraZeneca S.A./N.V. Tel: +32 2 370 48 11 | Lietuva UAB AstraZeneca Lietuva Tel: +370 5 2660550 |
???????? ??????????? ???????? ???? ???.: +359 24455000 | Luxembourg/Luxemburg AstraZeneca S.A./N.V. Tél/Tel: +32 2 370 48 11 |
Ceská republika AstraZeneca Czech Republic s.r.o. Tel: +420 222 807 111 | Magyarország AstraZeneca Kft. Tel.: +36 1 883 6500 |
Danmark AstraZeneca A/S Tlf: +45 43 66 64 62 | Malta Associated Drug Co. Ltd Tel: +356 2277 8000 |
Deutschland AstraZeneca GmbH Tel: +49 40 809034100 | Nederland AstraZeneca BV Tel: +31 79 363 2222 |
Eesti AstraZeneca Tel: +372 6549 600 | Norge AstraZeneca AS Tlf: +47 21 00 64 00 |
Ελλ?δα AstraZeneca A.E. Τηλ: +30 210 6871500 | Österreich AstraZeneca Österreich GmbH Tel: +43 1 711 31 0 |
España AstraZeneca Farmacéutica Spain, S.A. Tel: +34 91 301 91 00 | Polska AstraZeneca Pharma Poland Sp. z o.o. Tel.: +48 22 245 73 00 |
France AstraZeneca Tél: +33 1 41 29 40 00 | Portugal AstraZeneca Produtos Farmacêuticos, Lda. Tel: +351 21 434 61 00 |
Hrvatska AstraZeneca d.o.o. Tel: +385 1 4628 000 | România AstraZeneca Pharma SRL Tel: +40 21 317 60 41 |
Ireland AstraZeneca Pharmaceuticals (Ireland) Ltd Tel: +353 1609 7100 | Slovenija AstraZeneca UK Limited Tel: +386 1 51 35 600 |
Ísland Vistor hf. Sími: +354 535 7000 | Slovenská republika AstraZeneca AB, o.z. Tel: +421 2 5737 7777 |
Italia AstraZeneca S.p.A. Tel: +39 02 00704500 | Suomi/Finland AstraZeneca Oy Puh/Tel: +358 10 23 010 |
Κ?προς Αλ?κτωρ Φαρµακευτικ? Λτδ Τηλ: +357 22490305 | Sverige AstraZeneca AB Tel: +46 8 553 26 000 |
Latvija SIA AstraZeneca Latvija Tel: +371 67377100 | United Kingdom (Northern Ireland) AstraZeneca UK Ltd Tel: +44 1582 836 836 |
Date of last revision of this leaflet:
Other sources of information
Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu/
How much does LOKELMA 5 g ORAL SUSPENSION POWDER cost in Spain ( 2025)?
The average price of LOKELMA 5 g ORAL SUSPENSION POWDER in December, 2025 is around 233.7 EUR. Prices may vary depending on the region, pharmacy, and whether a prescription is required. Always check with a local pharmacy or online source for the most accurate information.
- Country of registration
- Average pharmacy price233.7 EUR
- Active substance
- Prescription requiredYes
- Manufacturer
- This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
- Alternatives to LOKELMA 5 g ORAL SUSPENSION POWDERDosage form: ORAL SOLUTION/SUSPENSION, 10 gActive substance: sodium zirconium cyclosilicateManufacturer: Astrazeneca AbPrescription requiredDosage form: TABLET, 800 mgActive substance: sevelamerManufacturer: Sanofi Winthrop IndustriePrescription requiredDosage form: ORAL SOLUTION/SUSPENSION, 2.4 gActive substance: sevelamerManufacturer: Laboratorios Rubio S.A.Prescription required
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