Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

12+ years of clinical experience in university hospitals in Germany and Spain.
International education: Ukraine – Germany – Spain.
Member of the German Society of Surgeons (BDC).
Certified in radiological diagnostics and robotic surgery.
Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use IOPIMAX 10 mg/ml EYE DROPS SOLUTION

Introduction

PACKAGE LEAFLET: INFORMATION FOR THE USER

IOPIMAX 10 mg/ml eye drops, solution

Apraclonidine hydrochloride

Read this leaflet carefully before you start using this medicine because it contains important information for you.

Keep this leaflet, you may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

What IOPIMAX is and what it is used for
What you need to know before you are given IOPIMAX
How IOPIMAX is given
Possible side effects
Storing IOPIMAX
Contents of the pack and other information

Your doctor will give you IOPIMAX eye drops. This leaflet is intended to provide you with information about the medicine.

1. What IOPIMAX is and what it is used for

IOPIMAX eye drops contain apraclonidine, which is used to control or prevent increased pressure inside the eye after laser surgery

2. What you need to know before you are given IOPIMAX

This medicine may not be suitable for you. It is important that you review all the following points, as your doctor may decide to prescribe you a different medicine if any of them apply to you:

IOPIMAX should not be given

to children (this medicine is not indicated for children under 18 years of age)
if you are allergicto clonidine, apraclonidine, or any of the other ingredients of this medicine (listed in section 6)
if you have a historyof any uncontrolled, unstable, or severe heart disease (including chest pain, angina, heart attacks, or heart failure)
if you are taking monoamine oxidase inhibitors (used to treat depression)

If you think any of the above points apply to you or you have doubts, consult your doctor before you are given this medicine.

Be cautious with IOPIMAX. Consult your doctor if:

You have or are taking medication for:
- heart disease (including chest pain, angina, heart attacks, or heart failure)
- high blood pressure
- circulatory problems (including stroke, Raynaud's disease, or Buerger's disease)
- vasovagal attacks (fainting episodes)
- reduced liver or kidney function

If any of these points apply to you, you may be at greater risk of effects on your heart or circulatory system, and your blood pressure and heart rate will be closely monitored.

? You suffer from depression, as clonidine and its derivatives can cause depression

? You suffer from diabetesor have low blood sugar levels, as this medicine can mask the signs and symptoms of a sudden drop in blood sugar, such as rapid heartbeat or tremors

? You regularly drink alcohol, as IOPIMAX can increase its effects

? You have had an exaggerated response to other medicinesthat lower eye pressure, in which case your eye pressure will be closely monitored.

If any of the above points apply to you or you have doubts, consult your doctor before you are given this medicine.

Other medicines and IOPIMAX

IOPIMAX should not be given

? If you are takingmonoamine oxidase inhibitors (used to treat depression), e.g., phenelzine, isocarboxazid, tranylcypromine, moclobemide

? If you are takingtricyclic antidepressants (frequently used to treat depression), e.g., amitriptyline, imipramine, doxepin, mianserin, trazodone, dosulepin, lofepramine

? If you are takingmedicines containing sympathomimeticsused to treat various diseases, including asthma (e.g., salbutamol, terbutaline, bambuterol), Parkinson's disease, and heart disease, and which may also be present in cough and cold medicines.

Be cautious with IOPIMAX

? If you are takingeye drops for glaucomathat contain sympathomimetics, e.g., phenylephrine, brimonidine, dipivefrine, as your blood pressure may increase

? If you are takingsleeping pills, pain relievers, or sedatives, as IOPIMAX can increase their effects

? If you are taking or have takenneuroleptics(very potent tranquilizers used to treat some mental illnesses, e.g., chlorpromazine, flupentixol, haloperidol), as your blood pressure may drop too low.

In case of potential effects on your blood pressure, it will be closely monitored, along with your heart rate.

Before you are given IOPIMAX, inform your doctor if you are taking, have recently taken, or might take any other medicine.

Using IOPIMAX with food and drinks

IOPIMAX should be used with caution if you have recently drunk alcohol or do so regularly.

Pregnancy, breastfeeding, and fertility

IOPIMAX should not be used if you are pregnant, think you may be pregnant, or are breastfeeding.

Your doctor should have informed you about this. If not, consult your doctor before using any medicine.

Driving and using machines

This type of medicine can cause drowsiness. If this happens, do not drive or operate tools or machines.

3. How IOPIMAX is given

Adults and elderly patients

IOPIMAX comes in a specially designed single-use container. Your doctor will give you one drop one hour before laser surgery and another drop immediately after surgery.

After you are given IOPIMAX, you will be instructed to press the edge of your eye, next to your nose, with your finger. This helps prevent IOPIMAX from entering the rest of your body.

If you are using other eye medicines, wait at least 5 minutes between giving this eye drop and the other eye medicines. Eye ointments should be given last.

Use in children

This medicine should not be used in children.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

When used before and after laser surgery,you may experience some or all of the following side effects in your eyes:

Common(may affect up to 1 in 10 people treated)

redness in one or both eyes
increased pupil size
inability to close the eye
eye disorder (white appearance of the eye surface)
unusual or uncomfortable sensation in the eye
dry eye sensation

Uncommon(may affect up to 1 in 100 people treated)

bleeding on the eye surface (conjunctival hemorrhage)
eye inflammation (which may include pain, burning, redness, or swelling of the eye)

eye

retraction or lifting of the upper eyelid
extremely low pressure inside the eye (your doctor will notice this during eye checks)

eye

blurred or reduced vision
bleeding on the eye surface
blurred vision
eye allergy
eye itching
eye irritation

You may also experience side effects in other parts of your body:

Common(may affect up to 1 in 10 people treated)

dryness in the nose
unpleasant taste

Uncommon(may affect up to 1 in 100 people treated)

irregular heartbeats
difficulty sleeping
disturbed dreams
fainting episodes
burning or tingling sensations
decreased libido
feeling irritable
slow or rapid heartbeats
feeling of fainting or dizziness when sitting or standing up
diarrhea
nausea or vomiting
stomach pain or discomfort
headaches
fatigue

Rare(may affect up to 1 in 1,000 people treated)

reduced sensitivity or numbness (tingling sensation)
difficulty breathing
runny nose or excessive saliva
dryness or burning sensation in the nose
dry mouth
increased sweating
skin itching
pain in arms or legs
chest tightness or pain
feeling hot or cold

Frequency not known(cannot be estimated from the available data)

low blood pressure
high blood pressure

If you experience an allergic reaction, unusual dizziness, or delirium, or have irregular heartbeats, inform your doctor immediately.

Reporting side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing IOPIMAX

Do not use IOPIMAX after the expiry date stated on the outer packaging and on the container after "EXP". The expiry date is the last day of the month shown.
Do not store above 25°C. Store in the outer packaging to protect from light.
Keep out of the reach and sight of children.
Use immediately after opening.

6. Contents of the pack and other information

Composition of IOPIMAX

The active ingredient is apraclonidine 10 mg/ml (as hydrochloride).
The other ingredients are sodium acetate, sodium chloride, and purified water. Small amounts of hydrochloric acid or sodium hydroxide may be added to make the drops more suitable for your eyes.

Appearance and packaging of the product

IOPIMAX 10 mg/ml eye drops, solution is pale yellow and comes in a 0.25 ml container.

Marketing authorization holder:

Essential Pharma Limited,

Vision Exchange Building

Triq it-Territorjals, Zone 1,

Central Business District,

Birkirkara, CBD 1070,

Malta

Manufacturer:

Alcon Couvreur N.V.

Rijksweg, 14

B-2870 Puurs, Belgium

Date of last revision of this leaflet:April 2018

IOPIMAX 10 mg/ml EYE DROPS SOLUTION

Yevgen Yakovenko

Antonio Cayatte

Yevgen Yakovenko

Antonio Cayatte