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GRANUPAS 4 g gastro-resistant granules

Ask a doctor about a prescription for GRANUPAS 4 g gastro-resistant granules

5.0(13)
Doctor

Tarek Agami

General medicine11 years of experience

Dr. Tarek Agami is a general practitioner registered in both Portugal and Israel, with broad experience in family and preventive medicine. He offers online consultations for adults and children, providing personalised support for primary care needs, chronic disease management, and everyday health concerns.

Dr. Agami received clinical training and worked in leading medical institutions in Israel (Kaplan Medical Center, Barzilai Medical Center, Wolfson Medical Center) and Portugal (European Healthcare City, Viscura Internacional, Hospital Dr. José Maria Grande, Hospital Vila Franca de Xira). His approach combines international medical standards with individualised attention to each patient.

Main areas of consultation:

  • Diagnosis and treatment of acute and chronic conditions (high blood pressure, diabetes, respiratory infections, cardiovascular symptoms)
  • Evaluation of symptoms and guidance on further diagnostic testing
  • Preventive check-ups and regular health monitoring
  • Medical support during travel or after relocation
  • Treatment adjustments and lifestyle recommendations based on your personal history
Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

Dr. Agami is committed to evidence-based, patient-centred care, ensuring that each person receives trusted medical support tailored to their health goals.

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Doctor

Nuno Tavares Lopes

Family medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use GRANUPAS 4 g gastro-resistant granules

Introduction

Package Leaflet: Information for the Patient

GRANUPAS 4 g Gastro-Resistant Granules

Para-aminosalicylic acid

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet

  1. What is GRANUPAS and what is it used for
  1. What you need to know before you take GRANUPAS
  2. How to take GRANUPAS
  1. Possible side effects
  2. Storage of GRANUPAS
  3. Contents of the pack and other information

1. What is GRANUPAS and what is it used for

GRANUPAS contains para-aminosalicylic acid which is used in adults and in children from 28 days of age or older to treat resistant tuberculosis, in combination with other medicines, in cases of resistance or intolerance to other treatments.

2. What you need to know before you take GRANUPAS

Do not take GRANUPAS

  • if you are allergic to para-aminosalicylic acid or any of the other ingredients of this medicine (listed in section 6).
  • if you have severe kidney disease.

If you are not sure, consult your doctor or pharmacist before taking GRANUPAS.

Warnings and precautions

Consult your doctor or pharmacist or nurse before starting treatment with GRANUPAS

  • if you have liver problems or mild or moderate kidney disease
  • if you have a stomach ulcer
  • if you are infected with HIV

Children

GRANUPAS is not recommended for use in newborn babies (less than 28 days old).

Other medicines and GRANUPAS

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

It is especially important that you tell your doctor if you are taking any of the following medicines:

  • Anti-tuberculosis medicines or ethionamide (other treatments for tuberculosis)
  • Vitamin B12
  • Digoxin (for heart disease)
  • Diphenhydramine (for allergic reactions)

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

GRANUPAS should not be taken during pregnancy and should only be used if your doctor considers it essential. Do not breast-feed while taking GRANUPAS, as small amounts of this medicine may pass into breast milk.

Driving and using machines

GRANUPAS is unlikely to affect your ability to drive or use machines. If this happens, tell your doctor or pharmacist.

3. How to take GRANUPAS

Follow exactly the administration instructions of this medicine given by your doctor.

In case of doubt, ask your doctor or pharmacist.

Adults

The recommended dose for adults is 1 sachet, 3 times a day, with a schedule of 1 sachet every 8 hours. Your doctor may need to start treatment with a lower dose to avoid possible side effects.

Do not take more than 3 sachets per day. The treatment is usually given for two years (24 months).

  • Empty the contents of the sachet into a glass of tomato or orange juice.
  • Drink it immediately.
  • If some granules remain in the glass, add a little more juice and drink it immediately.

Use in infants, children and adolescents

The doctor will calculate the dose for infants, children and adolescents based on the patient's body weight. The recommended total daily dose is 150 mg per kg of body weight. This daily amount is divided into two doses distributed throughout the day.

  • Use the measuring spoon provided with the medicine to measure the dose.
  • To measure the dose:
    1. The lines on the measuring spoon indicate the amount (in milligrams of para-aminosalicylic acid). Take the correct amount that your doctor has prescribed.
    1. Put the granules directly into the measuring spoon.
      1. Gently tap the measuring spoon on a table to level the granules horizontally and fill it more if necessary.
    • Sprinkle the granules over apple puree or yoghurt.
    • Have your child eat it immediately.

    Use of this medicine

    • Do not crush or chew the granules. Swallow the granules whole. It is important that you do not dissolve, crush or chew the granules, as they may not be absorbed correctly and may cause stomach pain or bleeding.
    • Do not use the sachet if it is swollen or the granules have lost their original light brown color.
    • You may see granules in the stool; this is normal.

    If you take more GRANUPAS than you should

    Consult your doctor or pharmacist.

    If you forget to take a dose of GRANUPAS

    Do not take a double dose to make up for forgotten doses. Wait until the next dose is due and take the usual dose.

    If you have any other questions on how to use this medicine, ask your doctor or pharmacist.

    4. Possible side effects

    Like all medicines, this medicine can cause side effects, although not everybody gets them.

    During the first 3 months of your treatment with GRANUPAS, you should pay attention to any signs of an allergic reaction (such as rash, red spots on the skin that itch, itching, hives, watery eyes, itchy eyes or nasal congestion) or hepatitis (such as fever, fatigue, dark urine, very light stools, abdominal pain, yellow skin and eyes). If you experience any of these symptoms, you should consult your doctor immediately.

    Common side effects (occurring in more than 1 patient in 100):

    • dizziness,
    • stomach pain (abdominal pain),
    • vomiting,
    • nausea,
    • hiccups,
    • diarrhea,
    • soft stools,
    • redness of the skin or rash,
    • alteration of gait or balance.

    Uncommon side effects (occurring in more than 1 patient in 1,000):

    • loss of appetite (anorexia)

    Rare side effects (occurring in more than 1 patient in 10,000):

    • thyroid problems*,
    • decreased ability to absorb nutrients from food,
    • ulcer, intestinal bleeding,
    • yellowing of the skin or eyes (jaundice),
    • metallic taste,
    • itchy rash.
    • In people also infected with HIV, thyroid problems, in particular insufficient thyroid activity or low levels of thyroid hormones, are a very common side effect that may affect more than 1 in 10 people. Periodic monitoring of thyroid function is recommended for all people with HIV.

    Very rare side effects (occurring in less than 1 patient in 10,000):

    • reduction in the number of blood platelets,
    • red spots on the skin,
    • reduction in the number of white blood cells,
    • reduction in the number of red blood cells,
    • reduction in the ability of red blood cells to release oxygen,
    • low blood sugar levels,
    • tendon pain, headache,
    • visual disturbances, nerve damage to hands and feet,
    • dizziness,
    • crystals in the urine.
    • prolonged bleeding time,
    • liver cell destruction,
    • high enzyme levels,
    • weight loss,

    Side effects of unknown frequency (cannot be estimated from the available data)

    • hepatitis

    Reporting of side effects

    If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

    5. Storage of GRANUPAS

    Keep this medicine out of the sight and reach of children.

    Do not use this medicine after the expiry date which is stated on the carton and sachet after EXP. The expiry date is the last day of the month stated.

    Do not store above 25°C. Once opened, the sachets can be stored below 25°C for up to 24 hours.

    Do not use this medicine if you notice that the sachets are swollen or the granules are dark brown or purple in color

    Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

    6. Contents of the pack and other information

    Composition of GRANUPAS

    The active substance is para-aminosalicylic acid.

    Each sachet of gastro-resistant granules contains 4 g of para-aminosalicylic acid.

    The other ingredients are colloidal silicon dioxide, dibutyl sebacate, methacrylic acid copolymer (1:1) dispersion 30%, hypromellose, microcrystalline cellulose, talc.

    Appearance and packaging of the product

    This medicine is presented as a light brown gastro-resistant granule in sachets.

    Each carton contains 30 sachets. A measuring spoon is provided.

    Marketing authorisation holder

    Eurocept International BV

    Trapgans 5

    1244 RL Ankeveen

    The Netherlands

    Manufacturer

    Lucane Pharma

    172 rue de Charonne

    75011 Paris

    France

    Eurocept International BV

    Trapgans 5

    1244 RL Ankeveen

    The Netherlands

    You can request more information about this medicine from the local representative of the marketing authorisation holder:

    Belgium/Belgique/Belgien

    Lithuania

    Lucane Pharma

    FrostPharma AB

    Tel: + 33 153 868 750

    Tel: +46 775 86 80 02

    [email protected]

    [email protected]

    Bulgaria

    Luxembourg/Luxemburg

    Lucane Pharma

    Lucane Pharma

    Tel: + 33 153 868 750

    Tel: + 33 153 868 750

    [email protected]

    [email protected]

    Czech Republic

    Hungary

    Lucane Pharma

    Lucane Pharma

    Tel: + 33 153 868 750

    Tel: + 33 153 868 750

    [email protected]

    [email protected]

    Denmark

    Malta

    FrostPharma AB

    Lucane Pharma

    Tel: +45 808 20 101

    Tel: + 33 153 868 750

    [email protected]

    [email protected]

    Germany

    Netherlands

    Lucane Pharma

    Eurocept International BV

    Tel: + 33 153 868 750

    Tel: +31 35 528 39 57

    [email protected]

    [email protected]

    Estonia

    Norway

    FrostPharma AB

    FrostPharma AB

    Tel: +46 775 86 80 02

    Tel: +47 815 03 175

    [email protected]

    [email protected]

    Greece

    Austria

    Lucane Pharma

    Lucane Pharma

    Tel: + 33 153 868 750

    Tel: + 33 153 868 750

    [email protected]

    [email protected]

    Spain

    Poland

    Lucane Pharma

    Lucane Pharma

    Tel: + 33 153 868 750

    Tel: + 33 153 868 750

    [email protected]

    [email protected]

    France

    Portugal

    Lucane Pharma

    Overpharma

    Tel: + 33 153 868 750

    Tel: +351 214 307 760

    [email protected]

    [email protected]

    Croatia

    Romania

    Lucane Pharma

    Lucane Pharma

    Tel: + 33 153 868 750

    Tel: + 33 153 868 750

    [email protected]

    [email protected]

    Ireland

    Slovenia

    Lucane Pharma

    Lucane Pharma

    Tel: + 33 153 868 750

    Tel: + 33 153 868 750

    [email protected]

    [email protected]

    Iceland

    Slovakia

    FrostPharma AB

    Lucane Pharma

    Tel: +46 775 86 80 02

    Tel: + 33 153 868 750

    [email protected]

    [email protected]

    Italy

    Finland

    Lucane Pharma

    FrostPharma AB

    Tel: + 33 153 868 750

    Tel: +35 875 32 51 209

    [email protected]

    [email protected]

    Cyprus

    Sweden

    Lucane Pharma

    FrostPharma AB

    Tel: + 33 153 868 750

    Tel: +46 775 86 80 02

    [email protected]

    [email protected]

    Latvia

    United Kingdom

    FrostPharma AB

    Lucane Pharma

    Tel: +46 775 86 80 02

    Tel: + 33 153 868 750

    [email protected]

    [email protected]

    Date of last revision of this leaflet:

    Other sources of information

    Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

    There are also links to other websites on rare diseases and orphan medicines.

Online doctors for GRANUPAS 4 g gastro-resistant granules

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for GRANUPAS 4 g gastro-resistant granules – subject to medical assessment and local rules.

5.0(13)
Doctor

Tarek Agami

General medicine11 years of experience

Dr. Tarek Agami is a general practitioner registered in both Portugal and Israel, with broad experience in family and preventive medicine. He offers online consultations for adults and children, providing personalised support for primary care needs, chronic disease management, and everyday health concerns.

Dr. Agami received clinical training and worked in leading medical institutions in Israel (Kaplan Medical Center, Barzilai Medical Center, Wolfson Medical Center) and Portugal (European Healthcare City, Viscura Internacional, Hospital Dr. José Maria Grande, Hospital Vila Franca de Xira). His approach combines international medical standards with individualised attention to each patient.

Main areas of consultation:

  • Diagnosis and treatment of acute and chronic conditions (high blood pressure, diabetes, respiratory infections, cardiovascular symptoms)
  • Evaluation of symptoms and guidance on further diagnostic testing
  • Preventive check-ups and regular health monitoring
  • Medical support during travel or after relocation
  • Treatment adjustments and lifestyle recommendations based on your personal history
Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

Dr. Agami is committed to evidence-based, patient-centred care, ensuring that each person receives trusted medical support tailored to their health goals.

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  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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Duarte Meneses

Family medicine5 years of experience

Dr. Duarte Meneses is a licensed family medicine and general practice doctor based in Portugal, with additional expertise in occupational health. He provides online consultations for adults, offering medical support for both acute symptoms and chronic health conditions.

  • Common symptoms such as fever, sore throat, cough, fatigue, or digestive issues
  • Chronic conditions including hypertension, diabetes, high cholesterol, and thyroid problems
  • Mental health concerns such as stress, sleep issues, anxiety, and burnout
  • Preventive care: health check-ups, lifestyle advice, and follow-up for existing conditions
  • Work-related health questions, sick leave documentation, and medical guidance for returning to work
Dr. Meneses graduated from the University of Beira Interior and has years of experience working with diverse patient populations. He is fluent in Portuguese, English, Spanish, and French.

His approach is friendly, clear, and focused on delivering practical medical advice tailored to each patient’s needs.

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His areas of focus include:

  • General and urgent care: fever, fatigue, infections, digestive issues, respiratory symptoms, and other common concerns
  • Chronic condition support: hypertension, high cholesterol, diabetes, thyroid issues
  • Aesthetic medicine and dermatology: acne, skin ageing, hyperpigmentation, personalised skincare guidance
  • Trichology: hair loss, scalp conditions, treatment strategies for men and women
  • Preventive care: health check-ups, lifestyle advice, second opinions

Dr. Correa combines medical knowledge with an aesthetic and holistic approach to help patients improve both health and quality of life.

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Her focus is on helping patients regain health through deep understanding of symptoms, personalised nutrition plans, and evidence-based correction of deficiencies, stress-related conditions, and metabolic imbalances. Dr Fedoryshyn works with adults experiencing chronic conditions, fatigue, hormonal disruption, and post-stress exhaustion.

She integrates medical analysis, psychological insight, and real-life behaviour change tools to offer treatment plans tailored to each patient’s biochemistry, mental state, and lifestyle.

Main areas of practice:

  • Chronic condition management and medical counselling
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  • Diagnosis and treatment of micronutrient deficiencies
  • Recovery from stress, burnout, and hormonal imbalances
  • Emotional support and psychosomatic symptom care
Her approach is never one-size-fits-all – each consultation begins with a deep dive into your unique health history, test results, and emotional landscape. Consultations are available in Ukrainian, Polish, and Russian.
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Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
  • questions about existing treatment and whether adjustments are needed
  • renewal of prescriptions when clinically appropriate
Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.

She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.

With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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Tomasz Grzelewski

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For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
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  • recurrent infections in children
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Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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  • assessment of sudden or unclear symptoms
  • ongoing care for chronic conditions
  • follow-up after hospital discharge
  • interpretation of test results
  • medical support while abroad
Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association.

Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

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Hocine Lokchiri

General medicine21 years of experience

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Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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