This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.

How to use CARDI-BRAUN REPERFUSION PERFUSION SOLUTION

Introduction

Leaflet: information for theuser

Cardi-Braun Reperfusion solution for perfusion

Read the entire leaflet carefully before starting tousethis medication.

Keep this leaflet, as you may need to read it again.
If you have any questions, consult your doctor or pharmacist.
If you think any of the side effects you are suffering from is serious or if you notice any side effect not mentioned in this leaflet, inform your doctor or pharmacist.

Contents of the leaflet

What Cardi-Braun Reperfusion is and what it is used for
Before using Cardi-Braun Reperfusion
How to use Cardi-Braun Reperfusion
Possible side effects
Storage of Cardi-Braun Reperfusion
Additional information

1. What is Cardi-Braun Reperfusion and what it is used for

The medications Cardi-Braun Maintenance and Cardi-Braun Reperfusion are solutions for intracardiac perfusion (administered directly to the heart through an external device that assumes the functions of the heart) that belong to the group of medications called cardioplegic solutions. The two solutions are used alternately during heart operations.

The cardioplegic solutions of B. Braun Medical are used in open-heart surgery to:

stop the heart and protect the heart muscle during the operation,
effectively resuscitate the heart function once the operation is finished.

2. Before using Cardi-Braun Reperfusion

Do not use Cardi-Braun Reperfusion

If you are allergic (hypersensitive) to the active ingredients or to any of the other components of Cardi-Braun Reperfusion.

If, in your clinical situation, the technique of stopping the heart with cardioplegic solutions may pose a threat to your life.

Be careful with Cardi-Braun Reperfusion

The cardioplegic solutions Cardi-Braun will only be used by qualified cardiac surgeons and specialists.

The cardioplegic solutions Cardi-Braun are not administered intravenously, they are released directly into the heart through an external device that assumes the functions of the heart during the operation.

During the operation, the medical team that assists you will carefully monitor your vital signs. In particular, they will evaluate:

the temperature of your heart,
the electrocardiogram (measures the electrical activity of the heart) and
the pressure and speed at which these solutions are administered.

For the recovery of the heart once the operation is finished, a defibrillation team (uses electric current to restore the heartbeat) and medications that increase the strength of the heart's contraction must be available.

Adequate intake of vitamins (particularly vitamin B1) must be ensured.

Use of other medications

Certain medications may influence the action of the Cardi-Braun solutions. In these cases, it may be necessary to change the dose or interrupt treatment with one of the medications.

Inform your doctor or pharmacist if you are using or have recently used other medications, including those purchased without a prescription.

Pregnancy and Breastfeeding

Consult your doctor or pharmacist before using any medication.

In case of pregnancy or breastfeeding, the medical team will decide on the convenience of using this medication.

Cardi-Braun Reperfusion contains sodium

This medication contains less than 23 mg of sodium (1 mmol) per 1 milliliter; that is, it is essentially "sodium-free".

3. How to use Cardi-Braun Reperfusion

This medication will always be administered by specialized medical personnel.

Your cardiac surgeon and medical team will decide on the most suitable dose for you.

This medication is injected directly into the heart (intracardiac perfusion) through a device called a heart-lung machine or pulmonary bypass.

This device assumes the functions of the heart and is responsible for pumping and circulating blood. This allows your heart to remain still during the intervention and allows the surgeons to operate on your heart without it moving or being filled with blood.

If you have been administered more Cardi-Braun Reperfusion than you should:

It is unlikely that this will happen because your doctor will determine the most suitable dose for you.

In case of overdose or accidental ingestion, consult the Toxicology Information Service. Phone (91) 562 04 20 indicating the product and the amount administered.

If you have any other questions about the use of this product, ask your doctor or pharmacist.

4. Possible side effects

Like all medications, Cardi-Braun Reperfusion can cause side effects, although not everyone will experience them.

Your surgeon will explain what the possible side effects are derived from the use of Cardi-Braun Reperfusion during the open-heart surgery you will undergo.

The following side effects of unknown frequency have been reported:

Cardiac disorders:

Myocardial infarction, ventricular arrhythmia, ventricular fibrillation.

Complementary tests:

Abnormal electrocardiogram, abnormal acid-base balance.

Metabolic and nutritional disorders:

Electrolyte imbalance, hyperglycemia (in patients receiving solutions with high glucose content; may require insulin administration).

Once the operation is finished and blood circulation is restored, the heartbeat may be delayed, so defibrillation of the heart (use of electric current to restore the heartbeat) and the use of medications to restore normal heart function may be necessary.

If you think any of the side effects you are suffering from is serious or if you notice any side effect not mentioned in this leaflet, inform your doctor or pharmacist.

Reporting side effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect that is not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: www.notificaRAM.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Cardi-Braun Reperfusion

Keep out of the reach and sight of children.

No special storage conditions are required.

Do not use Cardi-Braun Reperfusion after the expiration date indicated on the packaging. The expiration date is the last day of the month indicated.

Do not use Cardi-Braun Reperfusion if the solution is cloudy or sedimented.

Do not use Cardi-Braun Reperfusion if the packaging shows visible signs of deterioration.

Any unused solution must be disposed of in accordance with local requirements.

Medications should not be thrown away in drains or trash. Ask your pharmacist how to dispose of the packaging and medications you no longer need. This will help protect the environment.

6. Additional information

Composition of Cardi-Braun Reperfusion

The active ingredients are:

Per 1 mlPer 500 ml

Tromethamine 8.5620 mg 4.2810 g

Sodium citrate 6.1963 mg 3.0981 g

Citric acid monohydrate 0.7730 mg 0.3865 g

Sodium dihydrogen phosphate dihydrate 0.5913 mg 0.2956 g

Potassium chloride 2.3419 mg 1.1709 g

Glucose monohydrate 40.5530 mg 20.2765 g

Aspartic acid 7.8970 mg 3.9490 g

Glutamic acid 8.7990 mg 4.4000 g

Electrolyte composition:

Phosphates 3.79 mmol/l

Citrate 24.74 mmol/l

Sodium 186.2 mmol/l

Potassium 31.4 mmol/l

Chloride 31.4 mmol/l

Acetate 11 mmol/l

The other components are: Acetic acid (pH adjustment), sodium hydroxide, and water for injectable preparations.

Appearance of the product and packaging content

Cardi-Braun Reperfusion is a clear and transparent perfusion solution that comes in a single unit package containing a 500 ml flexible plastic bag.

Marketing authorization holder and manufacturer

Braun Medical SA

Ctra. de Terrassa, 121

08191-Rubí (Barcelona)

This leaflet was approved in:December 2024

This information is intended only for doctors or healthcare professionals:

Cardi-Braun Reperfusion perfusion solution is a ready-to-use solution.

Its administration is carried out through commercial systems that distribute the solution through the cardiopulmonary bypass device.

The volumes of solution that are perfused depend on the duration or type of open-heart surgical procedure.

The cardioplegic solutions Cardi-Braun can be administered to the coronary circulation through two routes - anterograde and retrograde - or in a mixed manner.

Cardi-Braun Reperfusion requires the addition of potassium chloride 2M for the induction phase.The addition of the potassium chloride solution must be carried out under strict aseptic conditions.

Instructions for the correct use of the Cardi-Braun cardioplegic solutions

Unfold the bag and place it on a hard surface. Open the central joint by pressing with both hands on one of the bag's chambers.

Pre-filled transparent syringe with yellow liquid and gray needle connected, ready for injection

Mix the contents by inverting the bag several times. The homogeneous mixture is ready for use.

Pre-filled transparent syringe with yellow liquid and gray needle connected, ready for injection

The addition of the potassium chloride solution can be incorporated directly into the bag through a syringe in the connector located at the bottom of the bag, using an aseptic procedure.

Pre-filled transparent syringe with yellow liquid and gray needle connected, ready for injection

Remove the white cap from the perfusion connector. Clean the connector and insert the intracardiac perfusion equipment. Perfuse according to protocol.

Pre-filled transparent syringe with yellow liquid and gray needle connected, ready for injection

Once the package is opened, use immediately.

Discard the unused fraction of the solution.

B|BRAUN

Country of registration
Spain
Active substance
cardioplegia solutions
Prescription required
Yes
Manufacturer
B Braun Medical S.A.
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
Alternatives to CARDI-BRAUN REPERFUSION PERFUSION SOLUTION
CARDI-BRAUN MAINTENANCE SOLUTION FOR INFUSION
Dosage form: INJECTABLE INFUSION, 500 ml
Active substance: cardioplegia solutions
Manufacturer: B Braun Medical S.A.
Prescription required
CARDIOPLEXOL SOLUTION FOR CARDIOPLEGIA
Dosage form: NULL, -
Active substance: cardioplegia solutions
Manufacturer: Mit Gesundheit Gmbh
Prescription required
CORHUM SOLUTION FOR CARDIOPLEGIA
Dosage form: NULL, -
Active substance: cardioplegia solutions
Manufacturer: S.A.L.F. S.P.A. Laboratorio Farmacologico
Prescription required

Alternatives to CARDI-BRAUN REPERFUSION PERFUSION SOLUTION in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to CARDI-BRAUN REPERFUSION PERFUSION SOLUTION in Poland

Glicophos

Dosage form: Concentrate, 216 mg/ml

Marketing authorisation holder (MAH): Fresenius Kabi Nederland B.V.

Prescription not required

Glicophos

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Marketing authorisation holder (MAH): Fresenius Kabi Nederland B.V.

Prescription not required

Peditrace

Marketing authorisation holder (MAH): Fresenius Kabi Hellas A.E.

Prescription not required

Glicophos

Dosage form: Concentrate, 216 mg/ml

Marketing authorisation holder (MAH): Fresenius Kabi AB

Prescription not required

Glicophos

Dosage form: Concentrate, 216 mg/ml

Marketing authorisation holder (MAH): Fresenius Kabi Hellas A.E.

Prescription not required

Addiphos

Dosage form: Concentrate, (170.1 mg + 133.5 mg + 14 mg)/ml

Manufacturer: Fresenius Kabi Norge AS

Prescription not required

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