Carvedilol
Vivacor, 6.25 mg, 12.5 mg or 25 mg, tablets contain the active substance carvedilol, which dilates blood vessels by blocking alpha-1 adrenergic receptors and inhibits the renin-angiotensin-aldosterone system by blocking beta-adrenergic receptors. Vivacor is indicated for the treatment of:
Before starting treatment with Vivacor, discuss it with your doctor or pharmacist.
As with all beta-adrenergic blocking agents, carvedilol should not be stopped abruptly. This is especially important for patients with coronary artery disease. The dose of carvedilol should be reduced gradually (over 2 weeks).
Tell your doctor or pharmacist about all the medicines you are taking now or have taken recently, as well as any medicines you plan to take. It is especially important to inform your doctor if you are taking:
Vivacor can be taken with or without food. Vivacor may enhance the effects of alcohol.
If you are pregnant or breastfeeding, think you may be pregnant, or plan to have a child, ask your doctor or pharmacist for advice before taking this medicine. Animal studies have shown a harmful effect on fertility. The potential risk to humans is unknown. Do not take Vivacor during pregnancy, unless the expected benefits of treatment outweigh the potential risks. Do not take Vivacor while breastfeeding, unless the expected benefits of treatment outweigh the potential risks.
As with many other medicines used to treat hypertension, remember that if you experience dizziness or other similar adverse effects, do not drive or operate machinery. This is especially important when starting treatment or changing your treatment, or when taking the medicine with alcohol.
Each Vivacor 6.25 mg tablet contains 50 mg of lactose and 12.5 mg of sucrose. Each Vivacor 12.5 mg tablet contains 62.5 mg of lactose. Each Vivacor 25 mg tablet contains 125 mg of lactose. If you have been told that you have an intolerance to some sugars, contact your doctor before taking this medicine.
The medicine contains less than 1 mmol (23 mg) of sodium per tablet, which means it is essentially 'sodium-free'.
Always take this medicine exactly as your doctor or pharmacist has told you. If you are not sure, ask your doctor or pharmacist. If you feel that the effect of Vivacor is too strong or too weak, talk to your doctor or pharmacist. Swallow the tablets with at least half a glass of water. Vivacor tablets should be taken with sufficient fluid. Patients with chronic heart failure should take the tablets with food. Vivacor tablets are available in the following strengths: 6.25 mg, 12.5 mg, and 25 mg.
Your doctor will adjust the dose of this medicine individually for you. Treatment with Vivacor will be started under the supervision of a doctor experienced in the treatment of heart failure and after assessing your clinical condition. Depending on the outcome of the clinical assessment, the medicine will be given in an outpatient or hospital setting.
Adults
The recommended initial dose is 3.125 mg twice daily for 2 weeks. If the medicine is well tolerated, the doctor will increase the dose at intervals of at least 2 weeks, according to the following scheme: to 6.25 mg twice daily, then to 12.5 mg twice daily, and up to 25 mg twice daily. The aim is to achieve the maximum tolerated dose by the patient. The maximum recommended dose for all patients with severe chronic heart failure and for patients with mild or moderate heart failure with a body weight below 85 kg is 25 mg twice daily. For patients with mild or moderate heart failure with a body weight above 85 kg, the maximum recommended dose is 50 mg twice daily.
In patients with systolic blood pressure <100 mmhg, during dose escalation of vivacor, there may be a worsening renal function and or an exacerbation heart failure. therefore, before each increase, the doctor will monitor assess severity subjective objective symptoms failure vasodilation.< p>
If treatment with Vivacor is interrupted for a period longer than 2 weeks, re-initiation of the medicine should start at a dose of 3.125 mg twice daily, and this dose should be gradually increased according to the above recommendations for dosing.
Elderly patients
Dosing is the same as for adults.
Children and adolescents
The safety and efficacy of Vivacor in children and adolescents (below 18 years) have not been established.
It is recommended to take the dose once daily.
Adults
The recommended initial dose is 12.5 mg once daily for the first 2 days. Then, the dose should be increased to 25 mg once daily. In most patients, this dose is sufficient, but if necessary, the doctor may increase the dose to a maximum of 50 mg, given as a single dose or in divided doses. Dose increases should be made at intervals of not less than 2 weeks.
Elderly patients
The recommended initial dose is 12.5 mg once daily. In many cases, this dose provides adequate blood pressure control. If the blood pressure-lowering effect is insufficient, the doctor may gradually increase the dose to the maximum recommended dose of 50 mg, given as a single dose or in divided doses.
Children and adolescents
The safety and efficacy of Vivacor in children and adolescents (below 18 years) have not been established.
Adults
The recommended initial dose is 12.5 mg twice daily for the first 2 days. Then, the dose should be increased to 25 mg twice daily.
Elderly patients
The maximum recommended daily dose is 50 mg, given in divided doses.
Children and adolescents
The safety and efficacy of Vivacor in children and adolescents (below 18 years) have not been established.
In patients with left ventricular dysfunction after myocardial infarction, the recommended initial dose is 6.25 mg twice daily. The patient will be monitored for 3 hours after the first dose. The doctor will increase the dose every 3-10 days to 12.5 mg twice daily, and then to 25 mg twice daily. In patients who do not tolerate a dose of 6.25 mg twice daily, the doctor will reduce the dose to 3.125 mg twice daily and continue this dose for 3-10 days. If this dose is well tolerated, it will be increased to 6.25 mg twice daily, and then gradually to 25 mg twice daily. The aim is to achieve the maximum tolerated dose by the patient.
Administration of Vivacor is contraindicated in patients with concomitant liver disease.
In patients with systolic blood pressure > 100 mmHg, there is no need to reduce the dose.
If you have taken more than the prescribed dose of Vivacor, contact your doctor or go to the nearest hospital immediately. Significant overdose may cause hypotension (low blood pressure), bradycardia (slow heart rate), heart failure, cardiogenic shock (inadequate blood supply to tissues and organs due to heart failure), and cardiac arrest. Respiratory disorders, bronchospasm, vomiting, impaired consciousness, and generalized seizures have also been observed.
Do not take a double dose to make up for a forgotten dose. If you miss a dose (or several doses), do not increase the next dose. Take the next dose at the usual time. Continue treatment as recommended by your doctor.
Treatment with Vivacor is long-term. Stopping the treatment abruptly may lead to the occurrence of chest pain and an increase in blood pressure, especially in patients with angina pectoris. The medicine should be discontinued gradually, according to your doctor's instructions. If you have any further questions about taking this medicine, ask your doctor or pharmacist.
Like all medicines, Vivacor can cause side effects, although not everybody gets them. Frequency of possible side effects:
Very common (occurring in more than 1 in 10 patients):
Common (occurring in up to 1 in 10 patients):
Uncommon (occurring in up to 1 in 100 patients):
Rare (occurring in up to 1 in 1000 patients):
Very rare (occurring in up to 1 in 10,000 patients):
In patients with congestive heart failure, during dose escalation of carvedilol, there may be an exacerbation of heart failure and fluid retention. In patients with chronic heart failure and low blood pressure, coronary heart disease, peripheral vascular disease, and/or concomitant renal dysfunction, during treatment with carvedilol, reversible worsening of renal function has been observed. The frequency of side effects does not depend on the dose, except for dizziness, visual disturbances, and bradycardia. The profile of side effects in patients with hypertension and angina pectoris treated with Vivacor is similar to that observed in patients with heart failure, although the frequency of these side effects is lower. Due to the beta-adrenergic blocking effect of Vivacor, during treatment, there may be an unmasking of latent diabetes, worsening of blood glucose control, and impairment of glucose regulation. Isolated cases of urinary incontinence in women have been reported, which resolved after discontinuation of treatment. Some patients treated with Vivacor may experience other side effects.
If you experience any side effects, including those not listed in this leaflet, please inform your doctor or pharmacist. Side effects can be reported directly to the Department of Drug Safety Monitoring, Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products, Al. Jerozolimskie 181C, 02-222 Warsaw, tel.: +48 22 49 21 301, fax: +48 22 49 21 309, website: https://smz.ezdrowie.gov.pl. Side effects can also be reported to the marketing authorization holder. By reporting side effects, you can help provide more information on the safety of this medicine.
Store in a temperature below 25°C. Vivacor 6.25 mg tablets: Store in the original package to protect from light and moisture. Vivacor 12.5 mg and 25 mg tablets: Store in the original package to protect from light. Keep out of the sight and reach of children. Do not use the medicine after the expiry date (EXP) stated on the package. The expiry date refers to the last day of the month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.
The active substance of Vivacor is carvedilol. One tablet contains 6.25 mg, 12.5 mg, or 25 mg of carvedilol. The other ingredients of Vivacor are: Vivacor 6.25 mg tablets - lactose monohydrate, crospovidone, sucrose, colloidal anhydrous silica, povidone K-25, magnesium stearate, and quinoline yellow (E 104). Vivacor 12.5 mg tablets - potato starch, lactose monohydrate, sodium lauryl sulfate, magnesium stearate, sodium croscarmellose, and colloidal anhydrous silica. Vivacor 25 mg tablets - potato starch, lactose monohydrate, sodium lauryl sulfate, magnesium stearate, sodium croscarmellose, and colloidal anhydrous silica.
Vivacor 6.25 mg tablets: Light yellow, elongated tablets with the marking "E 341" on one side and a score line on the other side. Vivacor 12.5 mg tablets: White or almost white, elongated, biconvex tablets with a score line on one side. Vivacor 25 mg tablets: White or almost white, round, biconvex tablets with a score line on one side. The tablets can be divided into equal doses. Vivacor 6.25 mg tablets are available in packs containing 30 or 60 tablets in OPA/Al/PVC/Al blisters, packaged in cardboard boxes. Vivacor 12.5 mg and 25 mg tablets are available in packs containing 30 or 60 tablets in PVC/Aluminum blisters, packaged in cardboard boxes.
PROTERAPIA Sp. z o.o., ul. Komitetu Obrony Robotników 45 D, 02-146 Warsaw
EGIS Pharmaceuticals PLC, 1165 Budapest, Bökényföldi út 118-120, Hungary
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