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Vasokinox

Ask a doctor about a prescription for Vasokinox

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Doctor

Tomasz Grzelewski

Dermatology20 years of experience

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use Vasokinox

B. PATIENT LEAFLET

2018-03-EU-4947-BE/H/134/001/IB/026

Leaflet included in the packaging: information for the user

VasoKINOX, 450 ppm mol/mol, medical gas, compressed

Nitric oxide
You should carefully read the contents of the leaflet before using the medicine, as it contains
important information for the user.

  • You should keep this leaflet, so that you can read it again if you need to.
  • If you have any further questions, you should ask your doctor.
  • If you experience any side effects, including any possible side effects not listed in the leaflet, you should tell your doctor.

Table of contents of the leaflet:

  • 1. What is VasoKINOX, 450 ppm mol/mol - medical gas, compressed and what is it used for
  • 2. Important information before using VasoKINOX, 450 ppm mol/mol, medical gas, compressed
  • 3. How to use VasoKINOX, 450 ppm mol/mol, medical gas, compressed
  • 4. Possible side effects
  • 5. How to store VasoKINOX, 450 ppm mol/mol, medical gas, compressed
  • 6. Contents of the packaging and other information

1. What is VasoKINOX and what is it used for

VasoKINOX is a gas mixture consisting of nitric oxide and nitrogen, used

  • • to treat newborns with respiratory failureassociated with increased pressure in the pulmonary circulation
  • • in the treatment of acute pulmonary hypertension(increase in blood pressure in the pulmonary circulation), which may occur during heart surgery in adults and newborns, infants and young children, children and adolescents from 0-17 years old.

2. Important information before using VasoKINOX

VasoKINOX should not be used:

  • in case of hypersensitivity to nitric oxide,
  • in newborns with certain heart defects, such as abnormal circulation in the heart (left-to-right or "bad" left-to-right shunt associated with the presence of a patent ductus arteriosus).

Warnings and precautions

  • VasoKINOX treatment should not be stopped suddenly.
  • Blood samples will be taken before starting treatment, and then regularly during administration of the medicine to monitor certain parameters.

Other medicines and VasoKINOX

  • Caution should be exercised when administering VasoKINOX in combination with the following medicines:
    • "nitric oxide donors" (such as medicines containing sodium nitroprusside and nitroglycerin). Their effect may be additive to the effect of VasoKINOX.
    • medicines that increase methemoglobin levels (such as medicines containing alkyl nitrates and sulfonamides, prilocaine). They may increase methemoglobin levels in the blood.

and sulfonamides, prilocaine). They may increase methemoglobin levels in the blood.

  • prostacyclin and its analogues
    • You should inform your doctor about all medicines you have taken recently.
    • It is up to the doctor to decide whether VasoKINOX and another medicine can be used at the same time.

Pregnancy, breastfeeding, and fertility:

Pregnancy:
The effect of using VasoKINOX in pregnant women is unknown.
As a precautionary measure, it is recommended to avoid using VasoKINOX during pregnancy.
Breastfeeding:
It is not known whether nitric oxide/metabolites pass into human milk.
A decision should be made to either stop breastfeeding or stop VasoKINOX treatment
after considering the benefits of breastfeeding for the baby and the benefits of treatment for the woman.
Fertility:
No studies have been conducted on the effects on fertility.
In case of pregnancy or breastfeeding, or if you are planning to become pregnant, you should consult your doctor before using this medicine.

3. How to use VasoKINOX

  • VasoKINOX is a medical gas administered exclusively in hospitals by medical personnel.
  • The doctor will determine the appropriate dose of VasoKINOX, as well as the duration of treatment, depending on the patient's clinical condition and age.
  • VasoKINOX is administered by inhalation using mechanical ventilationafter dilution of the air/oxygen mixture to patients in intensive care units as part of assisted breathing, as well as in the operating room.
  • After coming into contact with oxygen, nitric oxide can be converted into nitrogen dioxide, which has an irritating effect on the bronchi. Therefore, during therapy, the concentrations of inhaled nitric oxide and nitrogen dioxide are constantly measured.
  • In some clinical situations, administration of nitric oxide using a maskis possible for a very short period (5 to 10 minutes).

In case of overdose:

The doctor will take appropriate measures.

Stopping VasoKINOX treatment:

At the end of treatment in the intensive care unit, the doctor will gradually reduce the dose of VasoKINOX (weaning phase) while monitoring changes in the patient's condition.
In fact, sudden discontinuation of therapy after several hours of administration may affect the worsening of the patient's clinical condition, which is called the "rebound effect".
If you have any further questions about using this medicine, you should ask your doctor for additional information.
2018-03-EU-4947-BE/H/134/001/IB/026

4. Possible side effects

Like all medicines, VasoKINOX can cause side effects, although not everybody gets them.
Very common side effects (affecting more than 1 in 10 people) associated with VasoKINOX therapy include:

  • Low platelet count.

Common side effects (affecting more than 1 in 100 people) associated with VasoKINOX therapy include:

  • low blood pressure, decreased air volume in the lung or lung collapse.

Uncommon side effects (affecting between 1 in 100 and 1 in 1000 people) include:

  • increased methemoglobin levels (a form of hemoglobin that cannot carry oxygen), which reduces oxygen release to the body's tissues.

Rare side effects (frequency cannot be estimated from the available data) include:

  • bradycardia (slow heart rate) or low oxygen levels in the blood (hypoxemia) due to sudden discontinuation of treatment,
  • headache, dizziness, dry throat, and shortness of breath following accidental exposure to nitric oxide (e.g., due to equipment leak or cylinder leak).

If you experience any side effects, including any possible side effects not listed in the leaflet, you should tell your doctor or pharmacist or nurse.
Side effects can be reported directly to the Department of Adverse Reaction Monitoring of Medicinal Products of the Office for Registration of Medicinal Products, Medical Devices, and Biocidal Products
Al. Jerozolimskie 181C,
02-222 Warsaw ,
tel.: +48 22 49 21 301
fax: +48 22 49 21 309 e-mail: [email protected]
Side effects can also be reported to the marketing authorization holder.
By reporting side effects, you can help provide more information on the safety of this medicine.

5. How to store VasoKINOX

  • • The storage of VasoKINOX cylinders is ensured by the hospital.
  • • Store in a place inaccessible and invisible to children.
  • • Protect the cylinder from damage or falling and keep it away from flammable substances and materials and moisture.
  • There are no special recommendations for the storage temperature of the medicine.
  • • Securely fasten the cylinders to keep them in a vertical position and store them in a well-ventilated room.
  • Do not use this medicine after the expiry date stated on the label.
  • Do not dispose of the cylinder after it has been emptied. Empty cylinders will be collected by the supplier.

2018-03-EU-4947-BE/H/134/001/IB/026

6. Contents of the packaging and other information

What VasoKINOX contains

  • The active substance is nitric oxide, with a concentration of 450 ppm mol/mol
  • The other ingredient is nitrogen

What VasoKINOX looks like and what the pack contains

5-liter cylinder filled to 200 bar delivers 0.94 m
of gas at a pressure of 1 bar at a temperature of 15°C
11-liter cylinder filled to 200 bar delivers 2.1 m
of gas at a pressure of 1 bar at a temperature of 15°C
20-liter cylinder filled to 200 bar delivers 3.8 m
of gas at a pressure of 1 bar at a temperature of 15°C.
Not all pack sizes may be marketed.

Marketing authorization holder and manufacturer

Marketing authorization holder

AIR LIQUIDE S antéINTERNATIONAL
75 Quai d’Orsay
75341 PARIS Cedex 07
FRANCE

Manufacturer

AIR LIQUIDE S antéFRANCE
“Les Petits Carreaux”
2, avenue du Lys
94380 BONNEUIL-SUR-MARNE
FRANCE

Marketing authorization number

21898

This medicinal product is authorized in the Member States of the European Economic Area under the following names:

  • Austria: VasoKINOX, 450 ppm mol/mol Gas zur medizinischen Anwendung, druckverdichtet
  • Belgium: VasoKINOX
  • Denmark: Vasokinox
  • Germany: VasoKINOX, 450 ppm (mol/mol), Gas zur medizinischen Anwendung, druckverdichtet
  • Italy: VasoKINOX
  • Luxembourg: VasoKINOX
  • Norway: Vasokinox
  • Poland: VasoKINOX
  • Portugal: VasoKINOX
  • Spain: VasoKINOX
  • Sweden: Vasokinox
  • Netherlands: VasoKINOX

Prescription and dispensing conditions: 07/2018

Rpz - medicinal product dispensed with a doctor's prescription for restricted use.

Date of last revision of the leaflet:

-------------------------------------------------------
2018-03-EU-4947-BE/H/134/001/IB/026
The following information is intended exclusively for healthcare professionals:
In order to avoid accidents, you should carefully follow the following instructions:

  • check if the device is ready for use before using it.
  • securely fasten the cylinders using straps and hooks on the stand to prevent accidental falling
  • never open the valve suddenly: the valve should be slowly opened in the opposite direction to the clockwise direction until the end, and then turned in the clockwise direction.
  • never handle cylinders that do not have a protective cap and protective foil.
  • You should use a specific connector ISO 5145 (2004): No. 29 intended for NO/N2 (100 ppm
  • you should use a pressure regulator that provides a pressure of at least 1.5 times the maximum working pressure of the gas cylinder (200 bar)
  • when using the device for the first time, you should vent the pressure regulator/flow meter using the nitric oxide/nitrogen mixture
  • do not attempt to repair a faulty valve
  • do not tighten the pressure regulator/flow meter using wrenches, as this may cause the gasket to be crushed and the device to be damaged
  • exhaled gases should be discharged outside (avoiding areas where they may accumulate). Before use, you should ensure that the room has an appropriate ventilation system to discharge gases in case of an emergency or accidental leak.
  • since nitric oxide is colorless and odorless, it is recommended to use a detection system in all rooms where it will be used or stored.
  • American (NIOSH) and European authorities responsible for occupational safety and health recommend the following exposure limits:
    • - NO: 25 ppm over 8 hours (30 mg/m3)
    • - NO2: 2 ppm (4 mg/m3) In order to meet the above recommendations, it is necessary to analyze the content of nitric oxide and nitrogen dioxide in the atmosphere.
  • it is forbidden to install a permanent pipeline system supplying nitric oxide, including the station with reserve cylinders, stationary network, and inhalation sets.

2018-03-EU-4947-BE/H/134/001/IB/026

Alternatives to Vasokinox in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to Vasokinox in Spain

Dosage form: PULMONARY INHALATION, 800 PPM mol/mol
Active substance: nitric oxide
Prescription required
Dosage form: PULMONARY INHALATION, 1000 PPM mol/mol
Active substance: nitric oxide
Prescription required
Dosage form: PULMONARY INHALATION, 800 ppm mol/mol
Active substance: nitric oxide
Prescription required
Dosage form: PULMONARY INHALATION, 450 ppm mol/mol
Active substance: nitric oxide
Prescription required
Dosage form: PULMONARY INHALATION, 800 ppm (V/V)
Active substance: nitric oxide
Prescription required
Dosage form: PULMONARY INHALATION, 800 ppm mol/mol
Active substance: nitric oxide
Prescription required

Alternative to Vasokinox in Ukraine

Dosage form: gas, gas cylinder 2 liters
Active substance: nitric oxide
Manufacturer: Messer Avstria GmbH
Prescription required
Dosage form: tablets, 14 or 28 tablets in a container
Prescription required
Dosage form: capsules, 3.5 mg
Dosage form: capsules, 7 mg, 10 capsules in a blister
Dosage form: capsules, 7 mg, 10 capsules in a blister
Manufacturer: OM Farma SA
Prescription required
Dosage form: capsules, 3.5 mg; 10 capsules in a blister
Manufacturer: OM Farma SA
Prescription required

Online doctors for Vasokinox

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for Vasokinox – subject to medical assessment and local rules.

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Doctor

Tomasz Grzelewski

Dermatology20 years of experience

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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